ETIDIOH - NEW

Abstract An unprecedented outbreak of Oropouche virus (OROV) is occurring in the Americas, characterized by thousands of confirmed cases and a wide geographical spread, including areas outside the Amazon Basin. Little is known about this neglected arbovirus regarding its pathophysiological aspects and potentially different transmission modes . This study describes the clinical course of a man who returned from a trip to Cuba and presented to our hospital 4 days after the onset of febrile symptoms. The patient was diagnosed with Oropouche fever and was followed for 177 days after the onset of symptoms. We performed a longitudinal investigation of the samples collected from several body sites ( whole blood, serum, urine, and semen ) with the aim of providing further insights into OROV infection dynamics, using the detection of antigenomic RNA as a marker of active viral replication. Clinical samples that were longitudinally collected over the course of OROV infection showed consistently ...

{Extract} Since late 2023, more than 10 000 locally acquired cases of Oropouche virus have been reported in the Americas .1 Here, we describe the first cluster of Oropouche virus imported into France from Cuba , where transmission has been ongoing since at least May, 2024.2 Oropouche virus infection was documented in a group of five women (patients 1–5, confirmed cases) travelling to Cuba with two infants (patients 6–7, suspect cases) between July 28 and Aug 14, 2024. During their stay, patients 1–5 developed a dengue-like syndrome lasting 2–11 days, presenting symptoms similar to those described in the literature for Oropouche virus infection (appendix p 8).3 After recovery, patients 1, 2, and 5 experienced symptom relapse upon their return to France; the observed relapse rate aligns with recent estimates suggesting that 60% of patients with Oropouche virus experience a biphasic illness (appendix pp 7–8).4 During relapse, patient 1 sought medical advice, becoming the first diagnosed O...