ETIDIOH - NEW

  Abstract Background Most studies of human metapneumovirus (HMPV) epidemiology have been among inpatients . This study examined the epidemiology of HMPV compared with other common viruses among outpatients seeking care for an acute respiratory illness (ARI) during 5 influenza seasons (2016–2017 to 2019–2020, before the coronavirus disease 2019 pandemic, and in 2021–2022, during the pandemic). Methods Outpatients ≥6 months old seeking care for ARI and presenting with cough of ≤7 days’ duration provided nasal and pharyngeal swab samples , demographic data, and access to electronic medical record data. Samples were tested with reverse-transcription polymerase chain reaction assays for HMPV , influenza, parainfluenza virus (PIV) 1–4, respiratory syncytial virus (RSV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Student′s t and χ2 tests were used to compare HMPV cases with other ARIs. Results After exclusion of 68 coinfections , 7143 patients remained; 2017 had in...

  Abstract Background :  Continuous, non-invasive viral surveillance is essential to monitor emerging pathogens and guide public health responses. Most environmental surveillance studies use targeted qPCR approaches , and comparisons between wastewater and indoor air surveillance remain limited. We aimed to compare the utility of emergency department indoor air and urban wastewater for tracking circulating viruses and resolving genomic information.  Methods :  We conducted a matched-pair study comparing 19 weekly indoor air samples from the central ventilation exhaust shaft of an emergency department and 19 24-hour composite municipal wastewater samples in Leuven, Belgium , from December 2024 to April 2025. Both sample sets were processed using probe-based hybrid-capture viral metagenomics targeting over 3000 viral species , using influenza A as a clinically relevant test case.  Findings :  Wastewater captured higher overall viral diversity (233 versus 106 ...

  Ann Intern Med LALANI HS, DiResta R, Baron RJ, Scales D, et al Addressing Viral Medical Rumors and False or Misleading Information. Ann Intern Med. 2023 Jul 18. doi: 10.7326/M23-1218. PubMed           Abstract available Antimicrob Agents Chemother ZHENG X, You X, Liu Y, Wu B, et al Spatiotemporal dynamics and multiple driving factors of antimicrobial resistance in China during the COVID-19 pandemic (2019-2023): a provincial panel data analysis. Antimicrob Agents Chemother. 2026 Feb 9:e0160025. doi: 10.1128/aac.01600. PubMed           Abstract available Antiviral Res ZHANG T, Wang ZL, Li XY, Luo RH, et al Onvansertib and vilazodone inhibit SARS-CoV-2 replication via suppression of METTL3 RNA-m(6)A enzymatic activity. Antiviral Res. 2026 Feb 19:106376. doi: 10.1016/j.antiviral.2026.106376. PubMed           Abstract available YURGELONIS I, Rai DK, Li Z, Washington ...

  Ann Intern Med SACKS HS In older adults, high- vs. standard-dose influenza vaccine reduced hospitalization for influenza or pneumonia in those with CKD. Ann Intern Med. 2026 Mar 3. doi: 10.7326/ANNALS-26-00324. PubMed           Abstract available ANAND R, Glatt AE In healthy adults, a modified RNA vs. inactivated influenza vaccine reduced laboratory-confirmed influenza-like illness at >/=14 d. Ann Intern Med. 2026 Mar 3. doi: 10.7326/ANNALS-25-05681. PubMed           Abstract available Antiviral Res RUDRAMURTHY GR, Gudla CS, Harisha R, Selvam V, et al FNDR-11124, a broad-spectrum small molecule inhibitor of viral RNA polymerase, restricts replication of SARS-CoV-2 and Influenza virus in vitro and in vivo. Antiviral Res. 2026 Mar 2:106382. doi: 10.1016/j.antiviral.2026.106382. PubMed           Abstract available Arch Virol DUTTA M, Sarmah N, Siddique AI, Borah...

  Abstract Wastewater monitoring enables non-invasive, population-scale tracking of community infections independent of healthcare-seeking behavior and clinical diagnosis. Metagenomic sequencing extends this capability by enabling broad, pathogen-agnostic detection, genomic characterization , and identification of novel or unexpected threats . Here, we present data from CASPER (the Coalition for Agnostic Sequencing of Pathogens from Environmental Reservoirs), a U.S.-based wastewater metagenomic sequencing network designed for deep, untargeted pathogen monitoring at national scale. This release includes 1,206 samples collected between December 2023 and December 2025 from 27 sites across nine states , covering 13 million people . Deep sequencing (~1 billion read pairs per sample) generated 1.2 trillion read pairs ( 347 terabases ), enabling detection of even rare taxa , with CASPER representing 66% of all untargeted wastewater sequencing data currently available on the NCBI Sequence ...

  Arch Virol KOBAYASHI D, Hiono T, Adachi R, Igarashi M, et al Length and density of alpha2-3 sialyllactose-containing chains on glycopolymers determine receptor binding of avian influenza viruses. Arch Virol. 2026;171:100. PubMed          PARK SH, Lee SH, Seo YR, Kim DJ, et al Evolution and spread of H8Nx avian influenza viruses from wild birds in East Asia, 2019-2024. Arch Virol. 2026;171:95. PubMed           Abstract available NAVEED A The bovine mammary gland as a crucible for zoonotic influenza virus emergence: Receptor-mediated adaptation of HPAI H5N1 clade 2.3.4.4b. Arch Virol. 2026;171:89. PubMed          Biochem Biophys Res Commun SINGH VA, Nehul S, Saha A, Singh V, et al Bioengineered chimeric VLPs targeting chikungunya virus and SARS-CoV-2 show high immunogenicity in mice. Biochem Biophys Res Commun. 2026;805:153346. PubMed        ...

  Antiviral Res WRONSKI S, Obernolte H, Schaudien D, Braun A, et al Prophylactic intranasal administration of bacterial lysate OM-85 mitigates human rhinovirus (RV-A1b) lung infection and inflammation in mice. Antiviral Res. 2026;247:106362. PubMed           Abstract available HEDSKOG C, Rodriguez L, Hu Y, Li J, et al SARS-CoV-2 Resistance Analyses From the Phase 3 BIRCH Study of Obeldesivir in High-Risk Nonhospitalized Participants With COVID-19. Antiviral Res. 2026 Jan 19:106351. doi: 10.1016/j.antiviral.2026.106351. PubMed           Abstract available RODRIGUEZ L, Hu Y, Li J, Han D, et al SARS-CoV-2 Resistance Analyses From the Phase 3 OAKTREE Study of Obeldesivir in Low-Risk Nonhospitalized Participants With COVID-19. Antiviral Res. 2025 Dec 29:106339. doi: 10.1016/j.antiviral.2025.106339. PubMed           Abstract available Arch Virol LIM KS, Selvan ME, Ea CK...