#Coronavirus Disease Research #References (AMEDEO, July 25 '26)

 

BMJ

1. 
   Addressing the indirect health burden of covid-19.
   BMJ. 2026;394:e100376.
   PubMed        
   
   
2. 
   Reduced disease detection during covid-19.
   BMJ. 2026;394:e100377.
   PubMed        
   
   

   
   Clin Infect Dis

3. ISKANDER JK, Haridopolos S
   Making Invisible Illnesses Visible: Recognizing and Responding to Infection-Associated Chronic Conditions.
   Clin Infect Dis. 2026;83:e58-e61.
   PubMed         Abstract available
   
   

   
   Infect Control Hosp Epidemiol

4. MCGILL E, Lee D, Quach C, Leis JA, et al
   Hospital characteristics associated with healthcare-associated viral respiratory infection rates in a Canadian acute care network.
   Infect Control Hosp Epidemiol. 2026 Jul 22:1-9. doi: 10.1017/ice.2026.10490.
   PubMed         Abstract available
   
   

   
   Int J Infect Dis

5. JO S, Min KD, Cho SI
   Counterfactual Evaluation of COVID-19 Control Policies in South Korea: A Scenario-Based Modeling Study.
   Int J Infect Dis. 2026 Jul 22:108997. doi: 10.1016/j.ijid.2026.108997.
   PubMed         Abstract available
   
   

   
   Intensive Care Med

6. EHRMANN S, Li J, Liu L, Guerin C, et al
   Prone positioning in ARDS.
   Intensive Care Med. 2026 Jul 20. doi: 10.1007/s00134-026-08543.
   PubMed         Abstract available
   
   

   
   J Infect

7. QUINOT C, Lunt R, Kirsebom F, Andrews N, et al
   Serological outcomes of SARS-CoV-2 infection by vaccination status and variant in England.
   J Infect. 2026;93:106819.
   PubMed         Abstract available
   
   

   
   J Med Virol

8. ZUNIGA-HERNANDEZ ME, Reyes-Barrera KL, Hidalgo-Figueroa SN, Paez-Perez ED, et al
   ACE2- and HR2-Mimetic Peptides Inhibit Replication of Two SARS-CoV-2 Variants.
   J Med Virol. 2026;98:e71060.
   PubMed         Abstract available
   
   
9. RIZZO A, Salari F, Galli C, Maffeo M, et al
   Integrated Hospital, Emergency Department, and Community Surveillance for Respiratory Viruses in Milan, Italy.
   J Med Virol. 2026;98:e71073.
   PubMed         Abstract available
   
   
10. JAVED A, Hayat J, Haider SA, Jamal Z, et al
    Molecular Surveillance and Genomic Characterization of Influenza A(H3N2) Viruses From a Secondary-Care Surveillance Site in Pakistan During the 2025-2026 Winter Season.
    J Med Virol. 2026;98:e71075.
    PubMed         Abstract available
    
    

    
    J Virol

11. HERNANDEZ PC, Moeller NH, Aihara H
    Distinct modes of RNA degradation by the structurally related coronavirus and arenavirus exoribonucleases.
    J Virol. 2026 Jul 23:e0079826. doi: 10.1128/jvi.00798.
    PubMed         Abstract available
    
    
12. LIU X, Wang L, Liu Y, Xiong M, et al
    Single-cell RNA sequencing identifies uterine stromal cells as a previously unrecognized target of an alphacoronavirus underlying reproductive disorders.
    J Virol. 2026 Jul 22:e0023726. doi: 10.1128/jvi.00237.
    PubMed         Abstract available
    
    
13. XU Y, Mou C, Xiang Y, Liu H, et al
    HERPUD1 suppresses porcine epidemic diarrhea virus replication by recruiting HRD1 to degrade viral ORF3 protein.
    J Virol. 2026;100:e0062626.
    PubMed         Abstract available
    
    
14. BEETON K, Case JB
    Respiratory mucosal vaccines for emerging viruses: promise and challenges.
    J Virol. 2026 Jul 23:e0174825. doi: 10.1128/jvi.01748.
    PubMed         Abstract available
    
    
15. FANG P, Xiao W, Wang X, Xiong Y, et al
    Identification of TMEM41B TM6 as a critical domain for coronavirus replication in vitro and in vivo.
    J Virol. 2026 Jul 24:e0049326. doi: 10.1128/jvi.00493.
    PubMed         Abstract available
    
    

    
    JAMA

16. CAMILLERI M
    Gastroparesis: A Review.
    JAMA. 2026 Jul 22. doi: 10.1001/jama.2026.12181.
    PubMed         Abstract available
    
    

    
    Lancet Infect Dis

17. HOFFMANN M, Shandheep A, Pavlou A, Rahmel-Stein K, et al
    Pseudovirus-based analysis of host cell entry and vaccine-induced neutralisation of Bundibugyo virus.
    Lancet Infect Dis. 2026 Jul 23:S1473-3099(26)00407.
    PubMed        
    
    
18. WU M, Hong H, Guo Y, Daniel K, et al
    SARS-CoV-2 BA.3.2.2 is more evasive of neutralisation by plasma from young children.
    Lancet Infect Dis. 2026 Jul 22:S1473-3099(26)00349.
    PubMed        
    
    
19. ONYEAGHALA C
    A defining clinical moment during the COVID-19 pandemic in Nigeria.
    Lancet Infect Dis. 2026;26:e277.
    PubMed        
    
    
20. AHMAD N, Ure R, MacDonald L, Keegan S, et al
    Genomic epidemiology of invasive meningococcal disease in Scotland before, during, and after the COVID-19 pandemic: a retrospective observational study.
    Lancet Infect Dis. 2026 Jul 21:S1473-3099(26)00284.
    PubMed         Abstract available
    
    

    
    Nature

21. 
    Mapping drivers of life expectancy change in Asia from 1990 to 2023.
    Nature. 2026 Jul 22. doi: 10.1038/s41586-026-10739.
    PubMed         Abstract available
    

Characterization and evolutionary history of novel #SARS-CoV-2-related viruses in #bats from #Cambodia

 

Abstract

Circulating bat coronaviruses present a significant pandemic threat, yet our understanding of their genetic diversity and evolutionary dynamics remains limited. Over 3 years, we sampled 1,462 bats in Cambodia’s Steung Treng province, identifying extensive and diverse coronaviruses co-circulation. Using metatranscriptomic and amplicon sequencing, we generated 33 complete sarbecovirus genomes sequences, revealing novel lineages that cluster into four distinct groups, each associated with different Rhinolophus bat species. Our analysis highlights rapid migration and recombination of sarbecovirus lineages over short distances and timescales. Of note, the receptor-binding domains of two novel viral groups exhibit high similarity to SARS-CoV-2, and pseudovirus assays confirmed the ability of this spike protein to mediate entry into cells expressing human ACE2, suggesting a potential zoonotic risk. The observed genetic diversity underscores the urgent need for continuous surveillance to identify high-risk animal-to-human interfaces and inform pandemic preparedness.

Source: 

Link: https://www.nature.com/articles/s41467-026-75954-1

____

#Coronavirus Disease Research #References (AMEDEO, July 19 '26)

 

Clin Infect Dis

1. PAYNE DC, Weinberg GA, Halasa NB, Englund JA, et al
   The New Vaccine Surveillance Network: 25 years of active, population-based surveillance for pediatric infectious diseases in the United States.
   Clin Infect Dis. 2026 Jul 13:ciag434. doi: 10.1093.
   PubMed         Abstract available
   
   
2. MEYEROWITZ EA, Richterman A
   Hantavirus on a Cruise Ship: What COVID-19 Taught Us.
   Clin Infect Dis. 2026 Jul 11:ciag428. doi: 10.1093.
   PubMed         Abstract available
   
   

   
   Emerg Infect Dis

3. FALENDER R, Kaya D, Harry M, Hachimi O, et al
   Targeted Wastewater Surveillance during the World Athletics Championship, Oregon, USA, 2022.
   Emerg Infect Dis. 2026;32.
   PubMed         Abstract available
   
   

   
   Int J Infect Dis

4. AUBRY A, Brochot E, Demey B, Louchet-Ducoroy M, et al
   Epidemiological trends in viral CNS infections in a French university hospital from 2019 to 2024, as revealed by multiplex PCR testing of cerebrospinal fluid samples.
   Int J Infect Dis. 2026 Jul 12:108977. doi: 10.1016/j.ijid.2026.108977.
   PubMed         Abstract available
   
   

   
   J Infect

5. HANSEN CL, Shaikh N, Naeger S, Torcel-Pagnon L, et al
   Hospitalizations and deaths from major respiratory viruses in the US: An ensemble time series modeling study, 2016-2025.
   J Infect. 2026;93:106811.
   PubMed         Abstract available
   
   

   
   J Med Virol

6. RIZZUTO J, Amarin JZ, Polic A, Howe HL, et al
   Severe COVID-19 in Pregnant Versus Nonpregnant Women: Intensive Care Unit Outcomes and Perinatal Risks.
   J Med Virol. 2026;98:e71036.
   PubMed         Abstract available
   
   

   
   J Virol

7. LOU J, Guo Z, Chen K, Tian Y, et al
   Cyclo-C stabilizes PEX13 to inhibit porcine epidemic diarrhea virus replication by blocking pexophagy-mediated disruption of antiviral innate immunity.
   J Virol. 2026 Jul 17:e0078526. doi: 10.1128/jvi.00785.
   PubMed         Abstract available
   
   
8. OVERSTI S, Lytras S, Kawakubo S, Ito J, et al
   From sites to structure to serology: a roadmap for structure-aware molecular evolution of antigenically evolving viruses.
   J Virol. 2026 Jul 16:e0168725. doi: 10.1128/jvi.01687.
   PubMed         Abstract available
   
   
9. KAWAHARA S, Nao N, Tulakarnwong S, Suzuki S, et al
   GC content mismatch of transgene destabilizes RNA virus genomes.
   J Virol. 2026 Jul 13:e0088226. doi: 10.1128/jvi.00882.
   PubMed         Abstract available
   
   

   
   Lancet

10. CRIVELLI L, Suemoto CK, Sosa AL, Lopera F, et al
    Multidomain lifestyle intervention for the prevention of cognitive decline in at-risk older adults in Latin America (LatAm-FINGERS): a single-blind, multicentre, randomised controlled trial.
    Lancet. 2026 Jul 13:S0140-6736(26)01278-X. doi: 10.1016/S0140-6736(26)01278.
    PubMed         Abstract available
    
    

    
    Lancet Infect Dis

11. OPPEGAARD O, Blomberg B, Cox RJ, Iversen A, et al
    Nirmatrelvir for acute COVID-19 to prevent long COVID (PANORAMIC Norway): a double-blind, randomised, placebo-controlled trial.
    Lancet Infect Dis. 2026 Jul 16:S1473-3099(26)00244.
    PubMed         Abstract available
    
    
12. NAIDOO T, Morgenstern C, Doohan P, Earl R, et al
    A systematic review of Nipah virus disease epidemiological parameters, outbreaks, and mathematical models.
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    PubMed         Abstract available
    
    

    
    N Engl J Med

13. WARKENTIN TE, Greinacher A
    Platelet-Activating Anti-Platelet Factor 4 Disorders.
    N Engl J Med. 2026 Jul 13. doi: 10.1056/NEJMra2502459.
    PubMed         Abstract available
    
    

    
    Nature

14. 
    Party pooper: grandparents' COVID risk rose after grandchildren's birthdays.
    Nature. 2026 Jul 13. doi: 10.1038/d41586-026-02194.
    PubMed        
    
    
15. GULLAND A
    This microbiologist endured a four-year court battle over COVID-19 tests.
    Nature. 2026 Jul 13. doi: 10.1038/d41586-026-01654.
    PubMed        
    

#Coronavirus Disease Research #References (AMEDEO, July 11 '26)

 

Am J Respir Crit Care Med

1. JERRETT M, Nau CL, Young DR, Butler RK, et al
   Association Between Air Pollution and Post Acute Sequelae of SARS-CoV-2 (PASC).
   Am J Respir Crit Care Med. 2026 Jul 3:aamag341. doi: 10.1093.
   PubMed        
   
   

   
   Ann Intern Med

2. DARNALL BD, Perez L, Kao MC, Lorig K, et al
   Patient-Centered Prescription Opioid Tapering Methods : A Randomized Clinical Trial.
   Ann Intern Med. 2026 Jul 7. doi: 10.7326/ANNALS-25-04784.
   PubMed         Abstract available
   
   

   
   BMJ

3. HAQ ZU
   Ebola control is weakened by mistrust and cultural insensitivity.
   BMJ. 2026;394:e100190.
   PubMed        
   
   

   
   Clin Infect Dis

4. ROSTER KIO, White PJ, Grad YH
   Why Are Gonorrhea Case Rates Declining in the United States? A Research Agenda.
   Clin Infect Dis. 2026;82:1082-1090.
   PubMed         Abstract available
   
   

   
   Int J Infect Dis

5. MIYAKAWA K, Sano K, Seki Y, Sato R, et al
   Cross-neutralization of SARS-CoV-2 BA.3.2.2 lineage by JN.1 mRNA vaccine-induced immunity.
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   PubMed         Abstract available
   
   
6. JO Y, Hu Z, Joo H, Jung J, et al
   Time to Recovery from Long COVID: A Longitudinal Analysis of Symptom Duration and Risk Factors Using Accelerated Failure Time Models.
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   PubMed         Abstract available
   
   
7. CHUI CSL, Lau JC, Fan M, Chan BP, et al
   Concurrent comparison of severity of influenza and COVID-19 among hospitalized patients in Hong Kong: a target trial emulation on observational healthcare data.
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   PubMed         Abstract available
   
   
8. JABER F, Rawas SE, Faraj S, Zoghby LA, et al
   Value of the Pitt bacteremia score in predicting the outcome of non-bacteremic patients with infections caused by multidrug-resistant organisms.
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   PubMed         Abstract available
   
   
9. ACANFORA D, Nolano M, Acanfora C, Colella C, et al
   Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19: in vivo evidence of structural autonomic dysfunction.
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   PubMed         Abstract available
   
   

   
   J Infect

10. VINK E, Murphy ME, Gunson R, MacConnachie A, et al
    Respiratory viral detection in adult severe acute respiratory infection post-COVID-19 pandemic: implications for antimicrobial stewardship.
    J Infect. 2026;93:106805.
    PubMed         Abstract available
    
    

    
    J Med Virol

11. BUMBERGER AM, Kastner MT, Gawish R, Rusing L, et al
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    PubMed         Abstract available
    
    
12. WENINGER J, Zedginidze A, Katsounas A, Pohl M, et al
    Assessment of Residual-Serum SARS-CoV-2-N-Antigen Testing for Hospital Surveillance in Germany.
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    PubMed         Abstract available
    
    
13. GORIS M, Valdez M, Lamont L, Yang W, et al
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14. TUNER B, Agca H
    Molecular Types of Rhinovirus Among Cases of Acute Respiratory Infections in a University Hospital.
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    PubMed         Abstract available
    
    

    
    J Virol

15. LIANG Y-F, Li X, Zhu G-x, Song Y, et al
    Magnolol inhibits porcine epidemic diarrhea virus infection by suppressing cathepsin L expression in vitro and in vivo.
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    PubMed         Abstract available
    
    
16. ZHAO Y, Zhao J, Li Y, Duan L, et al
    Disruption of the S1/S2 multibasic cleavage site attenuates infectious bronchitis virus, while S2' partially restores viral virulence and expands tissue tropism.
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    PubMed         Abstract available
    
    
17. STEFANOS B, Green NRB, Nadig I, Lapierre LA, et al
    Coronavirus membrane protein with a fluorescent protein tag enables particle tracking for the study of virus assembly and egress in live cells.
    J Virol. 2026 Jul 6:e0222825. doi: 10.1128/jvi.02228.
    PubMed         Abstract available
    
    
18. ZHOU R, Yue M, Shen Q, Liu N, et al
    Glucagon-like peptide-1 receptor agonist prevents pulmonary fibrosis following acute COVID-19 infection associated with type 2 diabetes.
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    PubMed         Abstract available
    
    

    
    Lancet

19. DEZZA FC, Pulido LB, Borreguero IB, Perez FD, et al
    Temocillin versus carbapenems for bacteraemia due to third-generation cephalosporin-resistant Enterobacterales in Spain (ASTARTE): a multicentre, phase 3, open-label, non-inferiority, randomised clinical trial.
    Lancet. 2026 Jul 9:S0140-6736(26)00760-9. doi: 10.1016/S0140-6736(26)00760.
    PubMed         Abstract available
    
    

    
    Lancet Infect Dis

20. 
    Efficacy and safety of rivaroxaban, colchicine, and famotidine-loratadine with specialist supportive clinical care for fatigue in patients with post-COVID-19 condition in the UK: a multisite, open-label, randomised controlled trial.
    Lancet Infect Dis. 2026 Jul 8:S1473-3099(26)00242.
    PubMed         Abstract available
    
    

    
    MMWR Morb Mortal Wkly Rep

21. PATRICK R, Lee K, Kuan M, Chan M, et al
    Norovirus, COVID-19, and Influenza Outbreaks Among Residents and Staff Members at the Eaton Wildfire Evacuation Shelter - Pasadena, California, January-February 2025.
    MMWR Morb Mortal Wkly Rep. 2026;75:337-342.
    PubMed         Abstract available

#Genomic and structural #evidence of #SARS-CoV-2 and #MERS-CoV in migratory #birds

 

Significance

Coronaviruses are regarded as highly important pathogens of birds and mammals. Herein, we obtained three almost full-length severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes and one partial Middle East respiratory syndrome coronavirus (MERS-CoV) genome in the feces of migratory birds based on meta-transcriptome and PCR amplification. We determined the affinities and the complex structures between receptor-binding domain (RBD) of the SARS-CoV-2 viral spike protein and angiotensin-converting enzyme 2 (ACE2) protein of two migratory birds, Tundra and Black swans. Moreover, pseudotyped SARS-CoV-2 variants can enter into HeLa cells expressing ACE2 proteins of these birds. Altogether, our results expand our understanding of migratory birds as potential carrier of both SARS-CoV-2 and MERS-CoV.

Abstract

Migratory birds are the natural reservoir of influenza A virus (IAV), but their role as a carrier of SARS-CoV-2 remains unclear. Here, we report the identification of three almost full-length viral genome sequences of SARS-CoV-2 variants of concern (VOCs) in Tundra swans. These sequences are named hCoV-19/Tundra swan/Jiangxi/IMCAS_M1/2021 (IMCAS_M1), hCoV-19/Tundra swan/Jiangxi /IMCAS_M2/2021 (IMCAS_M2), and hCoV-19/Tundra swan/Jiangxi/IMCAS_M3/2021 (IMCAS_M3). IMCAS_M1 and IMCAS_M3 have the same mutations as the Beta VOC (K417N, E484K, and N501Y) in the receptor-binding domain (RBD) of the viral spike (S) protein, whereas IMCAS_M2 shares the same mutations as the Gamma VOC (K417T, E484K, and N501Y) in the RBD with all three showing their distinct mutations in the genomes. Virus receptor angiotensin-converting enzyme 2 (ACE2) proteins from both Tundra swan (tsACE2) and Black swan (bsACE2) can bind to the RBDs of all three viruses and the Alpha VOC, but not to RBD of the prototype (PT) virus. The polar contacts and hydrophobic interactions revealed by cryo-electron microscopy (cryo-EM) structures of the RBD–ACE2 complex, play key roles in virus–receptor engagement. Furthermore, HeLa cells expressing bsACE2 and tsACE2 proteins could be transduced by pseudotyped SARS-CoV-2 variants (Alpha, Beta, and Gamma) but not PT SARS-CoV-2. In addition, we obtained one partial genome of MERS-CoV named Bar-headed goose/Tibet/IMCAS_M4/2022 (IMCAS_M4) with 20,180 bp (~70.0% coverage). Our findings highlight the importance of migratory birds as potential carrier of both SARS-CoV-2 and MERS-CoV, thereby posing potential threat to public health.

Source: 

Link: https://www.pnas.org/doi/abs/10.1073/pnas.2400023123?af=R

____

Evaluation of a proposed #link between the #SARS-CoV-2 #furin #cleavage site and mouse-adapted #MERS-coronavirus MA30

 

Significance

This study formally evaluates a hypothesis that has been advanced by some scientists and public commentators in support of a nonnatural origin of SARS-CoV-2. The hypothesis proposes that the unique polybasic furin cleavage motif of SARS-CoV-2 may be technically or evolutionarily derived from a mouse-adapted laboratory strain of MERS-coronavirus (MA30). While the World Health Organization’s Scientific Advisory Group on the Origins of Novel Pathogens (SAGO) concluded that the available evidence was insufficient to support the proposed link, the underlying scientific rationale for this conclusion has not been published. We systematically assessed the evidence from genomic surveillance and conducted additional experimental studies. Together, these data do not support an evolutionary or genetic relationship.

Abstract

The origin of the polybasic furin cleavage site (FCS) of SARS-CoV-2 remains a central question in debates on the emergence of COVID-19. One hypothesis proposes a genetic relationship between the SARS-CoV-2 S1/S2 motif RRAR and the RRVR sequence found in the mouse-adapted MERS-CoV strain MERS-MA30. Here, we combined large-scale bioinformatic analysis with experimental virology to evaluate this scenario. Analysis of over 17 million SARS-CoV-2 genomes revealed that the S:684V substitution corresponding to RRVR occurred repeatedly but only sporadically, never became phylogenetically basal, and showed limited geographic and temporal spread. Using reverse genetics, we generated SARS-CoV-2 variants encoding RRVR and demonstrated that S:684V consistently reduced viral entry efficiency and competitive fitness in multiple cell systems, including human respiratory epithelial cultures. RRVR variants did not evolve toward RRAR but instead accumulated alternative substitutions. These findings do not support an evolutionary relationship between MERS-MA30 and the SARS-CoV-2 FCS.

Source: 

Link: https://www.pnas.org/doi/abs/10.1073/pnas.2601806123?af=R

____

#Coronavirus Disease Research #References (AMEDEO, July 5 '26)

 

Ann Intern Med

1. XIE Y, Choi T, Al-Aly Z
   Adverse Events After Same-Day COVID-19 and Influenza Vaccination Versus Influenza Vaccination Alone : A Target Trial Emulation.
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   PubMed         Abstract available
   
   
2. 
   Summary for Patients: Adverse Events After Same-Day COVID-19 and Influenza Vaccination Versus Influenza Vaccination Alone.
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   PubMed        
   
   

   
   BMJ

3. COZZOLINO A
   Covid-19 vaccine study pulled by US CDC is finally published.
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   J Infect

4. RAN J, Zhu L, Ning M, Zhang W, et al
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   J Med Virol

5. WIDANAGAMAACHCHI WN, Callahan AR, Willson TM, Barbeau B, et al
   How Many Veteran COVID-19 Cases Were There during the Pandemic?
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   J Travel Med

6. KASSIANOS G, Goodyer L, Gomensoro EEB, Doobaree U, et al
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   J Virol

7. ZHOU X, Ivanov KI, Ge X, Guo X, et al
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8. TIWAREKAR V, Ebenig A, Predota Y, Schrauf S, et al
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9. ZHANG L, Li Y, Zhao J, Liang R, et al
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   JAMA

10. LEUNG PB, Davis AM, Marks KM
    Antiviral Therapies for Adults With Mild to Moderate COVID-19 Infection.
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    PubMed        
    
    

    
    Lancet

11. BLAKNEY AK, Top KA, Cowling BJ, Larson HJ, et al
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    PubMed         Abstract available

#Coronavirus Disease Research #References (AMEDEO, June 27 '26)

 

Antiviral Res

1. WANG W, Wang S, Meng X, Zhao Y, et al
   Corrigendum to "A virus-like particle candidate vaccine based on CRISPR/Cas9 gene editing technology elicits broad-spectrum protection against SARS-CoV-2" [Antivir. Res. 225 (2024) 105854].
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   BMJ

3. BONVOISIN T, Todsen AL, Perinpanathan T
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   Int J Infect Dis

4. ZHANG H, Xiang C, Mu Y, Gu X, et al
   Association of acute-phase corticosteroid use with SARS-CoV-2 reinfection among hospitalized COVID-19 survivors:a 3-year follow-up study.
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   PubMed         Abstract available
   
   
5. VAN WEELDEN G, Rabie H, Redfern A, Barday MA, et al
   Evaluating Mucosal and Systemic Immunity in an Observational Cohort of South African Children Hospitalised with Acute Respiratory Tract Infections.
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   PubMed         Abstract available
   
   
6. VAN BILSEN CJA, Wijnen SMCE, Pagen DME, Hoebe CJPA, et al
   Workforce exit and work productivity loss in adults with and without post-COVID-19 condition: the PRIME post-COVID cohort study.
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   PubMed         Abstract available
   
   
7. JUBAIR M, Begum MN, Samia NSN, Alam MS, et al
   Epidemiological and Genomic Surveillance of Influenza virus A, RSV B and SARS-CoV-2 in Bangladesh (2022-2024).
   Int J Infect Dis. 2026 Jun 24:108910. doi: 10.1016/j.ijid.2026.108910.
   PubMed         Abstract available
   
   
8. ENA N, Garcia-Abellan J, Ledesma C, Fernandez-Gonzalez M, et al
   Low prevalence of bacterial coinfection at hospital admission in COVID-19 and the role of procalcitonin as a rule-out biomarker (Revised Version).
   Int J Infect Dis. 2026 Jun 25:108925. doi: 10.1016/j.ijid.2026.108925.
   PubMed         Abstract available
   
   
9. QUEK AML, Ooi DSQ, Teng O, Foon CH, et al
   Adiposity shapes the immune architecture independent of antibody responses in mild SARS-CoV-2 Infection.
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   PubMed         Abstract available
   
   
10. WAKAMATSU K, Tananari Y, Nakamura K, Nakamura T, et al
    Oropharyngeal swabs show higher bacterial loads than nasopharyngeal swabs for PCR detection of pertussis: a multicenter prospective study.
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    PubMed         Abstract available
    
    

    
    J Med Virol

11. HELAL A, Aljehani ND, Ghazwani A, Alsulaiman RM, et al
    Broadly Protective Antibody-Like Vaccines Against Highly Pathogenic Coronaviruses.
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    PubMed         Abstract available
    
    
12. SILVA RMD, Soper MS, Neves JH, Maciel CEA, et al
    Association Between Inflammatory Markers, Comorbidities, and Mortality in COVID-19 Patients Treated With Tocilizumab.
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    PubMed         Abstract available
    
    
13. FOURIE E, van Leeuwen LM, Euser SM, Wildenbeest JG, et al
    Long-Term Dynamics of Pediatric Respiratory Pathogens Before, During, and After the COVID-19 Pandemic: Evidence From Nine Years of Surveillance in the Netherlands (2015-2023).
    J Med Virol. 2026;98:e71022.
    PubMed         Abstract available
    
    
14. MOHI UD DIN MALIK M, Saraf A, Bhrushundi MP
    Comment on "Prevalence and Risk Factors for Persistent Post-COVID-19 Condition at 3, 6, 12, and 18 Months After Initial Infection Among Adults Living in a Community of Japan: Yao COVID-19 Study".
    J Med Virol. 2026;98:e71041.
    PubMed        
    
    
15. NABEYA D, Kinjo T, Nishiyama N, Kami W, et al
    Virus-Specific Impact of Respiratory Viruses on Adult Emergency Department Outcomes.
    J Med Virol. 2026;98:e71039.
    PubMed         Abstract available
    
    

    
    J Virol

16. BERMEJO-JAMBRINA M, Pauzuolis M, Kimpel J, Gerold G, et al
    Double trouble: how co- and superinfections shape viral dynamics and host responses.
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    PubMed         Abstract available
    
    

    
    N Engl J Med

17. RUELLA M, Paruzzo L, Chong ER, Chong EA, et al
    Ten-Year Outcomes after CAR T-Cell Therapy for B-Cell Lymphomas.
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    PubMed         Abstract available
    
    

    
    Nature

18. LOCCI M, Pardi N
    Immunological mechanisms of mRNA vaccines for infectious diseases.
    Nature. 2026;654:892-901.
    PubMed         Abstract available
    
    

    
    Radiol Artif Intell

19. SHU HJ, Chang ST, Gameiro RR, Gichoya JW, et al
    Impact of Exposure Parameters on Deep Learning Models in Chest Radiography and Implications for Deployment.
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    PubMed         Abstract available
    

Addressing the #zoonotic #threat of #merbecoviruses

 

Abstract

Merbecovirus is a subgenus of betacoronaviruses and exhibits high genetic diversity with a capacity for cross-species transmission. However, beyond Middle East respiratory syndrome coronavirus (MERS-CoV), our knowledge of the ecology and pathogenic potential of these viruses remains limited. Merbecoviruses were once thought to rely exclusively on dipeptidyl peptidase 4 for cell entry, but recent discoveries have revealed that several members can also engage with angiotensin-converting enzyme 2 or aminopeptidase N, expanding their receptor repertoire and potential host range. Here we summarize recent advances in understanding of the receptor usage of merbecoviruses and examine how these insights inform pandemic preparedness and risk assessment. We discuss the development of targeted diagnostics, broad-spectrum antivirals and vaccines, including pan-coronavirus strategies. Together, these advances provide a foundation for predictive surveillance and rational countermeasure design, enabling earlier detection and more effective containment of future merbecovirus spillover events before they escalate into epidemics.

Source: 

Link: https://www.nature.com/articles/s41564-026-02397-1

____

Deep #mutational #scanning of recent #SARS-CoV-2 #variants highlights changing amino acid preferences within epistatic hotspot residues

 

Abstract

Deep mutational scans across receptor-binding domains (RBDs) of diverging SARS-CoV-2 variants reveal ongoing changes to the effects of mutations, a phenomenon known as epistasis. Careful accounting for these altered mutational effects is important in viral surveillance and forecasting, and more broadly, for understanding the impacts of epistasis on real-world viral evolutionary trajectories. Using a yeast-display RBD deep mutational scanning (DMS) platform, we measure the impacts of virtually all single amino acid mutations and single-residue deletions in the Omicron KP.3.1.1 and LP.8.1 RBDs on folded RBD expression and binding affinity for the human ACE2 receptor. Our comprehensive maps reveal patterns of evolutionary accessibility and constraint at single-residue resolution and, when compared to prior datasets, highlight sites whose amino acid preferences continue to change across viral variants. Notably, sites 455, 456, and 493 – which have exhibited repeated substitutions and epistatic dependencies across Omicron subvariants going back to BA.1 – again demonstrate altered patterns of mutational accessibility and constraint. Therefore, it appears that these hotspots of repeated RBD evolution have not yet converged on fixed amino acid solutions but instead remain sites of ongoing epistatic reconfiguration. We compare our measurements of direct RBD:ACE2 affinity with recently published measurements of mutation impacts on ACE2 binding in the full quaternary spike context, which also integrates the effects of spike conformational dynamics; our analysis uncovers mutations like H505W that could favor adoption of the down/closed RBD conformation as a viral strategy for future antigenic evolution.

Source: 

Link: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1014074

____

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#Human ACE2‑specific benzothiazole-based allosteric #inhibitor against pan ‑ #sarbecoviruses

 

Abstract

Emerging SARS‑CoV‑2 variants and related zoonotic sarbecoviruses rely on ACE2 for cell entry, motivating host‑directed antivirals that block spike-ACE2 interaction. Here, we characterize MB‑32, a benzothiazole small molecule that binds ACE2, selectively disrupts binding of SARS‑CoV‑2 spike receptor‑binding domain to ACE2, and preserves ACE2 enzymatic activity across species. MB‑32 potently inhibits entry of SARS‑CoV‑2 variants, SARS‑CoV‑1 and diverse bat/pangolin sarbecoviruses in ACE2‑expressing cells, while sparing vesicular stomatitis virus and authentic MERS‑CoV, indicating non‑virucidal, ACE2‑focused activity. Biochemical and biophysical analyses, supported by ACE2 mutagenesis, support a model in which MB‑32 engages a non‑catalytic surface pocket on the ACE2 N‑terminal helix to allosterically disrupt spike attachment. Intranasal MB‑32 achieves high airway concentrations, protects male ACE2‑transgenic mice and hamsters from SARS‑CoV‑2 disease, and prevents contact transmission of Omicron‑lineage viruses without detectable cardiovascular toxicity. These findings establish MB‑32 as a host‑targeted ACE2 entry inhibitor and provide a framework for small‑molecule ACE2‑directed antivirals against current and future sarbecovirus spillovers.

Source: 

Link: https://www.nature.com/articles/s41467-026-73944-x

____

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16. EMANUEL N, Harrington E, Pallais A
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