ETIDIOH - NEW

  Antiviral Res HEDSKOG C, Rodriguez L, Hu Y, Li J, et al SARS-CoV-2 Resistance Analyses From the Phase 3 BIRCH Study of Obeldesivir in High-Risk Nonhospitalized Participants With COVID-19. Antiviral Res. 2026 Jan 19:106351. doi: 10.1016/j.antiviral.2026.106351. PubMed           Abstract available BMJ HIGGS J Help me piece my story together. BMJ. 2026;392:r2624. PubMed          RUSSELL MD, Schaffer A, Bechman K, Gibson M, et al Time trends in newly recorded diagnoses of 19 long term conditions before, during, and after the covid-19 pandemic: population based cohort study in England using OpenSAFELY. BMJ. 2026;392:e086393. PubMed           Abstract available Clin Infect Dis WINOKUR P, Diya O, Fitz-Patrick D, Dever M, et al Safety and Immunogenicity of a Fourth Dose of Omicron-BA.1-Adapted BNT162b2 COVID-19 Vaccines in Adults 18?55 Years Old. Clin Infect Dis. 2026 Jan 21...

  BMJ MARTIN DS, Doidge JC, Gould D, Shahid T, et al The impact of skin tone on performance of pulse oximeters used by NHS England COVID Oximetry @home scheme: measurement and diagnostic accuracy study. BMJ. 2026;392:e085535. PubMed           Abstract available Int J Infect Dis AMODIO E, Aiello R, Battisti M, Casuccio A, et al Past Behavior Predicts Future Protection: Uncovering Key Drivers of Influenza Vaccine Acceptance in Italy in the Post-Pandemic Era. Int J Infect Dis. 2026 Jan 8:108379. doi: 10.1016/j.ijid.2026.108379. PubMed           Abstract available SEO G, Joo H, Song K, Kim M, et al Static and Dynamic Scoring Systems for Post-acute Sequelae of SARS-CoV-2 in a Korean Cohort. Int J Infect Dis. 2026 Jan 9:108378. doi: 10.1016/j.ijid.2026.108378. PubMed           Abstract available PIOVESAN C, Fabiani M, Pezzotti P, Ramigni M, et al Mortality for causes un...

  BMJ FLINDERS M, Cairney P, Elliott IC Delivering change after the UK covid inquiry. BMJ. 2026;392:s18. PubMed          YAMEY G, Shaffer J Trump and RFK Jr are dismantling public health-aided and abetted by powerful doctors. BMJ. 2026;392:s19. PubMed          Clin Infect Dis RAO A, Johnson L, Bassit L, Sullivan J, et al Independent Testing to Accelerate the Development of Lateral Flow Assays for Influenza A, Influenza B and SARS-COV-2. Clin Infect Dis. 2026 Jan 9:ciaf660. doi: 10.1093. PubMed           Abstract available WANG XF, Calabrese C, Calabrese L Target Trial Emulation of Oral Antivirals for B-Cell-Depleted COVID-19 Patients-Reply to Chen et al. Clin Infect Dis. 2026 Jan 9:ciaf718. doi: 10.1093. PubMed          PURPURA L, Heisler T, Palmer S, Shah J, et al Overlapping Clinical Presentation of Long COVID and Postacute COVID-19 Vacc...

  Abstract Since its emergence in 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) has posed a significant threat to human health . Recently, novel MERS-like coronaviruses with the potential for cross-species transmission have been identified. In this study, we focused on two newly isolated bat strains with putative health concern: BatCoV/Ii/GD/2014-422 (2014-422) and BtTp-BetaCoV/GX2012 (GX2012). We determined the cryo-EM structures of the spike glycoprotein trimer in the closed state for these two viruses. These structures display a more compact conformation compared to MERS-CoV spike . Biochemical characterization demonstrates that the spike receptor-binding domains (RBDs) of 2014-422 and GX2012 can bind to human dipeptidyl peptidase 4 (hDPP4). To investigate the structural determinants of pseudovirus infection, we solved the cryo-EM structures of 2014-422 RBD-hDPP4 and GX2012 RBD-hDPP4 complexes. The binding mode of the complex is conserved, but the angle of the RB...

  Antiviral Res RODRIGUEZ L, Hu Y, Li J, Han D, et al SARS-CoV-2 Resistance Analyses From the Phase 3 OAKTREE Study of Obeldesivir in Low-Risk Nonhospitalized Participants With COVID-19. Antiviral Res. 2025 Dec 29:106339. doi: 10.1016/j.antiviral.2025.106339. PubMed           Abstract available Eur J Radiol YAO J, Zhang L, Huang S, Cao S, et al Changes in the cerebral glymphatic system after rehabilitation of COVID-19 patients: A five-year follow-up study. Eur J Radiol. 2025;195:112615. PubMed           Abstract available Int J Infect Dis DAVIDO B, Mamona C, Gault E, Annane D, et al "Three of a Kind?" Unmasking the Clinical Burden of Human Metapneumovirus and Parainfluenza Virus Compared to Respiratory Syncytial Virus in Hospitalized Adults: A Pre-COVID-19 Multicenter Cohort Study. Int J Infect Dis. 2025 Dec 26:108353. doi: 10.1016/j.ijid.2025.108353. PubMed         ...

  Abstract SARS-CoV, MERS-CoV, and SARS-CoV-2 have posed tremendous threats to human health, highlighting the necessity of monitoring cross-species transmission of animal coronaviruses to humans. Hedgehogs infected with coronaviruses have been reported in several countries across Europe and Asia, raising concerns about the potential transmission of coronaviruses from hedgehogs to humans. In this study, we investigated coronavirus infections in hedgehogs inhabiting greenspaces in metropolitan Beijing and identified a Merbecovirus subgenus coronavirus with a prevalence rate of 30% (95% CI: 25–35%) among 317 hedgehogs . Phylogenetic analysis of 23 complete viral genome sequences revealed a monophyletic origin , showing close relatedness to Erinaceus hedgehog coronavirus HKU31 (Ea-HedCoV HKU31) with genome-wide nucleotide identities of 93.24–96.42%, and evidence of recombination with Tylonycteris bat coronavirus HKU4 . These findings suggest that the increase in wildlife populations as...

  Infect Control Hosp Epidemiol LI Q, Novosad S, Rha B, Hua H, et al Trends of bloodstream infection incidence rates among patients on outpatient hemodialysis, National Healthcare Safety Network, 2012-2021. Infect Control Hosp Epidemiol. 2025 Dec 18:1-7. doi: 10.1017/ice.2025. PubMed           Abstract available Int J Infect Dis CHOI WS, Kim KH, Kim DS, Lee SH, et al Increased 30-day Mortality Risk in Coronavirus Disease 2019 Compared to Seasonal Influenza. Int J Infect Dis. 2025 Dec 17:108312. doi: 10.1016/j.ijid.2025.108312. PubMed           Abstract available RODGERS MA, Averhoff F, Berg MG, Anderson M, et al Robust mission-driven responses to infectious disease threats delivered by the Abbott pandemic defense coalition. Int J Infect Dis. 2026;162:108162. PubMed           Abstract available J Med Virol WU Y, Yang C, Wei X, Xiao T, et al Albendazole Suppresses S...

  Abstract The MERS-COV virus is a zoonotic coronavirus that emerged in 2012 in KSA and caused viral illness with a case fatality rate up to 35 %. Over a decade later, the virus is still evolving and circulating . The aim of this review is to discuss the current epidemiology of MERS-COV both in humans and animals, during and post the COVID-19 pandemic. We have found that MERS-COV is still evolving in camels with new lineages being detected in Saudi Arabia . Although the number of human cases has decreased , there is a gradual resurgence in the number of cases. Furthermore, many cases are being reported without exposure to camels and/or raw products, nor contact with known human cases . This necessitates global efforts in the surveillance of asymptomatic carriers in the community, role of unknown animal reservoirs in the virus spread if any, as well as extensive genomic surveillance of the virus. This is in order to unveil and assess the genetic changes that the virus is undergoing ...

  ABSTRACT Middle East respiratory syndrome coronavirus (MERS-CoV) causes a highly lethal respiratory infection for which no vaccines or antiviral therapeutics are currently available . Understanding the immune response is critical for designing effective therapeutics . Here, we comprehensively characterized the dynamics of B-cell responses in severely infected MERS-CoV patients and survivors with SARS-CoV-2 exposure history . Infected patients developed robust neutralizing antibody responses within 1 month of illness , with moderate-to-high cross-neutralization activity against SARS-CoV-2 . The enhanced neutralization activity coincided with an increased abundance of specific mutated, class-switched IgG clones. Notably, one such clone was detected at moderate prevalence in both patients, and its expansion was accompanied by high neutralization activity against both viruses . Conversely, MERS-CoV survivors demonstrated higher neutralization activity against MERS-CoV after vaccinati...

  Clin Infect Dis BIEBELBERG B, Chen T, McKenna C, Kanjilal S, et al Associations between antibiotic use and outcomes in patients hospitalized with community-acquired pneumonia and positive respiratory viral assays. Clin Infect Dis. 2025 Dec 11:ciaf687. doi: 10.1093. PubMed           Abstract available Emerg Infect Dis BRAUNFELD JB, Traub E, Chiou H, Amoon AT, et al Community-Driven, Text Message-Based COVID-19 Surveillance System, Los Angeles County, California, USA, 2020-2024. Emerg Infect Dis. 2025;31:2109-2117. PubMed           Abstract available Int J Infect Dis LI H, LiuPhD J, Fang Q, Li Z, et al Pathogen-specific immunity debt in children after prolonged nonpharmaceutical interventions: a cross-sectional study in China. Int J Infect Dis. 2025 Dec 3:108278. doi: 10.1016/j.ijid.2025.108278. PubMed           Abstract available JIANG Z, Shan T, Li Y, Han F, et ...

  Am J Respir Crit Care Med SARMA A, Christenson SA, Shoshana BZ, Oliveira AP, et al Acute Respiratory Distress Syndrome Molecular Phenotypes Have Distinct Lower Respiratory Tract Transcriptomes. Am J Respir Crit Care Med. 2025;211:2352-2362. PubMed           Abstract available Ann Intern Med SOUMARE A, Kapfer T, Botrel T, Adda L, et al Systemic Corticosteroids, Mortality, and Infections in Pneumonia and Acute Respiratory Distress Syndrome : A Systematic Review and Meta-analysis. Ann Intern Med. 2025 Dec 2. doi: 10.7326/ANNALS-25-03055. PubMed           Abstract available BMJ LOGAN M FDA claims 10 child deaths caused by covid-19 vaccine, vows to tighten vaccine approvals. BMJ. 2025;391:r2546. PubMed          Graefes Arch Clin Exp Ophthalmol NEO YN, Martinez-Alvarez L, Davagnanam I, Girafa G, et al Treatment of post-vaccination optic neuritis: implications from the glob...

{Summary} Context   Over five years since the detection of the first COVID-19 cases , SARS-CoV-2 continues to circulate globally, causing acute illness, hospitalization, and death , alongside prolonged negative impacts on individuals, health systems , and economies , including post-COVID-19 condition (PCC or Long COVID).  While global population-level immunity has increased significantly through both infection and vaccination, the virus continues to evolve, challenging control efforts and underscoring the need for long-term, sustainable disease management .  Confirming earlier warnings from MERS-CoV and SARS-CoV-1 , SARS-CoV-2 has demonstrated the pandemic potential of coronaviruses , which remain one of the most consequential infectious disease threats of our time .  Purpose of the strategic plan   This plan sets out WHO’s strategic framework to support Member States in the sustained, integrated, evidence-based management of coronavirus disease threats , includ...

  BMJ Analysis of peer reviewers' response to invitations by gender and geographical region: cohort study of manuscripts reviewed at 19 biomedical journals before and during covid-19 pandemic. BMJ. 2025;391:r2507. PubMed          Clin Infect Dis NGUYEN VAN JC, Pilmis B, El Helali N, Azria E, et al Implementing POCT in infectious diseases. Clin Infect Dis. 2025 Nov 27:ciaf650. doi: 10.1093. PubMed           Abstract available PANAGIOTOPOULOS AP, Anastassopoulou C, Tsakris A, Ioannidis JPA, et al Effective Antivirals in Pandemic Preparedness: Past Mistakes, Future Needs. Clin Infect Dis. 2025 Nov 25:ciaf648. doi: 10.1093. PubMed           Abstract available Int J Infect Dis HEMPEL H, Xue H, La Shu S, Jain S, et al Cancer and COVID-19: A review of Immune Insights and Partnerships to Inform Public Health Strategy. Int J Infect Dis. 2025 Nov 24:108252. doi: 10.1016/j.ijid.2...

  Abstract The membrane (M) protein of coronaviruses is essential for maintaining structural integrity during membrane virion budding and viral pathogenesis . Given its high conservation in lineages within the betacoronavirus genus , such as sarbecoviruses , the M protein presents as an attractive therapeutic target ; however, developing broad-spectrum antivirals targeting coronaviruses such as MERS-CoV is challenging due to lower sequence conservation and limited structural information available beyond that of the SARS-CoV-2 M protein . In this study, we report 3-3.2 Å resolution structures of MERS-CoV M protein, engineered with a SARS-CoV-2-like antibody interface, representing the first human merbecovirus M protein structure , and SARS-CoV M protein structures, with and without a previously identified SARS-CoV-2 M protein inhibitor, JNJ-9676. We highlight the structural differences between the MERS-CoV, SARS-CoV and SARS-CoV-2 M proteins, and present insights into the conservati...

  Clin Infect Dis LIANG C, Judy J, Chilson EL, Kelly SP, et al Estimating Risk of Guillain-Barre Syndrome in US Medicare-Enrolled Older Adults Following Medically Attended Respiratory Syncytial Virus Disease: A Self-Controlled Case Series Analysis. Clin Infect Dis. 2025 Nov 14:ciaf621. doi: 10.1093. PubMed           Abstract available ZUGER A Home testing for contagious illness: Historical context and modern caveats. Clin Infect Dis. 2025 Nov 14:ciaf623. doi: 10.1093. PubMed           Abstract available Int J Infect Dis AHMAD WA, Wolff-Sagy Y, Battat E, Arbel R, et al Mortality following recovery from COVID-19 hospitalization: a long-term cohort study. Int J Infect Dis. 2025 Nov 13:108223. doi: 10.1016/j.ijid.2025.108223. PubMed           Abstract available WANG C, Gao Y, Li W, Du J, et al Short-Term Risks of Influenza and COVID-19 Following Influenza Infection: A...