ETIDIOH - NEW

  Antiviral Res MARTINEZ-GZEGOZEWSKA Y, Rasmussen L, Nebane NM, McKellip S, et al High-throughput screening for identification of Influenza A inhibitors using a cell-based immunofluorescence assay. Antiviral Res. 2025 Jun 6:106209. doi: 10.1016/j.antiviral.2025.106209. PubMed           Abstract available Arch Virol LU Y, Ni J, Huang S, Guo Y, et al Epidemiological characteristics of human parainfluenza virus infections and phylogenetic analysis of human parainfluenza virus type 3 isolated from children with respiratory tract infections from 2020 to 2022 in Zhejiang, China. Arch Virol. 2025;170:157. PubMed           Abstract available JIN H, Cho YR, Jung YT Single-particle quantification of SARS-CoV-2 virus-like particles using flow virometry. Arch Virol. 2025;170:149. PubMed           Abstract available Cell STEVENS J, Culberson E, Kinder J, Ramiriqui A, et al Mic...

Abstract Previous studies investigating the 1918–1920 influenza pandemic have provided a comprehensive overview of the spread of the pandemic and possible explanations for high mortality rates in Alaska, USA . Our understanding of the role of nonpharmaceutical interventions (NPIs) is limited, however. To gain an overview of various agencies’ efforts to protect communities during the pandemic, we conducted a mixed-method assessment of a large pool of digitized historical newspapers and archival materials covering Alaska’s local and territorial responses to the pandemic. The study encompassed 14 local units of Alaska that implemented NPIs during October 1918–January 1919 . Analyses indicated that 8 local units avoided the outbreak by implementing NPIs and that the other 6 units controlled the spread of influenza by implementing NPIs after the virus was introduced. In addition, some Indigenous communities escaped the pandemic by implementing mandatory and voluntary restrictions . Informat...

  BMC Pediatr ALRASHED R, Almeshawi I, Alshammari A, Alhamoud W, et al Burden of bronchiolitis post-COVID-19 pandemic in children less than 2 years old in 2021-2024: experience from a tertiary center in Saudi Arabia. BMC Pediatr. 2025;25:453. PubMed           Abstract available BIGLARI HN, Ahmadi A, Alidousti K, Pouredalati M, et al Growth in the first two years in children born to mothers infected with COVID-19 during pregnancy: a cohort study. BMC Pediatr. 2025;25:448. PubMed           Abstract available CHENG J, Wu Y, Ma H, Tang M, et al C-reactive protein and serum amyloid A protein as complementary biomarkers in differentiating viral and bacterial community-acquired pneumonia in children. BMC Pediatr. 2025;25:445. PubMed           Abstract available J Gen Virol CAPELASTEGUI F, Goldhill DH H5N1 2.3.4.4b: a review of mammalian adaptations and risk of pandemic e...

Abstract Since multiple and unpredicted influenza viruses cause seasonal epidemics and even high-risk pandemics , developing a universal influenza vaccine is essential to provide broad protection against various influenza subtypes. Combined with the mRNA lipid nanoparticle-encapsulated (mRNA-LNP) vaccine platform and chimeric immunogen strategy , we developed a novel cocktail mRNA vaccine encoding chimeric HAs (cH5/1-BV, cH7/3) and intact M2 (termed Fluaxe), which confers broad protection against major circulating IAVs and IBVs , as well as highly pathogenic avian influenza . Two-dose intramuscular immunization of Fluaxe in mice elicited cross-reactive neutralizing antibodies , T cell responses, and long-lived immunity, resulting in robust protection against multiple lethal influenza virus infections and severe acute lung injuries . In particular, intramuscular administration stimulated systemic immunity together with a prominent lung tropism of memory cells . Moreover, Fluaxe immuniza...

Abstract The recent resurgence of highly pathogenic avian influenza H5N1 viruses in North America and Europe has heightened global concerns regarding potential influenza pandemics. Despite significant progress in the surveillance and prevention of emerging influenza viruses, effective tools for rapid and accurate risk assessment remain limited. Here, we present FluRisk , an innovative computational framework that integrates viral genomic data with artificial intelligence (AI) to enable rapid and comprehensive risk evaluation of emerging influenza strains. FluRisk incorporates a curated database of over 1,000 experimentally validated molecular markers linked to key viral phenotypes , including mammalian adaptation, mammalian virulence, mammalian transmission, human receptor-binding preference , and antiviral drug resistance . Leveraging these markers, we developed three state-of-the-art machine learning models to predict human adaptation, mammalian virulence, and human receptor-binding ...

  Arch Virol LIU X ACE2, a therapeutic target of COVID-19, needs to be treated with caution. Arch Virol. 2025;170:143. PubMed           Abstract available BMJ IBRAHIM S, Siemieniuk RAC, Oliveros MJ, Islam N, et al Drug treatments for mild or moderate covid-19: systematic review and network meta-analysis. BMJ. 2025;389:e081165. PubMed           Abstract available J Immunol DING C, Chen Q, Shi Y, Liu J, et al Impact of CD4+ T cell and TCR repertoires on SARS-CoV-2-Specific antibody responses in PLWH following COVID-19 vaccination. J Immunol. 2025 Apr 15:vkae040. doi: 10.1093. PubMed           Abstract available J Infect PETER RS, Sedelmaier L, Nieters A, Brockmann SO, et al Symptom burden and post-COVID-19 syndrome 24 months following SARS-CoV-2 infection: Longitudinal population-based study. J Infect. 2025;90:106500. PubMed        ...

  Am J Med LIPPI G, Sanchis-Gomar F, Lavie CJ The recent (2018-2022) US monthly mortality for acute myocardial infarction still peaks in December and January. Am J Med. 2025 Jan 18:S0002-9343(25)00035-X. doi: 10.1016/j.amjmed.2025. PubMed           Abstract available STAHLBERG M, Fischer K, Tahhan M, Zhao A, et al Post-Acute COVID-19 Syndrome: Prevalence of Peripheral Microvascular Endothelial Dysfunction and Associations With NT-ProBNP Dynamics. Am J Med. 2025;138:1019-1028. PubMed           Abstract available ZHOU T, Sawano M, Arun AS, Caraballo C, et al Internal Tremors and Vibrations in Long COVID: A Cross-Sectional Study. Am J Med. 2025;138:1010-1018. PubMed           Abstract available SANAL-HAYES NEM, Mclaughlin M, Hayes LD, Berry ECJ, et al Examining Well-Being and Cognitive Function in People With Long COVID and ME/CFS, and Age-Matched Healthy Controls: A...