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Showing posts from March 8, 2025

#Comparison of #patients presenting to #emergency departments infected with #RSV versus #influenza virus: a retrospective cohort study

Abstract Objective In recent years, there has been increased awareness of the impact of respiratory syncytial virus (RSV) on adult health, especially in elderly patients. Unlike influenza infection, its presentation and patient outcomes are not well studied. The aim of this study was to compare clinical outcomes in emergency department patients infected by RSV vs influenza. Methods This was a multicenter retrospective study in seven emergency departments (ED) in France . Patients with a laboratory-confirmed RSV or influenza infection in the ED were included between January 2017 and December 2022. The primary endpoint was in-hospital mortality truncated at day 28. Secondary endpoints included one year occurrence of thrombo-embolic event, acute coronary syndrome, and stroke. Results 3397 patient charts were screened , and 3224 were analyzed. Of these, 551 (17%) patients had RSV-positive PCR, and 2673 (83%) had influenza-positive PCR. Patients with RSV were older (median age 73 vs.68; dif...

#Sudan virus #disease - #Uganda {March 8 '25}

Situation at a glance Since the outbreak of Sudan virus disease (SVD) was declared in Uganda on 30 January 2025, and as of 5 March 2025, a total of 14 cases (including 12 confirmed cases and two probable cases) including four deaths (two confirmed and two probable) have been reported.  On 1 March 2025, the Ministry of Health released a press statement confirming the tenth case . The patient was a child under 5 years old who presented and died in the Mulago hospital on 23 February 2025.  As of 5 March, two additional confirmed cases and two probable deaths have been reported that are linked to this case. Both of these cases are currently admitted to treatment facilities.  Eight confirmed cases received care at treatment centres in the capital Kampala and in Mbale and were discharged on 18 February 2025.  As of 5 March 2025, 192 new contacts have been identified and are under follow-up in Kampala, Ntoroko and Wakiso. In the absence of licensed vaccines and therapeutics...

#Coronavirus Disease Research #References (by AMEDEO, March 8 '25)

  Antiviral Res PADEY B, Droillard C, Duliere V, Fouret J, et al Host-targeted repurposed diltiazem enhances the antiviral activity of direct acting antivirals against Influenza A virus and SARS-CoV-2. Antiviral Res. 2025 Mar 4:106138. doi: 10.1016/j.antiviral.2025.106138. PubMed           Abstract available Clin Infect Dis BULLOCK A, Dalton AF, Stockwell MS, McLaren SH, et al Ongoing Symptoms After Acute SARS-CoV-2 or Influenza Infection in a Case-Ascertained Household Transmission Study: 7 US Sites, 2021-2023. Clin Infect Dis. 2025 Feb 26:ciaf026. doi: 10.1093. PubMed           Abstract available SWARTWOOD NA, Cohen T, Marks SM, Hill AN, et al Effects of the COVID-19 pandemic on TB outcomes in the United States: a Bayesian analysis. Clin Infect Dis. 2025 Feb 27:ciaf092. doi: 10.1093. PubMed           Abstract available Emerg Infect Dis BI K, Bandekar SR, Bouchni...

#Influenza and Other Respiratory Viruses Research #References (by AMEDEO, March 8 '25)

  Antiviral Res PADEY B, Droillard C, Duliere V, Fouret J, et al Host-targeted repurposed diltiazem enhances the antiviral activity of direct acting antivirals against Influenza A virus and SARS-CoV-2. Antiviral Res. 2025 Mar 4:106138. doi: 10.1016/j.antiviral.2025.106138. PubMed           Abstract available INOUE A, Ichikawa T, Wada D, Maruyama S, et al M49L and other drug resistance mutations emerging in individuals after administration of ensitrelvir in Japanese clinical settings. Antiviral Res. 2025;236:106118. PubMed           Abstract available UEHARA T, Yotsuyanagi H, Ohmagari N, Doi Y, et al Ensitrelvir treatment-emergent amino acid substitutions in SARS-CoV-2 3CL(pro) detected in the SCORPIO-SR phase 3 trial. Antiviral Res. 2025 Jan 30:106097. doi: 10.1016/j.antiviral.2025.106097. PubMed           Abstract available Biochem Biophys Res Commun IMBIAKHA B, ...