ETIDIOH - NEW

Abstract Oropouche fever is caused by the Oropouche virus (OROV; Bunyaviridae , Orthobunyavirus), one of the most frequent arboviruses that infect humans in the Brazilian Amazon . This year, an OROV outbreak was identified in Brazil , and its vertical transmission was reported, which was associated with fetal death and microcephaly. We describe the clinical manifestations identified in three cases of congenital OROV infection with confirmed serology (OROV-IgM) in the mother-newborn binomial . One of the newborns died , and post-mortem molecular analysis using real-time RT-qPCR identified the OROV genome in several tissues . All three newborns were born in the Amazon region in Brazil , and the mothers reported fever, rash, headache, myalgia, and/or retro-orbital pain during pregnancy . The newborns presented with severe microcephaly secondary to brain damage and arthrogryposis , suggestive of an embryo/fetal disruptive process at birth . Brain and spinal images identified overlapping su...

Situation at a glance Between 1 January and 31 December 2024, a cumulative total of 151 Zika virus disease (ZVD) cases were reported from three states in India ( Gujarat, Karnataka, and Maharashtra states). Maharashtra State reported a cumulative total of 140 ZVD cases through the Integrated Disease Surveillance Programme (IDSP). Additionally, Karnataka and Gujarat states reported ten and one cases , respectively, in 2024. As of 31 December 2024, no cases of microcephaly and/or Guillain-Barre syndrome (GBS) associated with this outbreak have been reported. Zika virus (ZIKV) is transmitted to humans by the bite of an infected Aedes mosquito . Zika virus is also transmitted from mother to fetus during pregnancy, as well as through sexual contact, transfusion of blood and blood products, and possibly through organ transplantation. There is no specific treatment available for Zika virus infection or disease. Description of the situation Between 1 January and 31 December 2024, a cumulative ...