ETIDIOH - NEW

  Am J Med BILC M, Cramer H Use of Complementary Medicine Among US Adults with Post-COVID-19: Results from the 2022 National Health Interview Survey. Am J Med. 2025;138:862-869. PubMed           Abstract available MAURO M, Cegolon L, Bestiaco N, Zulian E, et al Heart Rate Variability Modulation Through Slow-Paced Breathing in Health Care Workers with Long COVID: A Case-Control Study. Am J Med. 2025;138:870-883. PubMed           Abstract available NAIK H, Wilton J, Tran KC, Janjua NZ, et al Long-Term Health-Related Quality of Life in Working-Age COVID-19 Survivors: A Cross-Sectional Study. Am J Med. 2025;138:850-861. PubMed           Abstract available PALACIO A, Bast E, Klimas N, Tamariz L, et al Lessons Learned in Implementing a Multidisciplinary Long COVID Clinic. Am J Med. 2025;138:843-849. PubMed           Abstract avail...

Abstract Gammacoronavirus (γ-CoV) primarily infects poultry, wild birds, and marine mammals . The widespread distribution and circulation of γ-CoV in the ecological environment may lead to sustained transmission and economic loss . To better understand the diversity of γ-CoV in wild birds , we collect 482 wild-bird fecal samples from Yunnan , encompassing fourteen bird species . We detected twelve γ-CoV positive samples in five bird species, with the characterization of five complete genomes - HNU5-1, HNU5-2, HNU5-3, HNU6-1, and HNU6-2 -indicating that these genomes represent two viral species . The HNU5 strains were derived from Black-headed gull (Chroicocephalus ridibundus), while the HNU6 strains were came from Mallard (Anas platyrhynchos), and both of those were recombinant. The HNU5 strain exhibited the highest sequence identity (95.45%) with a γ-CoV strain isolated from Numenius phaeopus (GenBank accession: PP845452). Similarly, the HNU6 strain showed 95.18% nucleotide identity w...

Abstract Circulating bat coronaviruses present a significant pandemic threat, yet our  understanding of  their genetic diversity and evolutionary dynamics remains limited.  Over 3 years, we sampled  1,462 bats in Cambodia’s Steung Treng province,  identifying extensive and diverse  coronaviruses co-circulation. Using  metatranscriptomic and amplicon sequencing, we  generated 33 complete  sarbecovirus genomes, revealing novel lineages that cluster into four  distinct  groups, each associated with different Rhinolophus bat species. Our analysis  highlights rapid migration and recombination of sarbecovirus lineages over  short distances  and timescales. Of note, the receptor-binding domains of two novel  viral groups exhibit high  similarity to SARS-CoV-2, and pseudovirus assays  confirmed the ability of this spike protein  to mediate entry into cells expressing  human ACE2, suggesting a potentia...

Abstract SARS-like betacoronaviruses (sarbecoviruses) endemic in bats pose a significant zoonotic threat to humans . Genetic pathways associated with spillover of bat sarbecoviruses into humans are incompletely understood. We previously showed that the WT spike of the rhinolophid bat coronavirus SHC014 -CoV has poor entry activity and uncovered two distinct genetic pathways outside the receptor-binding domain (RBD) that increased spike opening, ACE2 binding , and cell entry. Herein, we show that the widely studied bat sarbecovirus WIV1-CoV is likely a cell culture-adapted variant of Rs3367-CoV, which was sequenced from the same population of rhinolophid bats as SHC014-CoV. We demonstrate that the acquisition of a single amino-acid substitution in the ‘630-loop’ of the S1 subunit was the key spike adaptation event during the successful isolation of WIV1-CoV, and that it enhances spike opening, virus-receptor recognition, and cell entry in much the same manner as the substitutions we pre...

  Br J Anaesth GILLIS C, Hasil L, Keane C, Brassard D, et al A multimodal prehabilitation class for Enhanced Recovery After Surgery: a pragmatic randomised type 1 hybrid effectiveness-implementation trial. Br J Anaesth. 2025 Apr 7:S0007-0912(25)00153-9. doi: 10.1016/j.bja.2025. PubMed           Abstract available Clin Infect Dis IOANNOU GN, Berry K, Rajeevan N, Li Y, et al Target Trial Emulation of Severe Acute Respiratory Syndrome Coronavirus 2 Infection Versus No Infection and Risk of Post-Coronavirus Disease 2019 Conditions in the Omicron Variant Versus Prior Eras. Clin Infect Dis. 2025 Apr 10:ciaf087. doi: 10.1093. PubMed           Abstract available Int J Infect Dis JOLLIVET O, Urchueguia-Fornes A, Chung-Delgado K, Johannesen CK, et al Respiratory Syncytial Virus hospitalisation burden in children below 18 years in six European countries (2016-2023) pre- and post-COVID-19 pandemic. Int J Infect Dis...

Abstract Most human emerging infectious diseases are zoonotic , originating in animal hosts prior to spillover to humans . Prioritizing the surveillance of wildlife that overlaps with humans and human activities can increase the likelihood of detecting viruses with a high potential for human infection. Here, we obtained fecal swabs from two fruit bat species —Eidolon helvum (n = 6) and Epomophorus wahlbergi (n = 43) (family Pteropodidae)— in peridomestic habitats in Nairobi, Kenya , and used metagenome sequencing to detect microorganisms. A near-complete genome of a novel virus assigned taxonomically to the Coronaviridae family Betacoronavirus genus and Nobecovirus subclade was characterized from E. wahlbergi. Phylogenetic analysis indicates this unique Nobecovirus clade shares a common ancestor with Eidolon/Rousettus Nobecovirus subclades isolated from Madagascar, Kenya, and Cameroon . Recombination was detected across open reading frames, except the spike protein, in all BOOTSCAN ana...

Abstract Three studies recently published in Cell reveal distinct ACE2 binding interactions across the merbecoviruses , uncovering how HKU5 can use ACE2s of many non-human hosts and identifying a novel HKU5 lineage capable of using human ACE2. These findings highlight merbecovirus receptor plasticity and caution for preparedness against potential merbecovirus threats. Source: Cell, Host & Microbe,  https://www.cell.com/cell-host-microbe/abstract/S1931-3128(25)00096-4?rss=yes ____

  Ann Intern Med DACSO CC Coadministration of RSV + influenza or COVID-19 vaccines was noninferior to separate administration for immune responses in adults aged >/=50 y. Ann Intern Med. 2025 Apr 1. doi: 10.7326/ANNALS-25-00904. PubMed           Abstract available AMAN M, Jeevananthan A, Martinez-Cruz M, Namasingh N, et al Endocrinology: What You May Have Missed in 2024. Ann Intern Med. 2025 Apr 1. doi: 10.7326/ANNALS-25-00990. PubMed           Abstract available HAMED HKA, Nachman A, Riopel N, Schuster M, et al Infectious Diseases: What You May Have Missed in 2024. Ann Intern Med. 2025 Apr 1. doi: 10.7326/ANNALS-25-00925. PubMed           Abstract available CORONADO GD, Petrik AF, Thompson JH, Leo MC, et al Patient Navigation to Improve Colonoscopy Completion After an Abnormal Stool Test Result : A Randomized Controlled Trial. Ann Intern Med. 2025 Apr 1. doi: ...

  Ann Intern Med GRANWEHR BP CBT and rehabilitation improved long COVID symptoms. Ann Intern Med. 2025;178:JC28. PubMed           Abstract available BMJ WISE J Covid-19: Inquiry hears of doctors' lack of confidence in PPE as ministers defend VIP lane. BMJ. 2025;388:r584. PubMed          Clin Infect Dis ALLAN-BLITZ LT, Klausner JD Shifting the Focus in Acute SARS-CoV-2 Management to Include Prevention of Long-COVID. Clin Infect Dis. 2025 Mar 26:ciaf158. doi: 10.1093. PubMed          Emerg Infect Dis SANDER B, Mishra S, Swayze S, Sahakyan Y, et al Population-Based Matched Cohort Study of COVID-19 Healthcare Costs, Ontario, Canada. Emerg Infect Dis. 2025;31:710-719. PubMed           Abstract available Intensive Care Med BIHLMAIER K, Willam C, Herbst L, Hackstein H, et al Rapid clinical effects of convalescent plasma therapy in severe COV...

Abstract The coronavirus membrane protein (M) is the main organizer of coronavirus assembly. Here, we report on an M-targeting molecule , CIM-834, that blocks the assembly of SARS-CoV-2. CIM-834 was obtained through high-throughput phenotypic antiviral screening followed by medicinal-chemistry efforts and target elucidation. CIM-834 inhibits the replication of SARS-CoV-2 (including a broad panel of variants) and SARS-CoV. In SCID mice and Syrian hamsters intranasally infected with SARS-CoV-2, oral treatment reduced lung viral titres to nearly undetectable levels, even (as shown in mice) when treatment was delayed until 24 h before the end point. Treatment of infected hamsters prevented transmission to untreated sentinels. Transmission electron microscopy studies show that virion assembly is completely absent in cells treated with CIM-834. Single-particle cryo-electron microscopy reveals that CIM-834 binds and stabilizes the M protein in its short form, thereby preventing the conformati...

  Ann Intern Med Correction: Anticoagulation Among Patients Hospitalized for COVID-19. Ann Intern Med. 2025 Mar 18. doi: 10.7326/ANNALS-25-00916. PubMed          Antiviral Res SAFIRIYU AA, Hussain A, Dewangan N, Kasle G, et al The fusion peptide of the spike protein S2 domain may be a mimetic analog of beta-coronaviruses and serve as a novel virus-host membrane fusion inhibitor. Antiviral Res. 2025 Mar 16:106144. doi: 10.1016/j.antiviral.2025.106144. PubMed           Abstract available XU M, Zhang Z, Sun Y, Mai H, et al Corrigendum to "IgA class switching enhances neutralizing potency against SARS-CoV-2 by increased antibody hinge flexibility" [Antiv. Res. (2025) 106082]. Antiviral Res. 2025 Mar 20:106146. doi: 10.1016/j.antiviral.2025.106146. PubMed          Graefes Arch Clin Exp Ophthalmol ZUREIK A, Couturier A, Delcourt C Evolution of ophthalmological care in adult with ...

  Am J Obstet Gynecol TAN YY, Loy EXH, Tan WZ, Tay AT, et al Long COVID-19 in pregnancy: increased risk but modest incidence following mild Omicron infection in a boosted obstetric cohort during endemicity. Am J Obstet Gynecol. 2025 Mar 10:S0002-9378(25)00147. PubMed           Abstract available BMJ IACOBUCCI G Covid-19: Gove tried to "circumvent" regulations to buy Dyson ventilators, inquiry hears. BMJ. 2025;388:r502. PubMed          Clin Infect Dis BARTOLETTI M, Mozaffari E, Amin AN, Doi Y, et al A systematic review and meta-analysis of the effectiveness of remdesivir to treat SARS-CoV-2 infection in hospitalized patients: have the guidelines evolved with the evidence? Clin Infect Dis. 2025 Mar 11:ciaf111. doi: 10.1093. PubMed           Abstract available COX SN, Roychoudhury P, Frivold C, Acker Z, et al Household Transmission and Genomic Diversity of Respiratory Syn...

Significance To date, no study has investigated the relationships between air pollutants and the progression of COVID-19 , nor the potential role of genetic susceptibility on the associations. This large population-based cohort study investigates the associations between air pollutants and genetic susceptibility, both individually and in combination, with the risk of COVID-19-related outcomes. It involves 458,396 participants from UK Biobank and demonstrates that air pollutants interact with host genetic susceptibility in both multiplicative and additive manners, thereby influencing the risk of COVID-19 severity. This study with cutting-edge methods provides robust evidence for the interplay between environmental and genetic factors on COVID-19 outcomes. Abstract The relationships between air pollution, genetic susceptibility, and COVID-19-related outcomes, as well as the potential interplays between air pollution and genetic susceptibility, remain largely unexplored. The Cox proportio...

  Antiviral Res PADEY B, Droillard C, Duliere V, Fouret J, et al Host-targeted repurposed diltiazem enhances the antiviral activity of direct acting antivirals against Influenza A virus and SARS-CoV-2. Antiviral Res. 2025 Mar 4:106138. doi: 10.1016/j.antiviral.2025.106138. PubMed           Abstract available Clin Infect Dis BULLOCK A, Dalton AF, Stockwell MS, McLaren SH, et al Ongoing Symptoms After Acute SARS-CoV-2 or Influenza Infection in a Case-Ascertained Household Transmission Study: 7 US Sites, 2021-2023. Clin Infect Dis. 2025 Feb 26:ciaf026. doi: 10.1093. PubMed           Abstract available SWARTWOOD NA, Cohen T, Marks SM, Hill AN, et al Effects of the COVID-19 pandemic on TB outcomes in the United States: a Bayesian analysis. Clin Infect Dis. 2025 Feb 27:ciaf092. doi: 10.1093. PubMed           Abstract available Emerg Infect Dis BI K, Bandekar SR, Bouchni...