#Belgium - #Influenza A #H5N1 viruses of high pathogenicity (Inf. with) (non-poultry including wild birds) (2017-) - Immediate notification

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{Vlaanderen Region} 

    ° The birds in the infected aviary have been euthanized (Somateria mollissima, Anas bernieri, Lophodytes cucullatus, Mergellus albellus, brasiliensis brasiliensis, Spatula hottentota, Anas melleri, Aix galericulata) . 

    ° The other birds have not been culled but are being monitored (derogation from Regulation 2020/687, Article 13.2.d) 05/10/2026 

    ° Birds in other aviaries (ibises and geese) were showing symptoms and tested positive for the H5N1 virus. It was therefore decided to euthanise all the animals.

    ° The captive birds in the two infected aviaries were euthanized, as were the three hens in an uninfected aviary. 

    ° The other birds were not culled but are being monitored (derogation from Regulation 2020/687, Article 13.2.d: animals of high genetic, cultural or educational value, duly justified). ; 

    ° PRIMARY OUTBREAK (Tongeren: secondary outbreak linked to the purchase of ducks in Balen)

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Source: 

Link: https://wahis.woah.org/#/in-review/7868

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#Germany - #Influenza A #H5N1 viruses of high pathogenicity (Inf. with) (non-poultry including wild birds) (2017-) - Immediate notification

 

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    ° On 18 September 2026, Cologne Zoological Garden received 28 birds from an EU Member State. 

    ° These birds were housed in the zoo’s quarantine facility. 

    ° Current investigations suggest that the introduction of avian influenza (HPAI H5N1) occurred as a result of the movement of these animals. 

    ° Only birds in the quarantine facility are affected by avian influenza.

    ° {Species involved: Mandarin Duck (WILD), Anatidae (unidentified) (WILD), Anserinae (unidentified) (WILD), Greater Scaup (WILD), Hooded Merganser (WILD), Wood Duck (WILD), Smew (WILD), Swan Goose (WILD)}

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Source: 

Link: https://wahis.woah.org/#/in-review/7860

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#Chile - #Influenza A #H5N1 viruses of high pathogenicity (Inf. with) (non-poultry including wild birds) (2017-) - Immediate notification

Backyard captive birds in Los Ríos Region.

Source: 

Link: https://wahis.woah.org/#/in-review/7819

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#Chile - #Influenza A #H5N1 viruses of high pathogenicity (Inf. with) (non-poultry including wild birds) (2017-) - Immediate notification

 

Backyard captive birds in Los Lagos Region.

Source: 

Link: https://wahis.woah.org/#/in-review/7802

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#Chile - #Influenza A #H5N1 viruses of high pathogenicity (Inf. with) (non-poultry including wild birds) (2017-) - Immediate notification

 

Backyard non - poultry birds in the Maule Region.

Source: 

Link: https://wahis.woah.org/#/in-review/7490

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#Chile - #Influenza A #H5N1 viruses of high pathogenicity (Inf. with) (non-poultry including wild birds) (2017-) - Immediate notification

{Magallanes y Antártica Chilena} All the birds were culled. At this time, the SAG is on the field implementing all surveillance measures in the control zone.

Source: 

Link: https://wahis.woah.org/#/in-review/7402

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#Chile - #Influenza A #H5N1 viruses of high pathogenicity (Inf. with) (non-poultry including wild birds) (2017-) - Immediate notification

{Valparaíso} The birds shared a pond with wild birds. All birds were culled and buried on the property under strict biosecurity protocols. Cleaning and disinfection measures are being carried out.

Source: 

Link: https://wahis.woah.org/#/in-review/7357

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#Colombia - #Influenza A #H5N1 viruses of high pathogenicity (Inf. with) (non-poultry including wild birds) (2017-) - Immediate notification

 

Within the epidemiological surveillance carried out by the Colombian Agricultural Institute aimed at the early detection of clinical signs consistent with avian influenza, an outbreak of high pathogenicity avian influenza (HPAI) was confirmed in the village of Porvenir, in the municipality of Puerto Concordia in the department of Meta. The event concerns non-poultry in a backyard, for which respiratory and neurological signs were observed. The National Veterinary Authority activated epidemiological tracing and epidemiological monitoring actions in the area of origin of the affected birds. As a control measure, the stamping out of the birds in the epidemiological unit was carried out, and, as a complementary measure, epidemiological surveillance was strengthened in the surrounding area to identify other possible cases and prevent the spread of the disease.

Source: 

Link: https://wahis.woah.org/#/in-review/7345

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#Portugal - High pathogenicity avian #influenza #H5 viruses (#poultry) (Inf. with) - Immediate notification

 

{Porto Region}

Small farm keeping 197 mixed species poultry and 187 captive birds of exotic species.

Source: WOAH, https://wahis.woah.org/#/in-review/7015

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#Bulgaria - #Influenza A #H5N1 viruses of high pathogenicity (Inf. with) (non-poultry including wild birds) (2017-) - Immediate notification

 

{By Kandukuru Nagarjun from Bangalore, India - Peacock on tree, CC BY 2.0, https://commons.wikimedia.org/w/index.php?curid=119724930}

Captive Indian Peafowl birds in Haskovo Region.

Source: WOAH, https://wahis.woah.org/#/in-review/6999

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Evaluation of #therapeutic effect of #baloxavir marboxil against high pathogenicity avian #influenza virus infection in #duck model

 

Abstract

Since 2020, high pathogenicity avian influenza virus (HPAIV) infections in wild birds have been frequently reported. Because HPAIV infection has occasionally caused outbreaks in captive rare birds, application of antiviral drugs for treatment purposes against them has been considered from the perspective of conservation medicine. In this study, the therapeutic efficacy of baloxavir marboxil (BXM) was evaluated using a duck model to help establish the post-infection treatment for rare birds. Sixteen four-week-old ducks were divided into four groups and intranasally inoculated with the HPAIV strain A/crow/Hokkaido/0103B065/2022 (H5N1). BXM was orally administered once daily at doses of 12.5, 2.5, 0.5, and 0 mg/kg to each of the four groups from 2 to 6 days post-infection. Blood samples were collected at 2, 8, and 24 hours after the initial BXM administration to measure the plasma concentrations of its active form, baloxavir acid (BXA). All ducks were monitored until 14 days post-infection, and their oral and cloacal swabs were collected for virus recovery. All eight ducks administered with 12.5 or 2.5 mg/kg of BXM survived, demonstrating a significant reduction in virus recovery compared to the 0 mg/kg group. Pharmacokinetic/pharmacodynamic (PK/PD) analysis of BXA suggested that parameters such as Cmax and AUC0–24hr were correlated with the suppression of virus shedding. These findings demonstrated that BXM administration within 48 hours post-HPAIV infection in ducks effectively reduced mortality and virus shedding. The comparison of PK parameters may help estimate efficient BXM dosing strategies in rare birds.

Competing Interest Statement

This study was supported by a collaborative research project between Hokkaido University and Shionogi & Co., Ltd. M.S., R.D.O, H.O., and T.S. are employees of Shionogi & Co., Ltd. M.M. is a former employee of Shionogi & Co., Ltd. These affiliations did not influence the study design, data collection, analysis, or interpretation. The remaining authors declare no competing interests.

Funder Information Declared

Environmental Restoration and Conservation Agency, JPMEERF20254004

Japan Science and Technology Agency, JPMJSP2119

Japan Agency for Medical Research and Development, https://ror.org/004rtk039, JP223fa627005, JP24wm000125008

Source: BioRxIV, https://www.biorxiv.org/content/10.1101/2025.10.24.684283v1

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#Belgium - #Influenza A #H5N1 viruses of high pathogenicity (Inf. with) (non-poultry including wild birds) (2017-) - Immediate notification

Non-poultry birds at a hobbyist's premise in Wallonie Region.

Source: WOAH, https://wahis.woah.org/#/in-review/6908

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#India - #Influenza A #H5N1 viruses of high pathogenicity (Inf. with) (non-poultry including wild birds) (2017-) - Immediate notification

 

{By Charles J. Sharp - Own work, from Sharp Photography, sharpphotography.co.uk, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=116380120}

Nineteen captive Painted Storks in the National Zoological Park, Delhi.

Source: WOAH, https://wahis.woah.org/#/in-review/6803

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#Infection of #ratites with clade 2.3.4.4b HPAIV #H5N1: Potential implications for zoonotic #risk

 

Abstract

We detected H5N1 high pathogenicity avian influenza in captive Greater Rhea (Rhea americana). Viral genetic analysis revealed the mammalian associated PB2-E627K mutation, indicating selection of mammalian-relevant mutations in ratites. Pathologic investigation of available tissues demonstrated severe multifocal necrotising inflammation, and a strong vasculotropism.

Competing Interest Statement

The authors have declared no competing interest.

Source: BioRxIV, https://www.biorxiv.org/content/10.1101/2025.09.08.674895v1

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#Brazil - #Influenza A #H5N1 viruses of high pathogenicity (Inf. with) (non-poultry including wild birds) (2017-) - Immediate notification

 The Official Veterinary Services (OVS) received a notification of acute mortality and neurological signs in swans in a zoo. Laboratory analysis identified H5N1 virus clade 2.3.4.4b. OVS is conducting an epidemiological investigation of the event.

Source: WOAH, https://wahis.woah.org/#/in-review/6485

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#Ukraine - #Influenza A #H5 viruses of high pathogenicity (Inf. with) (non-poultry including wild birds) (2017-) - Immediate notification

Captive birds: 39 chickens, 23 ducks, 17 pheasants, 4 swans, 3 guinea fowls, 3 geese, 2 pigeons, 1 jay, 1 falcon in Kharkiv Region.

Source: WOAH, https://wahis.woah.org/#/in-review/6329

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#Portugal - #Influenza A #H5N1 viruses of high pathogenicity (Inf. with) (non-poultry including wild birds) (2017-) - Immediate notification

A Great Cormorant in Leiria Region. 

Backyard birds in Aveiro Region.

Source: WOAH, https://wahis.woah.org/#/in-review/6230

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#Cambodia - #Influenza A #H5N1 viruses of high pathogenicity (Inf. with) (non-poultry including wild birds) (2017-) - Immediate notification

Avian influenza was found in sick and dead wild birds along the shores of a lake in a bird sanctuary.

Location: Theay commune, Ba Phnum district, Prey Veng province.

Source: WOAH, https://wahis.woah.org/#/in-review/6273

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#Ukraine - #Influenza A #H5N1 viruses of high pathogenicity (Inf. with) (non-poultry including wild birds) (2017-) - Immediate notification

Unspecified species of domestic birds in Sumy Region.

Source: WOAH, https://wahis.woah.org/#/in-review/6251

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#Portugal - #Influenza A #H5N1 viruses of high pathogenicity (Inf. with) (non-poultry including wild birds) (2017-) - Immediate notification

 Unspecified domestic birds in Leiria Region.

Source: WOAH, https://wahis.woah.org/#/in-review/6214

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