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Showing posts from February 10, 2025

#USA, Confirmed #human #H5N1 #influenza virus case #summary since 2024, by state and exposure source: One new case in #Nevada (Feb. 10 '25)

{Excerpt} [ State - Exposure Source: Exposure Associated with Commercial Agriculture and Related Operations: Dairy Herds (Cattle) - Poultry Farms and Culling Operations - Other Animal Exposure† - Exposure Source Unknown‡ - State Total ] 1) California -  36 - 0 - 0 - 2 -  38 2) Colorado -  1 - 9 - 0 - 0 -  10 3) Iowa -  0 - 1 - 0 - 0 -  1 4) Louisiana -  0 - 0 - 1 - 0 -  1 5) Michigan -  2 - 0 - 0 - 0 -  2 6) Missouri -  0 - 0 - 0 - 1 -  1 7) Nevada -  1 - 0 - 0 - 0 - 1 {+1} 8) Oregon -  0 - 1 - 0 - 0 -  1 9) Texas -  1 - 0 - 0 - 0 -  1 10) Washington -  0 - 11 - 0 - 0 -  11 11) Wisconsin -  0 - 1 - 0 - 0 -  1 -- Source Total -  41 - 23 - 1 - 3 -  68 {+1} NOTE : One additional case was previ...

Novel #H16N3 avian #influenza viruses isolated from migratory #gulls in #China in 2023

Abstract As a rare subtype of avian influenza virus, H16 viruses are predominant in gulls but rarely found in domestic birds . The low prevalence of H16 viruses has limited our understanding of their epidemiology and evolutionary dynamics . In this study, we isolated three novel H16N3 viruses from migratory gulls in East Asian–Australasian Flyway in eastern China in 2023, which are significantly different from previously identified isolates. To fully understand the epidemiology and genetics characteristics of the global H16 viruses, we compared the host divergence of several rare subtypes and determined that the H13 and H16 subtypes were predominantly pooled into different species of gulls by sharing their internal genes, whereas the waterfowl of Anatidae served as the primary natural reservoirs of the H8, H11, H12, H14, and H15 subtypes. Detailed phylogenetic analysis revealed the evolutionary divergence of globally circulating H16 viruses and their frequent gene reassortment . Furthe...

Reduction of #Influenza A Virus #Prevalence in #Pigs at Weaning After Using Custom-Made Influenza #Vaccines in the Breeding #Herds of an Integrated Swine #Farm System

Abstract Vaccination is a common influenza A virus (IAV) control strategy for pigs. Vaccine efficacy depends on strain cross-protection and effective vaccination program implementation. We evaluated a multi-faceted IAV vaccination strategy which included (a) monthly surveillance of pigs at weaning , (b) selection of epidemiologically relevant strains from farms under surveillance, (c) updating IAV strains in custom-made vaccines, and (d) seasonal mass vaccination with custom-made vaccines given to sows in 35 farrow-to-wean farms within an integrated swine farm system. Reduction of IAV in pigs from vaccinated sows was determined by monthly monitoring of farms for 30 months by IAV rRT-PCR (PCR) testing of nasal wipes collected from litters of piglets at weaning. Hemagglutinin (HA) nucleotide and amino acid (AA) sequence homology of the circulating and vaccine strains was determined by pairwise alignment and AA comparison at antigenic sites. Of the 35 farms monitored, 28 (80%) tested posi...