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Showing posts from March 4, 2025

Role of #antiviral #CD8+ T cell #immunity to #SARS-CoV-2 #infection and #vaccination

ABSTRACT The COVID-19 pandemic has greatly enhanced our understanding of CD8+ T cell immunity and their role in natural infection and vaccine-induced protection. Rapid and early SARS-CoV-2- specific CD8+ T cell responses have been associated with efficient viral clearance and mild disease . Virus-specific CD8+ T cell responses can compensate for waning, morbidity-related , and iatrogenic reduction of humoral immunity. After infection or vaccination, SARS-CoV-2-specific memory CD8+ T cells are formed, which mount an efficient recall response in the event of breakthrough infection and help to protect from severe disease. Due to their breadth and ability to target mainly highly conserved epitopes, SARS-CoV-2-specific CD8+ T cells are also able to cross-recognize epitopes of viral variants , thus maintaining immunity even after the emergence of viral evolution. In some cases, however, CD8+ T cells may contribute to the pathogenesis of severe COVID-19. In particular, delayed and uncontrolle...

#Cluster of #community #deaths in Basankusu, Equateur- #DRC

Situation at a glance On 9 February 2025, officials in the Democratic Republic of the Congo reported to regional health authorities a cluster of 24 unexplained community deaths in a single village in Ekoto health area, Basankusu health zone, Equateur province .  As of 25 February, a total of 53 deaths have been reported , with the last death occurring on 22 February.  Deaths have occurred in all age groups , but adolescents and young adults , particularly males , appeared to be disproportionately affected in the initial cluster reported.  Disease progression appeared to be fast , with a median time from onset of symptoms to death of one day .  Given the rapid decline in the incidence of reported deaths, their geographic clustering, the age profile of deaths and the rapid disease progression in the initial cluster, working hypotheses include chemical poisoning or a rapid onset bacterial meningitis cluster , on a background of malaria and other infectious illnesses end...