ETIDIOH - NEW

Highlights •  A large B19V French outbreak of an unexpected magnitude occurred, with a monthly rate that has reached 21.4%. •  During this outbreak, 50% of infected pregnant women exhibited fetal complications. •  Phylogenetic analysis revealed the co-circulation of several B19V lineages of genotype 1a, the main epidemic lineage of which emerged in 2017. Abstract Background The human parvovirus B19 (B19V) infections cycle occurs in 3- to 4-year periods and is responsible for benign childhood erythema infectiosum . It is also associated with transient aplastic crisis in patients with underlying hemolytic diseases and with severe fetal sometimes fatal infection . This study investigated the epidemiological, clinical and molecular characteristics of an unusually large 2023-2024 outbreak of B19V. Methods . Laboratory-confirmed cases were retrospectively and prospectively recorded at the Clermont-Ferrand University Hospital, France , between January, 2018 and November, 2023 an...

  Am J Respir Crit Care Med BALTE PP, Kim JS, Sun Y, Allen N, et al Associations of Pre-Pandemic Lung Function and Structure with COVID-19 Outcomes: The C4R Study. Am J Respir Crit Care Med. 2025 Apr 16. doi: 10.1164/rccm.202408-1656. PubMed           Abstract available Antiviral Res KELLY JA, Aida-Ficken V, McMullan LK, Chatterjee P, et al Mechanisms of action of repurposed Ebola virus antivirals - the roles of phospholipidosis and cholesterol homeostasis. Antiviral Res. 2025 Apr 15:106167. doi: 10.1016/j.antiviral.2025.106167. PubMed           Abstract available Clin Infect Dis MESSCHENDORP AL, Zaeck LM, Bouwmans P, van den Broek DAJ, et al Replacing Mycophenolate Mofetil by Everolimus in Kidney Transplant Recipients to Increase Vaccine Immunogenicity: Results of a Randomized Controlled Trial. Clin Infect Dis. 2025 Apr 15:ciaf107. doi: 10.1093. PubMed           ...

  Am J Med BILC M, Cramer H Use of Complementary Medicine Among US Adults with Post-COVID-19: Results from the 2022 National Health Interview Survey. Am J Med. 2025;138:862-869. PubMed           Abstract available MAURO M, Cegolon L, Bestiaco N, Zulian E, et al Heart Rate Variability Modulation Through Slow-Paced Breathing in Health Care Workers with Long COVID: A Case-Control Study. Am J Med. 2025;138:870-883. PubMed           Abstract available NAIK H, Wilton J, Tran KC, Janjua NZ, et al Long-Term Health-Related Quality of Life in Working-Age COVID-19 Survivors: A Cross-Sectional Study. Am J Med. 2025;138:850-861. PubMed           Abstract available PALACIO A, Bast E, Klimas N, Tamariz L, et al Lessons Learned in Implementing a Multidisciplinary Long COVID Clinic. Am J Med. 2025;138:843-849. PubMed           Abstract avail...

Abstract Background Avian influenza virus (AIV), a zoonotic pathogen found worldwide , includes multiple subtypes, one of which is the H4 subtype frequently detected in wild birds and poultry . Despite its prevalence, research on H4 subtype AIV has been scarce, with a focus predominantly on the H4N2 and H4N6 subtypes. The zoonotic potential of H4N1 has not been investigated to date. Methods In this study, we used gene sequencing in conjunction with bioinformatics methodologies to analyze wild-type H4N1 AIV strain and mutant strains emerging from serial passaging in cell culture . Furthermore, we assessed the zoonotic potential of H4N1 and the alterations caused by mutations via a series of phenotype assays, including evaluation of receptor binding affinity, immunofluorescence assays, analyses of growth kinetics across different animal cell cultures, and in vivo pathogenicity studies. Results Our research reveals that H4N1 AIV can bind to human receptors and exhibits an affinity for hum...

Abstract Gammacoronavirus (γ-CoV) primarily infects poultry, wild birds, and marine mammals . The widespread distribution and circulation of γ-CoV in the ecological environment may lead to sustained transmission and economic loss . To better understand the diversity of γ-CoV in wild birds , we collect 482 wild-bird fecal samples from Yunnan , encompassing fourteen bird species . We detected twelve γ-CoV positive samples in five bird species, with the characterization of five complete genomes - HNU5-1, HNU5-2, HNU5-3, HNU6-1, and HNU6-2 -indicating that these genomes represent two viral species . The HNU5 strains were derived from Black-headed gull (Chroicocephalus ridibundus), while the HNU6 strains were came from Mallard (Anas platyrhynchos), and both of those were recombinant. The HNU5 strain exhibited the highest sequence identity (95.45%) with a γ-CoV strain isolated from Numenius phaeopus (GenBank accession: PP845452). Similarly, the HNU6 strain showed 95.18% nucleotide identity w...