#Influenza and Other Respiratory Viruses Research #References (AMEDEO, September 13 '26)

 

Antimicrob Agents Chemother

1. PENG Z, Yuan H, Huang J, Lin X, et al
   A novel ursodeoxycholic acid derivative exhibits broad-spectrum antiviral activity against influenza A virus and coronaviruses by multiphasic disruption of the viral life cycle.
   Antimicrob Agents Chemother. 2026 Sep 9:e0028426. doi: 10.1128/aac.00284.
   PubMed         Abstract available
   
   

   
   BMC Pediatr

2. BOZZOLA E, Piccotti E, D'Auria E, Trapani S, et al
   RESPIRIAMO - Italian hospital surveillance for lower respiratory tract infections: a multicenter retrospective cohort study of respiratory syncytial virus-associated hospitalizations in children under 2 years of age.
   BMC Pediatr. 2026;26:853.
   PubMed         Abstract available
   
   

   
   J Infect

3. ZHU X, Deng Y, Xiao G, Zhang J, et al
   Re-emergence of H10N3 Avian Influenza Viruses in China: Evolutionary Dynamics and Emerging Zoonotic Risk.
   J Infect. 2026 Sep 7:106848. doi: 10.1016/j.jinf.2026.106848.
   PubMed        
   
   

   
   J Virol Methods

4. EZEANYAEGBU CN, Toledo NP, Corkum CP, Nelder M, et al
   Evaluation of one-step amplicon-based targeted enrichment for SARS-CoV-2 whole-genome sequencing using the Midnight amplicon scheme.
   J Virol Methods. 2026;346:115448.
   PubMed         Abstract available
   
   
5. KAZEMIAN S, Pedroza S, Santana-Pereira ALR, Neasham PJ, et al
   An enhanced multisegment RT-PCR method for influenza A virus sequencing: Improved performance and reduced preparation time over traditional methods.
   J Virol Methods. 2026;347:115453.
   PubMed         Abstract available
   
   

   
   PLoS Comput Biol

6. QUILTY BJ, Chapman LAC, Munday JD, Wong KLM, et al
   Disentangling the drivers of heterogeneity in SARS-CoV-2 transmission from data on viral load and daily contact rates.
   PLoS Comput Biol. 2026;22:e1014715.
   PubMed         Abstract available
   
   
7. SONG P, de Vlas SJ, Emery T, Coffeng LE, et al
   Mapping spatial colleague connectivity patterns from individual-level registry data to inform regional pandemic interventions.
   PLoS Comput Biol. 2026;22:e1014721.
   PubMed         Abstract available
   
   
8. PANT B, Lalovic M, Kiss IZ, Santillana M, et al
   The paradox of neglecting changes in behavior: How standard epidemic models misestimate both transmissibility and final epidemic size.
   PLoS Comput Biol. 2026;22:e1014746.
   PubMed         Abstract available
   
   
9. YUAN Z, Zhang X, Lin G, Zou Q, et al
   AET5: A transcriptome-guided molecular generation framework with contrastive self-supervised learning.
   PLoS Comput Biol. 2026;22:e1014703.
   PubMed         Abstract available
   
   
10. BENHAMOU W, Howerton E, Park SW, Viboud C, et al
    Leveraging perturbations to infer the population dynamics of human rhinovirus and interaction of influenza A virus.
    PLoS Comput Biol. 2026;22:e1014784.
    PubMed         Abstract available
    
    

    
    PLoS Med

11. LENGLART L, Titomanlio L, Alberti I, Almeida L, et al
    Association between nirsevimab coverage and pediatric emergency department visits for bronchiolitis in 12 European countries: An interrupted time-series analysis.
    PLoS Med. 2026;23:e1005223.
    PubMed         Abstract available
    
    

    
    PLoS One

12. KWON K, Jang CY, Kim W, Son J, et al
    Kinetics of the PASC Index in Long COVID.
    PLoS One. 2026;21:e0357670.
    PubMed         Abstract available
    
    
13. BATTU S, Moore AR, Lebold K, Pacheco-Navarro A, et al
    Outcomes of immunocompromised and non-immunocompromised patients in the ICU diverge late in the pandemic.
    PLoS One. 2026;21:e0357181.
    PubMed         Abstract available
    
    
14. JI M, Dong H, Xu Y, Wang Y, et al
    Development of a multiplex real-time PCR assay with fluorescence probe-melting-curve analysis for one-tube detection of respiratory pathogens.
    PLoS One. 2026;21:e0357377.
    PubMed         Abstract available
    
    
15. GONG X, Liu L, Lu Y, Zhang G, et al
    Sleepless in America: A social sensing study of pandemic-era sleeplessness using nighttime social media data.
    PLoS One. 2026;21:e0356547.
    PubMed         Abstract available
    
    
16. BHATIA A, Elser J, Carrell SJ, Kronmiller B, et al
    Correlation assessment of SARS-CoV-2 variants and their subvariants present in clinical and wastewater samples in Oregon, USA (February 7, 2021 - February 26, 2022) using the Freyja bioinformatics approach.
    PLoS One. 2026;21:e0357591.
    PubMed         Abstract available
    
    
17. MOHD YUSOFF H, Yew SQ, Mohd Nawi A, Mohd Tohit N, et al
    Prevalence and risk factors of adverse work outcomes among manufacturing workers with Long COVID in Malaysia - A nationwide study.
    PLoS One. 2026;21:e0357125.
    PubMed         Abstract available
    
    
18. VALDES-LOPEZ JF, di Filippo D, Penagos S, Hernandez-Sarmiento LJ, et al
    SARS-CoV-2 infection induces functional impairment of vitamin D receptor signaling to drive interleukin 6-dependent hyperinflammation in mononuclear phagocytes.
    PLoS One. 2026;21:e0357030.
    PubMed         Abstract available
    
    
19. AMARSANAA J, Nguyen TXT, Khan MSR, Kadoya Y, et al
    The dynamics of loneliness: A longitudinal exploration of transitions in Japan across the COVID-19 period, 2020-2024.
    PLoS One. 2026;21:e0358269.
    PubMed         Abstract available
    
    

    
    Proc Natl Acad Sci U S A

20. LI L, Nguyen L, Qu H, Wu Q, et al
    Increased receptor binding and spike glycosylation, remodeled immune escape of surging SARS-CoV-2 subvariant BA.3.2.2/RE.2.2/Cicada.
    Proc Natl Acad Sci U S A. 2026;123:e2614163123.
    PubMed         Abstract available
    
    

    
    Vaccine

21. BUCKLIN R, Gauthreaux N, Faber E, Askelson N, et al
    Listening to micropolitan community leaders to support pandemic response efforts.
    Vaccine. 2025;60 Suppl 1:127255.
    PubMed         Abstract available
    
    
22. HOLLIDAY RC, Darkwa A, Brooks GA, Akintobi TH, et al
    Developing counter-narratives to address COVID-19 misinformation among 18-24 year olds in community and campus settings.
    Vaccine. 2025;60 Suppl 1:127135.
    PubMed         Abstract available
    
    
23. HEIMAN SL, Geiger N
    Overestimation of racial ingroup worry about the COVID-19 vaccine and medical racism.
    Vaccine. 2026;91:129046.
    PubMed         Abstract available
    
    
24. DUTTA S, Ngemera D, Jaillard P, Juneja S, et al
    Lessons learnt from one-year cold chain support for COVID-19 vaccination in 5 middle income countries of North Africa.
    Vaccine. 2026;91:128994.
    PubMed         Abstract available
    
    
25. CAMPBELL STATLER M, Bishop-Royse J, Sampson AT, Martin M, et al
    Heterogeneity among the vaccine hesitant: A secondary analysis of the national CEAL Common Survey data.
    Vaccine. 2026;91:129024.
    PubMed         Abstract available
    
    
26. KIM SJ, Kim HW, Son SE, Song JH, et al
    Wuhan-ancestral multi-antigen SARS-CoV-2 virus-like particles protect against the omicron sublineage JN.1 variant.
    Vaccine. 2026;91:129059.
    PubMed         Abstract available
    
    
27. FAHFOUHI Y, Fievez S, Cohen R, Levy C, et al
    A health-economic assessment of the impact of different RSVpreF maternal vaccine strategies to prevent RSV infections among young infants, in France: EPIPACT.
    Vaccine. 2026;91:129036.
    PubMed         Abstract available
    
    
28. BERIKOPOULOU MM, Tatsi EB, Siahanidou T, Michos A, et al
    Systematic review of the mutations in the active antigenic site O of the prefusion F protein of the Respiratory Syncytial Virus (RSV) following the implementation of monoclonal antibody prophylaxis.
    Vaccine. 2026;91:129069.
    PubMed         Abstract available
    
    
29. NUNES JPDS, Daher IP, Pires ADS, Yamamoto MM, et al
    Synergistic effect of AddaS03 and poly I:C adjuvants on antibody titers and Th1-biased T cell responses following RBD vaccination in BALB/c mice.
    Vaccine. 2026;91:129073.
    PubMed         Abstract available
    
    
30. MONOI A, Endo A, Kriznar M, Suzuki M, et al
    Comparing the potential impacts of seasonal immunisation against year-round immunisation to prevent RSV infant hospitalisations in Japan: A modelling study.
    Vaccine. 2026;91:129079.
    PubMed         Abstract available
    
    
31. SCHRARSTZHAUPT IN, Diaz-Quijano FA
    Effectiveness of COVID-19 vaccination schedules against severe COVID-19 in children aged 6 months to 4 years in Brazil: A population-based cohort study (2023-2024).
    Vaccine. 2026;91:129096.
    PubMed         Abstract available
    
    
32. ALAMI A, Lewis M, El-Chaar D, Walker M, et al
    Maternal vaccination with RSVpreF and risk of hypertensive disorders of pregnancy: a systematic review and meta-analysis.
    Vaccine. 2026;91:129070.
    PubMed         Abstract available
    
    
33. DENG L, Ye X, Chen X, Hu X, et al
    Secretory expression of tetrameric neuraminidase enhanced by signal peptide optimization elicits robust immunity against influenza infection in mice.
    Vaccine. 2026;92:129118.
    PubMed         Abstract available
    
    
34. SANBORN J, Robertson MM, Penrose K, Rane M, et al
    Gaps between willingness and uptake of influenza and COVID-19 vaccines during the 2025-26 respiratory virus season in a U.S. adult cohort.
    Vaccine. 2026;92:129126.
    PubMed         Abstract available
    
    
35. LU J, Ouyang Z, Huang F, Xie X, et al
    Real-world effectiveness of the influenza vaccine among school-aged children in Shenzhen, China, 2024-2025 season: A test-negative design study.
    Vaccine. 2026;92:129100.
    PubMed         Abstract available
    
    
36. THAKKAR V, Aryan Y, Gautam S, Joshi R, et al
    Influence of vaccine delivery route on immune imprinting in influenza vaccination.
    Vaccine. 2026;92:129109.
    PubMed         Abstract available
    
    
37. TORAIH EA, Hussein MH, Thomas SJ, Aiash H, et al
    Cardiac outcomes following SARS-CoV-2 infection versus BNT162b2 vaccination in adolescents and young adults: a cohort study of 4 million individuals.
    Vaccine. 2026;91:129001.
    PubMed         Abstract available
    
    
38. CABURNAY CA, Fu QJ, Carter T, Butler T, et al
    Identification of best outreach strategies and delivery modalities for population subgroups for COVID-19 vaccination.
    Vaccine. 2026;60 Suppl 1:128721.
    PubMed         Abstract available
    
    
39. CANACA G, Vicuna B, Hess JM, Cruz TH, et al
    From engagement to ownership: a qualitative study of a community-academic partnership to promote COVID-19 vaccine confidence among Latino/Hispanic communities in New Mexico.
    Vaccine. 2026;60 Suppl 1:128583.
    PubMed         Abstract available
    
    
40. STIEHL E, Negrete M, Flores G, Federmeyer L, et al
    Empowering communities during the COVID-19 pandemic: insights from trusted messengers about their work addressing COVID-19 vaccine hesitancy.
    Vaccine. 2026;60 Suppl 1:128559.
    PubMed         Abstract available
    
    
41. NUNO T, Soto S, Sepulveda R, Sierra LA, et al
    The Arizona prevention research center vaccine confidence network: A Mobile health unit intervention and survey results of barriers and facilitators to COVID-19 vaccination.
    Vaccine. 2025;60 Suppl 1:127970.
    PubMed         Abstract available
    
    
42. HARA-HUBBARD KK, Beaulieu A, Mendiola A, Gandhi P, et al
    Strategies for addressing COVID-19 vaccine equity with intermediaries, prevention research centers, and the vaccine confidence network.
    Vaccine. 2025;60 Suppl 1:127847.
    PubMed         Abstract available
    
    
43. CHUVILEVA YE, Kuiper NM, Ramakrishnan A, Goodman K, et al
    Weaving a public health network: Process and results from an evaluation of CDC's Prevention Research Centers Vaccine Confidence Network.
    Vaccine. 2025;60 Suppl 1:127636.
    PubMed         Abstract available
    
    
44. ALMUKHTAR S, McWhirter N, Mendiola A, Samuel S, et al
    Exploring lingering COVID-19 vaccine hesitancy in three diverse U.S. states: Alabama, Illinois, and Texas.
    Vaccine. 2025;60 Suppl 1:127664.
    PubMed         Abstract available
    
    
45. BEAULIEU A, LaMonaca K, Higginbottom J, Foster J, et al
    Utilizing the Program Impact Pathways framework for improving COVID-19 vaccine confidence and uptake: demonstrations of multi-sector collaboration from two geographies in Connecticut.
    Vaccine. 2025;60 Suppl 1:127623.
    PubMed         Abstract available
    
    
46. JEFFERS A, Kuiper NM, Ramakrishnan A, Swarna H, et al
    Building trust in community-academic partnerships: Strategies for enhancing vaccine confidence and demand - Lessons from Prevention Research Centers.
    Vaccine. 2025;60 Suppl 1:127624.
    PubMed         Abstract available
    
    
47. MCGEE RE, Barrett DA, Bednarczyk RA, Grant-Whitlock M, et al
    Engaging rural and non-Hispanic Black persons in conversations about the COVID-19 vaccine: a process evaluation of a natural helper intervention.
    Vaccine. 2025;60 Suppl 1:127587.
    PubMed         Abstract available
    
    
48. BORG A, Goulding M, Minkah P, Perrone D, et al
    Promotion of COVID-19 vaccination for youth and families in Worcester, Massachusetts: a Diffusion of Innovations approach.
    Vaccine. 2025;60 Suppl 1:127586.
    PubMed         Abstract available
    
    
49. SAVAS LS, Cuccaro P, Zhang K, Hernandez R, et al
    Factors influencing COVID-19 vaccine uptake among vulnerable communities in Texas: Perceptions of 2-1-1 helpline callers.
    Vaccine. 2025;60 Suppl 1:127554.
    PubMed         Abstract available
    
    
50. TOTZKAY D, Fraustino JD, Costello LM, Jarrett T, et al
    Building on West Virginia's innovative COVID-19 public health communication: associations between vaccination beliefs and vaccination messaging, partisanship, and social vulnerability.
    Vaccine. 2025;60 Suppl 1:127555.
    PubMed         Abstract available
    
    
51. O'CONNOR MH, Nyman AL, Ali S, Rothenberg R, et al
    Increasing vaccine uptake in a refugee resettlement community with high social vulnerability.
    Vaccine. 2025;60 Suppl 1:127552.
    PubMed         Abstract available
    
    
52. STIEHL E, Borg A, Cullen JP, Mendiola A, et al
    Engaging trusted messengers in public health response: Key strategies to building community trust among CDC'S prevention research center's vaccine confidence network.
    Vaccine. 2025;60 Suppl 1:127474.
    PubMed         Abstract available
    
    
53. HARA-HUBBARD KK, Flores Moreno MG, Sanchez M, Abdi N, et al
    The partnership for vaccine confidence: community-academic partnerships to promote COVID-19 vaccines to underserved urban and rural communities using the listen, plan, act, evaluate process.
    Vaccine. 2025;60 Suppl 1:127487.
    PubMed         Abstract available
    
    
54. MALLICK K, Handunge VL, Emmons KM, Blondet L, et al
    Engaging a community health ambassador model to promote COVID-19 vaccine in three Massachusetts communities.
    Vaccine. 2025;60 Suppl 1:127464.
    PubMed         Abstract available
    
    

    
    Virology

55. ISHIGAKI H, Otaki K, Kitagawa N, Ishida H, et al
    Pathogenicity of SARS-CoV-2 Omicron subvariants JN.1, EG.5.1, and BA.2.86.1 in immunologically naive cynomolgus macaques.
    Virology. 2026;624:111036.
    PubMed         Abstract available
    
    
56. LIU Z, Fan M, Zheng Y, Zeng Y, et al
    Transcriptome screening identifies circRNA-INSR as a novel host factor associated with avian influenza virus replication.
    Virology. 2026;625:111072.
    PubMed         Abstract available
    
    
57. MILLER AK, Heremia L, Waller SJ, Blanchard SL, et al
    Evaluating sampling strategies for the detection of avian influenza viruses in the environment.
    Virology. 2026;625:111069.
    PubMed         Abstract available
    
    

    
    Virus Res

58. ZHAO Y, Fan H
    Clinical impact of baloxavir-induced PA I38T/M substitutions in diverse influenza populations: a systematic review and meta-analysis.
    Virus Res. 2026;373:199797.
    PubMed         Abstract available

#Influenza and Other Respiratory Viruses Research #References (AMEDEO, Sept. 5 '26)

 

Antimicrob Agents Chemother

1. DE ANGELIS M, Gori Savellini G, Piselli E, Anichini G, et al
   Redox-sensitive factors as targets of thiol compounds to hinder SARS-CoV-2 replication and inflammatory response.
   Antimicrob Agents Chemother. 2026;70:e0051826.
   PubMed         Abstract available
   
   
2. JEENA N, Khan IA
   Targeting SARS-CoV-2 programmed -1 ribosomal frameshifting: structural dynamics and RNA-directed antiviral strategies.
   Antimicrob Agents Chemother. 2026;70:e0068726.
   PubMed         Abstract available
   
   
3. AVILA-PONCE DE LEON U, Esmaeili S, Owens K, Schiffer JT, et al
   Plasma concentrations of nirmatrelvir and molnupiravir required for inhibition of SARS-CoV-2 replication differ between rhesus macaques and humans.
   Antimicrob Agents Chemother. 2026 Aug 5:e0030726. doi: 10.1128/aac.00307.
   PubMed         Abstract available
   
   

   
   Antiviral Res

4. PU F, Guo Y, Pan X, Liu X, et al
   Dual-targeting engineered binding proteins block SARS-CoV-2 infection and complement activation.
   Antiviral Res. 2026;254:106515.
   PubMed         Abstract available
   
   
5. YURGELONIS I, Rai DK, Lee JT, Li Z, et al
   Antiviral activity of nirmatrelvir against contemporary SARS-CoV-2 variants.
   Antiviral Res. 2026;254:106517.
   PubMed         Abstract available
   
   

   
   Epidemiol Infect

6. NAQVI OH, Wendelboe AM, Beasley WH, Tyungu DL, et al
   Epidemiological characteristics of paediatric COVID-19 and influenza co-infections in the United States, 2020-2024 - CORRIGENDUM.
   Epidemiol Infect. 2026;154:e111.
   PubMed        
   
   

   
   J Infect Dis

7. ZHAO B, Zhang G, Wu J, Zhang W, et al
   Characterization of bronchiolitis and vaccine-induced enhanced respiratory disease in Syrian hamsters caused by respiratory syncytial virus infection.
   J Infect Dis. 2026 Mar 4:jiag136. doi: 10.1093.
   PubMed         Abstract available
   
   

   
   J Virol

8. BHAVSAR D, Civljak A, Bonnettaz B, Arunkumar GA, et al
   Broadly reactive antibodies against influenza B virus hemagglutinin neutralize and protect through distinct structural mechanisms.
   J Virol. 2026 Sep 4:e0080226. doi: 10.1128/jvi.00802.
   PubMed         Abstract available
   
   
9. LIU D, Zhang Y, Zhang M, Guo R, et al
   A neuraminidase-targeting nanobody as a therapeutic candidate against influenza A and B viruses.
   J Virol. 2026 Aug 31:e0087426. doi: 10.1128/jvi.00874.
   PubMed         Abstract available
   
   

   
   JAMA

10. SENERTH E, Sheikholeslamian SM, Sivakumaran K, Watson MA, et al
    Influenza Vaccine Effectiveness and Safety for the 2026-2027 Respiratory Season.
    JAMA. 2026 Sep 2. doi: 10.1001/jama.2026.18126.
    PubMed         Abstract available
    
    

    
    Pediatrics

11. CHAN OW, Cheng YT, Liu YH, Chou IJ, et al
    Anakinra in Severe RSV-Associated Autoinflammatory Encephalopathy With Delayed ADEM-Like Changes.
    Pediatrics. 2026;158:e2026076364.
    PubMed         Abstract available
    
    
12. PAYNE AB, Battan-Wraith S, Reese SE, Hathaway CA, et al
    Effectiveness of RSV Prevention Strategies in US Infants: 2024-2025.
    Pediatrics. 2026 Aug 4:e2026076089. doi: 10.1542/peds.2026-076089.
    PubMed         Abstract available
    
    
13. MIN J, Tam V, Jacoby SF, McDonald CC, et al
    Community Firearm Violence, Youth Depression, and Suicide Risk in Philadelphia: 2017-2024.
    Pediatrics. 2026;158:e2025075438.
    PubMed         Abstract available
    
    

    
    PLoS Comput Biol

14. FREEDMAN AS, Nielsen BF, Saad-Roy CM, Grenfell BT, et al
    Economic factors promoting vaccine nationalism in the face of viral evolution.
    PLoS Comput Biol. 2026;22:e1014466.
    PubMed         Abstract available
    
    

    
    PLoS Med

15. ELIAS KM, Mitchell A, Stadler E, Schlub TE, et al
    Neutralising antibodies and protection from progression to severe COVID-19: A meta-analysis.
    PLoS Med. 2026;23:e1005230.
    PubMed         Abstract available
    
    

    
    PLoS One

16. ADAMCZYK G, Jablonski A, Nowakowski PT, Ptaszek RT, et al
    Theodicy perspective as an effect of the interpenetration of mental and religious issues during the COVID-19 pandemic in Poland.
    PLoS One. 2026;21:e0355379.
    PubMed         Abstract available
    
    
17. JUNGMANN SM, Garbe Huedo SF, Jacobs KAS, Pothorn NK, et al
    Mental load in women and mothers: Causes of distress, personality traits, and psychopathology.
    PLoS One. 2026;21:e0356255.
    PubMed         Abstract available
    
    
18. MOUNADI N, Nour H, El Kouali M, Samadi A, et al
    Repositioning antiviral phytoconstituents as broad-spectrum inhibitors of influenza A neuraminidase and human metapneumovirus fusion protein.
    PLoS One. 2026;21:e0348517.
    PubMed         Abstract available
    
    
19. HAWKES BA, Hollister J, Porter C, Lyski ZL, et al
    Age-specific humoral immune response to SARS-CoV-2: A comparative analysis of antibody levels in children and adults after vaccination with primary series or infection.
    PLoS One. 2026;21:e0356178.
    PubMed         Abstract available
    
    
20. AVSAR FN, Kilicaslan N, Sahutoglu T
    Comparative associations of Anakinra and Tocilizumab initiation with in-hospital mortality in severe COVID-19: A single-center sequential cohort study.
    PLoS One. 2026;21:e0357671.
    PubMed         Abstract available
    
    
21. SEEGERT N, Gaulin M, Chaiyakunapruk N, Navarro-Sanchez F, et al
    The impact of state- versus county-level mask mandates on economic activity during the COVID-19 pandemic.
    PLoS One. 2026;21:e0332243.
    PubMed         Abstract available
    
    
22. HARDY MJ, Williams CK, Ladman BS, Pitesky ME, et al
    Using high frequency GPS data to assess wintering goose proximity to commercial poultry facilities on the Delmarva peninsula for avian influenza risk management and surveillance.
    PLoS One. 2026;21:e0355415.
    PubMed         Abstract available
    
    
23. KOPP J, Spies Rodriguez DC, Kunzi L, Puhan MA, et al
    Physical activity in post-COVID-19 condition: A cross-sectional study.
    PLoS One. 2026;21:e0357465.
    PubMed         Abstract available
    
    

    
    Proc Natl Acad Sci U S A

24. KARADAKIC R, Keating NL, Barnett ML
    Interpreting vaccine-associated survival differences in immune checkpoint inhibitor therapy.
    Proc Natl Acad Sci U S A. 2026;123:e2621501123.
    PubMed         Abstract available
    
    

    
    Vaccine

25. MOHAMMED H, Andraweera P, Marshall HS
    A cohort study to assess the safety and coverage of COVID-19, influenza, and pertussis vaccine in Australian pregnant women.
    Vaccine. 2026;91:129081.
    PubMed         Abstract available
    
    
26. SHEN AK, Tupps C, Bino S, Chipoya M, et al
    Investments in seasonal influenza vaccination programs pack a punch for pandemic preparedness.
    Vaccine. 2026;92:129098.
    PubMed         Abstract available
    
    
27. TRAN S, McClymont E, Blitz S, Barrett J, et al
    Self-reported reactogenicity after COVID-19 vaccination with and without influenza vaccine coadministration during pregnancy in Canada.
    Vaccine. 2026;92:129122.
    PubMed         Abstract available
    
    
28. MARIA DA, Martins IM, Porto GPM, Villas-Boas IM, et al
    Safety, humoral and cellular immune responses to a pre-pandemic adjuvanted influenza A (H5N8) vaccine.
    Vaccine. 2026;92:129049.
    PubMed         Abstract available
    
    
29. ZHENG Y, Qiao B, Gao Z, Zhang X, et al
    Development of a subunit vaccine candidate (RBD-HA trimer) provides dual protection against multi-subtype avian influenza viruses and QX-type infectious bronchitis virus.
    Vaccine. 2026;92:129121.
    PubMed         Abstract available
    
    
30. KORNUTA CA, Zhou G, Kane KP, Vliagoftis H, et al
    Mucosal adjuvant activity of a PAR-2-activating peptide enhances lymph node immune cell recruitment and promotes immune cell activation in a prime-boost influenza vaccination model.
    Vaccine. 2026;92:129110.
    PubMed         Abstract available
    
    

    
    Virology

31. BROGAARD L, Laybourn HA, Kristensen C, Welner S, et al
    Site-specific microRNA responses in lungs of pigs depend on the host-adaptation of H1N1 influenza A virus.
    Virology. 2026;624:111053.
    PubMed         Abstract available
    
    
32. SEKINE W, Kamiki H, Ishida H, Matsugo H, et al
    HA1-T138A and HA1-Q226L substitutions in H3N2 canine influenza virus contribute to binding to human-type alpha2,6-linked sialic acid receptors.
    Virology. 2026;625:111071.
    PubMed         Abstract available
    
    
33. OLDENSAND F, Rafati N, Van Hoef V, Lundkvist A, et al
    Single-cell transcriptomic landscape of avian influenza H9N2 virus infection in human and chicken cells.
    Virology. 2026;625:111070.
    PubMed         Abstract available
    

#Antibody profiles across #H5N1 and previously circulating viruses are highly dynamic and #age- and imprint- independent

 

Abstract

The increasing incidence of H5N1 influenza virus transmission from animal species to humans has heightened concerns about an imminent H5N1 pandemic. Prior studies using recombinant hemagglutinin and neuraminidase proteins have reported age-dependent cross-reactivity to H5N1, attributed to immune imprinting from an individual's first influenza virus exposure. However, whether this pattern holds when using whole inactivated virus (WIV), capturing antibodies against diverse viral proteins, and is stable over time remains unknown. We therefore aimed to determine whether H5N1 cross-reactivity of pre-existing antibodies to whole virus follows an age-dependent or imprinting-specific pattern, and whether this pattern is stable over a five-year period. To this end, we measured serum antibody levels in adolescents, adults and seniors by ELISA using whole inactivated H5N1 virus as antigen rather than purified proteins. Detectable, albeit generally low, levels of H5N1-reactive antibodies were present in most individuals, irrespective of age. Comparison of antibody levels against H5N1 with those to five historical influenza virus strains revealed a consistent positive correlation between H5N1-reactive antibodies and responses to the H1N1pdm09 strain A/California/7/2009 (CA), across all age groups. Using unbiased clustering of antibody titers against H5N1, CA, and the H3N2 strain A/Perth/16/2009 (PE), we identified seven distinct age-transcending antibody profiles. These profiles covered individuals with varying titers to all three included viruses but also identified individuals with high anti-CA levels, yet low anti-H5N1 levels and vice versa. Moreover, despite stable antibody levels over a five-year interval in the study population, individual antibody levels and profiles fluctuated considerably over this period. Taken together, our results confirm the presence of H5N1-reactive antibodies in human sera and their association with previously circulating strains. However, they also caution against inferring antibody levels against a new strain based solely on responses to antigenically related strains and highlight the limitations of extrapolating immune status from single timepoint measurements.

Competing Interest Statement

The authors have declared no competing interest.

Source: 

Link: https://www.medrxiv.org/content/10.64898/2026.08.26.26361396v1

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The return of #H1N1: Reemergence of the #influenza virus A subtype H1N1 in 1977

 

Abstract

Four major influenza pandemics and two notable outbreaks have been recorded since 1900. This paper discusses the history of the 1977 influenza virus A H1N1 outbreak and re-emergence, often referred to as the “Russian flu” or the “red flu". We describe the likely events leading to the outbreak, including a brief history of the 1976 H1N1 outbreak in a military base in the United States. We reconstruct the spread of the H1N1 virus across the globe in 1977–1978 and discuss the epidemiology of the outbreak. We describe the likely origins of this unusual outbreak mainly affecting young people, including opinions and evidence pointing towards an unnatural origin. Finally, we outline the vaccines developed and vaccination campaigns that were carried out to combat the outbreak.

Source: 

Link: https://www.sciencedirect.com/science/article/pii/S0264410X26007723?via%3Dihub

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