ETIDIOH - NEW

  Abstract Background Changes in the vaccine advisory process in the United States have disrupted immunization guidance , which reinforces the need for independent evidence review to inform decisions regarding immunization for respiratory viruses during the 2025–2026 season. Methods We conducted a systematic review of U.S.-licensed immunizations against coronavirus disease 2019 (Covid-19), respiratory syncytial virus (RSV), and influenza . We searched databases on PubMed/MEDLINE, Embase, and Web of Science for updates of the most recent review by the Advisory Committee on Immunization Practices (ACIP) Evidence-to-Recommendations for each disease, which was performed during the 2023–2024 period. Outcomes included vaccine efficacy and effectiveness against hospitalization, other clinical end points, and safety. Results Of 17,263 identified references, 511 studies met the inclusion criteria. Covid-19 mRNA vaccines against the XBB.1.5 subvariant had pooled vaccine effectiveness against...

  Antiviral Res BESSONNE M, Morel J, Nevers Q, Groutsch J, et al Inhibition of influenza virus replication by artificial proteins (alphaReps) targeting its RNA-polymerase. Antiviral Res. 2025 Oct 21:106300. doi: 10.1016/j.antiviral.2025.106300. PubMed           Abstract available BMC Pediatr WONG K, Ducharme R, Murphy MSQ, Clarke AE, et al SARS-CoV-2 infection in pregnancy and infant outcomes in the first year of life: a retrospective cohort study. BMC Pediatr. 2025;25:842. PubMed           Abstract available MAGGIO ABR, Palomo S, Joye R, Huguet H, et al Reduced aerobic capacity in children with multisystem inflammatory syndrome in children (MIS-C) after PICU admission: a retrospective cohort study, 2020-2022. BMC Pediatr. 2025;25:835. PubMed           Abstract available Cell HICKMAN HD, Moutsopoulos NM Don't forget to floss! An innovative approach for vaccine del...

  Abstract Background :  The purpose of this study was to retrospectively analyse the clinical presentation of RSV, Influenza , and SARS-CoV-2 infections in children across three consecutive seasons (2022/2023; 2023/2024; and 2024/2025).  Methods :  Of the 321 hospitalised patients , 129 ( 36% ) tested positive for RSV , 110 ( 38% ) for Influenza , and 82 ( 26% ) for SARS-CoV-2 . Children were aged ≤ 17 years (median: 15 months). The data were statistically analysed using the χ2 test, multinomial multivariable logistic regression, OR (odds ratio), and 95% CI (confidence interval).  Results :  Significant independent predictors of RSV infection were auscultatory abnormalities (OR: 15.9 [1.49–169]) and hospital admission ≥ 4 days after symptom onset (OR: 32.5 [1.19–907]). Among RSV-positive patients , compared with those aged < 6 months , those aged 7–24 months were more likely to present with higher CRP levels (OR 1.06 [1.003–1.13]), reduced appetite (OR ...

  Antiviral Res PATEL MC, Nguyen HT, Mishin VP, Pascua PNQ, et al Antiviral susceptibility monitoring: testing algorithm, methods, and findings for influenza season, 2023-2024. Antiviral Res. 2025 Oct 11:106299. doi: 10.1016/j.antiviral.2025.106299. PubMed           Abstract available ZHU C, Wang Z, Pan Z, Mai X, et al DMBT1 promotes SARS-CoV-2 infection and its SRCR-derived peptide inhibits SARS-CoV-2 infection. Antiviral Res. 2025 Sep 3:106269. doi: 10.1016/j.antiviral.2025.106269. PubMed           Abstract available TASHIMA R, Kuroda T, Nobori H, Miyagawa S, et al Ensitrelvir suppresses prolonged olfactory abnormalities derived from SARS-CoV-2 infection in hamsters. Antiviral Res. 2025 Sep 2:106270. doi: 10.1016/j.antiviral.2025.106270. PubMed           Abstract available BMC Pediatr WU LE, Wei JY, Lin ZH, Li HC, et al Clinical characteristics of children with ...

  Abstract Wastewater surveillance of respiratory pathogens can provide timely estimates of viral activity and disease trends in a population . Indoor air surveillance could be used similarly with some advantages but remains largely unvalidated at the community-scale. Here, an indoor air surveillance program was employed as part of public health environmental surveillance in Chicago, Illinois , USA. Ten air samplers were placed in healthcare and congregate living settings across the city. Weekly air samples were evaluated for influenza A, influenza B, respiratory syncytial virus, and SARS-CoV- 2 over two respiratory virus seasons. Citywide, aggregated air sample positivity and viral load were closely correlated with local clinical case and wastewater surveillance data across all respiratory viruses. Virus trends in air data often preceded clinical and wastewater, although this varied across pathogens and respiratory virus seasons. Further, whole-genome sequencing of SARS-CoV-2 show...

  Ann Intern Med LE VU M, Matthes KL, Schneider EB, Moerlen A, et al Maternal Influenza-Like Illness and Neonatal Health During the 1918 Influenza Pandemic in a Swiss City. Ann Intern Med. 2025 Oct 7. doi: 10.7326/ANNALS-24-03796. PubMed           Abstract available Antiviral Res SCHRELL L, Scheibner D, Dickmanns A, Stegmann KM, et al Inhibitors of pyrimidine synthesis synergize with N4-hydroxycytidine to diminish influenza virus replication. Antiviral Res. 2025 Oct 3:106286. doi: 10.1016/j.antiviral.2025.106286. PubMed           Abstract available Epidemiol Infect VAN DER ROEST B, Fischer EAJ, Klinkenberg D, Bootsma MCJ, et al Phylodynamic inference suggests introductions as main driver of Mpox Clade II outbreak in 2022 in Slovenia. Epidemiol Infect. 2025;153:e115. PubMed           Abstract available WOLDEGIORGIS M, Bloomfield L, Korda R, Cadby G, et al Factors a...

  Am J Med WAHID L, Kwon T, Kreuziger LB, Kasthuri RS, et al Extended Thromboprophylaxis in Patients Hospitalized with COVID-19 at Time of Discharge is Not Associated with Improvement in Quality of Life. Am J Med. 2025;138:1464-1468. PubMed           Abstract available Biochem Biophys Res Commun ZHANG L, Li Y, Ye K, Wang P, et al Article I. metformin affects H1N1-induced apoptosis in lung epithelial cells by the miR-130a-5p-regulated PI3K/AKT signaling pathway. Biochem Biophys Res Commun. 2025;782:152526. PubMed           Abstract available J Gen Virol HA Y, Lee YH, Jo HS, Kwon TW, et al Susceptibility of different mouse strains to SARS-CoV-2 spike receptor-binding domain protein-induced lung inflammation: a comparative study. J Gen Virol. 2025;106. PubMed           Abstract available J Infect Dis GAILLET A, Layese R, Fourati S, Celante H, et al Clinical Phenotype...