#Influenza and Other Respiratory Viruses Research #References (AMEDEO, Oct. 31 '26)

 

Arch Virol

1. GUDYMO AS, Kolosova NP, Panova AS, Shadrinova KN, et al
   Contact transmission of fur seal-derived genotype A3 influenza A(H5N1) virus in ferrets.
   Arch Virol. 2026;171:313.
   PubMed         Abstract available
   
   

   
   Epidemiol Infect

2. KONSTANTOPOULOU A, Velali K, Markopoulou P, Anastasiadou A, et al
   Impact of national RSV immunization programme on the epidemiology of bronchiolitis in Greece.
   Epidemiol Infect. 2026;154:e143.
   PubMed         Abstract available
   
   
3. HAYES B, Lamielle G, Moon M, Padungtod P, et al
   Effectiveness of live-animal and environmental samples for detecting high pathogenicity avian influenza viruses in live-bird markets in Southeast Asia, 2015-2022.
   Epidemiol Infect. 2026 Oct 28:1-24. doi: 10.1017/S0950268826102246.
   PubMed        
   
   
4. PLANCHAND S, Nivoix C, Fischer EAJ, Vergne T, et al
   Divide and reduce: systematic review and mathematical modelling of the impact of within-farm compartmentalisation on avian influenza transmission in poultry.
   Epidemiol Infect. 2026 Oct 27:1-30. doi: 10.1017/S0950268826102350.
   PubMed        
   
   
5. SCOTT M, Browning L, Roberts T, De Boer J, et al
   An investigation into post-pandemic ethnic group and deprivation inequalities in influenza and COVID-19 hospitalizations.
   Epidemiol Infect. 2026;154:e139.
   PubMed         Abstract available
   
   

   
   J Clin Microbiol

6. SHU B, Liddell J, Wong P, Duron ES, et al
   Update to the CDC influenza A(H3) subtyping assay for improved detection of influenza A(H3N2) viruses, including subclade K viruses.
   J Clin Microbiol. 2026 Oct 27:e0072726. doi: 10.1128/jcm.00727.
   PubMed         Abstract available
   
   

   
   J Immunol

7. CHANG LA, Burgess E, Noureddine M, Wells AJ, et al
   Vaccine immunity can drive eosinophil recruitment in influenza breakthrough infection with mouse strain-specific outcomes.
   J Immunol. 2026;215:vkag279.
   PubMed         Abstract available
   
   

   
   J Virol

8. FARRUKEE R, Xia Y, Morris R, Barnes JB, et al
   Bovine myxovirus resistance protein (Mx)1, but not Mx2, mediates antiviral activity against human and avian influenza A viruses, including H5N1 clade 2.3.4.4b.
   J Virol. 2026 Oct 28:e0137226. doi: 10.1128/jvi.01372.
   PubMed         Abstract available
   
   

   
   PLoS One

9. ABDOLLAHI K, Rezaei Ghahroodi Z, Mansourian M
   Causal discovery and inference in COVID-19: A multiscale longitudinal analysis using mixtures of DAGs.
   PLoS One. 2026;21:e0355553.
   PubMed         Abstract available
   
   
10. ZHANG L, Ton B, Mewton L, Schweizer S, et al
    Alcohol use and its associations with mental health across the first year of the COVID-19 pandemic.
    PLoS One. 2026;21:e0361854.
    PubMed         Abstract available
    
    
11. TIAN Y, Richards DK, Cox MJ
    Temporal and seasonal trends in public interest in nonalcoholic beverages and lifestyles: A Google Trends analysis, 2004-2026.
    PLoS One. 2026;21:e0361032.
    PubMed         Abstract available
    
    
12. BHUIYAN MRI, Sayem MA, Makhdum N
    Understanding the influencing factors of telemedicine service adoption in post-pandemic Bangladesh: An extended TAM and UTAUT2 model analysis.
    PLoS One. 2026;21:e0361691.
    PubMed         Abstract available
    
    
13. STENGLER AL, Mattern E, Ronellenfitsch U, Steckelberg A, et al
    Experiences and challenges of healthcare professionals in oncological surgery during the COVID-19 pandemic: A qualitative study.
    PLoS One. 2026;21:e0361492.
    PubMed         Abstract available
    
    
14. INUSAH AS, Xia H, Pasha A, Li Z, et al
    Longitudinal changes in BMI and obesity across COVID-19 pandemic periods among underrepresented populations: An analysis of the All of Us dataset.
    PLoS One. 2026;21:e0360745.
    PubMed         Abstract available
    
    
15. HABIB MI, Sayeed MA, Islam M, Sarker MFR, et al
    Epidemiological characterization of avian influenza virus circulation in pigeons and quail across different production systems in Chattogram, Bangladesh.
    PLoS One. 2026;21:e0361561.
    PubMed         Abstract available
    
    
16. MORITA T, Elsayed AMA, Hirakawa R, Lawal-Ayinde BM, et al
    Impact of low temperature on the efficacy of chlorous acid water and sodium hypochlorite solution for inactivating avian influenza virus on material surfaces.
    PLoS One. 2026;21:e0360392.
    PubMed         Abstract available
    
    
17. GARCES-ARILLA S, Fidalgo C, Mendez-Lopez M, Hidalgo V, et al
    Health-related quality of life in women and men with long COVID.
    PLoS One. 2026;21:e0357749.
    PubMed         Abstract available
    
    
18. SIMKHADA P, Lwin KS, Koirala B, Shrestha A, et al
    Barriers and facilitators of evidence-informed health policymaking in Nepal: A scoping review.
    PLoS One. 2026;21:e0358730.
    PubMed         Abstract available
    
    

    
    Proc Natl Acad Sci U S A

19. TURELLI P, Eray E, Raclot C, Trono D, et al
    Antigenic landscape of a highly mutated SARS-CoV-2 spike in ongoing viral evolution.
    Proc Natl Acad Sci U S A. 2026;123:e2608185123.
    PubMed         Abstract available
    
    
20. NILFOROSHAN H, Reisler J, Jahanparast E, Moor M, et al
    Revised estimates of types and duration of long COVID symptoms based on claims records from 245 million US patients.
    Proc Natl Acad Sci U S A. 2026;123:e2604414123.
    PubMed         Abstract available
    
    

    
    Vaccine

21. HUMBLE RM, Reifferscheid L, Gilbert NL, Dube E, et al
    Differences between Canadian parents' attitudes toward routine, influenza, and COVID-19 vaccines for their children, and changes in vaccine hesitancy since the pandemic: A national cross-sectional comparative study.
    Vaccine. 2026;96:129300.
    PubMed         Abstract available
    
    
22. ZHANG J, Shen Y, Shi W, Ma J, et al
    End-of-season influenza vaccine effectiveness against a(H3N2) and B/Victoria in Beijing, China, 2025/26 season.
    Vaccine. 2026;96:129273.
    PubMed         Abstract available
    
    
23. CHENG C, Chen X, Ge Y, Sung MH, et al
    Faster waning of immunity to influenza vaccine strains reintroduced into subsequent seasons: A human cohort study.
    Vaccine. 2026;95:129258.
    PubMed         Abstract available
    
    
24. MISHIN VP, Patel MC, Gao R, Grant L, et al
    Hemagglutinin- and neuraminidase-targeting antibody responses after receipt of egg-based inactivated or recombinant influenza vaccines among adults aged 18-64?years.
    Vaccine. 2026;95:129281.
    PubMed         Abstract available
    
    
25. CAI Z, Wang L, Ji S, Deng X, et al
    Quantifying the impact of pathogen interactions on vaccine effectiveness estimates in the test-negative design.
    Vaccine. 2026;94:129265.
    PubMed         Abstract available
    
    
26. YAMAMOTO S, Matsuda K, Maeda K, Mizoue T, et al
    Protection of Omicron XBB.1.5 vaccine, previous infection, and their induced neutralizing antibodies against symptomatic SARS-CoV-2 infection during Omicron KP.3 wave.
    Vaccine. 2026;94:129242.
    PubMed         Abstract available
    
    
27. MENEZES APO, Leite JLP, Pimenta FC, Larson S, et al
    Pneumococcal carriage and selected respiratory virus in children with clinical pneumonia in Salvador, Brazil during PCV10 era.
    Vaccine. 2026;94:129241.
    PubMed         Abstract available
    
    
28. ISHII H, Miyauchi K, Harada S, Nakamura-Hoshi M, et al
    Intranasal immunization expressing S1 antigen can confer functionally sterile protection against an intranasal SARS-CoV-2 challenge in mice.
    Vaccine. 2026;94:129259.
    PubMed         Abstract available
    
    
29. MAYR W, Knell AI, Boehm AK, Jager M, et al
    Longitudinal SARS-CoV-2 mRNA vaccine immunogenicity in inflammatory bowel disease in relation to anti-TNF therapy and age: a prospective cohort study.
    Vaccine. 2026;94:129224.
    PubMed         Abstract available
    
    
30. MALIBWA D, Lees S, Ewing V, Deogratias D, et al
    Influence of COVID-19 and COVID-19 rumours on trust and uptake of single-dose male HPV vaccination in the Add-Vacc cluster-randomised trial, northwest Tanzania.
    Vaccine. 2026;94:129231.
    PubMed         Abstract available
    
    
31. TOME J, Schwind JS, Richmond HL, Deloach B, et al
    Vaccine recipient and volunteer experiences from COVID-19 mass vaccine clinics at a university campus: drive-through and walk-through approaches.
    Vaccine. 2026;94:129229.
    PubMed         Abstract available
    
    
32. PRASERT K, Nakphook S, Kittiwatanachod J, Ditsungneon D, et al
    Safety and immunogenicity of Thailand Government Pharmaceutical Organization (GPO) produced, COVID-19 vaccine, 10 mug HXP-GPOVac: A Phase III, double-blind, randomized trial in comparison with VAXZEVRIA.
    Vaccine. 2026;94:129230.
    PubMed         Abstract available
    
    

    
    Virology

33. ARSANA A, Zhu W, Kang SM, Wang BZ, et al
    Towards influenza vaccine universality: Smart vaccine regimens and adjuvant-driven germinal center responses.
    Virology. 2026;625:111110.
    PubMed         Abstract available
    
    
34. SEGALIN JT, Weiss M, de Almeida G, Lenhard BF, et al
    Genotypic and phenotypic characterization of the main endemic swine influenza A virus subtypes in Brazil.
    Virology. 2026;625:111099.
    PubMed         Abstract available
    
    
35. ISAKOVA-SIVAK I, Matyushenko V, Rudenko L
    Influenza viruses as vaccine vectors: Historical background and future directions.
    Virology. 2026;625:111105.
    PubMed         Abstract available

Weekly #US #Influenza #Surveillance #Report: Key Updates for Week 42, ending October 24, 2026 (CDC, summary)

 

{Summary}

(...)

Key Points

    ° Seasonal influenza activity remains low nationally, but multiple surveillance indicators have been increasing since late August/early September 2026.

    ° This early-season influenza activity is currently higher than typically observed at this time of year but an earlier increase in activity does not necessarily lead to a higher seasonal peak or greater overall severity.

    ° During Week 42 (the week ending October 24, 2026), of the 466 influenza viruses reported by public health laboratories, 456 were influenza A and 10 were influenza B. Of the 371 influenza A viruses subtyped during Week 42, 367 (98.9%) were influenza A(H1N1)pdm09 and 4 (1.1%) were A(H3N2).

    ° Since Week 21 (the week ending May 30, 2026), 82.7% of the influenza A viruses reported have been A(H1N1)pdm09 and among these, the majority have been D.3.1.1 HA subclade.

    ° The influenza A(H1N1) viruses detected this season are still A(H1N1)pdm09 viruses, which emerged in 2009 and have caused seasonal epidemics globally since then. Influenza viruses are constantly changing, often requiring updates to influenza vaccine viruses each season.

    ° Historically, influenza A(H1N1)pdm09 viruses have changed less often than A(H3N2) viruses. Recently circulating influenza A(H1N1)pdm09 viruses (which are in an HA subclade called "D.3.1.1") have divided into distinct groups with different genetic changes in their HA genes. We are seeing more genetic diversity among co-circulating A(H1N1)pdm09 viruses than we have before.

    ° It is too early to know what viruses may predominate or to say whether there might be implications on flu vaccine effectiveness this season.

    ° The first influenza-associated pediatric death occurring during the 2026-27 influenza season was reported to CDC this week.

    ° Because case investigation takes time, flu-associated deaths in children may be reported to CDC weeks after they occur; counts are preliminary and may increase. All reported cases meet the influenza-associated pediatric mortality case definition.

    ° CDC estimates in-season disease burden across all ages each week. CDC estimates that there have been at least 1,000,000 illnesses, 16,000 hospitalizations, and 900 deaths from flu so far this season.

    ° CDC's FluSight forecasts predict a likely increase nationally in both flu hospital admissions and the percentage of emergency department visits associated with flu for the week ending November 14, 2026. The number of new flu hospital admissions is forecast to range from 4,800 to 23,200 admissions, while the national percentage of emergency department visits due to flu is forecast to range from 1% to 4.4%.

    ° Annual seasonal influenza (flu) vaccination is recommended. Influenza vaccines are available for persons aged 6 months and older. People who are recommended for influenza vaccination but have not been vaccinated yet this season are encouraged to be vaccinated now.

    ° There are prescription flu antiviral drugs that can treat flu illness; those should be started as early as possible and are especially important for patients at higher risk for influenza complications.1

    ° Influenza viruses are among several viruses contributing to respiratory disease activity. CDC is providing updated, integrated information about COVID-19, flu, and respiratory syncytial virus (RSV) activity on a weekly basis.

(...)

Source: US CDC, FluView, https://www.cdc.gov/fluview/surveillance/2026-week-42.html

____

#Taiwan, Seasonal #Influenza and #COVID19 #Epidemics - Weekly #Update (CDC, Oct. 27 '26): #H1N1pdm09 flu virus & #SARS-CoV-2 PQ.16.1.1 predominated

 

{Extracts}

(...)

    According to data from the Taiwan Centers for Disease Control (CDC), the domestic influenza epidemic is currently in its peak season. 

    During week 42 (October 18th-24th), there were 101,746 outpatient and emergency room visits for influenza-like illnesses, a decrease of 18.8% compared to the previous week, mainly due to outpatient closures caused by the typhoon holiday. 

    Last week (October 20-26), 85 new cases of severe influenza complications were reported (79 H1N1, 6 unidentified A cases) and 28 deaths (27 H1N1, 1 unidentified A case). 

    Laboratory surveillance data shows that the influenza virus currently circulating in the community is predominantly type A, with type A H1N1 accounting for 93.4%. 

    This flu season (2026-2027) has seen a cumulative total of 391 severe cases (380 H1N1, 9 unidentified A cases, 2 type B cases) and 57 deaths (54 H1N1, 3 unidentified A cases). 

    The majority of severe cases are among those aged 65 and above (69.1%) and those with a history of chronic illness (85.2%), and 99.7% of those who did not receive the flu vaccine this season. 

    While the number of COVID-19 cases has continued to decline recently, severe cases and deaths are still occurring. 

    In week 42 (October 18-24), there were 2,534 outpatient and emergency room visits related to COVID-19, a 35.3% decrease compared to the previous week (October 11-17). 

    Last week (October 20-26), there were 8 new severe cases and 4 new deaths. 

    This quarter (October 1, 2026-September 30, 2027) has seen a cumulative total of 64 severe cases, including 10 deaths. 

    In the past four weeks, the most common local variant strain has been PQ.16.1.1, followed by NB.1.8.1.

(...)

Source: 

Link: https://www.cdc.gov.tw/Bulletin/Detail/bducEkV6VKgqlJ2iaiFxiA?typeid=9

____

#Influenza and Other Respiratory Viruses Research #References (AMEDEO, Oct. 24 '26)

 

BMC Pediatr

1. PHUNG NTN, Tran TT, Van Nguyen N, Nguyen DH, et al
   Anticoagulation therapy in children with SARS-CoV-2 pneumonia: a retrospective observational study on dosage, efficacy, and safety.
   BMC Pediatr. 2026;26:1035.
   PubMed         Abstract available
   
   

   
   Epidemiol Infect

2. OWUSU-BOAITEY N, Meyer MJ, Herrera-Esposito D, Bottcher L, et al
   Estimating COVID-19 cumulative incidence from seroprevalence surveys accounting for time-varying seroreversion: A fully Bayesian methodology.
   Epidemiol Infect. 2026;154:e137.
   PubMed         Abstract available
   
   

   
   J Infect

3. PENG S, Deng Y, Liu J, Du X, et al
   From detection to prediction: Asymptomatic shedding-informed mass-balance modeling predicts travel-borne viral importation at airports.
   J Infect. 2026;93:106866.
   PubMed         Abstract available
   
   
4. BERES SB, Pagnossin D, Olsen RJ, Long SW, et al
   Clinical and population genomic epidemiology of invasive group A streptococcus in Scotland, 2014-2024.
   J Infect. 2026 Sep 18:106860. doi: 10.1016/j.jinf.2026.106860.
   PubMed         Abstract available
   
   
5. ORTEGA-FRANCISCO S, Prudente de Aquino MT, Chiuppesi F, Gutierrez-Franco MA Jr, et al
   Phase 2 evaluation of two GEO-CM04S1 dose levels shows comparable safety and broad immunogenicity.
   J Infect. 2026;93:106855.
   PubMed         Abstract available
   
   
6. WALKER JL, Ribeiro S, Litt D, Patel T, et al
   Antenatal pertussis vaccine effectiveness in England remains high post COVID-19.
   J Infect. 2026;93:106836.
   PubMed         Abstract available
   
   

   
   J Virol

7. MEINEKE R, Knittler M-C, Tagore R, Engling N, et al
   Respiratory syncytial virus-induced ADAM17 activity controls maintenance of epithelial barrier integrity and promotes syncytium formation.
   J Virol. 2026;100:e0115026.
   PubMed         Abstract available
   
   
8. BUGA CC, Valerio M, Alenquer M, Pires de Miranda M, et al
   Insights into the mechanism of action of the bipartite fusion module of SARS-CoV-2 spike protein.
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9. RODRIGUEZ GALVAN J, de Vries M, Belblidia S, Fisher A, et al
   Airway protease availability governs a reversible shift between syncytial and cell-free spread.
   J Virol. 2026;100:e0072726.
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10. ALVARADO RE, Chen J, Lokugamage KG, Zhou Y, et al
    Antagonism of stress granules is key to SARS-CoV-2 infection and pathogenesis.
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    PubMed         Abstract available
    
    

    
    PLoS One

11. FOOX Y, Yamin D, Chalutz-BenGal H, Ben-Gal I, et al
    Applying normalized p-control charts for early detection of local COVID-19 outbreaks.
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    PubMed         Abstract available
    
    
12. SONG A, Zuvia C, Talbot P
    Susceptibility of human neural stem cells to SARS-CoV-2: Entry mechanisms and glycocalyx influence.
    PLoS One. 2026;21:e0360734.
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13. THOMAS C, Ashton RE, Pretorius E, Owen R, et al
    Blood biomarkers of long COVID: A cross-sectional evaluation of key cytokines and the coordination of inflammation.
    PLoS One. 2026;21:e0360525.
    PubMed         Abstract available
    
    
14. REDMAN WT, Mullany LC
    Data-driven forecasting of Flu, RSV, and COVID-19 related outcomes in the United States and Canada via Hankel dynamic mode decomposition.
    PLoS One. 2026;21:e0360068.
    PubMed         Abstract available
    
    
15. MAHMOOD B, Hu J, Tang TS, Adu P, et al
    Impact of the COVID-19 pandemic and control measures on type 2 diabetes care among South Asians: the perspective of healthcare providers in British Columbia, Canada.
    PLoS One. 2026;21:e0359295.
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16. JUHASZ L, Garba NA, Moise IK, Bhoite PB, et al
    The detection paradox: How COVID-19 surveillance patterns shifted from lower-income to more affluent neighborhoods in Miami-Dade County.
    PLoS One. 2026;21:e0361211.
    PubMed         Abstract available
    
    

    
    Proc Natl Acad Sci U S A

17. HVID U, Nielsen BF, Sneppen K
    Bridging spatial scales in respiratory viral infection.
    Proc Natl Acad Sci U S A. 2026;123:e2614436123.
    PubMed         Abstract available
    
    

    
    Vaccine

18. KROKHIN A, Romanova J, Grillari R, Hackl M, et al
    AEX-1: A Vero cell variant with enhanced permissiveness for influenza virus replication.
    Vaccine. 2026;94:129237.
    PubMed         Abstract available
    
    
19. XU S, Sy LS, Hong V, Farrington P, et al
    Ischemic stroke after bivalent mRNA COVID-19 vaccination and influenza vaccination during the 2022-2023 season: a multi-site self-controlled case series study.
    Vaccine. 2026;95:129263.
    PubMed         Abstract available
    
    

    
    Virology

20. RZYMSKI P, Malecka I, Szczepanska B, Wasielewska Z, et al
    RSV, influenza, and COVID-19 in hospitalized children: A comparative analysis of the 2025/2026 epidemic season in Poland.
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    PubMed         Abstract available
    

#Taiwan, Seasonal #Influenza and #COVID19 #Epidemics - Weekly #Report (CDC, Oct. 20 '26): #H1N1pdm09 flu virus & #SARS-CoV-2 PQ.16.1.1 variant predominated

 

{Excerpts}

(...)

    According to CDC monitoring data, the domestic influenza epidemic is slowing but still high and in its peak season. 

    During week 41 (October 11-17), there were 123,820 outpatient and emergency room visits for influenza-like illnesses, a 5.4% decrease from the previous week. 

    Last week (October 13-19), 159 new cases of severe influenza were reported (151 H1N1, 7 unidentified A, and 1 B), and 44 deaths were reported (42 H1N1 and 2 unidentified A). 

    Laboratory surveillance data shows that the influenza virus currently circulating in the community is predominantly type A, with type A H1N1 accounting for 92.7%. 

    This flu season (2026-2027) has seen a cumulative total of 307 severe cases (298 H1N1, 7 unidentified A, and 2 B) and 42 deaths (40 H1N1 and 2 unidentified A). 

    Furthermore, the domestic COVID-19 epidemic has remained below the epidemic threshold for two consecutive weeks, indicating that the epidemic period has ended. 

    In week 41 (October 11-17), there were 3,873 outpatient and emergency room visits for COVID-19, a 27.7% decrease compared to the previous week (October 4-10). 

    In the past seven days (October 13-19), there were 25 new severe cases and 5 deaths. 

    This season (October 1, 2026-September 30, 2027), there have been a cumulative total of 56 severe cases, including 6 deaths. 

    In the past four weeks, the most common local variant strain has been PQ.16.1.1, followed by NB.1.8.1.

(...)

Source: 

Link: https://www.cdc.gov.tw/Bulletin/Detail/NmSGjiosphPs1mla9qRq6Q?typeid=9

____

#Influenza and Other Respiratory Viruses Research #References (AMEDEO, Oct. 17 '26)

 

Epidemiol Infect

1. ONTAS E
   Establishing influenza epidemic thresholds and intensity levels in Turkiye using the moving epidemic method and assessing concordance with WHO transmission zones: A sentinel surveillance analysis of ten seasons, 2013-2025.
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2. KUMBAROFF Z, Harvey EP, Whitehead J, O'Neale DRJ, et al
   Ethnic inequities in mathematical models for respiratory infectious disease: A systematic review.
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3. HAUSER-VAN WESTRHENEN ESEM, De Hoog MLA, Winkel AMAM, Junquera Guinovart L, et al
   Viral interference with SARS-CoV-2 during the COVID-19 pandemic: An individual participant data meta-analysis.
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4. TRIGO F, Guillen JM, Hernandez-Barrera V, Gil R, et al
   Burden of RSV hospital disease and its comorbidities in adults in Spain (2016-2023).
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5. PILAPIL JD, Mata MA, Del Rosario R, Pasciolco MJ, et al
   Genomic surveillance of COVID-19 in Hong Kong (2020-2023): Analysing SARS-CoV-2 variants, mutations, and their impact on viral entry.
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6. SPRONK M, Boyd A, Campman SL, Jongen V, et al
   Presence of post-COVID-19 condition in six ethnic groups in Amsterdam, the Netherlands: a retrospectively reconstructed time interval approach.
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   J Clin Microbiol

7. HEIMSCH KC, Stanoeva KR, Visser I, Rahou Y, et al
   SARS-CoV-2 and RSV external quality assessment on molecular detection and variant typing in European expert laboratories in 2025.
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8. SMITH K, Martinez J, Yu H, Harrison J, et al
   Development and evaluation of an ARTIC-based amplicon sequencing assay for whole-genome characterization of respiratory syncytial virus.
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   J Immunol

9. KOUTSAKOS M, Crawford JC, Grzelak L, Rizzetto S, et al
   TCRalphabeta repertoire plasticity defines universal CD8+ T cell responses directed at influenza-specific HLA-A*02:01-PB1413-421 epitope.
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   J Infect Dis

10. BAI X, Chen S, Yin S, Zhao Q, et al
    Characterization of Mucosal BPI fold-containing family A member 1-High-Expressing Neutrophils and their Immune Defense roles in Severe Acute Respiratory Syndrome Coronavirus 2 Breakthrough Infection via single-cell RNA sequencing.
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11. NARAYAN K, Tosh K, Holmes A, Hu L, et al
    Serum Virus-Neutralizing Antibody Titers in Clinical Trial Participants With and Without Immunocompromise Receiving Pemivibart, a Long-Acting Monoclonal Antibody for COVID-19.
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12. AVADHANULA V, Bournat J, Ferlic-Stark LL, Bond NL, et al
    Impact of Low Community Circulation of Respiratory Syncytial Virus (RSV) on Immunity Debt Against RSV in Adults During the Coronavirus Disease 2019 Pandemic.
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13. SUTCLIFFE CG, Sergent VM, Yazzie D, Brasinikas G, et al
    Post-COVID Rebound in Invasive Pneumococcal Disease Driven by Resurgence of Serotype 4 Among American Indian Individuals in the Southwest United States.
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15. EPSI NJ, Richard SA, Morris MJ, Lindholm DA, et al
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17. WAN T, Lautenbach E, Mannathoko N, Mosepele M, et al
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18. LEIS AM, Han JH, Hough CL
    Beyond the Acute Illness: Three Myths About Viral Respiratory Infection.
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    J Virol

19. WILLIAMS SL, Gygli SM, Bjorgen JC, Fan H, et al
    Avian influenza A virus polymerase gene leads to temperature-resistant genome replication.
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    PLoS Biol

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    R1-32-like public antibodies acquire tolerance to SARS-CoV-2 antigenic drift through somatic hypermutation.
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    PubMed         Abstract available
    
    

    
    PLoS One

21. BHUKHAI K, Tanhuad N, Srimorkun P, Manopwisedjaroen S, et al
    Omicron SARS-CoV-2 shows NRP1-linked susceptibility in adipose-derived MSCs and alters primitive cord blood CD34(+) HSPCs.
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22. SADIQ M, Wasim B, Khatoon A, Kumar A, et al
    Whole-exome sequencing identifies a missense variant in the cytoskeletal gene SVIL implicating actin remodeling in COVID-19 severity in a Pakistani cohort.
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23. REZENDE LMT, Silva KVC, Cuadro A, Signes VM, et al
    Consequences of COVID-19 infection on educators' executive functions: A systematic review and meta-analysis protocol.
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24. LI X, Ding J, Zhang Y, Hu T, et al
    Measuring destination image dissonance: A compositional data analysis of cross-media representations in Sanya's Tourism.
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25. YANG Y, Juntila-Raymond C, Callear A, Smith M, et al
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26. VERFAILLIE SCJ, Verveen A, Visser D, Nieuwkerk P, et al
    Post-acute sequelae of COVID-19 (PASC) are associated with distinct clinical phenotypes two years after SARS-CoV-2 infection: A data-driven approach.
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27. NGAMALEU MR, Tene H, Djounda R, Minomo R, et al
    Early inflammation-driven damage and delayed viral clearance are associated with prolonged biliary perturbation in a Cameroonian cohort of COVID-19 patients.
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28. JUNG H, Jung M
    A retrospective epidemiological study of screening-derived solid cancer incidence proxy rates in South Korea before and after COVID-19 using Korean National Health Insurance Service data.
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    PubMed         Abstract available
    
    

    
    Vaccine

29. BOER M, Klugkist I, Kroese F
    Educational background and vaccination beliefs in the Netherlands: A Bayesian Evidence Synthesis from four studies.
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30. SAIKI S, Kuroiwa M, Hashimoto K, Nakajima-Yoshida H, et al
    LP.8.1-directed recombinant protein COVID-19 vaccine S-268025, formulated with squalene-based adjuvant A-910823, elicits robust immunogenicity and neutralizing breadth in mice.
    Vaccine. 2026;93:129177.
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31. BAZARJAV P, Erdene-Ochir T, Sandagdorj A, Enkhtuvshin A, et al
    One-year antibody kinetics and effectiveness of a BNT162b2 booster after four primary COVID-19 vaccination regimens in Mongolia.
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    PubMed         Abstract available
    
    
32. GOULD S, Rohde CM, Destexhe E, Tiesjema B, et al
    Summary of 2025 Society of Toxicology Workshop "Vaccine Toxicology in the Post-COVID Era".
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33. BRADY C, Govender M, Mellors J, Tipton T, et al
    Spike antibody Fc is associated with protection from SARS-CoV-2 challenge in macaques.
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34. SHICHINOHE S, Li Q, Tanaka H, Anindita J, et al
    Cross-clade protection against human H5N1 isolates by a clade 2.3.4.4b HA mRNA vaccine in mice.
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35. BEOGO I, Xu Y, Kibret TC, Muray M, et al
    Perception of COVID-19 vaccine effectiveness perception in older racialized communities: role of major racial discrimination and health literacy.
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36. BEOGO I, Kibret TC, Zhang Q, Muray M, et al
    Ethnic disparities in COVID-19 vaccine uptake among among 55+ year-old Canadians: Exploring the role of racial discrimination, chronic disease comorbidities, and conspiracy beliefs.
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37. KOPP L, Hofner B, Mentzer D
    Mobile-app-based cohort event monitoring study (CEM) of COVID-19 vaccines.
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38. MARQUES DFP, Howard J, Alvarez ML, Machado A, et al
    Comparing two case definitions for including severe acute respiratory infection patients in influenza and COVID-19 vaccine effectiveness studies among older adults using the test-negative design: VEBIS hospital network, seven European countries, 2023/
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Differentiating #Avian and Seasonal #Influenza Viruses in #Wastewater by Digital #PCR

 

Abstract

Highly pathogenic avian influenza A(H5Nx) viruses, particularly clade 2.3.4.4b, pose substantial global health risks. We combined and piloted 2 duplex reverse transcription digital PCRs to discriminate between avian and seasonal influenza viruses in wastewater. This approach enabled rapid, strain-specific detection to reduce ambiguity in environmental surveillance for influenza viruses.

Source: 

Link: https://doi.org/10.3201/eid3211.261234

____

#Taiwan, Seasonal #Influenza and #COVID19 #Epidemics - Weekly Surveillance #Report (CDC, Oct. 13 '26): #H1N1pdm09 flu virus and #SARS-CoV-2 PQ.16.1.1 predominated

 

{Excerpts}

(...)

    According to CDC monitoring data, the domestic influenza epidemic is slowing down but is still in its epidemic period. 

    In week 40 (October 4-10), there were 128,847 outpatient and emergency room visits for influenza-like illnesses, a decrease of 8.9% from the previous week. 

    Last week (October 6-12), there were 144 new cases of severe influenza complications (132 H1N1, 10 untyped A, and 2 B) and 46 deaths (all H1N1). 

    Laboratory surveillance data shows that the influenza virus currently circulating in the community is predominantly type A, with type A H1N1 accounting for 91.8%. 

    This influenza season (115-116) saw a total of 149 severe cases (139 H1N1, 9 untyped A, and 1 type B) and 15 deaths (all H1N1). 

    The previous influenza season (114-115) saw a total of 1,887 severe cases (1,259 H1N1, 511 H3N2, 25 untyped A, and 92 type B) and 409 deaths (278 H1N1, 107 H3N2, 12 untyped A, and 12 type B). 

    Among the severe cases, the majority were elderly people over 65 years old (66.3%) and those with a history of chronic diseases (83.6%). 67.1% of the patients had not received the seasonal influenza vaccine. 

    The domestic COVID-19 epidemic is declining. 

    In the 40th week (October 4-10), there were 5,261 outpatient and emergency room visits for COVID-19, a 35.2% decrease compared to the previous week (September 27-October 3). 

    Last week (October 6-12), there were 21 new severe cases and 15 deaths. 

    This quarter (October 1, 2026-September 30, 2027) has seen a cumulative total of 31 severe cases, including 5 deaths. 

    In the previous quarter (October 1, 2025-September 30, 2026), there were a cumulative total of 783 cases of COVID-19 complicated by severe illness, including 173 deaths. 

    The majority of severe cases were among the elderly aged 65 and above (73.7%) and those with a history of chronic diseases (83.0%). 83.8% of them had not received the COVID-19 vaccine this season. 

    In the past four weeks, the most common local variants have been PQ.16.1.1 and NB.1.8.1.

(...)

Source: 

Link: https://www.cdc.gov.tw/Bulletin/Detail/qCnfUYmbvj-LcuzLkB2GZg?typeid=9

____

#Influenza and Other Respiratory Viruses Research #References (AMEDEO, Oct. 10 '26)

 

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   Correction to: Introduction and Update: Advances in Influenza Therapeutics.
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5. CIACCI ZANELLA G, Vincent ML, Flores L, Aljets EK, et al
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11. YEO D, Woo S, Kim J, Kim K, et al
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    Proc Natl Acad Sci U S A

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Persistent #influenza A #RNA detection in a #fatal #pediatric case of influenza-associated #encephalopathy

 

Abstract

Influenza-associated encephalopathy (IAE) is a life-threatening complication of influenza. We report a case of a 9-year-old boy diagnosed with fulminant IAE. The patient received life-sustaining support, intensive immunomodulatory therapy, and antiviral therapy. Following an initial single dose of baloxavir marboxil, persistent influenza A (H3N2) RNA detection prompted a multi-targeted antiviral regimen (oseltamivir, baloxavir marboxil, peramivir, and onradivir) as salvage therapy. Nevertheless, influenza A RNA remained detectable for more than 1 month, potentially reflecting severe neurological injury, immunosuppression, and impaired airway clearance.

Source: 

Link: https://doi.org/10.1016/j.jiph.2026.103380

____

#Taiwan, Seasonal #Influenza and #COVID19 #Epidemics - Weekly Situation #Update (CDC, Oct. 6 '26): #H1N1pdm09 flu virus & #SARS-CoV-2 PQ.16.1.1 predominate

 

{Excerpt}

(...)

    According to CDC monitoring data, the domestic influenza epidemic remains stable and is still in its epidemic period. 

    In week 39 (September 27 - October 3), there were 139,060 outpatient and emergency room visits for influenza-like illnesses, a slight decrease of 1.4% from the previous week. 

    Last week (September 29 - October 5), there were 219 new cases of severe influenza complications (210 H1N1, 1 H3N2, 7 unidentified A cases, and 1 B case) and 44 deaths (41 H1N1, 1 H3N2, and 2 unidentified A cases). 

    Laboratory surveillance data shows that the influenza virus currently circulating in the community is predominantly type A, with type A H1N1 accounting for 90.7%. 

    This flu season (2025-2026) saw a total of 30 severe cases (all H1N1); the previous flu season (2024-2025) saw a total of 1,862 severe cases (1,225 H1N1, 511 H3N2, 35 unidentified A cases, and 91 B cases) and 378 deaths (247 H1N1, 107 H3N2, 12 unidentified A cases, and 12 B cases). 

    Among the severe cases, the majority were elderly people over 65 years old (66.4%) and those with a history of chronic diseases (83.6%), and 67.2% had not received the flu vaccine for this season. 

    Regarding the COVID-19 pandemic, the number of COVID-19 cases in the country has declined, but it is still in the epidemic period. 

    In the 39th week (September 27 - October 3), there were 7,836 outpatient and emergency visits for COVID-19, a decrease of 26.7% compared with the previous 7 days (September 24 - September 30). 

    Last week (September 29 - October 5), there were 37 new local severe cases and 16 local deaths. 

    This quarter (October 1, 2026 - September 30, 2027) saw a cumulative total of 12 local severe cases, with no deaths. 

    In the previous quarter (October 1, 2025 - September 30, 2026), there were a cumulative total of 781 local cases of COVID-19 complicated with severe illness, of which 163 died. 

    The majority of severe cases were among the elderly aged 65 and above (73.6%) and those with a history of chronic diseases (83.0%). 83.9% of these cases had not received the COVID-19 vaccine that quarter. In the past four weeks, the most common local case variants were PQ.16.1.1 and NB.1.8.1.

(...)

Source: 

Link: https://www.cdc.gov.tw/Bulletin/Detail/tC7VIc05_kkg8wOlIPpQIw?typeid=9

____

Increased circulation of #influenza #H1N1pdm09 viruses with reduced susceptibility to #oseltamivir, #Germany 2024–2026

 

Highlights

    • The National Influenza Center for Germany (Germany NIC) detected an increase in the prevalence of A(H1N1)pdm09 viruses carrying the neuraminidase substitution NA-S247N, rising from 1.16% circulating in the 2024/25 influenza season to 56.8% in the 2025/26 season.

    • The NA-S247N substitution reduced oseltamivir susceptibility slightly; combined NA-S247N/NA-I223V/T substitutions showed reduced inhibition according WHO criteria.

    • Continuous molecular and phenotypic surveillance is essential for public health and the early detection of viruses with reduced susceptibility to antiviral drugs.

    • Rapid pyrosequencing supports the routine surveillance of neuraminidase substitutions associated with reduced susceptibility to antivirals.

    • The findings illustrate the Germany NIC's 30-year contribution to antiviral susceptibility monitoring.

Abstract

Background

Oseltamivir is still considered to be the first-line antiviral treatment for severe seasonal influenza. However, resistance to neuraminidase (NA) inhibitors poses significant challenges to influenza management. Since the 2023/24 season, A(H1N1)pdm09 viruses carrying neuraminidase substitutions (NA-I223V and/or NA-S247N) have emerged in Germany, other EU/EEA countries, and some of the World Health Organization (WHO) regions. These viruses have been linked to reduced oseltamivir susceptibility.

Methods

A rapid RT-PCR/pyrosequencing assay was developed and validated to detect NA-I223X and NA-S247X substitutions. Subsequently, a total of 765 A(H1N1)pdm09 viruses detected in Germany during the 2024/25 and 2025/26 influenza seasons were characterized phenotypically using fluorometric NA inhibition testing and/or genotypically using next-generation sequencing and pyrosequencing.

Results

The prevalence of A(H1N1)pdm09 viruses bearing the NA-S247N substitution increased from 1.2% in the 2024/25 season to 56.8% in the 2025/26 season, accounting for up to 80% of analyzed viruses by March 2026. Viruses carrying NA-S247N exhibited higher oseltamivir IC50 values than wild-type viruses. Combinations of NA-S247N with substitutions at position 223 demonstrated an additional increase. In viruses carrying the combined NA-S247N and NA-I223V/T substitutions oseltamivir showed reduced inhibition with increased IC50 values of up to 17-fold compared to wild type viruses.

Conclusions

The accumulation of NA substitutions in A(H1N1)pdm09 influenza viruses, particularly NA-S247N in combination with NA-I223V/T, substantially reduces susceptibility to oseltamivir. The marked increase in NA-S247N prevalence suggests that this substitution is becoming persistent rather than transient. Targeted pyrosequencing is a practical tool for the early detection of emerging resistance-associated substitutions.

Source: 

Link: https://doi.org/10.1016/j.ijmm.2026.151745

____

#Influenza and Other Respiratory Viruses Research #References (AMEDEO, Oct. 3 '23)

 

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