#USA, MDHHS confirms detection of #influenza A #H1N2 variant (#swine flu) in #Michigan resident (August 15 '26)

 

    LANSING, Mich. – The Michigan Department of Health and Human Services (MDHHS), Kent County Health Department (KCHD) and Ionia County Health Department have identified a human case of influenza A H1N2 variant (swine flu) in an Ionia County resident who was a swine exhibitor at the Kent County Youth Fair. 

    The fair took place Aug. 3-8 at the Grand Agricultural Center of West Michigan in Lowell.

    The individual tested presumptive positive at the MDHHS Bureau of Laboratories for swine flu and was confirmed by the Centers for Disease Control and Prevention (CDC) on Friday.

    MDHHS and KCHD have been reaching out to swine exhibitors and their families who visited the swine barns at the Kent County Youth Fair to identify any additional illnesses in those who may have been exposed to influenza from infected pigs. 

    KCHD has alerted providers in the area to watch for patients presenting with respiratory symptoms who report exposure to swine or visited the fair.

    “While the risk to the general public remains low, we want visitors who attended the Kent County Youth Fair to be alert to symptoms and take appropriate precautions,” said Dr. Natasha Bagdasarian, chief medical executive. 

    “Anyone who develops flu‑like symptoms after possible exposure should contact their health care provider and let them know about their recent contact with pigs at the fair. Individuals who are sick should stay home until they have fully recovered.”

    “It’s not unusual for flu viruses to occur in pigs, and while rare, those flu viruses can be transmitted to people by sick pigs,” said Dr. Nora Wineland, State Veterinarian, Michigan Department of Agriculture and Rural Development (MDARD). 

    “MDARD encourages exhibitors to follow disease prevention practices and work with their veterinarian if they suspect illness in an animal. It is still safe to enjoy your local fair, and visitors are encouraged to follow simple hygiene practices to help keep both people and animals healthy.”

    Pigs may be infected with swine influenza viruses that are different from human flu viruses. Swine flu viruses spread among pigs and – while rare – they can spread from pigs to people too. Spread of swine flu viruses from a pig to a person is thought to happen in the same way that human flu viruses spread; mainly through droplets when infected pigs cough and sneeze.

    MDHHS reiterates precautions the public can take to avoid potential exposure at farms, fairs and exhibits:

        ° Do not eat or drink in livestock barns or show rings.

        ° Do not take toys, pacifiers, cups, baby bottles, strollers or similar items into pig areas.

        ° Anyone who is at high risk of serious flu complications should avoid contact with pigs and swine barns when attending a fair.

        ° Get an annual influenza vaccination.

Below are some steps you can take to protect yourself and prevent the spread of any illness:

        ° Wash hands often with soap and water. If soap and water are not available, use an alcohol-based hand rub. 

        ° Avoid touching your eyes, nose and mouth. Germs spread this way. 

        ° Cover your nose and mouth with a tissue when you cough or sneeze. Throw the tissue in the trash after you use it. 

        ° Avoid close contact with sick people. If you are sick, stay home from work or school until your illness is over.

        ° Avoid contact with pigs if you have flu-like symptoms. Wait seven days after your illness started or until you have been without fever for 24 hours without the use of fever-reducing medications, whichever is longer. 

    Symptoms of variant influenza infection in people are similar to those of seasonal flu viruses and may include:

        ° Fever.

        ° Cough.  

        ° Runny nose.

        ° Body aches.

        ° Nausea.

        ° Vomiting.

        ° Diarrhea.

    Variant influenza infections, including influenza A H1N2 can sometimes cause severe disease, even in healthy people.

    Severe illness can include complications, such as pneumonia, which may require hospitalization, and in some cases can result in death.

    People who are at high risk of developing complications if they get variant influenza infection include:

        ° Children younger than five years of age.

        ° People 65 years of age and older.

        ° Pregnant people.

    People with certain long-term health conditions, such as asthma, diabetes, heart disease, weakened immune systems and neurological or neurodevelopmental conditions.

    The time period it takes from exposure to illness for variant influenza is similar to that of seasonal influenza, which can be up to 10 days, but is most commonly three days. 

    Currently, there is no human vaccine for swine flu and the seasonal flu vaccine will not protect against swine flu; however, prescription antiviral drugs, such as oseltamivir and zanamivir, are effective in treating swine flu in humans. 

    Early treatment works best and may be especially important for people with a high-risk condition.

    For more information, visit CDC.gov/Swine-Flu.

Source: 

Link: https://www.michigan.gov/mdhhs/inside-mdhhs/newsroom/2026/08/14/mdhhs-confirms-detection-of-influenza-a-h1n2-variant-in-michigan-resident

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Seasonal #surveillance in #humans in 2026 for #WNV - Weekly Update (ECDC, August 14 '26): 429 cases so far, of which 224 in #Italy

 

{Summary}

Week 33, 2026 | Produced on 14 August 2026 at 06:00, based on data submitted up until and including 13 August 2026.

Current situation

    Since the beginning of the 2026 transmission season, and as at 13 August, 77 areas affected by West Nile virus (WNV) have been identified in nine countries across Europe.

    These areas are located in 

        § Italy (40), 

        § Greece (13), 

        § Romania (12), 

        § France (four), 

        § North Macedonia (three), 

        § Spain (two), 

        § Germany (one), 

        § Kosovo* (one) and 

        § Serbia (one).

    This week, 19 areas are reported as affected for the first time this season. (...)

    The nine countries have reported 429 locally acquired human cases of WNV infection: 

        § Italy has reported 224, 

        § Greece 105, 

        § Spain 42, 

        § North Macedonia 30, 

        § Romania 18, 

        § France six, 

        § Serbia two, 

        § Germany one and 

        § Kosovo* one case.

(...)

Source: 

Link: https://www.ecdc.europa.eu/en/west-nile-fever/surveillance-and-disease-data/disease-data-ecdc

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Seasonal #surveillance in #humans and #animals in 2026 for #WNV, Monthly Report (ECDC, August 12 '26): 245 cases so far

 

August 2026 | Produced on 12 August 2026 at 12:00 based on data submitted up until and including 5 August 2026

Epidemiological summary

Findings from human surveillance

    In 2026, and as at 5 August, seven countries in Europe have reported 245 locally acquired {1} human cases of West Nile Virus (WNV) infection. 

    The earliest and latest date of onset were on 12 May 2026 and 1 August 2026, respectively. 

    Locally acquired cases have been reported by Italy (139 cases), Greece (65, of which four with unknown place of infection), Spain (17 cases), North Macedonia (13 cases), Romania (six cases), France (four cases) and Germany (one case). 

    In Europe, 12 deaths have been reported by Greece (six deaths), Italy (five deaths) and Romania (one death).

    The number of human cases reported so far (245 cases) is below the average for the corresponding period over the past decade (403 cases). 

    However, reporting delays may result in an under-estimation of the current burden, as the 2026 data remain provisional, whereas the ten-year average is based on consolidated data from previous years. 

    In addition, this ten-year average is influenced by several particularly intense WNV transmission seasons, notably in 2018 (1 065 cases reported up to the corresponding week), 2022 (781 cases) and 2024 (654 cases).

    To date, most cases have been reported in Italy (139 cases) and Greece (65 cases). 

    Although the number of cases reported in Italy is lower than during the same period in 2025 (168 cases), it remains the most affected country in Europe in 2026. 

    Greece has reported more cases in 2026 than during the same period in 2025 (65 cases compared with 26 cases). 

    WNV circulation is currently most intense in the Attica NUTS 2 region (48 cases), with Anatoliki Attiki (East Attica, 34 cases) and Voreios Tomeas Athinon (North Athens, seven cases) most affected.

    As at 5 August 2026, locally acquired human cases of WNV infection had been reported in 58 NUTS 3 regions across seven countries. 

    This is higher than at the same point in 2025, when cases were reported in 40 NUTS 3 regions across six countries. 

    However, the geographical spread observed so far in 2026 remains well below the final extent recorded in recent seasons: by the end of 2025, affected regions numbered 160 and in 2024 there were 218. 

    The 2024 season remains the largest WNV season on record in terms of geographical spread.

    This year, six regions reported locally acquired human cases of WNV infection for the first time ever: France in Pyrénées-Orientales (FRJ15); Germany in Rhein-Pfalz-Kreis (DEB3I); Italy in Campobasso (ITF22) and Viterbo (ITI41); North Macedonia in Pelagoniski (MK005) and Vardarski (MK001).

    Similar to previous years, most cases were reported among males aged 65 years and above. 

    Most cases were hospitalised (72%) and presented with neurological symptoms (58%). 

    The proportion hospitalised was lower than the average reported during the previous decade (87%), while the proportion with neurological symptoms was also slightly lower than the historical 10-year average (64%). 

    The case fatality rate was approximately 5%, lower than the average reported during the previous decade (11%). 

    However, this estimate should be interpreted with caution, as clinical outcomes may not yet be known for all reported cases and additional deaths may be recorded as the season progresses and data are consolidated.

    Owing to delays in diagnosis and reporting, and because most WNV infections are asymptomatic or subclinical, the reported case numbers probably underestimate the true number of infections. Seasonal surveillance in humans primarily captures laboratory-confirmed cases, which may further contribute to reporting delays.

Findings from veterinary surveillance

    From the veterinary perspective, 17 WNV outbreaks among equids and 74 outbreaks among birds have been reported in Europe in 2026. 

    The earliest start date of an outbreak among equids and birds was on 30 March 2026 in France and 31 March 2026 in Italy, while the latest onset of an outbreak among equids and birds was, respectively, on 31 July 2026 in Netherlands and 28 July 2026 in Italy. 

    Outbreaks among equids have been reported by France (five outbreaks), Greece (five outbreaks), Italy (five outbreaks), the Netherlands (one outbreak) and Spain (one outbreak). 

    Outbreaks among birds have been reported by Italy (64 outbreaks), France (five outbreaks), Spain (three outbreaks), Austria (one outbreak) and Belgium (one outbreak).

    No information was available on the equid species involved in the outbreaks reported in the Animal Disease Information System (ADIS). 

    The bird species most frequently associated with the reported outbreaks were the common magpie (23) and the hooded crow (20), followed by the carrion crow (5), the common kestrel (5), the Eurasian blackbird (5), the yellow-legged gull (3), Adalbert’s eagle (2), the common wood-pigeon (2), and the little owl (2). 

    Single outbreaks were associated with the common loon, the common raven, the European turtle-dove, the golden eagle, the grey heron, the house sparrow and the northern goshawk.

    The monthly number of WNV outbreaks in equids reported during the first part of 2026 was comparable to the corresponding 10-year monthly average (2016−-2025). 

    However, the number of equid outbreaks in July 2026 remained below the levels observed in July 2018, 2024 and 2025, years characterised by particularly high WNV intensity. 

    In contrast, the number of WNV outbreaks in birds slightly exceeded the corresponding four-year monthly average (2022–2025) in April and May, and was substantially higher in June. 

    This trend reversed in July 2026, when the number of reported outbreaks in birds fell below the four-year average, although it remained higher than in July 2025. However, it should be noted that reporting delays may affect the July numbers, as some outbreaks occurring during that month may be notified in August.

    As at 5 August 2026, outbreaks in birds and/or equids have been reported in 43 NUTS 3 regions across seven countries. This compares with 55 regions (10 countries) during the same period in 2025 and 42 regions (eight countries) in 2024. All seven countries reported WNV outbreaks in birds and/or equids in 2025 and in prior years, reflecting endemic WNV activity in these territories. However, as at 5 August, outbreaks in birds and/or equids were reported to ADIS for the first time in the following six regions: by France in Hauts-de-Seine (FR105) and Seine-et-Marne (FR102); by Belgium in Arr. Namur (BE352), by Greece in Drama (EL514), by Italy in Genova (ITC33) and by the Netherlands in Delf en Westland (NL362).

Patterns across human and veterinary surveillance

    Four countries – France, Greece, Italy, and Spain – reported both human WNV infections and outbreaks in equids and/or birds. 

    As at 5 August, Italy accounted for most of the reported human cases (56.7%) and animal outbreaks (75.8%). 

    Greece reported the second-largest share of human cases (26.5%) but only five equid outbreaks and no bird outbreaks, representing 5.5% of all reported animal outbreaks.

    Differences in the patterns observed across European countries may reflect a combination of ecological, climatic and surveillance-related factors. 

    Favourable climatic conditions and the presence of ecological hotspots, such as wetlands and agricultural areas, may support mosquito vector populations and influence the distribution and behaviour of animal hosts, thereby facilitating WNV circulation. At the same time, differences in WNV surveillance systems across Europe may affect detection and reporting rates.

    The first indication of WNV activity may arise from either human or animal surveillance, depending on local epidemiology, detection capacity and surveillance system sensitivity. Therefore, the absence of reports from one sector should not be interpreted as evidence that WNV is not circulating. 

    In France (Pyrénées-Orientales, FRJ15), Greece (Drama, EL514), and Italy (Genova, ITC33), human cases were reported before, or in the absence of, notified outbreaks in birds or equids. 

    Conversely, in Belgium (Arr. Namur, BE352), France (Hauts-de-Seine, FR105 and Seine-et-Marne, FR102) and the Netherlands (Delft en Westland, NL362), animal detections preceded human cases. 

    Belgium is a relevant example, as WNV was first reported in the country in 2025 through avian surveillance, with no previous detections in humans and animals. In 2026, it has again been identified in birds in a previously unaffected region, highlighting the role of avian surveillance in detecting local virus circulation and geographical spread.

    Active mosquito surveillance is also important for the early detection of WNV circulation. However, results on WNV detection in mosquitoes are not included in this report because they are not legally required to be reported at European level, and the available information is therefore scattered and often project-based.

Seasonal outlook

    Given the favourable weather conditions for WNV transmission in Europe, ECDC and EFSA expect further human cases and outbreaks in equids and birds to be reported in the coming weeks. In previous years, transmission has typically peaked in August and September.

    ECDC and EFSA continue to closely monitor the situation in Europe.

(...)

Source: 

Link: https://www.ecdc.europa.eu/en/infectious-disease-topics/west-nile-virus-infection/surveillance-and-disease-data/monthly-updates

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#Livestock production intensity and mucosal #IgA and #IgG responses to #H5N1 highly pathogenic avian #influenza A virus, North Carolina, 2021-2022

 

Abstract

Background. 

Direct livestock exposure is a risk factor for zoonotic influenza, including H5N1 highly pathogenic avian influenza (HPAI) A virus. But whether living in regions of high poultry and swine production intensity (PPI, SPI) increases risk of exposure to zoonotic influenza viruses independent of occupational livestock contact remains unclear. 

Objectives. 

To determine whether livestock workers and community members with no occupational livestock exposure in North Carolina, where poultry and swine production are increasingly co-located, are at higher risk of exposure to zoonotic influenza. 

Methods. 

Saliva samples from industrial livestock operation worker (ILO-W), ILO neighbor (ILO-N) and metropolitan area (Metro) households were analyzed for mucosal influenza A (H5N1, H1N1, and H3N2) hemagglutinin (HA) IgA and IgG antibodies to determine associations of PPI, SPI, exposure group, and detection of a swine-specific fecal contamination marker (Pig-2-Bac DNA) with influenza A antibody levels. 

Results. 

Residing in the highest PPI and SPI tertile was associated with significantly higher mucosal H5 and H1 HA IgA levels, including among residents without occupational livestock exposure. Households with occupational poultry or swine contact had significantly higher H5 IgA and IgG and H1 IgA levels compared to Metro households. In regression models accounting for clustering at the participant level, log10 anti-H5 HA mucosal IgA increased 0.16 (95% CI: 0.06, 0.27, p<0.005) and 0.10 (95% CI: 0.03, 0.17, p<0.005), per log10 increase in PPI and SPI, respectively, and 0.16 (95% CI: 0.03, 0.19, p<0.02) when Pig-2-Bac DNA was detected on household surfaces. 

Conclusions. 

Mucosal H5 HA IgA and IgG and H1 HA IgA were consistently elevated across different metrics of livestock exposure intensity, including residential exposure, occupational contact within a household, and a molecular marker of household swine fecal contamination in a state with intensive poultry and swine production.

Competing Interest Statement

The authors have declared no competing interest.

Source: 

Link: https://www.medrxiv.org/content/10.64898/2026.08.06.26359901v1

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Seasonal #surveillance in #humans in 2026 for West Nile virus in #Europe (#WNV) (ECDC, August 7 '26): 241 cases so far of which 139 in #Italy

 

{Excerpt}

Week 32, 2026 | Produced on 7 August 2026 at 10:00, based on data submitted up until and including 5 August 2026.

Current situation

    Since the beginning of the 2026 transmission season, and as at 5 August, 59 areas affected by West Nile virus (WNV) have been identified in seven countries across Europe.

    These areas are located in: 

        § Italy (36), 

        § Greece (nine), 

        § Romania (six), 

        § North Macedonia (three), 

        § France (two), 

        § Spain (two) and 

        § Germany (one).

    The seven countries have reported 241 locally acquired human cases of WNV infection: 

        § Italy has reported 139, 

        § Greece 61, 

        § Spain 17, 

        § North Macedonia 13, 

        § Romania six, 

        § France four and 

        § Germany one case.

    This week, 10 areas are reported as affected for the first time this season. The affected areas identified as at 5 August 2026 are listed in Table 1 and shown in Map 1 below.

(...)

{WNV Affected Areas - Click on Image to Enlarge}

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Source: 

Link: https://www.ecdc.europa.eu/en/west-nile-fever/surveillance-and-disease-data/disease-data-ecdc

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A cohort study of persons exposed to highly pathogenic avian #influenza #H5N1 at premises with infected #animals, #England, 2023 to 2025

 

Abstract

BACKGROUND

The ongoing panzootic of highly pathogenic avian influenza A(H5N1) presents a risk to human health both from infections resulting from exposure to infected birds or mammals, and from potential mutations enabling human-to-human transmission of a virus to which there is little or no population immunity.

AIM

This cohort study was designed with the aim of informing assessments of the risk of avian influenza to human health and the public health management of influenza A(H5N1) exposures.

METHODS

We recruited 428 individuals at 34 highly pathogenic avian influenza A(H5N1) outbreak sites between April 2023 to March 2025, throughout England. Through nasopharyngeal samples and questionnaires, we investigated risk factors including exposure periods and usage of personal protective equipment (PPE), and characteristics of influenza A(H5N1) infection.

RESULTS

The median participant age was 37 years (interquartile range: 28–51 years), 296 (69%) were male. Most participants (85%) reported full PPE use when exposed, and 82 (19%) were vaccinated against seasonal influenza. Six persons tested PCR-positive for influenza A(H5N1), of whom three (< 1%) met the case definition for infection (two confirmed, one unclear) attributable to exposure periods. No severe illness was reported; no secondary cases were identified. None of the six cases with positive detections were vaccinated against seasonal influenza; two of them reported not wearing full PPE when exposed.

CONCLUSION

We recommend continued conscientious PPE use and the resumption of enhanced surveillance following detection of an increased risk of animal-human transmission, with a One Health focus, to mitigate pandemic risk of influenza A(H5N1).

Source: 

Link: https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2026.31.31.2500906?emailalert=true#abstract_content

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Avian #Influenza #Report: July 26 – August 1, '26 (Wk 31) (HK CHP, August 4, 2026): Four New #Human #Infection with #H9N2 virus in #China

 

{Excerpt}

(...)

Avian influenza A(H9N2): 

    ° Gansu Province: 

        § A three-year-old girl with onset on July 11, 2026. 

    ° Jiangsu Province: 

        § A 12-year-old boy with onset on July 6, 2026. 

    ° Jiangxi Province: 

        § A 72-year-old woman with onset on July 5, 2026. 

    ° Yunnan Province: 

        § A 58-year-old woman with onset on July 13, 2026. 

(...)

Source: 

Link: https://www.chp.gov.hk/files/pdf/2026_avian_influenza_report_vol22_wk31.pdf

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Seasonal #surveillance in #humans in 2026 for West Nile virus (#WNV) (ECDC, July 31 '26): 158 cases so far of which 94 from #Italy

 

{Summary}

Week 31, 2026 | Produced on 30 July 2026 at 12:00, based on data submitted up until and including 29 July 2026.

Current situation

    ° Since the beginning of the 2026 transmission season, and as at 29 July, 49 areas affected by West Nile virus (WNV) have been identified in seven countries across Europe.

    ° These areas are located in: 

        § Italy (30), 

        § Greece (eight), 

        § Romania (four), 

        § France (two), 

        § North Macedonia (two), 

        § Spain (two) and 

        § Germany (one).

    ° The seven countries have reported 158 locally acquired human cases of WNV infection: 

        § Italy has reported 94, 

        § Greece 42, 

        § North Macedonia seven, 

        § Spain seven, 

        § Romania five, 

        § France two and 

        § Germany one case.

    ° This week, 14 areas are reported as affected for the first time this season. The affected areas identified as at 29 July 2026 are listed in Table 1 and shown in Map 1 below.

(...)

{Click on Image to Enlarge}

__

{In Yellow, areas already affected since the beginning of the season.}

{In Red, areas newly affected this week.}

__

Source: 

Link: https://www.ecdc.europa.eu/en/west-nile-fever/surveillance-and-disease-data/disease-data-ecdc

____

#Zoonotic neglected tropical #diseases at the animal-human interface in the Greater #Mekong Subregion: Two decades of surveillance in #Laos and #Cambodia

 

Abstract

Zoonotic neglected tropical diseases (NTDs) remain a substantial but under-recognised source of human morbidity and economic concern in the Greater Mekong Subregion, particularly in settings characterised by close human–animal interaction. This article represents a narrative synthesis of zoonotic disease research conducted in Laos and Cambodia between 2000 and 2025. The review integrates published literature with findings from long-term surveillance programmes conducted by the authors and collaborating institutions in Laos, with comparative insights from Cambodia, to examine the presence, distribution, diversity, and drivers of zoonotic pathogens at the human–animal interface. Evidence demonstrates the endemic presence of a wide range of parasitic, bacterial, and viral zoonoses, including Taenia solium, Trichinella spp., Streptococcus suis, rickettsial infections, melioidosis, hepatitis E virus, and Japanese encephalitis virus. Some of these pathogens are sustained within smallholder livestock systems, informal slaughter, farming practises, food networks, and wet market environments, where limited diagnostic capacity and fragmented surveillance obscure true disease presence. Surveillance innovations, including abattoir-based sampling, cross-sectoral serological studies, environmental surveillance approaches, and molecular diagnostic tools, have improved pathogen detection but have also highlighted persistent structural and behavioural barriers to control. Socio-cultural practices, occupational exposure, wildlife trade, and economic dependencies reinforce transmission dynamics, indicating that biomedical interventions alone are insufficient. Instead, zoonotic disease persistence reflects the interaction of livestock production systems, environmental conditions, diagnostic limitations, and entrenched human behaviours. This review emphasises the need for integrated One Health approaches that combine strengthened surveillance, improved diagnostics, behavioural interventions, and regional collaboration. Addressing zoonotic NTDs in Laos and Cambodia requires coordinated strategies that account for both biological complexity and socio-economic context to achieve sustainable disease control and improved public health outcomes.

Source: 

Link: https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0014584

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#Mutations in severe #human #H5N1 cases facilitate #evasion from human mucus and #antivirals

 

Abstract

In late 2024, two individuals in Canada and the United States were treated in intensive care for acute respiratory distress caused by infection with the avian Influenza A Virus H5N1 2.3.4.4b genotype D1.1. Viral sequence data obtained from sampling these patients indicated mixed alleles at haemagglutinin (HA) positions 190 and 226. Mutations at these positions are key determinants of HA usage of α2,6-linked sialic acids (SA), the most abundant influenza receptors in human upper respiratory tracts. Thus, these mutations raised concerns about human adaptation and pandemic potential of the H5N1 virus. In this study, we investigated the impact of the mutations at residues 190 and 226 in H5 HA. We studied the receptor binding properties, cell entry phenotypes and fitness impacts of the mutations using recombinant proteins, pseudotyped lentiviruses, and in the context of influenza viruses using reverse genetics. The mutations did not confer any detectable α2,6-linked sialic acid receptor usage either alone or in combination. Rather, viruses carrying these mutations exhibit weakened binding towards α2,3-linked sialic acid receptors. This correlated with an enhanced capacity to evade human airway mucus, and a reduced susceptibility to oseltamivir and zanamivir. This research underscores that in addition to the way HA interacts with SA as entry receptors, other factors that impact the HA/NA balance might influence the evolutionary trajectory of a zoonotic virus in the human respiratory tract. This study presents a new paradigm for the evolutionary drivers of HA, where reduced sialic acid binding can serve as an advantage for escape from host barriers and antivirals.

Competing Interest Statement

The authors have declared no competing interest.

Funder Information Declared

Medical Research Council, https://ror.org/03x94j517, MR/Y03368X/1, MR/Y015061/1, CC2127

Biotechnology and Biological Sciences Research Council, BB/Y007298/1, APP104179, BBS/E/PI/23NB000, BBS/E/PI/23NB0003

Wellcome Trust, https://ror.org/029chgv08, CC2127, 218304/Z/19/Z

Department for Environment Food and Rural Affairs, BB/Y007298/1

The Pirbright Institute, BBS/E/PI/230002A, BBS/E/PI/230001C, BBS/E/PI/230002B

Cancer Research UK, CC2127

UK Research and Innovation, https://ror.org/001aqnf71, UKRI3602

Source: 

Link: https://www.biorxiv.org/content/10.64898/2026.07.28.740943v1

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Avian #Influenza #Report: July 19 25, '26 (Wk 30) (HK CHP, July 28 '26): Three new #human #infection with #H9N2 virus in #China

 

{Excerpt}

(...)

Avian influenza A(H9N2): 

{China}

    ° Guangdong Province: 

        § A 44-year-old man with onset on June 26, 2026. 

    ° Guangxi Zhuang Autonomous Region: 

        § A four-year-old boy with onset on June 26, 2026.  

    ° Jiangsu Province: 

        § A four-year-old boy with onset on June 22, 2026. 

(...)

Source: 

Link: https://www.chp.gov.hk/files/pdf/2026_avian_influenza_report_vol22_wk30.pdf

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Mapping Reported Modes of #Transmission of Highly Pathogenic Avian #Influenza #H5N1 to #Humans: A Scoping Review

 

Abstract

Background

Highly Pathogenic Avian Influenza A (subtype H5N1) poses a threat to human health, and its pandemic potential emphasizes the need to better understand detailed reported transmission pathways to humans. Existing literature is outdated or lacks detailed, comprehensive analysis of the range of transmission routes and how the virus may enter the human body.

Objective

To comprehensively map all reported H5N1 transmission pathways to humans, as well as viral entry routes.

Methods

CINAHL, Embase, MEDLINE, Scopus, PubMed, grey literature, and reference lists (of included studies) were searched up to October 29th, 2025, with no language restrictions. Observational studies and grey literature reporting H5N1 transmission evidence to humans were included. Two reviewers conducted duplicate screening independently (two of three reviewers per record). One reviewer completed data extraction, which was cross-verified for accuracy by a second. Findings were summarized narratively.

Results

120 sources met inclusion criteria (70 studies, 50 grey literature). Reported H5N1 transmission pathways were classified into animal-to-human (109 of 120 sources, 90.8%; including poultry-to-human in 100 sources [83.3%] and cattle-to-human in nine sources [7.5%]), environment-to-human (32 of 120 sources, 26.7%), and human-to-human (14 of 120 sources, 11.7%). Reported transmission pathways were further classified as direct or indirect contact, synthesized, and linked to suspected routes of human entry, including mucosal entry (eyes, nose, mouth), inhalation of aerosols or droplets, ingestion, and percutaneous exposure. Entry routes are biologically plausible and do not imply relative likelihood or causal attribution.

Conclusions

There are multiple reported pathways of H5N1 exposure, and a single pathway may involve multiple ways to infect humans. Further research is needed to determine causal mechanisms, identify specific risk factors and measures of association, and strengthen evidence-based prevention strategies.

Source: 

Link: https://www.sciencedirect.com/science/article/pii/S235277142600176X?via%3Dihub

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Seasonal #surveillance in #humans in 2026 for #WNV (West Nile Virus) (ECDC, July 24 '26): 81 confirmed cases so far of which 46 in #Italy

 

{Excerpt}

Week 30, 2026 | Produced on 23 July 2026 at 09:45, based on data submitted up until and including 22 July 2026.

Current situation

    ° Since the beginning of the 2026 transmission season, and as at 22 July, 35 areas affected by West Nile virus (WNV) have been identified in six countries across Europe.

    ° These areas are located in: 

        § Italy (20), 

        § Greece (six), 

        § Romania (four), 

        § North Macedonia (two), 

        § Spain (two) and 

        § France (one).

    ° The six countries have reported 81 locally acquired human cases of WNV infection: 

        § Italy has reported 46, 

        § Greece 21, 

        § North Macedonia five, 

        § Romania five, 

        § Spain three and 

        § France one case.

    ° This week, nine areas are reported as affected for the first time this season. The affected areas identified as at 22 July 2026 are listed in Table 1 and shown in Map 1 below.

(...)

Table 1. Areas affected by West Nile virus during the 2026 transmission season at 22 July, by country and NUTS3 or GAUL1 area

{Click on Images to Enlarge}

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Source: 

Link: https://www.ecdc.europa.eu/en/west-nile-fever/surveillance-and-disease-data/disease-data-ecdc

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#Oseltamivir #Resistance in #Human #Influenza #H5N1 and #H7N9 Infections: A Mini Review

 

Abstract

Avian influenza viruses (AIVs) have been reported to cause infections in humans following avian-to-human transmission, resulting in a range of clinical outcomes. A(H5N1) and A(H7N9) infections, which constitute the majority of human AIV cases, are responsible for severe infections leading to high mortality. The neuraminidase inhibitor oseltamivir is expected to play a major role for the control of AIV infections in humans. However, the emergence of resistance may compromise the impact of antiviral therapy. The objective of this article is to review human cases of A(H5N1) and A(H7N9) infections for which mutations of oseltamivir resistance were detected. Neuraminidase mutations rapidly occurred in a subtype-specific manner, with H274Y and N294S substitutions predominating in A(H5N1) cases and the R292K substitution in A(H7N9) cases. Serious clinical outcomes and mortality were seen in most A(H5N1) and A(H7N9) cases despite oseltamivir therapy, thus highlighting the need for improving antiviral strategies against these AIVs.

Source: 

Link: https://academic.oup.com/ofid/article/13/7/ofag393/8722865

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A lethal #human #H5N5 #influenza virus isolate exhibits low #pandemic #risk traits

 

Abstract

In fall of 2025, a fatal infection of highly pathogenic avian influenza (HPAI) virus H5N5 occurred. To define the risk of this emerging virus to humans, we performed a comprehensive analysis based on our established triage. Serological analysis revealed that humans across all birth years had no detectable neutralizing antibodies to this H5N5 isolate. Further characterization revealed a lack of phenotypic signatures associated with epidemiologically successful influenza viruses in humans, including reduced replication in human airway cells and an avian-like pH of inactivation. Additionally, assessment of H5N5 in ferrets revealed a lack of direct contact transmission and moderate disease severity. H5N5 infection in ferrets with prior immunity against the 2009 H1N1 pandemic strain resulted in fewer clinical signs and reduced viral shedding. Together our data suggest that the current H5N5 HPAI lineage poses a low pandemic risk.

Source: 

Link: https://www.biorxiv.org/content/10.64898/2026.07.20.739507v1

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Avian #Influenza #Report: July 12 - 18 '26 (Wk 29) (HK CHP, July 21 '26): 1 New #Human Case of Infection with #H5 virus in #Bangladesh

 

{Excerpt}

(...)

    ° Avian influenza A(H5): 

        § Bangladesh: 

            - Sylhet Division: A child with onset on May 17, 2026. 

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Source: 

Link: https://www.chp.gov.hk/files/pdf/2026_avian_influenza_report_vol22_wk29.pdf

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#WNV in #humans, the European Region, Weekly #Report (ECDC, July 17 '26): #Italy (21), #Greece (7), North #Macedonia (2), #Romania (2) & #Spain (2) cases so far

 

{Excerpt}

Week 29, 2026 | Produced on 17 July 2026 at 08:30, based on data submitted up until and including 15 July 2026.

Current situation

    ° Since the beginning of the 2026 transmission season, and as at 15 July, 28 areas affected by West Nile virus (WNV) have been identified in five countries across Europe {1}.

    ° These areas are located in: 

        § Italy (17), 

        § Greece (five), 

        § North Macedonia (two), 

       § Romania (two) and 

        § Spain (two).

    ° The five countries have reported 34 locally acquired {2} human cases of WNV infection: 

        § Italy has reported 21, 

        § Greece seven,     

        § North Macedonia two, 

        § Romania two and 

        § Spain two cases.

    ° This week, 17 areas are reported as affected for the first time this season. The affected areas identified as at 15 July 2026 are listed in Table 1 and shown in Map 1 below.

(...)

Table 1. Areas affected by West Nile virus during the 2026 transmission season at 15 July, by country and NUTS3 or GAUL1 area

{Click on Images to Enlarge}

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* ‘First reported this week’ indicates that the affected area was not included in the previous weekly overview.

(...)

Source: 

Link: https://wnv-weekly.ecdc.europa.eu/

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#Autoantibodies against type I #interferons in patients with #zoonotic #H7N9 #influenza: an observational case–control study

 

Summary

Background

The determinants of the species barrier preventing human infections with avian influenza A viruses (IAV) are incompletely understood. We previously identified loss-of-function variants of the interferon-regulated antiviral factor MxA as a genetic factor for increased susceptibility to infections with the H7N9 subtype. Given the central role of type I IFNs (IFN-I) in antiviral defence, we hypothesised that IFN-I-neutralising autoantibodies may similarly predispose to zoonotic H7N9 infection.

Methods

In this observational case–control study, serum samples collected between 2013 and 2017 from 199 Chinese patients with laboratory-confirmed H7N9 infection and 531 healthy, uninfected controls (269 poultry workers, 262 close contacts) were screened for IgG autoantibodies binding IFNα2, IFNβ1b, or IFNω using a multiplex bead-based assay. Positive samples were tested for IFN-neutralising activity in a luciferase-based reporter assay. To confirm their ability to block IFNα2-mediated antiviral activity, selected samples (n = 19) were analysed in IAV infection experiments. Associations between age, sex, H7N9 case status, case fatality, and the presence of neutralising autoantibodies were evaluated by logistic regression. Available whole-genome sequencing data from 26 individuals with neutralising autoantibodies were screened for variants in genes linked to IFN-I autoimmunity.

Findings

Neutralising autoantibodies against at least one IFN-I were detected in 19.1% (38/199) of patients but in only 1.1% (6/531) of controls, consistent with published general population data. Most patient sera targeted IFNα2 and/or IFNω (35/199), and 18.1% (36/199) neutralised even high IFN-I concentrations of 1–10 ng/ml. The presence of neutralising autoantibodies was associated with 8.2- to 25.3-fold higher odds of H7N9 infection (p < 0.0001), depending on antibody specificity and reference group. Autoantibody prevalence increased significantly with age in patients (44.8% ≥70 years; OR = 1.05; 95% CI 1.02–1.07; p = 0.0001), but was not associated with sex (OR for males vs. females = 0.52; 95% CI 0.23–1.14; p = 0.106). All selected sera containing neutralising autoantibodies blocked IFNα2-induced antiviral activity in cell culture. No known genetic predisposition for IFN-I autoimmunity was identified.

Interpretation

Our findings suggest that IFN-I-targeting autoimmunity is associated with susceptibility to zoonotic IAV infection with the H7N9 subtype, and possibly also other subtypes, including panzootic H5N1. Given the ease of implementation, screening for anti-IFN-I autoantibodies could be readily integrated into surveillance or targeted testing. This could be relevant in environments with increased exposure to zoonotic IAVs.

Funding

Shenzhen Medical Research Fund, National Natural Science Foundation of China, Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences, Guangdong Provincial Science and Technology Program, Program for Youzuzhikeyan of Shenzhen University, German Research Foundation, Swiss National Science Foundation.

Source: 

Link: https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(26)00271-9/fulltext

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