ETIDIOH - NEW

ABSTRACT The Henipavirus genus comprises five viral species, of which the prototype members, Hendra virus (HeV) and Nipah virus (NiV), are reported to infect humans. In humans and other spill-over hosts , HeV/NiV can cause severe respiratory and/or encephalitic disease , with mortality rates exceeding 50%; currently, there are no approved human vaccines and only limited therapeutic options . As members of the family Paramyxoviridae , henipaviruses have six “core” structural proteins and typically three additional accessory proteins that are expressed from the P gene. Several of these proteins are multifunctional, with roles in forming intracellular interfaces with the host (in particular, M, P, V, W, and C proteins), to modulate processes including antiviral responses, supporting viral replication. Understanding the molecular basis of these interfaces and their functions is critical to delineate the mechanisms of pathogenesis and may inform new strategies to combat infection and diseas...

{Excerpt} To the Editor : The article “Henipavirus in northern short-tailed shrew, Alabama, USA,” (1), describing the discovery of Camp Hill virus (family Paramyxoviridae ) in the northern short-tailed shrew (Blarina brevicauda), sparked major media attention and raised concerns about zoonotic transmission and potential pandemic risk. However, it would be advisable to reevaluate this virus discovery within the broader context of related viruses. The increase in identified henipa-like viruses in various shrew species (2–4) led the International Committee on Taxonomy of Viruses to classify these henipa-like viruses into a distinct genus, Parahenipavirus (5), acknowledging their genetic difference from the highly pathogenic Hendra and Nipah virus. (...) Source: US Centers for Disease Control and Prevention,  https://wwwnc.cdc.gov/eid/article/31/8/25-0401_article ____

Abstract We report 1.3% (19/1,511) of Egyptian rousette bats (ERBs) in Uganda and Sierra Leone were co-infected with different combinations of Marburg, Sosuga, Kasokero, or Yogue viruses . To prevent infection by those viruses, we recommend avoiding ERB-populated areas, avoiding ERBs and ERB-contaminated objects, and thoroughly washing harvested fruits before consumption. Source: US Centers for Disease Control and Prevention,  https://wwwnc.cdc.gov/eid/article/31/5/24-1669_article ____