ETIDIOH - NEW

  ABSTRACT Systemic spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to extrapulmonary tissues has been observed following acute infections. Autopsy studies further indicate tissue-specific virus diversity, including in immune-privileged sites . Questions remain on the viral dynamics leading to the tissue tropism of SARS-CoV-2, including evolutionary trajectories and functional adaptations that could impact persistence and transmission . In this study, we characterized SARS-CoV-2 genomes from 27 distinct tissues collected from an autopsy case where the patient had a primary immune deficiency . We identified tissue-specific virus genotypes , in some instances coexisting within the same sites, with mutations primarily in the receptor-binding domain of the spike protein. Protein simulations and isolation of infectious virus indicate combinations of spike substitutions that would lead to increased protein stability and stronger binding of the virus to host cells. ...

  Br J Anaesth THOMAS C, Pearse RM Socioeconomic deprivation and health inequity: independently associated with postoperative outcomes, and does this matter? Br J Anaesth. 2025;135:1141-1143. PubMed           Abstract available Clin Infect Dis TARTOF SY, Aliabadi N, Goodwin G, Slezak J, et al Estimated Vaccine Effectiveness for Respiratory Syncytial Virus-Related Acute Respiratory Illness in Older Adults: Findings From the First Postlicensure Season. Clin Infect Dis. 2025 Oct 21:ciaf496. doi: 10.1093. PubMed           Abstract available MANABE YC, Hamill MM, Palamountain KM, Achenbach CJ, et al The Critical Importance of Clinical Use Case to Inform Point-of-Care Technology Development: A Case Study of Human Immunodeficiency Virus Nucleic Acid Assays in the United States. Clin Infect Dis. 2025 Oct 23:ciaf510. doi: 10.1093. PubMed           Abstract available Graefe...

  Antiviral Res BESSONNE M, Morel J, Nevers Q, Groutsch J, et al Inhibition of influenza virus replication by artificial proteins (alphaReps) targeting its RNA-polymerase. Antiviral Res. 2025 Oct 21:106300. doi: 10.1016/j.antiviral.2025.106300. PubMed           Abstract available BMC Pediatr WONG K, Ducharme R, Murphy MSQ, Clarke AE, et al SARS-CoV-2 infection in pregnancy and infant outcomes in the first year of life: a retrospective cohort study. BMC Pediatr. 2025;25:842. PubMed           Abstract available MAGGIO ABR, Palomo S, Joye R, Huguet H, et al Reduced aerobic capacity in children with multisystem inflammatory syndrome in children (MIS-C) after PICU admission: a retrospective cohort study, 2020-2022. BMC Pediatr. 2025;25:835. PubMed           Abstract available Cell HICKMAN HD, Moutsopoulos NM Don't forget to floss! An innovative approach for vaccine del...

  Abstract Background :  The purpose of this study was to retrospectively analyse the clinical presentation of RSV, Influenza , and SARS-CoV-2 infections in children across three consecutive seasons (2022/2023; 2023/2024; and 2024/2025).  Methods :  Of the 321 hospitalised patients , 129 ( 36% ) tested positive for RSV , 110 ( 38% ) for Influenza , and 82 ( 26% ) for SARS-CoV-2 . Children were aged ≤ 17 years (median: 15 months). The data were statistically analysed using the χ2 test, multinomial multivariable logistic regression, OR (odds ratio), and 95% CI (confidence interval).  Results :  Significant independent predictors of RSV infection were auscultatory abnormalities (OR: 15.9 [1.49–169]) and hospital admission ≥ 4 days after symptom onset (OR: 32.5 [1.19–907]). Among RSV-positive patients , compared with those aged < 6 months , those aged 7–24 months were more likely to present with higher CRP levels (OR 1.06 [1.003–1.13]), reduced appetite (OR ...

  Abstract Background :  The COVID-19 pandemic , driven by the SARS-CoV-2 virus, has become an unprecedented global public health challenge . Comprehensive investigation of the virus transmission dynamics requires exploration of all potential routes , including the role of animal reservoirs . This study aimed to assess the presence of SARS-CoV-2 RNA and antibodies in urban rodents captured within two landscape units (low-income neighborhoods and green spaces) in the metropolitan area of Buenos Aires (MABA), Argentina. Methods :  Between July 2020 and September 2022, 125 synanthropic rodents (68 Rattus norvegicus, 22 R. rattus, and 35 Mus musculus) from seven low-income neighborhoods and seven green spaces in the MABA were captured and examined for SARS-CoV-2 exposure and infection by indirect immunofluorescence serology and RT-qPCR, targeting the N, E, and ORF1ab genes. Results :  Two M. musculus and six R. norvegicus from five different low-income neighborhoods test...

  AJR Am J Roentgenol LITTLE BP Imaging and Reporting of Post-COVID-19 Lung Abnormalities at CT: International Panel of Experts Provides Welcome Guidance. AJR Am J Roentgenol. 2025 Oct 15. doi: 10.2214/AJR.25.33999. PubMed          Infect Control Hosp Epidemiol ELHAISSOUNI N, Arthur A, Prochaska EC, Colantuoni E, et al Association of pandemic precautions and Staphylococcus aureus in the NICU. Infect Control Hosp Epidemiol. 2025 Oct 13:1-3. doi: 10.1017/ice.2025.10319. PubMed           Abstract available Int J Infect Dis OPPONG AE, Coelewij L, Hutchinson M, Carpenter B, et al Simple hyperinflammation scores predict mortality in hospitalised patients with COVID-19 and offer a personalised medicine approach to dexamethasone intervention. Int J Infect Dis. 2025 Oct 13:108119. doi: 10.1016/j.ijid.2025.108119. PubMed           Abstract available J Infect TANG X, Ma T, Yao Z,...

  Antiviral Res PATEL MC, Nguyen HT, Mishin VP, Pascua PNQ, et al Antiviral susceptibility monitoring: testing algorithm, methods, and findings for influenza season, 2023-2024. Antiviral Res. 2025 Oct 11:106299. doi: 10.1016/j.antiviral.2025.106299. PubMed           Abstract available ZHU C, Wang Z, Pan Z, Mai X, et al DMBT1 promotes SARS-CoV-2 infection and its SRCR-derived peptide inhibits SARS-CoV-2 infection. Antiviral Res. 2025 Sep 3:106269. doi: 10.1016/j.antiviral.2025.106269. PubMed           Abstract available TASHIMA R, Kuroda T, Nobori H, Miyagawa S, et al Ensitrelvir suppresses prolonged olfactory abnormalities derived from SARS-CoV-2 infection in hamsters. Antiviral Res. 2025 Sep 2:106270. doi: 10.1016/j.antiviral.2025.106270. PubMed           Abstract available BMC Pediatr WU LE, Wei JY, Lin ZH, Li HC, et al Clinical characteristics of children with ...

  Abstract Wastewater surveillance of respiratory pathogens can provide timely estimates of viral activity and disease trends in a population . Indoor air surveillance could be used similarly with some advantages but remains largely unvalidated at the community-scale. Here, an indoor air surveillance program was employed as part of public health environmental surveillance in Chicago, Illinois , USA. Ten air samplers were placed in healthcare and congregate living settings across the city. Weekly air samples were evaluated for influenza A, influenza B, respiratory syncytial virus, and SARS-CoV- 2 over two respiratory virus seasons. Citywide, aggregated air sample positivity and viral load were closely correlated with local clinical case and wastewater surveillance data across all respiratory viruses. Virus trends in air data often preceded clinical and wastewater, although this varied across pathogens and respiratory virus seasons. Further, whole-genome sequencing of SARS-CoV-2 show...

  ABSTRACT SARS-CoV-2 is under strong evolutionary selection to acquire mutations in its spike protein that reduce neutralization by human polyclonal antibodies. Here, we use pseudovirus-based deep mutational scanning to measure how mutations to the spike from the recent KP.3.1.1 SARS-CoV-2 strain affect cell entry, binding to the ACE2 receptor, RBD up/down motion, and neutralization by human sera and clinically relevant antibodies. The spike mutations that most affect serum antibody neutralization sometimes differ between sera collected before versus after recent vaccination or infection, indicating that these exposures shift the neutralization immunodominance hierarchy. The sites where mutations cause the greatest reduction in neutralization by post-vaccination or infection sera include receptor-binding domain (RBD) sites 475, 478, and 487, all of which have mutated in recent SARS-CoV-2 variants . Multiple mutations outside the RBD affect sera neutralization as strongly as any RB...

  Antiviral Res SCHRELL L, Scheibner D, Dickmanns A, Stegmann KM, et al Inhibitors of pyrimidine synthesis synergize with N4-hydroxycytidine to diminish influenza virus replication. Antiviral Res. 2025 Oct 3:106286. doi: 10.1016/j.antiviral.2025.106286. PubMed           Abstract available BMJ WISE J Covid-19: Excluding doctors from vaccination programme puts patients at risk, clinicians warn. BMJ. 2025;391:r2141. PubMed          Clin Infect Dis ATMAR RL, Abate G, Deming ME, George SL, et al Emerging and Pandemic Pathogens: Lessons Learned From a Clinical Research Network. Clin Infect Dis. 2025;81. PubMed           Abstract available JANO K, Babu TM, Kottkamp AC, Rebolledo PA, et al Historical Advances in Clinical Trial Design and Expanding Representation as the New Frontier for Innovation. Clin Infect Dis. 2025;81. PubMed         ...

  Ann Intern Med LE VU M, Matthes KL, Schneider EB, Moerlen A, et al Maternal Influenza-Like Illness and Neonatal Health During the 1918 Influenza Pandemic in a Swiss City. Ann Intern Med. 2025 Oct 7. doi: 10.7326/ANNALS-24-03796. PubMed           Abstract available Antiviral Res SCHRELL L, Scheibner D, Dickmanns A, Stegmann KM, et al Inhibitors of pyrimidine synthesis synergize with N4-hydroxycytidine to diminish influenza virus replication. Antiviral Res. 2025 Oct 3:106286. doi: 10.1016/j.antiviral.2025.106286. PubMed           Abstract available Epidemiol Infect VAN DER ROEST B, Fischer EAJ, Klinkenberg D, Bootsma MCJ, et al Phylodynamic inference suggests introductions as main driver of Mpox Clade II outbreak in 2022 in Slovenia. Epidemiol Infect. 2025;153:e115. PubMed           Abstract available WOLDEGIORGIS M, Bloomfield L, Korda R, Cadby G, et al Factors a...