ETIDIOH - NEW

ABSTRACT Betacoronaviruses, which have caused three human outbreaks within the last two decades, are thought to originate from bats , raising the concern that bat coronaviruses could cause a novel human outbreak in the future. To determine whether the bat merbecovirus EjCoV-3 strain , previously detected in Eptesicus japonensis in Japan , has the potential to infect humans, we analyzed its cellular entry mechanism. Cellular entry of EjCoV-3 via the spike protein requires protease treatment and is mediated by an unknown receptor, other than DPP4 or ACE2 . We generated cultivable recombinant EjCoV-3 using bacterial artificial chromosome-based reverse genetics and found that it efficiently replicated in human respiratory and intestinal cell cultures as well as nasal ciliated epithelium in hamsters. These findings suggest that bat merbecovirus with ACE2- and DPP4-independent cell entry has the potential to cause human infections , highlighting the importance of extensive bat surveillance f...

Summary Background The number of older people in need of long-term care is increasing, and health-care-associated infections (HAIs) are a major cause of morbidity and mortality for residents of long-term care facilities (LTCFs). This study, organised by the European Centre for Disease Prevention and Control (ECDC), provided data on the incidence of HAIs and related adverse outcomes in LTCFs in European countries, supplementing the available estimates from repeated point prevalence surveys conducted by the ECDC. Methods In this longitudinal, prospective cohort study, we analysed all HAIs collected in a convenience sample of residents from 65 LTCFs (including general nursing homes, residential homes, and mixed facilities) in nine EU or European Economic Area (EEA) countries ( Belgium, Finland, France, Italy, Lithuania, Luxembourg, the Netherlands, Poland , and Spain ) over 12 months. Eligible residents were those expected to stay in the LTCF for at least the entire study period. Data wer...

{Automatic translation} The Ministry of Health of Cambodia notified a case of avian influenza A(H5N1) : the patient is a 65-years-old woman from Kraing Ampil, Takeo Province . The patient is now hospitalized in Intensive Care Unit . She developed fever, cough, shortness of breath, did not report contact with diseased birds. A Response Team is investigating actively, adopting prevention and control measures. The case has been confirmed by Pasteur Institute of Cambodia . (...) Despite investigations so far excluded direct contact with diseases or dead poultry, the patient's relatives own birds and more analysis are being conducted. The Rapid Response Team continues to investigate the outbreak with the cooperation of local health authorities to find possible source of infection among poultry and humans. Close contacts of the patient are being searched and will be offered the antiviral oseltamivir for post-exposure prophylaxis. (...) Source: Cambodia Ministry of Health,  https://moh.go...