ETIDIOH - NEW

  {Excerpt} Phnom Penh (ANTARA) - A 3-year-old girl from Kampong Speu Province, western Cambodia, has been confirmed to have contracted H5N1 bird flu , bringing the number of cases to 16 so far this year, the Cambodian Ministry of Health said in a statement on Thursday (16/10) evening local time. Laboratory results from Cambodia's National Institute of Public Health on October 15 showed the girl tested positive for the H5N1 virus, the statement said. The patient had symptoms of fever, diarrhea, cough, and abdominal pain , and is currently undergoing intensive care with a team of doctors, the statement added. The girl is a resident of Chek Village, Basedth District. Investigations found that chickens and ducks had contracted the disease and died at the girl's home and at her neighbor's about a week before she fell ill, the statement said. (...) Source: Antara,  https://www.antaranews.com/berita/5181569/balita-di-kamboja-barat-jadi-korban-flu-burung-ke-16-pada-2025 ____

  Abstract Avian influenza A viruses pose ongoing threats to human and animal health, with H7 subtypes causing outbreaks globally . In Mexico , highly pathogenic H7N3 viruses have circulated in poultry since 2012, causing sporadic human infections . Here we analyzed genetic markers in hemagglutinin sequences from Mexican H7N3 isolates and conducted serological assays on human populations with poultry exposure . Our results show conserved avian-like receptor binding sites , thus limiting human adaptation , alongside antigenic drift and acquisition of glycosylation sites likely driven by vaccination. Serological testing of 1103 individuals revealed no detectable antibodies against H7N3, indicating a naïve population . Phylogenetic analyses revealed multiple virus clades circulating regionally. These findings suggest that while current H7N3 viruses have limited capacity for sustained human transmission, the lack of population immunity underscores the importance of continued surveillan...

  New human cases {1,2}:  -- From 26 August to 29 September 2025 , based on reporting date, the detection of influenza A(H5) in one human , influenza A(H5N1) in one human , influenza A(H9N2) in eight humans and an influenza A(H1N1) variant ((H1N1)v) virus in one human were reported officially.   Circulation of influenza viruses with zoonotic potential in animals :  -- High pathogenicity avian influenza (HPAI) events in poultry and non-poultry animal species continue to be reported to the World Organisation for Animal Health (WOAH).{3}  -- The Food and Agriculture Organization of the United Nations (FAO) also provides a global update on avian influenza viruses with pandemic potential.{4}  Risk assessment {5}:  -- Sustained human to human transmission has not been reported from these events.  -- Based on information available at the time of this risk assessment update , the overall public health risk from currently known influenza A viruses d...

  {Excerpt} Influenza A H9N2 -- Hunan Province : - 1) A two-year-old boy with onset on September 28, 2025.  -- Jiangxi Province : - 2) A 70-year-old woman with onset on September 23, 2025.  (...) Source: Centre for Health Protection, Hong Kong PRC SAR,  https://www.chp.gov.hk/files/pdf/2025_avian_influenza_report_vol21_wk41.pdf ____

{Summary} -- During current epidemiological week , a rise in the West Nile Virus human cases has been observed although with reduced intensity compared most recent weeks.  -- Twenty-two new confirmed human cases have been reported during surveillance week from 2 to 8 October 2025.  -- The cumulative number of cases rose to 740  (they were 718 last week), of these:  - 354 were West Nile Neuroinvasive Disease (WNND): 16 in Piedmont, 53 Lombardy, 33 Veneto, 4 Friuli-Venezia Giulia, 1 Liguria, 30 Emilia-Romagna, 11 Tuscany, 1 Marche, 84 Latium, 2 Molise, 81 Campania, 2 Apulia, 2 Basilicata, 5 Calabria, 3 Sicily, 26 Sardinia, - 57 were asymptomatic cases in blood donors ,  - 318 were West Nile Fever cases , of which 1 imported from Kenya , 1 from Egypt and 1 from Maldives ,  - 4 asymptomatic cases,  - 7 unspecified cases.  -- Among confirmed cases there were 68 fatalities : 7 in Piedmont, 9 Lombardy, 2 Emilia-Romagna, 18 Latium, 28 Campania, 2 Cal...

  Significance Since pigs serve as intermediate hosts between humans and the natural reservoir of influenza viruses in wild birds, they play a key role in the emergence of influenza strains with pandemic potential , as demonstrated by the 2009 pandemic. Therefore, influenza pandemic preparedness will benefit from the development of vaccines that broadly protect pigs against diverse influenza A strains. However, progress is limited by our poor molecular understanding of porcine antibody responses to influenza virus. This study isolates and characterizes a panel of broadly neutralizing influenza antibodies from pigs . Our findings not only have significant implications for the development of broadly protective influenza vaccines for pigs, but also reveal the molecular differences in the antibody responses between pigs and humans. Abstract Antibody responses to the influenza virus hemagglutinin (HA) stem, a major target for broadly protective vaccine development , have been extensivel...

  Situation at a glance In 2025, a resurgence of chikungunya virus (CHIKV) disease was noted in a number of countries , including some that had not reported substantial case numbers in recent years.  Between 1 January and 30 September 2025, a total of 445 271 suspected and confirmed CHIKV disease cases and 155 deaths were reported globally from 40 countries , including autochthonous and travel imported cases.  Some WHO Regions are experiencing significant increases in case numbers compared to 2024, although others are currently reporting lower case numbers.  This uneven distribution of cases across regions makes it challenging to characterize the situation as a global rise, however, given the ongoing outbreaks reported globally in 2025, the potential for further spread remains significant .  CHIKV disease can be introduced into new areas by infected travelers and local transmission may be established if there is the presence of Aedes mosquito and a susceptible p...

  {Summary} -- During current epidemiological week (from  25 September to 1rst October 2025),  38 new confirmed human infection with West Nile Virus have been reported.  -- Since the beginning of the epidemic season, 718 confirmed cases have been recorded in Italy (they were 680 in the last bulletin), of these:  - 341 were West Nile Neuroinvasive Disease (WNND): 15 in Piedmont, 51 Lombardy, 30 Veneto, 4 Friuli-Venezia Giulia, 1 Liguria, 27 Emilia-Romagna, 11 Tuscany, 1 Marche, 84 Latium, 2 Molise, 79 Campania, 2 Apulia, 2 Basilicata, 5 Calabria, 2 Sicily, 25 Sardinia,  - 57 were asymptomatic cases in blood donors ,  - 309 were West Nile Fever cases (1 imported from Kenya , 1 Egypt , and one Maldives ),  - 4 asymptomatic cases,  - 7 unspecified cases.  -- Among confirmed cases , there have been 49 fatalities : 7 in Piedmont, 5 Lombardy, 2 Emilia-Romagna, 18 Latium, 14 Campania, 2 Calabria, 1 Sardinia.  - The Case-Fatality Rate in WNN...

  Abstract In China, low pathogenic avian influenza (LPAI) H3N8 virus is widespread among chickens and has recently caused three zoonotic infections , with the last one in 2023 being fatal . Here we evaluated the relative pandemic risk of this 2023 zoonotic H3N8 influenza virus, utilizing our previously published decision tree. Serological analysis indicated that a large proportion of the human population does not have any cross-neutralizing antibodies against this H3N8 strain. LPAI H3N8 displayed a dual affinity for a2-3 and a2-6 sialic acids and replicated efficiently in human bronchial epithelial cells . Furthermore, we observed H3N8 transmission via direct contact but not aerosols to ferrets with pre-existing H3N2 immunity. Although pre-existing H3N2 immunity resulted in a shortened disease course in ferrets, it did not reduce disease severity or replication in the respiratory tract. This study suggests that this zoonotic H3N8 strain has moderate pandemic potential and emphasiz...

  {Summary} -- During current surveillance week (from 18 to 24 Sept. '25), 33 new confirmed human cases of West Nile Virus have been detected.  -- Since the beginning of the epidemic season , there have been 680 cases in total , (they were 647 last week); of these:  - 321 were West Nile Neuroinvasive Disease (WNND): 15 in Piedmont, 44 Lombardy, 27 Veneto, 2 Friuli-Venezia Giulia, 1 Liguria, 25 Emilia-Romagna, 8 Tuscany, 1 Marche, 83 Latium, 2 Molise, 79 Campania, 2 Apulia, 2 Basilicata, 5 Calabria, 1 Sicily, 24 Sardinia),  - 54 were asymptomatic cases in blood donors ,  - 296 were West Nile Fever cases (1 imported from Kenya , 1 Egypt and 1 Maldives ),  - 3 asymptomatic cases,   - 6 unspecified cases.  --  Among confirmed cases , there were 48 deaths : 7 in Piedmont, 5 Lombardy, 2 Emilia-Romagna, 17 Latium, 14 Campania, 2 Calabria, 1 Sardinia.  - The Case-Fatality Rate among WNND cases was 14.9% (it was 20% in 2018 and 14% in 2024)....

  {Excerpt} Highly pathogenic avian influenza caused by H5N1 viruses emerged in East Asia in the late 1990s and spread to Europe, Africa, and the Middle East , circulating in wild and domestic birds and occasionally spilling over into mammals and humans . These viruses are classified into genetic lineages called clades based on differences in the gene encoding hemagglutinin , a key surface protein involved in cell entry. In 2021, one such lineage, clade 2.3.4.4b , crossed from Europe to Canada . It spread rapidly, reaching the southern tip of South America in less than 2 years and causing massive mortality in seabirds and marine mammals , including South American sea lions (Otaria flavescens) and southern elephant seals (Mirounga leonina) (1). However, human mortality has been markedly lower in the present H5N1 outbreak than in past ones. If the virus evolves the capacity to transmit from human to human, understanding this reduction will be essential for mounting an effective respo...

  ABSTRACT The global spread of the A/goose/Guangdong/1/96-lineage H5N1 highly pathogenic avian influenza (HPAI) viruses has been accompanied by an expanded host range and the establishment of sustained viral transmission among dairy cattle . To evaluate if the evolving H5N1 viruses have changed tissue tropism over time , we compared the binding patterns of recombinant hemagglutinin (HA) proteins derived from clade 1 (A/Vietnam/1203/04, H5VN) and circulating clade 2.3.4.4b viruses detected from wild bird (A/Eurasian Teal/Hong Kong/AFCD-HKU-23-14009-01020/2023, H5HK) and dairy cattle (A/bovine/Ohio/B24OSU-439/2024, H5OH). The HA protein of A(H1N1)pdm09 virus was included for comparison . Using bio-layer interferometry , H1 protein preferentially bound to the α2,6-linked sialoside 6′SLNLN , while H5 proteins preferentially bound to the α2,3-linked sialoside 3′SLN . H5OH showed higher binding affinity to 3′SLN than H5HK and H5VN. The attachment patterns of H1 and H5 proteins to the re...

  Context and significance The avian influenza A virus subtype H10N3 is a possible candidate for causing a fatal flu and may present a serious public health threat . Research increasingly shows that the avian influenza virus H10N3 can be transmitted from birds to humans , causing severe viral pneumonia and potentially leading to acute respiratory distress syndrome and respiratory failure . Researchers at the Fourth People’s Hospital of Nanning (China) provide evidence supporting the cross-species transmission of the avian influenza virus H10N3 to humans, which can give rise to severe pneumonia. The authors report that a female patient with avian influenza virus H10N3 infection, who was suffering from severe pneumonia , respiratory failure, pneumothorax , and numbness and dysesthesia in her feet , recovered after receiving appropriate therapy and was discharged from the hospital. Highlights •  A young woman contracted the avian influenza virus H10N3 •  Secondary infections...

  {Summary} -- During current epidemiological week ( 11– 17 September 2025),  65 new confirmed human cases of infection with West Nile Virus have been reported.  -- The total number of confirmed cases , since the beginning of the epidemic season, has thus risen to 647 (it was 582 last week), of these:  - 300 were West Nile Neuroinvasive Disease (WNND): 15 in Piedmont, 39 Lombardy, 24 Veneto, 2 Friuli-Venezia Giulia, 1 Liguria, 23 Emilia-Romagna, 5 Tuscany, 83 Latium, 2 Molise, 77 Campania, 2 Apulia, 2 Basilicata, 5 Calabria, 1 Sicily, 19 Sardinia,  - 54 were asymptomatic cases detected among blood donors ,  - 284 were West Nile Fever cases (one imported from Kenya),  - 3 asymptomatic cases and  - 6 unspecified casese.  -- Among confirmed cases, there were 47 death cases : 7 in Piedmont, 5 Lombardy, 1 Emilia-Romagna, 16 Latium, 15 Campania, 2 Calabria, 1 Sardinia.  - The Case-Fatality Rate in WNND cases was 15.8% (it was 20% in 2018 and...

  Situation at a glance Between 1 January and 29 August 2025, the International Health Regulations National Focal Point (IHR NFP) for Bangladesh notified WHO of four confirmed fatal Nipah virus (NiV) infection cases , temporally unrelated , reported from four different districts across three separated geographical divisions (Barisal, Dhaka, and Rajshahi) in Bangladesh.  NiV infection is a zoonotic disease transmitted to humans through infected animals (such as bats or pigs ), or food contaminated with saliva, urine , and excreta of infected animals .  It can also be transmitted directly from person to person through close contact with an infected person.  Fruit bats or flying foxes (Pteropus species) are the natural hosts for the virus.  Human NiV infection is an epidemic-prone disease that can cause severe disease in humans and animals, with a high mortality rate , and outbreaks primarily occurring in South and South-East Asia .  Since the first recognized...