ETIDIOH - NEW

  Am J Respir Crit Care Med SARMA A, Christenson SA, Shoshana BZ, Oliveira AP, et al Acute Respiratory Distress Syndrome Molecular Phenotypes Have Distinct Lower Respiratory Tract Transcriptomes. Am J Respir Crit Care Med. 2025;211:2352-2362. PubMed           Abstract available Ann Intern Med SOUMARE A, Kapfer T, Botrel T, Adda L, et al Systemic Corticosteroids, Mortality, and Infections in Pneumonia and Acute Respiratory Distress Syndrome : A Systematic Review and Meta-analysis. Ann Intern Med. 2025 Dec 2. doi: 10.7326/ANNALS-25-03055. PubMed           Abstract available BMJ LOGAN M FDA claims 10 child deaths caused by covid-19 vaccine, vows to tighten vaccine approvals. BMJ. 2025;391:r2546. PubMed          Graefes Arch Clin Exp Ophthalmol NEO YN, Martinez-Alvarez L, Davagnanam I, Girafa G, et al Treatment of post-vaccination optic neuritis: implications from the glob...

{Summary} Context   Over five years since the detection of the first COVID-19 cases , SARS-CoV-2 continues to circulate globally, causing acute illness, hospitalization, and death , alongside prolonged negative impacts on individuals, health systems , and economies , including post-COVID-19 condition (PCC or Long COVID).  While global population-level immunity has increased significantly through both infection and vaccination, the virus continues to evolve, challenging control efforts and underscoring the need for long-term, sustainable disease management .  Confirming earlier warnings from MERS-CoV and SARS-CoV-1 , SARS-CoV-2 has demonstrated the pandemic potential of coronaviruses , which remain one of the most consequential infectious disease threats of our time .  Purpose of the strategic plan   This plan sets out WHO’s strategic framework to support Member States in the sustained, integrated, evidence-based management of coronavirus disease threats , includ...

  BMJ Analysis of peer reviewers' response to invitations by gender and geographical region: cohort study of manuscripts reviewed at 19 biomedical journals before and during covid-19 pandemic. BMJ. 2025;391:r2507. PubMed          Clin Infect Dis NGUYEN VAN JC, Pilmis B, El Helali N, Azria E, et al Implementing POCT in infectious diseases. Clin Infect Dis. 2025 Nov 27:ciaf650. doi: 10.1093. PubMed           Abstract available PANAGIOTOPOULOS AP, Anastassopoulou C, Tsakris A, Ioannidis JPA, et al Effective Antivirals in Pandemic Preparedness: Past Mistakes, Future Needs. Clin Infect Dis. 2025 Nov 25:ciaf648. doi: 10.1093. PubMed           Abstract available Int J Infect Dis HEMPEL H, Xue H, La Shu S, Jain S, et al Cancer and COVID-19: A review of Immune Insights and Partnerships to Inform Public Health Strategy. Int J Infect Dis. 2025 Nov 24:108252. doi: 10.1016/j.ijid.2...

  Abstract The membrane (M) protein of coronaviruses is essential for maintaining structural integrity during membrane virion budding and viral pathogenesis . Given its high conservation in lineages within the betacoronavirus genus , such as sarbecoviruses , the M protein presents as an attractive therapeutic target ; however, developing broad-spectrum antivirals targeting coronaviruses such as MERS-CoV is challenging due to lower sequence conservation and limited structural information available beyond that of the SARS-CoV-2 M protein . In this study, we report 3-3.2 Å resolution structures of MERS-CoV M protein, engineered with a SARS-CoV-2-like antibody interface, representing the first human merbecovirus M protein structure , and SARS-CoV M protein structures, with and without a previously identified SARS-CoV-2 M protein inhibitor, JNJ-9676. We highlight the structural differences between the MERS-CoV, SARS-CoV and SARS-CoV-2 M proteins, and present insights into the conservati...

  Clin Infect Dis LIANG C, Judy J, Chilson EL, Kelly SP, et al Estimating Risk of Guillain-Barre Syndrome in US Medicare-Enrolled Older Adults Following Medically Attended Respiratory Syncytial Virus Disease: A Self-Controlled Case Series Analysis. Clin Infect Dis. 2025 Nov 14:ciaf621. doi: 10.1093. PubMed           Abstract available ZUGER A Home testing for contagious illness: Historical context and modern caveats. Clin Infect Dis. 2025 Nov 14:ciaf623. doi: 10.1093. PubMed           Abstract available Int J Infect Dis AHMAD WA, Wolff-Sagy Y, Battat E, Arbel R, et al Mortality following recovery from COVID-19 hospitalization: a long-term cohort study. Int J Infect Dis. 2025 Nov 13:108223. doi: 10.1016/j.ijid.2025.108223. PubMed           Abstract available WANG C, Gao Y, Li W, Du J, et al Short-Term Risks of Influenza and COVID-19 Following Influenza Infection: A...

  Int J Infect Dis SILVA CAC, Bomfim AP, Medeiros JD, Silva JJ, et al Nasal Microbiota and Clinical Features in Acute Flu-Like Illness: COVID-19 Status and Long COVID Follow-Up. Int J Infect Dis. 2025 Nov 11:108196. doi: 10.1016/j.ijid.2025.108196. PubMed           Abstract available SONG J, Jeong S, Chun AY, Jung J, et al Incidence of Respiratory Infections after the COVID-19 Pandemic (2023-2024) and Its Association of Vaccination Among Entire Populations in Korea. Int J Infect Dis. 2025 Nov 7:108194. doi: 10.1016/j.ijid.2025.108194. PubMed           Abstract available VERGORI A, Matusali G, Lepri AC, Cimini E, et al Supporting equitable booster strategies: one-year real-world immunogenicity data in people with HIV (PWH) receiving different variant-adapted COVID-19 vaccines. Int J Infect Dis. 2025 Nov 7:108189. doi: 10.1016/j.ijid.2025.108189. PubMed           Ab...

  {Excerpt} The constant emergence of novel SARS-CoV-2 variants has driven the COVID-19 pandemic and sustains the current endemic . Saltation variants , such as BA.2.86 ,1 encode highly mutated spike (S) proteins that efficiently evade neutralising antibodies . In November, 2024, a potential saltation variant, BA.3.2 , was detected in South Africa but its spread remained uncertain. Early studies on BA.3.2 did not include comparisons among its subvariants or with dominant variants NB.1.8.1 and XFG.2 ,3 Moreover, the effect of the often overlooked S protein insertion of Ala-Ser-Asp-Thr at position 214 remained unexamined. In this Correspondence, we provide an epidemiological and virological update on BA.3.2, with the use of BA.3 (parental lineage) and NB.1.8.1 and XFG (currently prevalent) as references. (...) Source: The Lancet Infectious Diseases,  https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00658-9/fulltext?rss=yes ____

  Abstract Bats are associated with some of the most significant and virulent emerging zoonoses globally , yet research and surveillance of bat pathogens remains limited across parts of the world. We surveyed the prevalence and genetic diversity of coronaviruses from bats in Taita Hills, southeastern Kenya , as part of ongoing surveillance efforts in this remote part of eastern Africa. We collected fecal and intestinal samples in May 2018 and March 2019 from 16 bat species . We detected one genus of coronavirus (alphacoronavirus), with an overall RNA prevalence of 6.5% (30/463). The prevalence of coronavirus RNA was 3.8% (9/235) and 11.6% (21/181) for the two most captured free-tailed bat species, Mops condylurus and M. pumilus respectively, with no detections from other bat species (0/90). Phylogenetic analyses based on the partial RNA-dependent RNA polymerase gene and whole genome sequences revealed that the sequences clustered together and were closely related to alphacoronaviru...

  Acad Emerg Med OHLE R, Roy D, Baraku E, Patel K, et al A Prospective Multi-Center Implementation Study to Improve the Diagnosis and Treatment of Benign Paroxysmal Positional Vertigo. Acad Emerg Med. 2025 Nov 3. doi: 10.1111/acem.70177. PubMed           Abstract available Am J Obstet Gynecol YE Y, Mahati S, Aihemaiti W, Lu G, et al A postpartum-adapted algorithm for safe management of suspected pulmonary embolism: a retrospective cohort study. Am J Obstet Gynecol. 2025 Nov 1:S0002-9378(25)00813. PubMed           Abstract available Antiviral Res DENG X, Zou J, Liang Z, Ren P, et al A Dual-Reporter HCoV-OC43 for Coronavirus Biology and Countermeasure Development. Antiviral Res. 2025 Nov 3:106306. doi: 10.1016/j.antiviral.2025.106306. PubMed           Abstract available BMJ WISE J Covid-19: Major study compares myocarditis risk in children after vaccination or infec...

  Abstract Dipeptidyl peptidase-4 (DPP4) is an established receptor for Middle East respiratory syndrome-related coronaviruses (MERSr-CoVs), while recent studies have identified angiotensin-converting enzyme 2 (ACE2) usage in multiple merbecovirus clades . Yet, receptor usage of many genetically diverse bat MERSr-CoVs remains unclear . Here we show that broadly distributed HKU25 clade merbecoviruses use ACE2 , rather than DPP4, as their receptor. Cryo-electron microscopy revealed that HsItaly2011 and VsCoV-a7 strains engage ACE2 similarly to HKU5 but with remodelled interfaces and distinct orthologue selectivity, suggesting a shared evolutionary origin of ACE2 recognition . EjCoV-3, a close relative of the DPP4-using BtCoV422, showed broad multi-species ACE2 tropism and preadaptation to human ACE2 . Several ACE2 glycans and residues within or near the binding interface were identified as determinants of orthologue selectivity. These viruses remain sensitive to several broadly neutr...

  Clin Infect Dis CALABRESE C, Wang Y, Duggal A, Huang S, et al Effectiveness of Nirmatrelvir/Ritonavir or Molnupiravir Use in Immunocompromised Patients on B-Cell-Depleting Therapy With COVID-19: A Target Trial Emulation Study. Clin Infect Dis. 2025 Oct 24:ciaf521. doi: 10.1093. PubMed           Abstract available FONG Y, Huang Y, Huang Y, Woo W, et al Analysis of antibody markers as immune correlates of risk of severe COVID-19 in the PREVENT-19 efficacy trial of the NVX-CoV2373 recombinant protein vaccine. Clin Infect Dis. 2025 Oct 25:ciaf558. doi: 10.1093. PubMed           Abstract available KABORE JL, Laffont B, Diop M, Tardif MR, et al Real-World Effectiveness of Nirmatrelvir-Ritonavir in Preventing Coronavirus Disease 2019-Associated Hospitalization: A Population-Based Cohort Study in the Province of Quebec, Canada. Clin Infect Dis. 2025 Oct 29:ciaf145. doi: 10.1093. PubMed    ...

  Br J Anaesth THOMAS C, Pearse RM Socioeconomic deprivation and health inequity: independently associated with postoperative outcomes, and does this matter? Br J Anaesth. 2025;135:1141-1143. PubMed           Abstract available Clin Infect Dis TARTOF SY, Aliabadi N, Goodwin G, Slezak J, et al Estimated Vaccine Effectiveness for Respiratory Syncytial Virus-Related Acute Respiratory Illness in Older Adults: Findings From the First Postlicensure Season. Clin Infect Dis. 2025 Oct 21:ciaf496. doi: 10.1093. PubMed           Abstract available MANABE YC, Hamill MM, Palamountain KM, Achenbach CJ, et al The Critical Importance of Clinical Use Case to Inform Point-of-Care Technology Development: A Case Study of Human Immunodeficiency Virus Nucleic Acid Assays in the United States. Clin Infect Dis. 2025 Oct 23:ciaf510. doi: 10.1093. PubMed           Abstract available Graefe...

  Abstract Background :  The COVID-19 pandemic , driven by the SARS-CoV-2 virus, has become an unprecedented global public health challenge . Comprehensive investigation of the virus transmission dynamics requires exploration of all potential routes , including the role of animal reservoirs . This study aimed to assess the presence of SARS-CoV-2 RNA and antibodies in urban rodents captured within two landscape units (low-income neighborhoods and green spaces) in the metropolitan area of Buenos Aires (MABA), Argentina. Methods :  Between July 2020 and September 2022, 125 synanthropic rodents (68 Rattus norvegicus, 22 R. rattus, and 35 Mus musculus) from seven low-income neighborhoods and seven green spaces in the MABA were captured and examined for SARS-CoV-2 exposure and infection by indirect immunofluorescence serology and RT-qPCR, targeting the N, E, and ORF1ab genes. Results :  Two M. musculus and six R. norvegicus from five different low-income neighborhoods test...

  AJR Am J Roentgenol LITTLE BP Imaging and Reporting of Post-COVID-19 Lung Abnormalities at CT: International Panel of Experts Provides Welcome Guidance. AJR Am J Roentgenol. 2025 Oct 15. doi: 10.2214/AJR.25.33999. PubMed          Infect Control Hosp Epidemiol ELHAISSOUNI N, Arthur A, Prochaska EC, Colantuoni E, et al Association of pandemic precautions and Staphylococcus aureus in the NICU. Infect Control Hosp Epidemiol. 2025 Oct 13:1-3. doi: 10.1017/ice.2025.10319. PubMed           Abstract available Int J Infect Dis OPPONG AE, Coelewij L, Hutchinson M, Carpenter B, et al Simple hyperinflammation scores predict mortality in hospitalised patients with COVID-19 and offer a personalised medicine approach to dexamethasone intervention. Int J Infect Dis. 2025 Oct 13:108119. doi: 10.1016/j.ijid.2025.108119. PubMed           Abstract available J Infect TANG X, Ma T, Yao Z,...