Showing posts with label flavivirus. Show all posts
Showing posts with label flavivirus. Show all posts

Friday, September 11, 2026

#Usutu virus promotes #WNV #replication in #Culex pipiens biotype molestus during simultaneous and sequential #coinfections

 


Abstract

The epidemiological co-circulation of the two flaviviruses West Nile virus (WNV) and Usutu virus (USUV) in several European countries poses the risk of co-infections in vertebrate hosts and mosquito vectors. WNV is an important human pathogen, whereas USUV is primarily relevant in veterinary and wildlife health. Co-infections have been detected in birds and, occasionally, in humans. To determine the potential consequences of co-exposure and co-infections in mosquitoes on viral transmission, lab-reared Culex pipiens biotype molestus were orally infected with both viruses either simultaneously or sequentially at 7-day intervals with German isolates of WNV lineage 2 and USUV lineage Europe 3. Simultaneous exposure resulted in a significantly increased WNV infection rate, while infection and transmission of USUV were inhibited at the same time. During sequential exposure, prior WNV exposure also had a negative effect on susceptibility to USUV, whereas conversely, WNV infection rates were not altered by prior USUV exposure. Furthermore, mosquitoes with established co-infections after simultaneous co-exposure exhibited higher WNV viral loads than those infected exclusively with WNV. The study reveals complex interactions between WNV, USUV, and the mosquito vector, which could influence vector competence and vector capacity of Culex pipiens biotype molestus in areas with co-circulation of WNV and USUV.

Source: 


Link: https://doi.org/10.1371/journal.ppat.1014601

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Seasonal #surveillance in #humans in 2026 for #WNV - Weekly Report (ECDC, September 11 '26): 1,285 cases so far, of which 590 in #Italy

 


{Excerpt, Summary}

(...)

Week 37, 2026Published on 11 September 2026, based on data submitted up until and including 10 September 2026.


Current situation

    ° Since the beginning of the 2026 transmission season, and as at 10 September, 161 areas affected by West Nile virus (WNV) have been identified in 15 countries across Europe.

    ° These areas are located in: 

        § Italy (64), 

        § Greece (21), 

        § Romania (20), 

        § France (14), 

        § the Netherlands (10), 

        § Serbia (7), 

        § Croatia (5), 

        § Spain (5), 

        § North Macedonia (4), 

        § Hungary (3), 

        § Austria (2), 

        § Germany (2), 

        § Albania (1), 

        § Cyprus (1) and 

        § Kosovo (1).

    ° This week, 16 areas are reported as affected for the first time this season. 

    ° The 15 countries have reported 1 285 locally acquired human cases of WNV infection: 

        § Italy (590 cases), 

        § Greece (319 cases, of which 9 had an unknown place of infection), 

        § Spain (104 cases), 

        § Romania (77 cases), 

        § North Macedonia (57 cases), 

        § France (49 cases), 

        § Serbia (37 cases), 

        § the Netherlands (19 cases), 

        § Croatia (10 cases), 

        § Cyprus (10 cases), 

        § Austria (5 cases), 

        § Hungary (4 cases), 

        § Germany (2 cases), 

        § Albania (1 case) and 

        § Kosovo (1 case)

(...)

Source: 


Link: https://www.ecdc.europa.eu/en/west-nile-fever/surveillance-and-disease-data/disease-data-ecdc

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Thursday, September 10, 2026

#Italy, #WNV & #Usutu Virus Seasonal #Surveillance #Report No. 7, September 10 '26 (ISS, summary): 594 human cases & 41 deaths

 


{Excerpt}

(...)

{Highlights}

    ° Since the beginning of 2026 season in Italy594 confirmed human cases of infection with West Nile Virus have been recorded (they were 521 in the last week report). Of these: 

        § 306 were WNND (West Nile Neuroinvasive Disease) (5 imported: 1 from Maldives, 1 France, 1 Belgium, 1 Greece and 1 the Netherlands), 

        § 81 were asymptomatic cases among blood donors

        § 202 were West Nile Fever (1 imported case from Burkina Faso), 

        § 4 were cases of unspecified nature, 

        § 1 was an asymptomatic case.

    ° The number of affected provinces has risen to 79 in 19 Regions.

    ° Among confirmed cases, 41 fatalities have been recorded. The case-fatality rate (CFR) among WNND cases is now at 13.3% (last year it was at 15.0%).

    ° So far this season 12 confirmed human cases of infection with Usutu virus have been reported (of which 7 in Lombardy, 1 Emilia-Romagna, 1 Marche, 1 Latium, 1 Piedmont, 1 Veneto).

(...)

{Click on Image to Enlarge}

___

(...)

Source: 


Link: https://www.epicentro.iss.it/westnile/bollettino/Bollettino_WND_2026_7.pdf

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Friday, September 4, 2026

Seasonal #surveillance in #humans in 2026 for #WNV (ECDC, Sept. 4 '26), Weekly Update: 1,086 cases so far, of which 516 in #Italy




{Excerpt, Summary}

(...)

Week 36, 2026 Published on 04 September 2026, based on data submitted up  until and including 3 September 2026.


Current situation

    ° Since the beginning of the 2026 transmission season, and as at 3 September, 144 areas affected by West Nile virus (WNV) have been identified in 15 countries across Europe.

    ° These areas are located in: 
        
        § Italy (62), 

        § Greece (19), 

        § Romania (17), 

        § France (13), 

        § Serbia (seven), 

        § the Netherlands (five), 

        § Croatia (four), 

        § Spain (four), 

        § Hungary (three), 

        § North Macedonia (three), 

        § Germany (two), 

        § Albania (one), 

        § Austria (one), 

        § Cyprus (one) and 

        § Kosovo* (one).

    ° This week, 20 areas are reported as affected for the first time this season. (...)

    ° The 15 countries have reported 1 086 locally acquired human cases of WNV infection: 
    
        § Italy (516 cases), 

        § Greece (284 cases, of which 11 with unknown place of infection), 

        § Spain (88 cases), 

        § Romania (56 cases), 

        § North Macedonia (55 cases), 

        § France (36 cases), 

        § Serbia (18 cases), 

        § the Netherlands (nine cases), 

        § Croatia (seven cases), 

        § Cyprus (six cases), 

        § Austria (four cases), 

        § Hungary (three cases), 

        § Germany (two cases), 

        § Albania (one case) and 

        § Kosovo* (one case)

(...)

Source: 


____

#Italy, #WNV & #Usutu Virus Weekly #Surveillance #Report No. 6 (ISS, Sept. 4 '26): 521 human cases so far this season, 26 fatal

 


{Excerpt, Summary}

(...)

    ° Since the beginning of the epidemic season and as of September 2 '26, 521 human cases of confirmed infection with West Nile Virus were reported. They were 432 in the last week report

        § Of these, 269 were WNND (West Nile Neuroinvasive Disease), of which 4 were imported: 1 from Maldives, 1 France, 1 Belgium and 1 Greece; 

        § 70 cases were detected among blood donors

        § 179 cases were of West Nile Fever (1 case imported from Burkina Faso), 

        § 2 cases were of unspecified nature; 

        § 1 case was asymptomatic. 

    ° The number of affected provinces has risen to 75 in 19 Regions.

    ° Among confirmed cases, 26 fatalities have been recorded. The Case-Fatality Rate is now at 9.4% (during 2025, it was 14.6%).

    ° So far this season, 10 human cases of infection with Usutu virus have been confirmed (6 in Lombardy, 1 Emilia-Romagna, 1 Marche, 1 Latium, 1 Piedmont).

(...)

Source: 


____

Friday, August 28, 2026

Seasonal #surveillance in #humans in 2026 for #WNV #infection (ECDC, August 28 '26): 877 cases so far, of which 428 in #Italy

 


{Summary}

Week 35, 2026 | Produced on 27 August 2026 at 12:45, based on data submitted up until and including 26 August 2026.


Current situation

    ° Since the beginning of the 2026 transmission season, and as at 26 August, 124 areas affected by West Nile virus (WNV) have been identified in 15 countries across Europe.

    ° These areas are located in: 

        § Italy (55), 

        § Greece (17), 

        § Romania (15), 

        § France (13), 

        § Serbia (six), 

        § Spain (four), 

        § North Macedonia (three), 

        § Croatia (two), 

        § Germany (two), 

        § Albania (one), 

        § Austria (one), 

        § Cyprus (one), 

        § Hungary (one), 

        § Kosovo* (one) and 

        § the Netherlands (one).

    ° This week, 25 areas are reported as affected for the first time this season. (...).

    ° The 15 countries have reported 877 locally acquired human cases of WNV infection: 

        § Italy (428 cases), 

        § Greece (222 cases, of which eight with unknown place of infection), 

        § Spain (79 cases), 

        § North Macedonia (49 cases), 

        § Romania (45 cases), 

        § France (28 cases), 

        § Serbia (11 cases), 

        § Croatia (three cases), 

        § the Netherlands (three cases), 

        § Austria (two cases), 

        § Cyprus (two cases), 

        § Germany (two cases), 

        § Albania (one case), 

        § Hungary (one case) and 

        § Kosovo* (one case)

(...)

Source: 


Link: https://www.ecdc.europa.eu/en/west-nile-fever/surveillance-and-disease-data/disease-data-ecdc

____

Thursday, August 27, 2026

#Italy, #WNV & #Usutu Virus #Human Cases Weekly #Surveillance Report (ISS, August 27 '26): 432 cases so far this season, of which 223 #WNND

 


{Excerpt}

(...)

Highlights

    ° Since the beginning of surveillance season and as of August 26 '26, 432  human cases of infection with West Nile Virus have been confirmed in Italy. They were 312 last week. 

    ° Of these: 

        § 223 were WNND (of these, three were imported: 1 from Maldives, 1 from France and 1 from Belgium), 

        § 63 were asymptomatic cases in blood donors

        § 144 were West Nile Fever cases, 

    ° Among confirmed cases, 17 were fatal. 

    ° Case Fatality Rate (CFR) is so far at 7.2% (last year it was 13.9%) for severe neuroinvasive cases.

    ° So far this season, 10 human cases of infection with Usutu virus have been confirmed.

(...)

Source:


Link: https://www.epicentro.iss.it/westnile/bollettino/Bollettino_WND_2026_5.pdf

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Wednesday, August 26, 2026

Person died from a #WNV #infection acquired in the #Netherlands (RIVM, August 26 '26)

 


    In the province of Utrecht, someone has died from West Nile fever


    The person contracted the West Nile virus in the Netherlands and died in a hospital. Due to privacy and out of respect for the relatives, RIVM will not make any further statements about this person. 

    So far in 2026, there have been three cases of West Nile virus infections reported that were probably contracted in the Netherlands. 

    It is still very unlikely for people to contract West Nile fever in the Netherlands.


West Nile fever

    The West Nile virus occurs in birds. The common house mosquito can contract the virus when feeding on the blood of an infected bird. An infected mosquito can then pass the virus on to other birds, to mammals such as horses, and to humans. Humans and horses can fall ill with the West Nile virus, but they cannot pass the virus on to others. The disease caused by the West Nile virus is called West Nile fever.

    About 80% of people who contract the West Nile virus do not show any symptoms. Around 19% experience flu-like symptoms, and 1 per cent may develop neurological symptoms. People over 50 and people with weakened immune systems due to illness or medication have a higher risk of becoming very ill from West Nile fever. A small proportion of people who have a severe form of West Nile fever may die.


Alert on West Nile virus

    Experts from various organisations are closely keeping an eye on how often West Nile virus occurs in the Netherlands among humans, horses, birds, and mosquitoes. 

    So far this year, West Nile virus has been found in the provinces of Utrecht, North Brabant, and South Holland. It is possible that the virus is also present in other parts of the Netherlands. That is why RIVM has asked doctors across the country to be alert if they see people with symptoms that match West Nile fever.


What can you do to prevent West Nile fever?

    The West Nile virus is spread by common house mosquitoes that feed on the blood of an infected bird. Mosquitoes are mostly active at dusk. 

    To avoid mosquito bites as much as possible, you can, for example:

        ° wear clothing that covers the skin (long sleeves, long trousers)

        ° keep mosquitoes out (insect screens for windows/doors)

        ° use mosquito repellents on exposed skin

        ° sleep under a mosquito net

Source: 


Link: https://www.rivm.nl/en/news/person-died-from-west-nile-virus-infection-acquired-in-netherlands

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Friday, August 21, 2026

#Surveillance in #humans in 2026 for #WNV - Weekly #Report (ECDC, August 21 '26): 625 cases so far, of which 311 in #Italy

 


{Week 34 / 2026 - Summary}


Current situation

    Since the beginning of the 2026 transmission season, and as at 21 August, 99 areas affected by West Nile virus (WNV) have been identified in 12 countries across Europe.

    These areas are located in: 

        ° Italy (46), 

        ° Greece (17), 

        ° Romania (14), 

        ° France (eight), 

        ° North Macedonia (three), 

        ° Serbia (three), 

        ° Spain (three), 

        ° Albania (one), 

        ° Austria (one), 

        ° Germany (one), 

        ° Kosovo* (one) and 

        ° the Netherlands (one).


    This week, 21 areas are reported as affected for the first time this season. (...)

    The 12 countries have reported 625 locally acquired human cases of WNV infection: 

        ° Italy (311 cases), 

        ° Greece (157, of which seven with unknown place of infection), 

        ° Spain (63 cases), 

        ° North Macedonia (37 cases), 

        ° Romania (28 cases), 

        ° France (17 cases), 

        ° Serbia (six cases), 

        ° the Netherlands (two cases), 

        ° Albania (one case), 

        ° Austria (one case), 

        ° Germany (one case) and 

        ° Kosovo* (one case)

(...)

Source: 


Link: https://www.ecdc.europa.eu/en/west-nile-fever/surveillance-and-disease-data/disease-data-ecdc

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Tuesday, August 18, 2026

#USA, Public health officials report first #Idaho #WNV #encephalitis case of 2026 (DoH, August 18 '26)

 


    Idaho’s first reported case of human West Nile virus (WNV) meningitis this year was identified in a Canyon County resident over the age of 65. This person had been hospitalized for the illness but is recovering at home. 

    WNV is spread by the bite of an infected mosquito and can lead to severe disease in some people. West Nile neuroinvasive disease is a rare but serious complication of West Nile virus infection that occurs when the virus affects the brain or spinal cord, causing conditions such as meningitis, encephalitis (swelling of the brain), or paralysis.

    “If you or someone you know takes medications that suppress your immune system, such as treatments for cancer, autoimmune diseases, or organ transplants, your risk of developing severe West Nile virus illness after a mosquito bite, including death may be up to 40% higher,” said Southwest District Health Epidemiologist Lekshmi Rita Venugopal. 

    “With West Nile virus detected in mosquitoes in Southwest Idaho again this summer, it's especially important for people with weakened immune systems to avoid mosquito bites.”

    Idaho State Epidemiologist Dr. Christine Hahn said public health officials strongly encourage Idahoans to protect themselves and their families from mosquito bites.

    “The report of the first severe West Nile virus disease of the season in an Idaho resident is a good reminder for all of us to take protective measures against mosquito bites,” she said. 

    “This includes wearing insect repellent and protective clothing in addition to reducing standing water around gardens and homes where mosquitoes can lay eggs.”

    Symptoms of WNV infection often include fever, headache, body aches, nausea, and sometimes swollen lymph glands or a skin rash. 

    WNV infection can result in severe illness, especially in people 50 years or older, leading to hospitalization and even death. Talk to your healthcare provider about testing for WNV to confirm your illness.

    There are no licensed vaccines or medicines to prevent WNV disease in people. 

    To protect against WNV infection, people should avoid mosquitoes, particularly between dusk and dawn when the mosquitoes that spread WNV are most active. 

    In addition, everyone should:

        § Wear long, loose-fitting shirts and pants when outdoors and apply DEET or other EPA-approved insect repellent to exposed skin and clothing. Carefully follow instructions on the product label, especially for children.

        § Keep mosquitoes outside the home by using screens on windows and doors or air conditioning, if available. Repair or replace damaged screens. 

        § Reduce standing water on property. Check and drain toys, flowerpots, buckets, kiddie pools, and other items left outdoors that can hold water.

        § Change bird baths, static decorative ponds, kiddie pools, and animal water tanks weekly to reduce suitable mosquito habitats.

        § Consider larvicides for bodies of water that will not be used for drinking and cannot be covered or dumped out.

    WNV activity in mosquitoes has been detected in seven Idaho counties this year by participating mosquito abatement districts.

    For more information, visit the following resources:

        ° https://westnile.idaho.gov

        ° www.cdc.gov/west-nile-virus/index.html

        ° www.epa.gov/insect-repellents

        ° www.cdc.gov/mosquitoes/mosquito-control/mosquito-control-at-home.html

        ° www.cdc.gov/han/php/notices/han00532.html

(...)

Source: 


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Monday, August 17, 2026

#Netherlands, #WNV detected in a #blood #donor (RIVM, August 17 '26): First case since 2020

 


    A West Nile virus infection has been confirmed in a blood donor in the Netherlands

    This occurred in August 2026 during a Sanquin study among blood donors from areas where the West Nile virus had previously been detected in humans, horses, birds or mosquitoes. 

    A laboratory test (PCR) detected the virus in the donor, who had no symptoms and is still not showing any. 

    The person lives in the province of Utrecht and has not been abroad recently. It is therefore likely that the infection was contracted in the Netherlands.


First confirmed case of infection in a human in 2026

    This is the first confirmed case of a human infection in 2026 that originated in the Netherlands. The last time people contracted a West Nile virus infection in the Netherlands was in 2020.


West Nile virus and West Nile fever

    The West Nile virus occurs in birds

    The common house mosquito can contract the virus when feeding on the blood of an infected bird. 

    An infected mosquito can then pass the virus on to other birds, to mammals such as horses, and to humans. 

    Humans and horses can fall ill with the West Nile virus, but they cannot pass the virus on to others. 

    The disease caused by the West Nile virus is called West Nile fever. 

    80 per cent of people with West Nile fever have no symptoms, 19 per cent have flu-like symptoms and 1 per cent may develop neurological symptoms

    People over 50 and people with weakened immune systems due to illness or medication have a higher risk of becoming very ill from West Nile fever. 

    A small proportion of people who have a severe form of West Nile fever may die.


Mosquitoes capable of transmitting West Nile virus are active

    The fact that, within a short space of time, a horse, a bird and a human have now tested positive for the West Nile virus in different parts of the Netherlands shows that there are mosquitoes active in the Netherlands that carry the West Nile virus. It is still very unlikely for people in the Netherlands to contract West Nile fever.


What can you do to prevent West Nile virus?

    Mosquitoes are mainly active at dusk. To minimise the risk of being bitten, you could, for example:

        § wear clothing that covers the skin (long sleeves, long trousers)

        § keep mosquitoes out (insect screens for windows/doors)

        § use mosquito repellents on exposed skin

        § sleep under a mosquito net


Cooperation and monitoring

    Experts from organisations including the National Institute for Public Health and the Environment (RIVM), the GGDs, Erasmus MC, Royal GD, WBVR, UU, Sanquin and the NVWA are monitoring the situation closely.

Source: 


Link: https://www.rivm.nl/en/news/west-nile-virus-detected-in-a-blood-donor

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Friday, August 14, 2026

Seasonal #surveillance in #humans in 2026 for #WNV - Weekly Update (ECDC, August 14 '26): 429 cases so far, of which 224 in #Italy

 


{Summary}

Week 33, 2026 Produced on 14 August 2026 at 06:00, based on data submitted up until and including 13 August 2026.


Current situation

    Since the beginning of the 2026 transmission season, and as at 13 August, 77 areas affected by West Nile virus (WNV) have been identified in nine countries across Europe.

    These areas are located in 

        § Italy (40), 

        § Greece (13), 

        § Romania (12), 

        § France (four), 

        § North Macedonia (three), 

        § Spain (two), 

        § Germany (one), 

        § Kosovo* (one) and 

        § Serbia (one).

    This week, 19 areas are reported as affected for the first time this season. (...)

    The nine countries have reported 429 locally acquired human cases of WNV infection: 

        § Italy has reported 224

        § Greece 105

        § Spain 42

        § North Macedonia 30

        § Romania 18

        § France six

        § Serbia two

        § Germany one and 

        § Kosovo* one case.

(...)

Source: 


Link: https://www.ecdc.europa.eu/en/west-nile-fever/surveillance-and-disease-data/disease-data-ecdc

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Wednesday, August 12, 2026

Seasonal #surveillance in #humans and #animals in 2026 for #WNV, Monthly Report (ECDC, August 12 '26): 245 cases so far

 


August 2026 | Produced on 12 August 2026 at 12:00 based on data submitted up until and including 5 August 2026


Epidemiological summary

Findings from human surveillance

    In 2026, and as at 5 August, seven countries in Europe have reported 245 locally acquired {1} human cases of West Nile Virus (WNV) infection. 

    The earliest and latest date of onset were on 12 May 2026 and 1 August 2026, respectively. 

    Locally acquired cases have been reported by Italy (139 cases), Greece (65, of which four with unknown place of infection), Spain (17 cases), North Macedonia (13 cases), Romania (six cases), France (four cases) and Germany (one case). 

    In Europe, 12 deaths have been reported by Greece (six deaths), Italy (five deaths) and Romania (one death).

    The number of human cases reported so far (245 cases) is below the average for the corresponding period over the past decade (403 cases). 

    However, reporting delays may result in an under-estimation of the current burden, as the 2026 data remain provisional, whereas the ten-year average is based on consolidated data from previous years. 

    In addition, this ten-year average is influenced by several particularly intense WNV transmission seasons, notably in 2018 (1 065 cases reported up to the corresponding week), 2022 (781 cases) and 2024 (654 cases).

    To date, most cases have been reported in Italy (139 cases) and Greece (65 cases). 

    Although the number of cases reported in Italy is lower than during the same period in 2025 (168 cases), it remains the most affected country in Europe in 2026. 

    Greece has reported more cases in 2026 than during the same period in 2025 (65 cases compared with 26 cases). 

    WNV circulation is currently most intense in the Attica NUTS 2 region (48 cases), with Anatoliki Attiki (East Attica, 34 cases) and Voreios Tomeas Athinon (North Athens, seven cases) most affected.

    As at 5 August 2026, locally acquired human cases of WNV infection had been reported in 58 NUTS 3 regions across seven countries

    This is higher than at the same point in 2025, when cases were reported in 40 NUTS 3 regions across six countries. 

    However, the geographical spread observed so far in 2026 remains well below the final extent recorded in recent seasons: by the end of 2025, affected regions numbered 160 and in 2024 there were 218. 

    The 2024 season remains the largest WNV season on record in terms of geographical spread.

    This year, six regions reported locally acquired human cases of WNV infection for the first time ever: France in PyrĂ©nĂ©es-Orientales (FRJ15); Germany in Rhein-Pfalz-Kreis (DEB3I); Italy in Campobasso (ITF22) and Viterbo (ITI41); North Macedonia in Pelagoniski (MK005) and Vardarski (MK001).

    Similar to previous years, most cases were reported among males aged 65 years and above

    Most cases were hospitalised (72%) and presented with neurological symptoms (58%). 

    The proportion hospitalised was lower than the average reported during the previous decade (87%), while the proportion with neurological symptoms was also slightly lower than the historical 10-year average (64%). 

    The case fatality rate was approximately 5%, lower than the average reported during the previous decade (11%). 

    However, this estimate should be interpreted with caution, as clinical outcomes may not yet be known for all reported cases and additional deaths may be recorded as the season progresses and data are consolidated.

    Owing to delays in diagnosis and reporting, and because most WNV infections are asymptomatic or subclinical, the reported case numbers probably underestimate the true number of infections. Seasonal surveillance in humans primarily captures laboratory-confirmed cases, which may further contribute to reporting delays.


Findings from veterinary surveillance

    From the veterinary perspective, 17 WNV outbreaks among equids and 74 outbreaks among birds have been reported in Europe in 2026. 

    The earliest start date of an outbreak among equids and birds was on 30 March 2026 in France and 31 March 2026 in Italy, while the latest onset of an outbreak among equids and birds was, respectively, on 31 July 2026 in Netherlands and 28 July 2026 in Italy

    Outbreaks among equids have been reported by France (five outbreaks), Greece (five outbreaks), Italy (five outbreaks), the Netherlands (one outbreak) and Spain (one outbreak). 

    Outbreaks among birds have been reported by Italy (64 outbreaks), France (five outbreaks), Spain (three outbreaks), Austria (one outbreak) and Belgium (one outbreak).

    No information was available on the equid species involved in the outbreaks reported in the Animal Disease Information System (ADIS). 

    The bird species most frequently associated with the reported outbreaks were the common magpie (23) and the hooded crow (20), followed by the carrion crow (5), the common kestrel (5), the Eurasian blackbird (5), the yellow-legged gull (3), Adalbert’s eagle (2), the common wood-pigeon (2), and the little owl (2). 

    Single outbreaks were associated with the common loon, the common raven, the European turtle-dove, the golden eagle, the grey heron, the house sparrow and the northern goshawk.

    The monthly number of WNV outbreaks in equids reported during the first part of 2026 was comparable to the corresponding 10-year monthly average (2016−-2025). 

    However, the number of equid outbreaks in July 2026 remained below the levels observed in July 2018, 2024 and 2025, years characterised by particularly high WNV intensity. 

    In contrast, the number of WNV outbreaks in birds slightly exceeded the corresponding four-year monthly average (2022–2025) in April and May, and was substantially higher in June. 

    This trend reversed in July 2026, when the number of reported outbreaks in birds fell below the four-year average, although it remained higher than in July 2025. However, it should be noted that reporting delays may affect the July numbers, as some outbreaks occurring during that month may be notified in August.

    As at 5 August 2026, outbreaks in birds and/or equids have been reported in 43 NUTS 3 regions across seven countries. This compares with 55 regions (10 countries) during the same period in 2025 and 42 regions (eight countries) in 2024. All seven countries reported WNV outbreaks in birds and/or equids in 2025 and in prior years, reflecting endemic WNV activity in these territories. However, as at 5 August, outbreaks in birds and/or equids were reported to ADIS for the first time in the following six regions: by France in Hauts-de-Seine (FR105) and Seine-et-Marne (FR102); by Belgium in Arr. Namur (BE352), by Greece in Drama (EL514), by Italy in Genova (ITC33) and by the Netherlands in Delf en Westland (NL362).


Patterns across human and veterinary surveillance

    Four countries – France, Greece, Italy, and Spain – reported both human WNV infections and outbreaks in equids and/or birds

    As at 5 August, Italy accounted for most of the reported human cases (56.7%) and animal outbreaks (75.8%). 

    Greece reported the second-largest share of human cases (26.5%) but only five equid outbreaks and no bird outbreaks, representing 5.5% of all reported animal outbreaks.

    Differences in the patterns observed across European countries may reflect a combination of ecological, climatic and surveillance-related factors

    Favourable climatic conditions and the presence of ecological hotspots, such as wetlands and agricultural areas, may support mosquito vector populations and influence the distribution and behaviour of animal hosts, thereby facilitating WNV circulation. At the same time, differences in WNV surveillance systems across Europe may affect detection and reporting rates.

    The first indication of WNV activity may arise from either human or animal surveillance, depending on local epidemiology, detection capacity and surveillance system sensitivity. Therefore, the absence of reports from one sector should not be interpreted as evidence that WNV is not circulating. 

    In France (PyrĂ©nĂ©es-Orientales, FRJ15), Greece (Drama, EL514), and Italy (Genova, ITC33), human cases were reported before, or in the absence of, notified outbreaks in birds or equids. 

    Conversely, in Belgium (Arr. Namur, BE352), France (Hauts-de-Seine, FR105 and Seine-et-Marne, FR102) and the Netherlands (Delft en Westland, NL362), animal detections preceded human cases. 

    Belgium is a relevant example, as WNV was first reported in the country in 2025 through avian surveillance, with no previous detections in humans and animals. In 2026, it has again been identified in birds in a previously unaffected region, highlighting the role of avian surveillance in detecting local virus circulation and geographical spread.

    Active mosquito surveillance is also important for the early detection of WNV circulation. However, results on WNV detection in mosquitoes are not included in this report because they are not legally required to be reported at European level, and the available information is therefore scattered and often project-based.


Seasonal outlook

    Given the favourable weather conditions for WNV transmission in Europe, ECDC and EFSA expect further human cases and outbreaks in equids and birds to be reported in the coming weeks. In previous years, transmission has typically peaked in August and September.

    ECDC and EFSA continue to closely monitor the situation in Europe.

(...)

Source: 


Link: https://www.ecdc.europa.eu/en/infectious-disease-topics/west-nile-virus-infection/surveillance-and-disease-data/monthly-updates

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Friday, August 7, 2026

Seasonal #surveillance in #humans in 2026 for West Nile virus in #Europe (#WNV) (ECDC, August 7 '26): 241 cases so far of which 139 in #Italy

 


{Excerpt}

Week 32, 2026Produced on 7 August 2026 at 10:00, based on data submitted up until and including 5 August 2026.


Current situation

    Since the beginning of the 2026 transmission season, and as at 5 August, 59 areas affected by West Nile virus (WNV) have been identified in seven countries across Europe.

    These areas are located in: 

        § Italy (36), 

        § Greece (nine), 

        § Romania (six), 

        § North Macedonia (three), 

        § France (two), 

        § Spain (two) and 

        § Germany (one).

    The seven countries have reported 241 locally acquired human cases of WNV infection: 

        § Italy has reported 139

        § Greece 61

        § Spain 17

        § North Macedonia 13

        § Romania six

        § France four and 

        § Germany one case.

    This week, 10 areas are reported as affected for the first time this season. The affected areas identified as at 5 August 2026 are listed in Table 1 and shown in Map 1 below.

(...)


{WNV Affected Areas - Click on Image to Enlarge}

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Source: 


Link: https://www.ecdc.europa.eu/en/west-nile-fever/surveillance-and-disease-data/disease-data-ecdc

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Saturday, August 1, 2026

Synergistic #antiviral effect of #Asunaprevir and #Ribavirin in combination against Murray Valley #Encephalitis Virus replication

 


Highlights

    • Renilla luciferase-based MVEV sub-genomic replicon was constructed and applied in antiviral drug evaluation.

    • Removal of Stem Loop I from 3’UTR impairs viral genome replication.

    • Asunaprevir and ribavirin exhibit synergistic antiviral activity against MVEV.

    • A single-round MVEV infectious particle platform was developed.


Abstract

Murray Valley encephalitis virus (MVEV) is a mosquito-borne flavivirus known for causing severe neurological diseases in humans. Despite the rising number of reported infections and high mortality rate among hospitalized patients, no antiviral therapies or licensed vaccines are available. To strengthen preparedness against this reemerging virus, we establish a subgenomic replicon (SGR) platform and a complementary single-round infectious particles (SRIPs) production system, using widely circulating genotype 1 (G1) MVEV as backbone. Stem-loop I(SLI) from 3’UTR stands for the major difference among 4 MVEV genotypes and removal of SLI resulted in mild decrease of genome replication. Through screening a mini anti-flavivirus drug library, we identified that asunaprevir (ASV) and ribavirin (RBV) inhibit MVEV infection independently. Combination of ASV and RBV also showed synergistic activity against MVEV. These results underscore the value of the MVEV replicon system as a versatile tool for evaluating antiviral compounds, supporting the potential of ASV and RBV as a combinatorial therapeutic approach.

Source: 


Link: https://www.sciencedirect.com/science/article/abs/pii/S0166354226001567?via%3Dihub

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