Showing posts with label seasonal influenza. Show all posts
Showing posts with label seasonal influenza. Show all posts

Saturday, July 11, 2026

#Influenza and Other Respiratory Viruses Research #References (AMEDEO, July 11 '26)

 


    BMC Pediatr

  1. HEIBA D, Salem N, Antonios M, Shoman W, et al
    Comparative study of post- COVID-19 Kawasaki disease and multisystem inflammatory syndrome cases at Alexandria University Children's Hospital.
    BMC Pediatr. 2026;26:644.
    PubMed         Abstract available

  2. LIN C, Zhu Z, Li Y, Wei J, et al
    Diagnostic value of cytokine detection in children with Mycoplasma pneumoniae pneumonia complicated by bacterial or viral co-infections.
    BMC Pediatr. 2026;26:629.
    PubMed         Abstract available


    Epidemiol Infect

  3. DAVOODI Z, Laurie C, Tingley K, Skidmore B, et al
    Risk-of-bias assessment of vaccine effectiveness studies: a scoping review of systematic reviews.
    Epidemiol Infect. 2026;154:e95.
    PubMed         Abstract available

  4. ROSCA EC, Oke J, Jefferson T, Brassey J, et al
    Serial cycle threshold to assess the infectious potential of SARS-CoV-2: A systematic review.
    Epidemiol Infect. 2026;154:e89.
    PubMed         Abstract available


    J Clin Microbiol

  5. MCTAGGART LR, Eshaghi A, Cronin K, Patel SN, et al
    Post-pandemic surge of Mycoplasma pneumoniae in Ontario, 2024: molecular surveillance and resistance trends relative to 2018-2023.
    J Clin Microbiol. 2026;64:e0018826.
    PubMed         Abstract available


    J Infect

  6. LI Y, Zhang T, Gao J
    Home-Based Rapid Testing and Early Antiviral Treatment as a Potential Strategy to Blunt Pediatric Influenza Peak.
    J Infect. 2026 Jul 7:106807. doi: 10.1016/j.jinf.2026.106807.
    PubMed        


    J Infect Dis

  7. SKELLINGTON CN, Schmidt K, Schofield C, Ganesan A, et al
    The Effect of Prevaccination Analgesics on Influenza Vaccine Immunogenicity and Effectiveness.
    J Infect Dis. 2026 Jul 10:jiag334. doi: 10.1093.
    PubMed         Abstract available


    J Virol

  8. JIA H, Lin C, Guo Y, Cai W, et al
    A neuraminidase-targeted nanobody confers broad protection against influenza B virus.
    J Virol. 2026 Jul 10:e0076226. doi: 10.1128/jvi.00762.
    PubMed         Abstract available

  9. BARRON-CASTILLO U, Berube N, Swan CL, Javed MA, et al
    Receptor profiling and growth assessment of influenza A virus in porcine mammary and non-mammary tissues and derived cells.
    J Virol. 2026 Jul 6:e0061526. doi: 10.1128/jvi.00615.
    PubMed         Abstract available


    MMWR Morb Mortal Wkly Rep

  10. PATRICK R, Lee K, Kuan M, Chan M, et al
    Norovirus, COVID-19, and Influenza Outbreaks Among Residents and Staff Members at the Eaton Wildfire Evacuation Shelter - Pasadena, California, January-February 2025.
    MMWR Morb Mortal Wkly Rep. 2026;75:337-342.
    PubMed         Abstract available


    Pediatrics

  11. LEONARD JS, Reinhart K, Lu PJ, Santibanez TA, et al
    Influenza Vaccine Effectiveness Against Pediatric Death in the United States: 2016-2025.
    Pediatrics. 2026 Jul 6:e2026076453. doi: 10.1542/peds.2026-076453.
    PubMed         Abstract available

  12. HAHN C, Sardi A, Ratner AJ
    Averting the Unthinkable: Immunization to Prevent Childhood Deaths From Influenza.
    Pediatrics. 2026 Jul 6:e2026076867. doi: 10.1542/peds.2026-076867.
    PubMed        


    PLoS Comput Biol

  13. WANG B, Valdano E
    Redefining and estimating the early-phase reproduction ratio for epidemic outbreaks in spatially structured populations.
    PLoS Comput Biol. 2026;22:e1014425.
    PubMed         Abstract available


    PLoS One

  14. LI W, Tan HL, Zhuang CY, Li JY, et al
    Parental knowledge, vaccine hesitancy, and practices regarding seasonal influenza vaccination for preschool-aged children in Shenzhen, China: Insights from a cross-sectional survey.
    PLoS One. 2026;21:e0353478.
    PubMed         Abstract available

  15. SANOGO IN, Puryear WB, Simulynas AF, DiGiovanni R, et al
    Serological evidence of SARS-CoV-2 exposure in marine mammals in the United States between 2020 and 2025.
    PLoS One. 2026;21:e0351734.
    PubMed         Abstract available

  16. HIRATA K, Chiba T, Takaku R, Meilai C, et al
    Beyond the freedom to refuse patient: A retrospective comparative study of emergency transportation during the COVID-19 pandemic in Japan.
    PLoS One. 2026;21:e0331535.
    PubMed         Abstract available

  17. HAKKI S, Nevin S, Conibear E, Madon KJ, et al
    Full blood count dynamics in immunologically naive individuals with mild COVID-19: A prospective community cohort study.
    PLoS One. 2026;21:e0353142.
    PubMed         Abstract available

  18. BURCHARDI JM, Brunger M, Freitag H, Brock A, et al
    Improving the care of people affected by post-COVID syndrome (LCovB):study protocol of a mixed-methods study.
    PLoS One. 2026;21:e0353270.
    PubMed         Abstract available

  19. AL-AGHBARI N
    Serum albumin and blood urea as independent predictors of in-hospital mortality in hospitalized COVID-19 patients: A retrospective cohort study.
    PLoS One. 2026;21:e0353456.
    PubMed         Abstract available

  20. JEWELL M, Marye A, Barbeau B, Oakeson K, et al
    Beyond traditional outbreak investigation: Using genomic data for enhanced detection of COVID-19 disease clusters in Utah.
    PLoS One. 2026;21:e0342637.
    PubMed         Abstract available

  21. IIDA K, Mori H, Remez D, Krokva D, et al
    Epidemiological characteristics of amebiasis in Japan from 2001 to 2022.
    PLoS One. 2026;21:e0318901.
    PubMed         Abstract available

  22. FREDERIKSEN L, Subedi S, Choong K, Anderson J, et al
    Respiratory and bloodstream coinfections and antimicrobial use in hospitalised patients with moderate to severe COVID-19: An Australian retrospective cohort study.
    PLoS One. 2026;21:e0352344.
    PubMed         Abstract available

  23. FUKUDA T, Haruyama R, Tanaka Y, Natori S, et al
    Development of a COVID-19 Vaccination Anxiety Scale to measure COVID-19 vaccine anxiety in Japanese adults.
    PLoS One. 2026;21:e0330146.
    PubMed         Abstract available

  24. MICHALAKI E, Van Zanten A, Najjar J, Byagathvalli G, et al
    A piezoelectric electroporator (Piezopen) for enhanced "naked" RNA vaccine delivery.
    PLoS One. 2026;21:e0353214.
    PubMed         Abstract available

  25. GACH D, van Osch FHM, van den Bergh JP, Posthuma R, et al
    Long-term multidimensional health status of individuals with and without post COVID-19 condition: A cross-sectional study.
    PLoS One. 2026;21:e0352332.
    PubMed         Abstract available

  26. CONGDON C, Malik F, Jina R, Kumar D, et al
    A multi-country qualitative evaluation of rapid mortality surveillance during the COVID-19 pandemic.
    PLoS One. 2026;21:e0333157.
    PubMed         Abstract available


    Vaccine

  27. ZHANG L, Lin T, Wang M, Ma X, et al
    Retraction notice to "Effectiveness of prescription-based influenza vaccination services among older adults in Binzhou, China: A cluster-randomized controlled trial" [Vaccine 82 (2026) 128588].
    Vaccine. 2026 Jul 6:128885. doi: 10.1016/j.vaccine.2026.128885.
    PubMed        

Sunday, July 5, 2026

#Influenza and Other Respiratory Viruses Research #References (AMEDEO, July 5 '26)

 


    Ann Intern Med


  1. Summary for Patients: Adverse Events After Same-Day COVID-19 and Influenza Vaccination Versus Influenza Vaccination Alone.
    Ann Intern Med. 2026 Jun 30. doi: 10.7326/ANNALS-26-00217.
    PubMed        

  2. XIE Y, Choi T, Al-Aly Z
    Adverse Events After Same-Day COVID-19 and Influenza Vaccination Versus Influenza Vaccination Alone : A Target Trial Emulation.
    Ann Intern Med. 2026 Jun 30. doi: 10.7326/ANNALS-26-00217.
    PubMed         Abstract available


    Antiviral Res

  3. YANG X, Wu L, Wan G, Chen R, et al
    The anti-respiratory syncytial virus activity of biochemicals from Pyrola incarnata.
    Antiviral Res. 2026;252:106473.
    PubMed         Abstract available


    Arch Virol

  4. ALVES MCS, Falcao RM, de Jesus Palmeira OF, de Sa Leitao Paiva-Junior S, et al
    Genomic and epidemiological characterization of SARS-CoV-2 in Northeastern Brazil: a comprehensive analysis (2020-2024).
    Arch Virol. 2025;171:1.
    PubMed         Abstract available

  5. NEHUL S, Nagaraj SK, Narayan R, Singh A, et al
    A novel molecule inhibits SARS-CoV-2 RBD binding to the ACE2 receptor, blocks viral entry and exhibits antiviral activity in a murine model.
    Arch Virol. 2026;171:98.
    PubMed         Abstract available

  6. MOYUE X, Liang S, Ying X, Yang Y, et al
    Research progress of nucleocapsid protein of novel coronavirus: structure, function and targeted therapy.
    Arch Virol. 2026;171:120.
    PubMed         Abstract available

  7. CHEPURNOV A, Miroshnichenko S, Ivanov M, Solomatina M, et al
    Specific features of the infection caused by SARS-CoV-2 variants in Vero cell culture.
    Arch Virol. 2026;171:133.
    PubMed         Abstract available

  8. JONES LR, D'Andrea JS, Levite J, Brito M, et al
    Viral genotype and the pace of epidemic waves: an assessment from SARS-CoV 2 genomics and wastewater surveillance data.
    Arch Virol. 2026;171:163.
    PubMed         Abstract available


    BMC Pediatr

  9. ASAFO-AGYEI SB, Ameyaw E, Nguah SB, Paintsil V, et al
    Immunisation status and clinical outcomes in children admitted to a Paediatric emergency unit in Ghana: a prospective cohort study.
    BMC Pediatr. 2025;25:981.
    PubMed         Abstract available

  10. PU F, Hao YQ
    Impact of COVID-19 epidemic prevention and control measures on the incidence of asthma in children.
    BMC Pediatr. 2026;26:8.
    PubMed         Abstract available

  11. AVSAR H, Bulbul A, Bas EK, Uslu HS, et al
    Maternal-infant vitamin D coupling and neonatal hypocalcemia: a six-year cohort integrating preterm risk, onset timing, and pandemic effects.
    BMC Pediatr. 2026 Jan 27. doi: 10.1186/s12887-026-06532.
    PubMed        

  12. MOHAMMADI R, Barzegar H, Zamani Z, Gorji M, et al
    Hospitalization outcomes and laboratory correlations in pediatric MIS-C patients: a retrospective cross-sectional study in Tehran, Iran.
    BMC Pediatr. 2026;26:205.
    PubMed         Abstract available

  13. MIYAGI Y, Morimoto Y, Satake E, Iwashima S, et al
    Identification of key clinical features for pediatric respiratory syncytial virus infection using machine learning.
    BMC Pediatr. 2026;26:266.
    PubMed         Abstract available

  14. COBAN Y, Evren G, Yildizdas D, Zengin N, et al
    Burden, risk factors, and outcomes respiratory syncytial virus (RSV) infection in pediatric intensive care units in Turkiye (RSVP Study 2020-2024).
    BMC Pediatr. 2026 Mar 5. doi: 10.1186/s12887-026-06562.
    PubMed        

  15. AKALIN H, Kilic A, Ozcetin M, Yildiz I, et al
    The effect of Covid 19 pandemic on childhood obesity in Turkey.
    BMC Pediatr. 2026;26:310.
    PubMed         Abstract available

  16. SCHMIDT L, Feddern S, Kossow A, Niessen J, et al
    Severe acute COVID-19 and early long COVID signals in paediatric cohorts: an analysis of real-world data from two health departments, Germany.
    BMC Pediatr. 2026;26:280.
    PubMed         Abstract available

  17. HANSEN G, Holt T
    RSV bronchiolitis versus COVID-19: could pediatric intensive care units have done more during the pandemic?
    BMC Pediatr. 2026 Apr 11. doi: 10.1186/s12887-026-06850.
    PubMed        


    J Gen Virol

  18. KUOK DIT, Ma APY, Ching RHH, Ng KC, et al
    Assessment of influenza virus and coronavirus tropism, replication competence and disease severity in ex vivo and in vitro cultures of the human respiratory tract.
    J Gen Virol. 2026;107:002281.
    PubMed         Abstract available


    J Virol

  19. LI P, Zheng Y-M, Liu S-L
    Altered infectivity, cell-cell fusion, and immune evasion of SARS-CoV-2 BA.3.2 and LP.8.1 variants.
    J Virol. 2026 May 12:e0001626. doi: 10.1128/jvi.00016.
    PubMed         Abstract available

  20. MCCABE M, Groves HE, Getty E, Campbell E, et al
    Age-dependent expression and antiviral activity of interferon epsilon in respiratory epithelium.
    J Virol. 2026 May 12:e0057825. doi: 10.1128/jvi.00578.
    PubMed         Abstract available

  21. SIVARAJAN R, Kirchgatterer PC, Lawrenz J, Tanner-Matiz E, et al
    Tonic and early interferons defend against respiratory viruses in primary human lung organoid-derived air-liquid interface cultures.
    J Virol. 2026 May 20:e0210425. doi: 10.1128/jvi.02104.
    PubMed         Abstract available

  22. FAN L, Gao X, Feng W, Huang Q, et al
    SARS-CoV-2 ORF3a suppresses host antiviral interferon responses by promoting STUB1-mediated PTEN proteasomal degradation.
    J Virol. 2026 Jun 2:e0018626. doi: 10.1128/jvi.00186.
    PubMed         Abstract available

  23. SUSMA B, Spronken M, van Nieuwkoop S, Kalverda B, et al
    Increased or decreased numbers of CpG dinucleotide motifs in the genome of influenza A virus do not affect in vitro virus phenotype.
    J Virol. 2026 Jun 22:e0004726. doi: 10.1128/jvi.00047.
    PubMed         Abstract available

  24. ZHANG Q, Zhang Y, Sun H, Li H, et al
    Single-cell and spatial transcriptomic profiling reveals distinct immune landscapes in murine lungs infected with H1N1 versus H5N1 influenza viruses.
    J Virol. 2026 Jun 29:e0074626. doi: 10.1128/jvi.00746.
    PubMed         Abstract available

  25. KATO K, Okamura K, Nakamura Y, Iwata M, et al
    Influenza A virus infection induces initial proliferation of commensal Streptococcus pneumoniae in the larynx leading to dissemination into the lower respiratory tract.
    J Virol. 2026 Jun 29:e0055526. doi: 10.1128/jvi.00555.
    PubMed         Abstract available


    Pediatrics

  26. GERHART J, Leister-Tebbe H, Chan PLS, McComsey GA, et al
    Nirmatrelvir/Ritonavir for the Treatment of COVID-19 in Children Aged 6 Years and Older.
    Pediatrics. 2026 Jun 25:e2025073999. doi: 10.1542/peds.2025-073999.
    PubMed         Abstract available

  27. ZMUDA E, Hannon TS, Valentic J
    The Role of the Pediatrician to Promote Effective Approaches for Child and Adolescent Nutrition in Schools: Policy Statement.
    Pediatrics. 2026 Jun 15:e2026077404. doi: 10.1542/peds.2026-077404.
    PubMed         Abstract available

  28. MEHROTRA-VARMA S, Nguyen HQ, Henry S, Collins J, et al
    Long-Term Outcomes of Multisystem Inflammatory Syndrome in Children up to 4.5 Years After COVID-19.
    Pediatrics. 2026;158:e2025075578.
    PubMed         Abstract available


    PLoS One

  29. HUANG L, Wang TM, Sugimoto JD, Heberer KR, et al
    Association of SARS-CoV-2 infection with incident diabetes among U.S. Veterans in a prospective longitudinal cohort.
    PLoS One. 2026;21:e0351992.
    PubMed         Abstract available

  30. ALLARDET-SERVENT J, Hezard N, Pissier C, Bardin N, et al
    Circulating biomarkers of bronchoalveolar injury help predict the need for mechanical ventilation in patients with moderate to severe COVID-19 pneumonia: A prospective cohort study.
    PLoS One. 2026;21:e0337792.
    PubMed         Abstract available

  31. NAZIR A, Shorfuzzaman M, Lotfi ML, Kamalov F, et al
    Forecasting COVID-19 new cases using NBEATS deep learning and mobility data.
    PLoS One. 2026;21:e0350264.
    PubMed         Abstract available

  32. WERTZ E, Babinska M, Batorski D, Louison-Lavoy D, et al
    Ad-based social media interventions increase belief accuracy and generate pro-social opinions among non-news readers.
    PLoS One. 2026;21:e0352588.
    PubMed         Abstract available

  33. HERNANDEZ-ORTIZ BA, Dos Santos TA, Appolinario CM, Arcila-Cardona AM, et al
    Spatial association of seabirds and aquatic birds with highly pathogenic avian influenza (H5N1) outbreaks in Brazil: A nationwide ecological and statistical modelling approach.
    PLoS One. 2026;21:e0350505.
    PubMed         Abstract available

  34. KEARNEY GD, Obi ON, Maddipati V, Levitin G, et al
    Social vulnerability and spatial patterns of COVID-19 mortality: Global implications for respiratory health equity.
    PLoS One. 2026;21:e0352270.
    PubMed         Abstract available

  35. KATUSIIME L, Agbola FW
    Determinants of mobile money loan disbursements: Evidence from Uganda's post pandemic digital credit boom.
    PLoS One. 2026;21:e0338535.
    PubMed         Abstract available

  36. KIERNAN EA, Guzman JD
    Paying in public: Peer effects, impression management, and willingness to pay on digital payment platforms.
    PLoS One. 2026;21:e0340550.
    PubMed         Abstract available


    Proc Natl Acad Sci U S A

  37. CAO J, Liu S, Su C, Wang L, et al
    Genomic and structural evidence of SARS-CoV-2 and MERS-CoV in migratory birds.
    Proc Natl Acad Sci U S A. 2026;123:e2400023123.
    PubMed         Abstract available

  38. METZGER SM, Jones TC, Meier JIJ, Richter A, et al
    Evaluation of a proposed link between the SARS-CoV-2 furin cleavage site and mouse-adapted MERS-coronavirus MA30.
    Proc Natl Acad Sci U S A. 2026;123:e2601806123.
    PubMed         Abstract available

  39. TYLLIS TS, Norton TS, Abbott C, McPeake DJ, et al
    B cell-intrinsic CXCR3 drives efficient generation of ectopic pulmonary germinal center responses to influenza A virus infection.
    Proc Natl Acad Sci U S A. 2026;123:e2535787123.
    PubMed         Abstract available

  40. SOEWONGSONO AC, Thompson A, Landis MJ
    Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.
    Proc Natl Acad Sci U S A. 2026;123:e2535042123.
    PubMed         Abstract available


    Vaccine

  41. YADEGARYNIA D, Keyvanfar A, Keyvani H, Tehrani S, et al
    Corrigendum to "Immunogenicity and safety of a quadrivalent recombinant influenza vaccine manufactured in Iran (FluGuard) in volunteers aged 18-60 years: A double-blind, non-inferiority, randomized controlled trial" [Vaccine 42(9) (2024) 2254-2259].
    Vaccine. 2026;88:128881.
    PubMed        

  42. BARBAROUX A, Serati I, Milhabet I
    Effectiveness and acceptability of an opt-out nudge to promote influenza vaccination among medical residents: A randomized controlled trial.
    Vaccine. 2026;89:128894.
    PubMed         Abstract available

  43. MORRIS SE, O'Halloran A, Sundaresan D, Olson SM, et al
    Public health benefits of maternal influenza vaccination among pregnant women and infants <6 months in the United States, 2011-2020.
    Vaccine. 2026;89:128895.
    PubMed         Abstract available

  44. HALWE NJ, Krammer F
    Vaccine strategies and development before and during the 1968 H3N2 influenza pandemic.
    Vaccine. 2026;89:128877.
    PubMed         Abstract available

Saturday, June 27, 2026

#Pixavir Marboxil: First Approval

 


Abstract

Pixavir marboxil (Yilikang®; 壹立康®) is an oral cap-snatching endonuclease inhibitor being developed by TaiGen Biotechnology for the treatment of influenza virus infections. Pixavir marboxil recently received approval in China for the treatment of uncomplicated influenza A and B in previously healthy adults and adolescents aged ≥ 12 years. This article summarizes the milestones in the development of pixavir marboxil leading to this first approval for uncomplicated influenza A and B infections.

Source: 


Link: https://link.springer.com/article/10.1007/s40265-026-02320-2

____

#Influenza and Other Respiratory Viruses Research #References (AMEDEO, June 27 '26)

 


    BMC Pediatr

  1. LU Q, Yu D, Liang Y, Meng Q, et al
    Antimicrobial resistance of Group A Streptococcus isolates from patients in Shenzhen, China during COVID-19 pandemic.
    BMC Pediatr. 2026 Jan 9. doi: 10.1186/s12887-025-06448.
    PubMed        

  2. DOKHAN-VURAL S, Kahlert CR, Roduit C, Heldt K, et al
    Health-related quality of life, glycaemic control, lifestyle characteristics and SARS-CoV-2 prevalence in children with type 1 diabetes during the COVID-19 pandemic: results of a longitudinal, prospective single-centre Swiss study.
    BMC Pediatr. 2026 Jan 6. doi: 10.1186/s12887-025-06375.
    PubMed         Abstract available

  3. TIAN L, Hu X, Qin Y, Li L, et al
    Early prediction of severe RSV-associated ALRTI in Asian pediatric patients: a simple nomogram.
    BMC Pediatr. 2025;25:968.
    PubMed         Abstract available

  4. IBRAHIM HM, Kotby A, El-Ghoneimy DH, El Gendy YG, et al
    "Characteristics of children with multisystem inflammatory syndrome in children during different COVID-19 waves "Single centre Study".
    BMC Pediatr. 2025;25:988.
    PubMed         Abstract available

  5. YANG M, Wang Y, Gao J, Yao C, et al
    Impact of SARS-CoV-2 variants and vaccination on pediatric febrile seizures: a retrospective cohort study.
    BMC Pediatr. 2025;25:929.
    PubMed        


    Cell

  6. WACHARAPLUESADEE S, Saikruang W, Lytras S, Matsumoto K, et al
    Virological characteristics of SARS-CoV-2-related coronaviruses dynamically circulating in Southeast Asia.
    Cell. 2026;189:4075-4093.
    PubMed         Abstract available


    Drugs

  7. KANG C
    Pixavir Marboxil: First Approval.
    Drugs. 2026;86:1141-1145.
    PubMed         Abstract available


    J Virol Methods

  8. IKRAR T, Muchsin W, Sophian A
    Beyond strain-specific immunity: Conserved antigenic targets, emerging platforms, and translational challenges in universal influenza and pan-coronavirus vaccine development.
    J Virol Methods. 2026;345:115432.
    PubMed         Abstract available


    Pediatrics

  9. ARCHER HI, Watson A, Liao LD, Jacobson KB, et al
    Concordance Between Maternal and Infant COVID-19 and Influenza Vaccination Status.
    Pediatrics. 2026 Jun 24:e2025075163. doi: 10.1542/peds.2025-075163.
    PubMed         Abstract available


    PLoS Comput Biol

  10. DONG W, Yang Q, Xu L, Li X, et al
    TCRBinder: Unified pre-trained language model with paired-chain synergy for predicting T-cell receptor binding specificity.
    PLoS Comput Biol. 2026;22:e1014396.
    PubMed         Abstract available


    PLoS Med

  11. GHISI GLM, Carson RP, Turk Adawi K, Ding R, et al
    Comparisons of core component delivery in cardiac rehabilitation programs by country income classification and decade based on the 2025 Global Audit Update: A survey study.
    PLoS Med. 2026;23:e1005151.
    PubMed         Abstract available


    PLoS One

  12. ISHIGAKI Y, Fujita N, Kato T, Ochiai T, et al
    Airborne spread of severe acute respiratory syndrome coronavirus 2 between rooms in a sealed, mechanically ventilated ward: Evidence from a hospital outbreak investigation.
    PLoS One. 2026;21:e0350608.
    PubMed         Abstract available

  13. MARTINS A, Bosco Santos MF, Nascimento J, da Silva Chui FM, et al
    Effectiveness of CoronaVac in a pioneer risk-based allocation clinical trial during the COVID-19 pandemic.
    PLoS One. 2026;21:e0351566.
    PubMed         Abstract available

  14. CHEN YH, Lin CH, Liu JH, Lin HA, et al
    Effects of incentive spirometer training on dyspnea and functional status in patients with long COVID.
    PLoS One. 2026;21:e0351553.
    PubMed         Abstract available

  15. BETTIO F, Tavares FF, Ticci E
    Intimate partner violence during lockdown in Tuscany, Italy: Economic or confinement-related shocks?
    PLoS One. 2026;21:e0349889.
    PubMed         Abstract available

  16. CHEN X, Gao J, Qin Q, Wang C, et al
    Will there be new trends in the public's attention to express services in the post-COVID-19 era?
    PLoS One. 2026;21:e0348096.
    PubMed         Abstract available

  17. CHASCIAR V, Chasciar DR, Coman C, Gherhes V, et al
    Workplace changes, perceived difficulties and migration intentions among Romanian construction workers during the covid-19 pandemic.
    PLoS One. 2026;21:e0335155.
    PubMed         Abstract available

  18. KEITA NY, Onywera H, Abdou M, Dicko Z, et al
    A tale of SARS-CoV-2 genomic surveillance in Mali: Variants introductions and transmission dynamics.
    PLoS One. 2026;21:e0352020.
    PubMed         Abstract available

  19. RAVINDRARAJAH R, Gittins M, Paterson L, Rogers G, et al
    Clinical and cost-effectiveness of the digital intervention, MyWay Diabetes, in people with type 2 diabetes living in Greater Manchester during the COVID-19 pandemic.
    PLoS One. 2026;21:e0349232.
    PubMed         Abstract available

  20. MAJEWSKA M, Mazdziarz MA, Lepiarczyk E, Lipka A, et al
    Severity-dependent metabolic rewiring in COVID-19 based on untargeted metabolomic profiling of patient plasma.
    PLoS One. 2026;21:e0352437.
    PubMed         Abstract available

  21. YU J, Bekerian DA, Khandelwal R
    Why do people comply with health guidelines in a competing information environment?
    PLoS One. 2026;21:e0352421.
    PubMed         Abstract available

  22. YUMIYA Y, Itakura M, Shiroma N, Murayama H, et al
    Factors associated with the duration of telephone observation and consultation sessions provided by the Hiroshima Prefecture Follow-up Center in the later stages of the COVID-19 pandemic in Japan.
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Wednesday, June 24, 2026

Identification of HLA-A33-restricted #CD8+ T cell epitopes from avian #influenza #H5N1

 


Abstract

The rapid evolution of avian influenza A/H5N1, including the recent U.S. clade 2.3.4.4b outbreak, highlights its pandemic potential and the urgent need for durable, broadly protective vaccines. Given the capacity of CD8+ T cells to mediate cross-strain immunity, we investigated whether geographically distinct HLA-A33 allotypes, HLA-A*33:01 in East/Southeast Asia and HLA-A*33:03 in South Asia, differentially shape the influenza immunopeptidome and influence antiviral immunity. Antigen-presenting cells overexpressing HLA-A*33:01 or HLA-A*33:03 were transfected with single A/H5N1 antigens or infected with A/X-31 (H3N2) as a control comparison representing current seasonal influenza virus. We identified novel ligands restricted to HLA-A*33:01 (57 from A/H5N1; 55 from A/X-31) and HLA-A*33:03 (29 from A/H5N1; 45 from A/X-31). Although fewer peptides were recovered for HLA-A*33:03, a larger proportion of A/X-31-derived peptides were predicted as high-affinity binders (74%) compared with HLA-A*33:01 (61%), indicating qualitative differences in antigen presentation. To determine immunogenicity, peripheral blood lymphocytes from HLA-A*33:03-positive, A/H5N1-naĂ¯ve donors were stimulated with four conserved peptides: PB2GTF, PB2KTY, NPSVQ and PB1MTK. All elicited robust CD8+ T cell activation despite the absence of prior A/H5N1 exposure, demonstrating cross-recognition by memory T cells primed against seasonal influenza. These findings define HLA-A33-restricted influenza epitopes and reveal allotype-specific presentation features that shape CD8+ T cell immunity. Conserved, immunogenic peptides identified here represent promising candidates for rational design of broadly cross-reactive vaccines to protect HLA-A33-expressing populations against severe A/H5N1 disease. Data are available via ProteomeXchange with identifier PXD078870.


Competing Interest Statement

AWP is a scientific advisor for Bioinformatics Solutions Inc (Canada), a shareholder and scientific advisor for Evaxion Biotech (Denmark), and a co-founder of Resseptor Therapeutics (Australia). These organisations had no role in the design of the study in the collection, analyses, or interpretation of data in the writing of the manuscript or in the decision to publish the results. All other authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.


Funder Information Declared

NHMRC, 1122099, 2016596

Source: BioRxIV, https://www.biorxiv.org/

Link: https://www.biorxiv.org/content/10.64898/2026.06.21.733083v1

____

Tuesday, June 23, 2026

#Antibodies against #influenza #H1N1pdm2009 and B/Victoria strains but not #H3N2 are increased in recent onset type 1 #narcolepsy versus matched controls

 


Abstract

Study Objectives

Onsets of Narcolepsy type-1 (NT1) increased following A/H1N1 vaccination with PandemrixTM in Europe and with A/H1N1pdm2009 infections in China and other countries. To test if other strains could trigger narcolepsy, we measured strain-specific antibodies in patients with recent onset NT1 compared to controls. 

Methods

Antibodies against hemagglutinin (HA) and neuraminidase (NA) were tested in 62 patients with very recent onset (onset and blood collection following a single flu season, mean +/- SEM: 0.44 +/- 0.06 years since onset) and 100 controls matched by age, sex, season and year of collection (2000-2025). Results were next extended to 181 recent onset patients (mean +/- SEM: 1.00 +/- 0.05 years) versus 260 controls, matched by sex, season and year, but having a slightly higher mean age. HA inhibition (HAI) and NA inhibition (NAI) assays were conducted using flu strains known to circulate during the corresponding flu seasons. HAI results are shown as % positive (titers >= 40) and NAI results as geometric mean titers. Odds ratio (OR) and coefficient were used to compare antibody titers in NT1 versus controls. The contribution of each assay to prediction was finally quantified in the larger sample set using Shapley decomposition. 

Results

NT1 patients had increased anti-HA and anti-NA antibodies against A/H1N1pdm2009 (anti-HA OR = 3.86, anti-NA coefficient = 0.35) and B/Victoria (anti-HA OR =1.90, anti-NA coefficient = 0.22), but not A/H1N1pre2009, A/H3N2, or B/Yamagata, independent of HLA-DQB1*06:02 status, age, sex, and flu season. Correlations between anti-HA and anti-NA antibodies titers were weak to moderate but significant (r2=-0.10 to 0.34). Multivariable model outperformed age-only baseline (McFadden R2 = 0.19 vs. 0.03; AUC = 0.79 vs. 0.64; likelihood-ratio test X2 = 51, p<0.001), with anti-HA against A/H1N1pdm2009 (coefficient = 0.78, p < 0.001) and anti-NA against B/Victoria (coefficient = 0.69, p < 0.001) emerging as the strongest independent predictors. 

Conclusions

A/H1N1pdm2009 and B/Victoria, but not other strains can trigger the autoimmune process leading to orexin cell loss in narcolepsy.


Competing Interest Statement

The authors have declared no competing interest.

Source: 


Link: https://www.medrxiv.org/content/10.64898/2026.06.13.26355596v1

____

Saturday, June 20, 2026

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Monday, June 15, 2026

#HK CHP continues to actively follow up on a #human case of #H9N2 virus infection and reminds public of possibility of "twin-peaks" for seasonal #influenza and #COVID19 during summer

 


    The Centre for Health Protection (CHP) of the Department of Health (DH) today (June 15) continued to actively follow up on a case of human infection with influenza A (H9) in collaboration with the relevant government departments. 

    Following whole genome sequencing and analysis of the patient's clinical specimens, the virus strain was confirmed to be a low-pathogenic avian influenza A (H9N2) virus

    All of the virus genes were avian in origin and no significant genetic variations were detected

    The patient is currently in stable condition and all six of his household contacts have remained asymptomatic

    As the H9N2 avian influenza virus has long been present in local poultry with low mortality rate for birds, and that the H9N2 avian influenza virus involved in this case has not shown evidence of human-to-human transmission or significant genetic variation, the CHP currently assessed the risk of a local avian influenza pandemic as low

    Nevertheless, the CHP once again strongly urged the public to maintain good personal and environmental hygiene at all times, avoid contact with live poultry, birds or their droppings, thoroughly cook poultry meat and eggs before consumption, and wash hands thoroughly after visiting places where live poultry is sold, so as to reduce the risk of avian influenza infection.

    In addition, with the recent rise in the activity of seasonal influenza and COVID-19, the CHP does not rule out the possibility that the activity of these two respiratory diseases will continue to rise in the coming months, leading to a "twin-peaks" phenomenon. Members of the public, particularly high-risk individuals, are advised to receive vaccination in a timely manner to reduce the risk of severe disease and death.

 

Human infection with influenza A (H9) virus

    In relation to the recent influenza A (H9) infection in a two-year-old boy, the Public Health Laboratory Services Branch of the CHP conducted whole genome sequencing and analysis of the virus, confirming that the virus strain is a low-pathogenic H9N2 avian influenza virus and that no significant genetic variations were detected. 

    The CHP has collected 17 environmental samples from the residence of the patient, the fresh provision shop at Wo Che Market he had visited, as well as a park in Fung Wo Estate

    One sample collected from a metal tray placed at the bottom of a live chicken cage inside the shop that was used to collect chicken droppings was tested positive for the H9 avian influenza virus. 

    The remaining 16 samples tested negative

    The CHP will conduct further analysis on the positive environmental sample. 

    The CHP believed that it is more likely for the boy to have contracted H9 avian influenza by touching a contaminated surface at the fresh food shop selling live poultry in Wo Che Market. Thorough disinfection and cleaning will be conducted at the fresh food shop in question.  

     The patient remains hospitalised in stable condition. His symptoms remain mild. Neither his family members nor the staff at the fresh provision shop concerned have developed any symptoms. The CHP has provided them with preventive medication and will continue to put them under medical surveillance.

     Based on the above epidemiological and virological evidence, the CHP assessed that the recent local case of infection has not changed the current risk level. The risk of an influenza pandemic due to local avian influenza remains low. The Government's response level under the "Preparedness Plan for Influenza Pandemic" remains at "Alert" level.

    Avian influenza viruses are generally classified as highly pathogenic or low pathogenic, and they mainly affect birds and poultry. Birds are also natural hosts for avian influenza viruses. 

    In occasional circumstances, cross-species transmission may occur when human come into close contact with infected poultry or contaminated environments. 

    However, there is currently no scientific evidence to suggest that the existing avian influenza viruses are capable of sustained and efficient human-to-human transmission. 

    No novel influenza virus arising from genetic reassortment between human seasonal influenza viruses and animal influenza viruses has been found either.

    Since 1999, a total of 11 cases of human influenza A (H9N2) have been recorded in Hong Kong, including five local cases and six imported cases. No fatal case has been recorded so far.

     According to data published by the World Health Organization (WHO), more than 160 cases of human infection with influenza A (H9) have been recorded globally in the past decade. The vast majority of patients presented with mild symptoms. As poultry is a natural host of the virus in many regions, sporadic human infections caused by contact with infected poultry or contaminated environments are expected to continue occurring worldwide.

     The CHP will continue to strengthen public education and publicity efforts to reduce the risk of avian influenza infection among the general public. A letter has been issued to all doctors in Hong Kong to update them on the latest situation regarding influenza A (H9), urging them to heighten vigilance and report any suspected cases.

 

Seasonal influenza and COVID-19

     Influenza activity in Hong Kong has increased in recent weeks but remains below the baseline level

    Based on past experience, Hong Kong may experience two influenza seasons each year. The onset of summer influenza season began at a later time than usual last year, and sustained a longer period, extending from early September last year to early January this year, resulting in the absence of the winter influenza season that traditionally occurs in the first quarter of each year. Since the summer influenza season typically occurs between July and August, it cannot be ruled out that it may begin earlier than usual this year.

     Regarding COVID-19, while overall local activity remains at a relatively low level, a slight increase has been recorded continually since early May. 

    The COVID-19 activity levels fluctuate, with an upsurge period seen approximately every six to nine months in recent years. Each upsurge is associated with changes in predominant circulating variants and a decline in community herd immunity. It has been nearly a year since the end of the last periodic upsurge of COVID-19 activity in Hong Kong, and it cannot be ruled out that the overall COVID-19 activity will rise further in the coming one to two months.

 

Government's vaccination programmes

     Vaccination remains the most effective way to prevent seasonal influenza, COVID-19 and its complications. It also reduces the risk of hospitalisation and death.

       The WHO has earlier announced its recommendations for the composition for seasonal influenza and COVID-19 vaccines in the upcoming season. Vaccine manufacturers are currently producing vaccines in accordance with the recommendations. A new batch of seasonal influenza vaccines will arrive in Hong Kong in this September, while COVID-19 vaccines will arrive in the fourth quarter.

     The COVID-19 vaccine provided under the Government's COVID-19 Vaccination Programme (the Programme) for children and adults will expire in mid-July and early September this year respectively. As the production and delivery of COVID-19 vaccines to Hong Kong with the new composition take time, eligible persons will not be able to receive free COVID-19 vaccines through the Programme for a short period during the transition period before a new batch of vaccines arrive in Hong Kong. Therefore, those in need are advised to make appointments as early as possible. Existing vaccination services will continue until the following dates:

         ° Individuals aged six months to 11 years: COVID-19 vaccination services will be available until July 10, 2026.

        ° Individuals aged 12 or above: COVID-19 vaccination services will be available until September 5, 2026.

     In addition, the shelf life of vaccines under the Government's Seasonal Influenza Vaccination (SIV) Programmes will expire at the end of July. The DH launched the 2025/26 SIV Programmes in September last year. With the government's active promotion and the cooperation of various stakeholders, over 2.03 million doses of vaccines have been administered. Members of the public who have not received vaccinations, particularly children, the elderly and chronic disease patients, should receive influenza vaccination as soon as possible.

     To prevent respiratory diseases, members of the public should maintain good personal, hand and environmental hygiene at all times. Members of the public with respiratory symptoms, even if the symptoms are mild, should wear a surgical mask, avoid crowded places and seek medical advice promptly. They should maintain hand hygiene before putting on and after removing a mask. When there is a rise in activity levels of respiratory diseases, high-risk persons should wear surgical masks when visiting public places. The general public should also wear a surgical mask when taking public transport or staying in crowded places.

     The public may visit the CHP's webpages for more information: Avian Influenza Webpage, Avian Influenza Report, COVID-19 Vaccination Programme, Seasonal Influenza Vaccination Programmes, Facebook page and Youtube channel. 

 

Ends/Monday, June 15, 2026 | Issued at HKT 22:10 | NNNN

Source: 


Link: https://www.info.gov.hk/gia/general/202606/15/P2026061500852.htm?fontSize=1

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