ETIDIOH - NEW

  Abstract While treatment with nirmatrelvir/ritonavir or molnupiravir is effective in lowering the rate of severe COVID-19 , the effectiveness of these antivirals in reducing the risk of cardiovascular outcomes, especially among the hospitalized population, remains largely unknown . In this study, we assessed the real-world effectiveness of nirmatrelvir/ritonavir and molnupiravir on short- and long-term cardiovascular complications of COVID-19 using a target trial emulation design. Two target trials of COVID-19 antivirals were emulated by using a territory-wide, population-based, retrospective cohort of hospitalized patients in Hong Kong . Nine cardiovascular outcomes were evaluated in both short-term (day 0–21) and long-term (day 22–365) post-SARS-CoV-2 infection. Compared with the control group , the use of nirmatrelvir/ritonavir was associated with a significantly lower one-year risk of cardiovascular mortality , composite cardiovascular complications, major adverse cardiac eve...

Abstract The risk of cardiovascular outcomes following SARS-CoV-2 infection has been reported in adults , but evidence in children and adolescents is limited . This paper assessed the risk of a multitude of cardiac signs, symptoms, and conditions 28-179 days after infection , with outcomes stratified by the presence of congenital heart defects (CHDs), using electronic health records (EHR) data from 19 children’s hospitals and health institutions from the United States within the RECOVER consortium between March 2020 and September 2023. The cohort included 297,920 SARS-CoV-2-positive individuals and 915,402 SARS-CoV-2-negative controls. Every individual had at least a six-month follow-up after cohort entry. Here we show that children and adolescents with prior SARS-CoV-2 infection are at a statistically significant increased risk of various cardiovascular outcomes, including hypertension, ventricular arrhythmias , myocarditis, heart failure, cardiomyopathy, cardiac arrest, thromboemboli...