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Showing posts with the label sierra leone

#Genomic Characterization of the Index Case of #Human #Monkeypox Virus Infection in #Mali, 2025

  Abstract Mpox is a zoonosis caused by the monkeypox virus . Here, we report Mali’s index Mpox case , which was clinically identified at the Mali–Guinea border by the national telemedicine center and confirmed by PCR . The library prepared with NextGenPCR™ MPXV Sequencing Library Prep and sequenced on Minion MK1C revealed a genome length of 197,122 bp with an average depth of 1284.4×. The strain belonged to Clade IIb G1 lineage and exhibited 85 mutations relative to NC_063383.1. To decipher genomic epidemiology, genomes ≥ 195 kb were retrieved from NCBI and aligned with MAFFT. Time-resolved phylogenetic reconstruction and ancestral trait inference were performed with TreeTime v0.11.4. A median joining network was built with Popart v1.7. Phylogeographic analysis revealed clustering with Clade IIb (G.1 lineage) linked to the May 2025 outbreak in Sierra Leone . Source:  Link:  https://www.mdpi.com/1999-4915/18/3/294 ____

Co-Infections with #Orthomarburgviruses, #Paramyxoviruses, and #Orthonairoviruses in Egyptian Rousette #Bats, #Uganda and Sierra Leone

Abstract We report 1.3% (19/1,511) of Egyptian rousette bats (ERBs) in Uganda and Sierra Leone were co-infected with different combinations of Marburg, Sosuga, Kasokero, or Yogue viruses . To prevent infection by those viruses, we recommend avoiding ERB-populated areas, avoiding ERBs and ERB-contaminated objects, and thoroughly washing harvested fruits before consumption. Source: US Centers for Disease Control and Prevention,  https://wwwnc.cdc.gov/eid/article/31/5/24-1669_article ____