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Showing posts from March 15, 2025

#Coronavirus Disease Research #References (by AMEDEO, March 15 '25)

  Am J Obstet Gynecol TAN YY, Loy EXH, Tan WZ, Tay AT, et al Long COVID-19 in pregnancy: increased risk but modest incidence following mild Omicron infection in a boosted obstetric cohort during endemicity. Am J Obstet Gynecol. 2025 Mar 10:S0002-9378(25)00147. PubMed           Abstract available BMJ IACOBUCCI G Covid-19: Gove tried to "circumvent" regulations to buy Dyson ventilators, inquiry hears. BMJ. 2025;388:r502. PubMed          Clin Infect Dis BARTOLETTI M, Mozaffari E, Amin AN, Doi Y, et al A systematic review and meta-analysis of the effectiveness of remdesivir to treat SARS-CoV-2 infection in hospitalized patients: have the guidelines evolved with the evidence? Clin Infect Dis. 2025 Mar 11:ciaf111. doi: 10.1093. PubMed           Abstract available COX SN, Roychoudhury P, Frivold C, Acker Z, et al Household Transmission and Genomic Diversity of Respiratory Syn...

#Influenza and Other Respiratory Viruses Research #References (by AMEDEO, March 15 '25)

  Biochemistry (Mosc) FILIPPOVA TA, Masamrekh RA, Farafonova TE, Khudoklinova YY, et al Determination of SARS-CoV-2 Main Protease (M(pro)) Activity Based on Electrooxidation of Tyrosine Residue of a Model Peptide. Biochemistry (Mosc). 2025;90:120-131. PubMed           Abstract available BMC Pediatr JAYARATNE K, Illangasinghe P, Wanniarachchi S, Hettiarachchi D, et al Epidemic profile of COVID-19 child deaths in Sri Lanka: a retrospective nationwide analysis. BMC Pediatr. 2025;25:174. PubMed           Abstract available Cell XING L, Liu Z, Wang X, Liu Q, et al Early fusion intermediate of ACE2-using coronavirus spike acting as an antiviral target. Cell. 2025;188:1297-1314. PubMed           Abstract available J Epidemiol Community Health COSTE M, Prah JJ Applying the health capability profile: an analytical study of leading causes of death in the USA and of pressing...

Altered #receptor-binding #specificity of #gull-adapted #H13 avian #influenza viruses corresponds to their unique host preferences

Highlights •  H13 HAs exhibit binding specificity for fucosylate α2-3 sialosides. •  The 130-loop and K227 are critical for H13 HA binding specificity. •  Fucosylated α2-3 sialosides are widely distributed in slaty-backed gulls. Abstract Avian influenza viruses (AIVs) recognize α2-3 sialosides as receptors . Previous studies showed that the structural diversity within α2-3 sialosides is related to the host specificity of AIVs. H13 AIVs are primarily isolated from gulls , although almost all AIV subtypes have been isolated from ducks , the natural hosts of AIVs. To elucidate the molecular basis of the host specificity of H13 viruses to gulls, the receptor-binding specificity of H13 hemagglutinins (HAs) and the distribution of viral receptors in gulls were investigated. The results revealed that recombinant HA (rHA) of H13 viruses had a binding preference for fucosylated α2-3 sialosides, which were distributed widely in the respiratory tract and intestines of gulls but not ...