ETIDIOH - NEW

  J Infect NURMI V, Mayne R, Knight C, Almonacid-Mendoza HL, et al Individual patient and donor seroprofiles in convalescent plasma treatment of COVID-19 in REMAP-CAP clinical trial. J Infect. 2025 Jan 9:106412. doi: 10.1016/j.jinf.2025.106412. PubMed           Abstract available RJOOB K, Antonelli M, Murray B, Molteni E, et al Symptom Evolution in Individuals with Ongoing Symptomatic COVID-19 and Post COVID-19 Syndrome After SARS-CoV-2 Vaccination Versus Influenza Vaccination. J Infect. 2025 Jan 10:106406. doi: 10.1016/j.jinf.2024.106406. PubMed           Abstract available WENDEL-GARCIA PD, Ceccato A, Motos A, Franch-Llasat D, et al Empirical antibiotic therapy improves outcomes in mechanically ventilated patients with COVID-19: An emulated targeted trial within a prospective, multicentre cohort study. J Infect. 2025 Jan 13:106411. doi: 10.1016/j.jinf.2025.106411. PubMed    ...

  Biochem Biophys Res Commun DU S, Yang L, Chen X, Chen Y, et al Engineering mRNA vaccine with broad-spectrum protection against SARS-cov-2 variants. Biochem Biophys Res Commun. 2025;746:151224. PubMed           Abstract available BMC Pediatr YANG SI, Choi CH, Lee EJ, Jee SH, et al Impact of pediatric COVID-19 isolation on children's well-being and caregiver mental health. BMC Pediatr. 2025;25:37. PubMed           Abstract available Epidemiol Infect NOSTAEVA A, Shimansky V, Apalko S, Kuznetsov I, et al Case-control association study between polygenic risk score and COVID-19 severity in a Russian population using low-pass genome sequencing. Epidemiol Infect. 2024;153:e13. PubMed           Abstract available J Infect RJOOB K, Antonelli M, Murray B, Molteni E, et al Symptom Evolution in Individuals with Ongoing Symptomatic COVID-19 and Post COVID-19 Sy...

 Aztec Art, Postclassic (ca. 900-1580), basalt. Public Domain. Source: WikiArt,  https://www.wikiart.org/en/aztec-art/seated-deity-macuilcoatl# _____

Abstract Background Our study aims to enhance future pandemic preparedness by integrating lessons from historical pandemics, focusing on the multidimensional analysis of past outbreaks. It addresses the gap in existing modelling studies by combining various pandemic parameters in a comprehensive setting. Using Zurich as a case study, we seek a deeper understanding of pandemic dynamics to inform future scenarios. Data and methods We use newly digitized weekly aggregated epidemic/pandemic time series (incidence, hospitalisations, mortality and sickness absences from work) to retrospectively model the 1918–1920 pandemic in Zurich and investigate how different parameters correspond, how transmissibility changed during the different waves, and how public health interventions were associated with changes in these pandemic parameters. Results In general, the various time series show a good temporal correspondence , but differences in their expression can also be observed. The first wave in th...

ABSTRACT The host range of HPAIV H5N1 was recently expanded to include ruminants , particularly dairy cattle in the United States (US). Shortly after, human H5N1 infection was reported in a dairy worker in Texas following exposure to infected cattle. Herein, we rescued the cattle-origin influenza A/bovine/Texas/24-029328-02/2024(H5N1, rHPbTX) and A/Texas/37/2024(H5N1, rHPhTX) viruses, identified in dairy cattle and human, respectively, and their low pathogenic forms , rLPbTX and rLPhTX, with monobasic HA cleavage sites . Intriguingly, rHPhTX replicated more efficiently than rHPbTX in mammalian and avian cells . Still, variations in the PA and NA proteins didn’t affect their antiviral susceptibility to PA and NA inhibitors. Unlike rHPbTX and rLPbTX, both rHPhTX and rLPhTX exhibited higher pathogenicity and efficient replication in infected C57BL/6J mice . The lungs of rHPhTX-infected mice produced higher inflammatory cytokines/chemokines than rHPbTX-infected mice. Our results highlight ...