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Showing posts with the label pandemic influenza

#Influenza and Other Respiratory Viruses Research #References (by AMEDEO, November 22 '25)

Ann Intern Med QASEEM A, Wilt TJ, Harrod CS, Obley AJ, et al Influenza Vaccines for 2025-2026 in Adults Who Are Not Pregnant or Immunocompromised: Rapid Practice Points From the American College of Physicians. Ann Intern Med. 2025 Nov 18. doi: 10.7326/ANNALS-25-04056. PubMed Abstract available Web Exclusive. Annals Video Summary - Comparative Effectiveness and Harm of Seasonal Influenza Vaccines in Adults Who Are Not Pregnant or Immunocompromised: A Rapid Review for the American College of Physicians. Ann Intern Med. 2025 Nov 18:e2504658VS. doi: 10.7326/ANNALS-25-04658. PubMed DOBRESCU AI, Sharifan A, Sommer I, Neubauer-Bruckner CIA, et al Comparative Effectiveness and Harm of Seasonal Influenza Vaccines in Adults Who Are Not Pregnant or Immunocompromised: A Rapid Review for the American College of Physicians. Ann Intern Med. 2025 Nov 18. doi: 10.7326/ANNALS-25-04028. PubMed ...

#Influenza and Other Respiratory Viruses Research #References (by AMEDEO, Nov. 15 '25)

Arch Virol WANG P, Fu J, Wu H, Zhu L, et al Amino acid substitutions associated with adaptation of novel H10N3 and H10N5 avian influenza viruses to mice. Arch Virol. 2025;170:242. PubMed Drug Saf WONG J, Donegan K, Harrison K, Jan T, et al Implementation and Results of Active Vaccine Safety Monitoring During the COVID-19 Pandemic in the UK: A Regulatory Perspective. Drug Saf. 2025;48:1365-1385. PubMed Abstract available VAN HOLLE L Observed Versus Expected Analysis-How Does It Fit in the Pharmacovigilance Toolkit? Drug Saf. 2025;48:1325-1330. PubMed Abstract available Drugs LEE A Onradivir: First Approval. Drugs. 2025;85:1609-1612. PubMed Abstract available J Clin Microbiol HOGAN CA, Le AT, Khan A, Su LD, et al Comprehensive metabolomics combined with machine learning for the identificatio...

#Commentary: Preparing for the Next #Influenza #Pandemic: #Vaccine Progress, #Challenges, and Prospects

Abstract Influenza pandemics arise when novel influenza virus subtypes emerge in populations with little or no pre-existing immunity . The recent expansion of H5N1 virus circulation in mammals — including documented spread in cattle and sporadic human infections — coupled with the emergence of mutations associated with enhanced pandemic potential , underscores the persistent threat of novel influenza strains. Pandemic preparedness critically depends on developing effective vaccines capable of providing broad protection across diverse viral strains. While vaccination remains the most effective strategy for preventing influenza and its complications, pandemic vaccine development faces substantial challenges . These include the rapid mutation rates characteristic of influenza viruses, driven by error-prone RNA replication, broad host range, environmental selection pressures, and frequent genetic recombination. Such factors complicate predictions of which strain will trigger the next...

#Influenza and Other Respiratory Viruses #Research #References (by AMEDEO, November 8 '25)

Antimicrob Agents Chemother YAO B-F, Yang Y, Xu S-S, Tang B-H, et al Model-informed drug development in public health emergency of international concern: accelerating marketing authorization of simnotrelvir. Antimicrob Agents Chemother. 2025 Sep 18:e0061425. doi: 10.1128/aac.00614. PubMed Abstract available LODISE TP, Min J, Nathanson BH, Yucel E, et al Comparison of early treatment with ceftolozane/tazobactam versus polymyxin-based therapy of pneumonia due to MDR Pseudomonas aeruginosa (PUMA). Antimicrob Agents Chemother. 2025;69:e0056925. PubMed Abstract available DE LA PORTE DES VAUX C, Veyrenche N, Silva KD, Chavarot N, et al Immunocompromised patients with persistent SARS-CoV-2 viral shedding >/=8 weeks, clinical outcomes, and virological dynamics: a retrospective multicenter cohort study, 2020-2024. Antimicrob Agents Chemother. 2025 Sep 26:e0065825. doi: 10.1128/aac.00658....

#Influenza and Other Respiratory Viruses Research #References (by AMEDEO, October 1 '25)

Arch Virol YIN Y, Chen J, Chen S, Huang J, et al The SARS-CoV-2 N protein disrupts G3BP1 function and alters lipid metabolism in COVID-19 pathogenesis. Arch Virol. 2025;170:237. PubMed Abstract available Biochem Soc Trans CALL MJ, Call ME, Wu X Insights from deep mutational scanning in the context of an emerging pathogen. Biochem Soc Trans. 2025;53:1169-1179. PubMed Abstract available BMC Pediatr VASQUEZ-LOARTE T, Guerra GA, Saldarriaga EM, Torres-Gomez L, et al Healthcare access satisfaction before and during the COVID-19 pandemic among Peruvian children with down syndrome. BMC Pediatr. 2025;25:874. PubMed Abstract available Drugs SYED YY Clesrovimab: First Approval. Drugs. 2025;85:1487-1492. PubMed Abstract available J Exp Med BISSETT C, Yong L, Spencer AJ, Ma FNL, et al Heterologo...

#Influenza and Other Respiratory Viruses Research #References (by AMEDEO, October 25 '25)

Antiviral Res BESSONNE M, Morel J, Nevers Q, Groutsch J, et al Inhibition of influenza virus replication by artificial proteins (alphaReps) targeting its RNA-polymerase. Antiviral Res. 2025 Oct 21:106300. doi: 10.1016/j.antiviral.2025.106300. PubMed Abstract available BMC Pediatr WONG K, Ducharme R, Murphy MSQ, Clarke AE, et al SARS-CoV-2 infection in pregnancy and infant outcomes in the first year of life: a retrospective cohort study. BMC Pediatr. 2025;25:842. PubMed Abstract available MAGGIO ABR, Palomo S, Joye R, Huguet H, et al Reduced aerobic capacity in children with multisystem inflammatory syndrome in children (MIS-C) after PICU admission: a retrospective cohort study, 2020-2022. BMC Pediatr. 2025;25:835. PubMed Abstract available Cell HICKMAN HD, Moutsopoulos NM Don't forget to floss! An innovative approach for vaccine del...