ETIDIOH - NEW

  {Summary} Situation at a glance On 17 May 2025, the Timor-Leste government reported to the World Health Organization (WHO) a fatal human case of rabies from Ermera Municipality.  Between May and mid-June 2025, Timor-Leste confirmed four human rabies deaths in the municipalities of Bobonaro (n=2), Ermera (n=1) and Oecusse (n=1).  All cases involved individuals exposed to dogs' bites months prior to symptom onset, with rabies virus confirmed via Reverse Transcription Polymerase Chain Reaction (RT-PCR) testing.  Since March 2024, a total of 106 animal rabies cases —mostly in dogs—have been reported, and over 1400 dog bites or scratches have occurred, with a total of six fatalities .  Access to and completion of post-exposure prophylaxis remains limited.  The spread of rabies into non-border areas like Ermera signals a growing public health concern.  The public health response is ongoing and includes vaccination of dogs , risk communication, training of ...

Abstract In this report, we document and analyze a case in which the Irkut virus (IRKV) (Mononegavirales: Rhabdoviridae) caused a fatal human case following a bat bite in June 2021. Unfortunately, the available data did not permit a detailed taxonomic classification of the carrier bat ( Chiroptera ). The event occurred in the southwestern part of the Sikhote-Alin mountain region (Russian Far East) covered by the Ussuri taiga forest . The symptoms of the illness began with the following: fever ; pronounced psychomotor and motor agitation ; tremor of the lower jaw and tongue ; aphasia; dyslexia; and dysphagia . These rapidly developed, leading to a severe and fatal encephalitis . The patient was not vaccinated for rabies and did not receive rabies immunoglobulin. Using brain sections prepared from the deceased, molecular diagnostics were performed: immunofluorescence (polyclonal anti-rabies immunoglobulin) indicating the presence of the lyssavirus antigen ; and RT-PCR indicating traces o...