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Showing posts with the label RSV

Shifting tides: increased #severity despite fewer visits for #infant respiratory #infections across two consecutive post-pandemic winters in Northern #Italy

By G.M.
  Abstract This study compares infant (0–24 months) respiratory infection presentations to a Northern Italian paediatric emergency department across two post-pandemic winters ( 2022–2023 vs 2023–2024 ). Despite an approximate 44% reduction in visits in 2023–2024 (N=176 in 2023–2024 vs N=317 in 2022–2023), infants in the 2023–2024 season experienced significantly higher proportions of ventilatory support (51.1% vs 32.8%, p<0.001) and intensive care unit admission (15.9% vs 1.9%, p<0.001) than those presenting in 2022–2023, with a non-significant trend towards higher hospitalisation (88.1% vs 81.7%, p=0.052). Respiratory syncytial virus re-emerged as the dominant pathogen (43.2% vs 27.7%, p<0.001) in 2023–2024, alongside increased human metapneumovirus and influenza A H1N1 . These findings highlight a concerning shift towards increased severity, underscoring the need for ongoing surveillance. Source: BMJ Paediatric Open,  https://bmjpaedsopen.bmj.com/content/9/1/e003695...
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#Influenza and Other Respiratory Viruses Research #References (by AMEDEO, September 13 '25)

By G.M.
  Antiviral Res ICHIKAWA T, Tamura T, Nao N, Suzuki H, et al Characterization of remdesivir resistance mutations in COVID-19 patients with various immunosuppressive diseases. Antiviral Res. 2025;242:106264. PubMed           Abstract available BI W, Zhu T, Xu Y, Chen Y, et al An engineered chimeric ACE2-HR2 peptide exhibits potent and broad-spectrum activity against SARS-CoV-2 variants. Antiviral Res. 2025;242:106265. PubMed           Abstract available TERATAKE Y, Okamura T, Ishizaka Y SMAD5 phosphorylation by ALK1 is modulated by the interaction of the spike protein of SARS-CoV-2 and angiotensin-converting enzyme 2. Antiviral Res. 2025;242:106261. PubMed           Abstract available YAO G, Shi X, Jiang H, Duan A, et al Design, synthesis, and biological evaluation of novel 6-aminoalkyl- and 7-heteroaryl substituted 7-deazapurine nucleoside analogs against SARS-CoV...
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#Influenza and Other Respiratory Viruses Research #References (by AMEDEO, September 6 '25)

By G.M.
  Antimicrob Agents Chemother YAMADA AY, de Souza AR, Madalosso G, de Assis DB, et al Emergence of carbapenem-resistant Acinetobacter baumannii clonal complex 2 in multiple hospitals in Sao Paulo state, Brazil. Antimicrob Agents Chemother. 2025 Jul 23:e0186524. doi: 10.1128/aac.01865. PubMed           Abstract available Biochemistry XIA H, Wei D, Guo Z, Chung LW, et al Machine Learning on the Impacts of Mutations in the SARS-CoV-2 Spike RBD on Binding Affinity to Human ACE2 Based on Deep Mutational Scanning Data. Biochemistry. 2025;64:3790-3800. PubMed           Abstract available Cell KONG W, Lu WJ, Dubey M, Suryawanshi RK, et al Neuroendocrine cells orchestrate regeneration through Desert hedgehog signaling. Cell. 2025;188:5020-5038. PubMed           Abstract available J Gen Virol POKHAREL BR, Majumdar N, Williams F, Dickerson A, et al SARS-CoV-2 infection of su...
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#Influenza and Other Respiratory Viruses Research #References (by AMEDEO, August 30 '25)

By G.M.
  Arch Virol HU Y, Hu C, Su J, Zhu B, et al Two cross-neutralizing antibodies isolated from a COVID-19 convalescent via single B cell sorting. Arch Virol. 2025;170:199. PubMed           Abstract available Biochemistry ADEWOYE A, Ezeigbo E, Vo QH, Legleiter J, et al Amyloidogenic SARS-CoV-2 Spike Protein-Derived Peptides Form Oligomers and Selectively Damage Lipid Membranes. Biochemistry. 2025;64:3610-3622. PubMed           Abstract available Epidemiol Infect PARRADO R, Cuba-Grandy CX, Fuentes-Luppichini E, Torrico Villarroel NG, et al Multiplex RT-qPCR strategy for SARS-CoV-2 variants detection in developing countries without ngs: The Bolivian experience. Epidemiol Infect. 2025;153:e94. PubMed           Abstract available BUBAR K, Middleton C, Larremore D, Gostic K, et al A fundamental limit to the effectiveness of traveller screening with molecular tests. Epidemi...
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#Influenza and Other Respiratory Viruses Research #References (by AMEDEO, August 26 '25)

By G.M.
  Antiviral Res GUAN S, Wang Q, Nie J, Yao X, et al Optimization of the monoclonal antibody 3E1 through W32I mutation enhances antiviral efficacy against influenza virus subtypes H1N1 and H3N2. Antiviral Res. 2025;242:106260. PubMed           Abstract available Biochem Biophys Res Commun GABELMANN A, Biesel A, Loretz B, Lehr CM, et al Exploring the future of mRNA delivery: Beyond lipid nanoparticles. Biochem Biophys Res Commun. 2025;778:152347. PubMed           Abstract available Biochemistry SUBRAMANIAM S, Saville JW, Feng F, Freiburger L, et al Therapeutic Antibodies for Infectious Diseases: Recent Past, Present, and Future. Biochemistry. 2025;64:3487-3494. PubMed           Abstract available Epidemiol Infect CHOI H, Hwang M, Coppin JD, Chatterjee P, et al Penetration of SARS-CoV-2 Alpha, Delta, and Omicron variants in the United States. Epidemiol Infect. 2025;1...
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