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Showing posts with the label sarbecovirus

#Coronavirus Disease Research #References (by AMEDEO, October 1 '25)

Clin Infect Dis CALABRESE C, Wang Y, Duggal A, Huang S, et al Effectiveness of Nirmatrelvir/Ritonavir or Molnupiravir Use in Immunocompromised Patients on B-Cell-Depleting Therapy With COVID-19: A Target Trial Emulation Study. Clin Infect Dis. 2025 Oct 24:ciaf521. doi: 10.1093. PubMed Abstract available FONG Y, Huang Y, Huang Y, Woo W, et al Analysis of antibody markers as immune correlates of risk of severe COVID-19 in the PREVENT-19 efficacy trial of the NVX-CoV2373 recombinant protein vaccine. Clin Infect Dis. 2025 Oct 25:ciaf558. doi: 10.1093. PubMed Abstract available KABORE JL, Laffont B, Diop M, Tardif MR, et al Real-World Effectiveness of Nirmatrelvir-Ritonavir in Preventing Coronavirus Disease 2019-Associated Hospitalization: A Population-Based Cohort Study in the Province of Quebec, Canada. Clin Infect Dis. 2025 Oct 29:ciaf145. doi: 10.1093. PubMed ...

#Coronavirus Disease Research #References (by AMEDEO, October 25 '25)

Br J Anaesth THOMAS C, Pearse RM Socioeconomic deprivation and health inequity: independently associated with postoperative outcomes, and does this matter? Br J Anaesth. 2025;135:1141-1143. PubMed Abstract available Clin Infect Dis TARTOF SY, Aliabadi N, Goodwin G, Slezak J, et al Estimated Vaccine Effectiveness for Respiratory Syncytial Virus-Related Acute Respiratory Illness in Older Adults: Findings From the First Postlicensure Season. Clin Infect Dis. 2025 Oct 21:ciaf496. doi: 10.1093. PubMed Abstract available MANABE YC, Hamill MM, Palamountain KM, Achenbach CJ, et al The Critical Importance of Clinical Use Case to Inform Point-of-Care Technology Development: A Case Study of Human Immunodeficiency Virus Nucleic Acid Assays in the United States. Clin Infect Dis. 2025 Oct 23:ciaf510. doi: 10.1093. PubMed Abstract available Graefe...

Spatial #Variation of #SARS-CoV-2 #Exposure in Urban #Rodents from the Metropolitan Area of Buenos Aires, #Argentina: Implications for Public Health in Latin American Cities

Abstract Background : The COVID-19 pandemic , driven by the SARS-CoV-2 virus, has become an unprecedented global public health challenge . Comprehensive investigation of the virus transmission dynamics requires exploration of all potential routes , including the role of animal reservoirs . This study aimed to assess the presence of SARS-CoV-2 RNA and antibodies in urban rodents captured within two landscape units (low-income neighborhoods and green spaces) in the metropolitan area of Buenos Aires (MABA), Argentina. Methods : Between July 2020 and September 2022, 125 synanthropic rodents (68 Rattus norvegicus, 22 R. rattus, and 35 Mus musculus) from seven low-income neighborhoods and seven green spaces in the MABA were captured and examined for SARS-CoV-2 exposure and infection by indirect immunofluorescence serology and RT-qPCR, targeting the N, E, and ORF1ab genes. Results : Two M. musculus and six R. norvegicus from five different low-income neighborhoods test...

#Coronavirus Disease Research #References (by AMEDEO, October 18 '25)

AJR Am J Roentgenol LITTLE BP Imaging and Reporting of Post-COVID-19 Lung Abnormalities at CT: International Panel of Experts Provides Welcome Guidance. AJR Am J Roentgenol. 2025 Oct 15. doi: 10.2214/AJR.25.33999. PubMed Infect Control Hosp Epidemiol ELHAISSOUNI N, Arthur A, Prochaska EC, Colantuoni E, et al Association of pandemic precautions and Staphylococcus aureus in the NICU. Infect Control Hosp Epidemiol. 2025 Oct 13:1-3. doi: 10.1017/ice.2025.10319. PubMed Abstract available Int J Infect Dis OPPONG AE, Coelewij L, Hutchinson M, Carpenter B, et al Simple hyperinflammation scores predict mortality in hospitalised patients with COVID-19 and offer a personalised medicine approach to dexamethasone intervention. Int J Infect Dis. 2025 Oct 13:108119. doi: 10.1016/j.ijid.2025.108119. PubMed Abstract available J Infect TANG X, Ma T, Yao Z,...

#Bat #sarbecovirus WIV1-CoV bears an adaptive #mutation that alters #spike dynamics and enhances #ACE2 binding

Abstract SARS-like betacoronaviruses (sarbecoviruses) endemic in bats pose a significant zoonotic threat to humans . Genetic pathways associated with spillover of bat sarbecoviruses into humans are incompletely understood. We previously showed that the wild-type spike of the rhinolophid bat coronavirus SHC014-CoV has poor entry activity and uncovered two distinct genetic pathways outside the receptor-binding domain (RBD) that increased spike opening, ACE2 binding , and cell entry. Herein, we show that the widely studied bat sarbecovirus WIV1-CoV is likely a cell culture-adapted variant whose progenitor bears a spike resembling that of Rs3367-CoV, which was sequenced from the same population of rhinolophid bats as SHC014-CoV. Our findings suggest that the acquisition of a single amino-acid substitution in the ‘630-loop’ of the S1 subunit was the key spike adaptation event during the successful isolation of WIV1-CoV, and that it enhances spike opening, virus-receptor recognition, a...

#Coronavirus Disease Research #References (by AMEDEO, October 11 '25)

Antiviral Res SCHRELL L, Scheibner D, Dickmanns A, Stegmann KM, et al Inhibitors of pyrimidine synthesis synergize with N4-hydroxycytidine to diminish influenza virus replication. Antiviral Res. 2025 Oct 3:106286. doi: 10.1016/j.antiviral.2025.106286. PubMed Abstract available BMJ WISE J Covid-19: Excluding doctors from vaccination programme puts patients at risk, clinicians warn. BMJ. 2025;391:r2141. PubMed Clin Infect Dis ATMAR RL, Abate G, Deming ME, George SL, et al Emerging and Pandemic Pathogens: Lessons Learned From a Clinical Research Network. Clin Infect Dis. 2025;81. PubMed Abstract available JANO K, Babu TM, Kottkamp AC, Rebolledo PA, et al Historical Advances in Clinical Trial Design and Expanding Representation as the New Frontier for Innovation. Clin Infect Dis. 2025;81. PubMed ...

First serological #evidence of equine #coronavirus and #SARS-CoV-2 in #horses in North #Africa

Abstract Viral diseases cause significant economic losses within the equine population. Horses are susceptible to equine coronavirus (ECoV) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), although only ECoV has been associated to clinical disease . The aim of this study was to investigate, for the first time in Algeria , the seroprevalence of ECoV and SARS-CoV-2 antibodies and the prevalence of ECoV infection in horses . In 2022, a total of 299 serum samples was collected from horses aged 1 to 27 years . Serological analysis for the presence of ECoV and SARS-CoV-2 was performed using a validated in-house and a commercially available ELISA, respectively. In addition, fecal samples of these animals were tested for the presence of ECoV RNA by RT-qPCR . SARS-CoV-2-ELISA positive sera with high S/P ratios and negative samples close to the doubtful threshold were retested using a virus neutralization test ( VNT ). The seroprevalence of ECoV and SARS-CoV-2 in the teste...

#Coronavirus Disease Research #References (by AMEDEO, October 4 '25)

Int J Infect Dis TENG Z, Li L, Che T, Liang J, et al A Novel Balamuthia Lineage Causing Fatal Granulomatous Amoebic Encephalitis in an Immunocompetent Infant. Int J Infect Dis. 2025 Sep 17:108063. doi: 10.1016/j.ijid.2025.108063. PubMed Abstract available J Med Virol PLICANTI E, Deiana A, Nottoli S, Lottini G, et al A Pyrido-Quinoxaline Derivative That Downregulates Reticulon 3 Protein Exhibits Potent Antiviral Activity Against Zika Virus. J Med Virol. 2025;97:e70605. PubMed Abstract available J Virol TSUJINO S, Tsuda M, Nao N, Okumura K, et al Evolution of BA.2.86 to JN.1 reveals that functional changes in non-structural viral proteins are required for fitness of SARS-CoV-2. J Virol. 2025 Sep 23:e0090825. doi: 10.1128/jvi.00908. PubMed Abstract available HAMMER E, Flynn C, Rossler J, Erder J, et al Prediction of COVID-19 disease pr...

#Coronavirus Disease Research #References (by AMEDEO, September 27 '25)

Broadly #Sarbecovirus-Neutralizing #Antibodies Induced by Ancestral #SARS-CoV-2 #Infection

Abstract The COVID-19 pandemic, driven by SARS-CoV-2, continues to challenge global health due to emerging variants and the potential risk posed by related sarbecoviruses . Neutralizing antibodies targeting the spike (S) glycoprotein, particularly the receptor-binding domain (RBD), play a crucial role in viral neutralization and vaccine design . Although broadly neutralizing anti-RBD antibodies have been identified, the nature of cross-reactive humoral responses induced by natural infection with ancestral SARS-CoV-2 strains remains incompletely understood. Here, we isolated 105 S-specific monoclonal antibodies (mAbs) from individuals recovered from prototype SARS-CoV-2 infection. Of these, 30 mAbs cross-recognized SARS-CoV-1 , including 25 RBD-directed mAbs, of which 12 displayed cross-neutralizing activity against both viruses . Among them, mAb 12C2 potently neutralized SARS-CoV-1 and multiple SARS-CoV-2 variants, likely through mechanisms that include inhibition of membrane fus...

#Coronavirus Disease Research #References (by AMEDEO, September 20 '25)

J Infect GRANVIK C, Persson IL, Barros GWF, Ahlm C, et al Long-term Physical Capacity Following COVID-19: A Prospective, Three-Year Study. J Infect. 2025 Sep 12:106614. doi: 10.1016/j.jinf.2025.106614. PubMed Abstract available J Med Virol BADAR N, Salman M, Ahad A, Mirza HA, et al Tracking SARS-CoV-2 Lineages in Pakistan's 2025 COVID-19 Resurgence: Insights From Genomic Surveillance. J Med Virol. 2025;97:e70607. PubMed LIU S, Shao C, Ding Y, Wang Y, et al Ubiquitination: A Double-Edged Mechanism in Coronavirus Infections. J Med Virol. 2025;97:e70589. PubMed Abstract available J Virol CHIOK KL, Jenik K, Fenton M, Falzarano D, et al MERS-CoV and SARS-CoV-2 infection in diverse human lung organoid-derived cultures. J Virol. 2025 Sep 18:e0109825. doi: 10.1128/jvi.01098. PubMed Abstract availa...

#MERS-CoV and #SARS-CoV-2 #infection in diverse #human lung #organoid-derived cultures

ABSTRACT Cell cultures are widely used to study infectious respiratory diseases and to test therapeutics; however, they do not faithfully recapitulate the architecture and complexity of the human respiratory tract . Lung organoids have emerged as an alternative model that partially overcomes this key disadvantage. Lung organoids can be cultured in various formats that offer potential for studying highly pathogenic viruses . However, the effects of these different formats on virus infection remain unexplored, leaving their relative value unclear. In this study, we generated primary lung organoids from human donor cells and used them to derive monolayers and air-liquid interface (ALI) cultures with the goal of comparing the replication kinetics of two circulating highly pathogenic coronaviruses , severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) and Middle East respiratory syndrome coronavirus ( MERS-CoV ). Infection studies revealed that organoid-derived monolayers di...

#Coronavirus Disease Research #References (by AMEDEO, September 13 '25)

Am J Respir Crit Care Med GORDHAN BG, Sewcharran A, Waja Z, Martinson N, et al Oral Rinse as an Alternative Diagnostic Specimen for Detection of Tuberculosis. Am J Respir Crit Care Med. 2025 Sep 12. doi: 10.1164/rccm.202503-0723. PubMed CRESCIOLI E, Klitgaard TL, Riis JO, Weinreich UM, et al Oxygenation Targets and Long-Term Cognitive and Pulmonary Functions in Hypoxemic Respiratory Failure. Am J Respir Crit Care Med. 2025 Sep 8. doi: 10.1164/rccm.202412-2499. PubMed Abstract available Clin Infect Dis NADIG N, Bhimraj A, Cawcutt K, Chiotos K, et al 2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Abatacept. Clin Infect Dis. 2025 Sep 9:ciaf354. doi: 10.1093. PubMed Abstract available Infect Control Hosp Epidemiol WILLIAMS V, Volpentesta K, Avaness M, Chan C, ...

#Coronavirus Disease Research #References (by AMEDEO, September 6 '25)

Am J Obstet Gynecol ROSSEN LM, Hoyert DL, Horon I, Branum AM, et al Trends in Maternal Mortality Rates by State, United States, 2018-2023. Am J Obstet Gynecol. 2025 Aug 28:S0002-9378(25)00585. PubMed Abstract available Antiviral Res BI W, Zhu T, Xu Y, Chen Y, et al An engineered chimeric ACE2-HR2 peptide exhibits potent and broad-spectrum activity against SARS-CoV-2 variants. Antiviral Res. 2025;242:106265. PubMed Abstract available ICHIKAWA T, Tamura T, Nao N, Suzuki H, et al Characterization of remdesivir resistance mutations in COVID-19 patients with various immunosuppressive diseases. Antiviral Res. 2025;242:106264. PubMed Abstract available TASHIMA R, Kuroda T, Nobori H, Miyagawa S, et al Ensitrelvir suppresses prolonged olfactory abnormalities derived from SARS-CoV-2 infection in hamsters. Antiviral Res. 2025 Sep 2:106270. doi...