ETIDIOH - NEW

  Am J Respir Crit Care Med BALTE PP, Kim JS, Sun Y, Allen N, et al Associations of Pre-Pandemic Lung Function and Structure with COVID-19 Outcomes: The C4R Study. Am J Respir Crit Care Med. 2025 Apr 16. doi: 10.1164/rccm.202408-1656. PubMed           Abstract available Antiviral Res KELLY JA, Aida-Ficken V, McMullan LK, Chatterjee P, et al Mechanisms of action of repurposed Ebola virus antivirals - the roles of phospholipidosis and cholesterol homeostasis. Antiviral Res. 2025 Apr 15:106167. doi: 10.1016/j.antiviral.2025.106167. PubMed           Abstract available Clin Infect Dis MESSCHENDORP AL, Zaeck LM, Bouwmans P, van den Broek DAJ, et al Replacing Mycophenolate Mofetil by Everolimus in Kidney Transplant Recipients to Increase Vaccine Immunogenicity: Results of a Randomized Controlled Trial. Clin Infect Dis. 2025 Apr 15:ciaf107. doi: 10.1093. PubMed           ...

  Am J Med BILC M, Cramer H Use of Complementary Medicine Among US Adults with Post-COVID-19: Results from the 2022 National Health Interview Survey. Am J Med. 2025;138:862-869. PubMed           Abstract available MAURO M, Cegolon L, Bestiaco N, Zulian E, et al Heart Rate Variability Modulation Through Slow-Paced Breathing in Health Care Workers with Long COVID: A Case-Control Study. Am J Med. 2025;138:870-883. PubMed           Abstract available NAIK H, Wilton J, Tran KC, Janjua NZ, et al Long-Term Health-Related Quality of Life in Working-Age COVID-19 Survivors: A Cross-Sectional Study. Am J Med. 2025;138:850-861. PubMed           Abstract available PALACIO A, Bast E, Klimas N, Tamariz L, et al Lessons Learned in Implementing a Multidisciplinary Long COVID Clinic. Am J Med. 2025;138:843-849. PubMed           Abstract avail...

Abstract Circulating bat coronaviruses present a significant pandemic threat, yet our  understanding of  their genetic diversity and evolutionary dynamics remains limited.  Over 3 years, we sampled  1,462 bats in Cambodia’s Steung Treng province,  identifying extensive and diverse  coronaviruses co-circulation. Using  metatranscriptomic and amplicon sequencing, we  generated 33 complete  sarbecovirus genomes, revealing novel lineages that cluster into four  distinct  groups, each associated with different Rhinolophus bat species. Our analysis  highlights rapid migration and recombination of sarbecovirus lineages over  short distances  and timescales. Of note, the receptor-binding domains of two novel  viral groups exhibit high  similarity to SARS-CoV-2, and pseudovirus assays  confirmed the ability of this spike protein  to mediate entry into cells expressing  human ACE2, suggesting a potentia...

  Br J Anaesth GILLIS C, Hasil L, Keane C, Brassard D, et al A multimodal prehabilitation class for Enhanced Recovery After Surgery: a pragmatic randomised type 1 hybrid effectiveness-implementation trial. Br J Anaesth. 2025 Apr 7:S0007-0912(25)00153-9. doi: 10.1016/j.bja.2025. PubMed           Abstract available Clin Infect Dis IOANNOU GN, Berry K, Rajeevan N, Li Y, et al Target Trial Emulation of Severe Acute Respiratory Syndrome Coronavirus 2 Infection Versus No Infection and Risk of Post-Coronavirus Disease 2019 Conditions in the Omicron Variant Versus Prior Eras. Clin Infect Dis. 2025 Apr 10:ciaf087. doi: 10.1093. PubMed           Abstract available Int J Infect Dis JOLLIVET O, Urchueguia-Fornes A, Chung-Delgado K, Johannesen CK, et al Respiratory Syncytial Virus hospitalisation burden in children below 18 years in six European countries (2016-2023) pre- and post-COVID-19 pandemic. Int J Infect Dis...

Abstract The risk of cardiovascular outcomes following SARS-CoV-2 infection has been reported in adults , but evidence in children and adolescents is limited . This paper assessed the risk of a multitude of cardiac signs, symptoms, and conditions 28-179 days after infection , with outcomes stratified by the presence of congenital heart defects (CHDs), using electronic health records (EHR) data from 19 children’s hospitals and health institutions from the United States within the RECOVER consortium between March 2020 and September 2023. The cohort included 297,920 SARS-CoV-2-positive individuals and 915,402 SARS-CoV-2-negative controls. Every individual had at least a six-month follow-up after cohort entry. Here we show that children and adolescents with prior SARS-CoV-2 infection are at a statistically significant increased risk of various cardiovascular outcomes, including hypertension, ventricular arrhythmias , myocarditis, heart failure, cardiomyopathy, cardiac arrest, thromboemboli...

  Ann Intern Med DACSO CC Coadministration of RSV + influenza or COVID-19 vaccines was noninferior to separate administration for immune responses in adults aged >/=50 y. Ann Intern Med. 2025 Apr 1. doi: 10.7326/ANNALS-25-00904. PubMed           Abstract available AMAN M, Jeevananthan A, Martinez-Cruz M, Namasingh N, et al Endocrinology: What You May Have Missed in 2024. Ann Intern Med. 2025 Apr 1. doi: 10.7326/ANNALS-25-00990. PubMed           Abstract available HAMED HKA, Nachman A, Riopel N, Schuster M, et al Infectious Diseases: What You May Have Missed in 2024. Ann Intern Med. 2025 Apr 1. doi: 10.7326/ANNALS-25-00925. PubMed           Abstract available CORONADO GD, Petrik AF, Thompson JH, Leo MC, et al Patient Navigation to Improve Colonoscopy Completion After an Abnormal Stool Test Result : A Randomized Controlled Trial. Ann Intern Med. 2025 Apr 1. doi: ...

  Ann Intern Med GRANWEHR BP CBT and rehabilitation improved long COVID symptoms. Ann Intern Med. 2025;178:JC28. PubMed           Abstract available BMJ WISE J Covid-19: Inquiry hears of doctors' lack of confidence in PPE as ministers defend VIP lane. BMJ. 2025;388:r584. PubMed          Clin Infect Dis ALLAN-BLITZ LT, Klausner JD Shifting the Focus in Acute SARS-CoV-2 Management to Include Prevention of Long-COVID. Clin Infect Dis. 2025 Mar 26:ciaf158. doi: 10.1093. PubMed          Emerg Infect Dis SANDER B, Mishra S, Swayze S, Sahakyan Y, et al Population-Based Matched Cohort Study of COVID-19 Healthcare Costs, Ontario, Canada. Emerg Infect Dis. 2025;31:710-719. PubMed           Abstract available Intensive Care Med BIHLMAIER K, Willam C, Herbst L, Hackstein H, et al Rapid clinical effects of convalescent plasma therapy in severe COV...

Abstract The coronavirus membrane protein (M) is the main organizer of coronavirus assembly. Here, we report on an M-targeting molecule , CIM-834, that blocks the assembly of SARS-CoV-2. CIM-834 was obtained through high-throughput phenotypic antiviral screening followed by medicinal-chemistry efforts and target elucidation. CIM-834 inhibits the replication of SARS-CoV-2 (including a broad panel of variants) and SARS-CoV. In SCID mice and Syrian hamsters intranasally infected with SARS-CoV-2, oral treatment reduced lung viral titres to nearly undetectable levels, even (as shown in mice) when treatment was delayed until 24 h before the end point. Treatment of infected hamsters prevented transmission to untreated sentinels. Transmission electron microscopy studies show that virion assembly is completely absent in cells treated with CIM-834. Single-particle cryo-electron microscopy reveals that CIM-834 binds and stabilizes the M protein in its short form, thereby preventing the conformati...

A mink farm in Lombardy Region. The minks were controlled in the framework of a national surveillance plan. Source: WOAH,  https://wahis.woah.org/#/in-review/6367?reportId=173318&fromPage=event-dashboard-url ____

Abstract In the past two decades, two pandemic respiratory viruses (H1N1 and SARS-CoV-2) have emerged via spillover from animal reservoirs . In an effort to avert future pandemics, surveillance studies aimed at identifying zoonotic viruses at high risk of spilling over into humans act to monitor the `viral chatter' at the animal-human interface . These studies are hampered, however, by the diversity of zoonotic viruses and the limited tools available to assess pandemic risk. Methods currently in use include the characterization of candidate viruses using in vitro laboratory assays and experimental transmission studies in animal models . However, transmission experiments yield relatively low-resolution outputs that are not immediately translatable to projections of viral dynamics at the level of a host population. To address this gap, we present an analytical framework to extend the use of measurements from experimental transmission studies to generate more quantitative risk assessm...

  Ann Intern Med Correction: Anticoagulation Among Patients Hospitalized for COVID-19. Ann Intern Med. 2025 Mar 18. doi: 10.7326/ANNALS-25-00916. PubMed          Antiviral Res SAFIRIYU AA, Hussain A, Dewangan N, Kasle G, et al The fusion peptide of the spike protein S2 domain may be a mimetic analog of beta-coronaviruses and serve as a novel virus-host membrane fusion inhibitor. Antiviral Res. 2025 Mar 16:106144. doi: 10.1016/j.antiviral.2025.106144. PubMed           Abstract available XU M, Zhang Z, Sun Y, Mai H, et al Corrigendum to "IgA class switching enhances neutralizing potency against SARS-CoV-2 by increased antibody hinge flexibility" [Antiv. Res. (2025) 106082]. Antiviral Res. 2025 Mar 20:106146. doi: 10.1016/j.antiviral.2025.106146. PubMed          Graefes Arch Clin Exp Ophthalmol ZUREIK A, Couturier A, Delcourt C Evolution of ophthalmological care in adult with ...

Abstract Infections caused by endemic viruses , and the vaccines used to control them, often provide cross-protection against related viruses. This cross-protection has the potential to alter the transmission dynamics and likelihood of emergence of novel zoonotic viruses with pandemic potential. Here, we investigate how changes in population immunity after the COVID-19 pandemic have impacted the likelihood of emergence of a novel sarbecovirus , termed SARS-CoV-X. We show that sera from patients with different COVID-19 immunological histories possess cross-neutralising antibodies against the spike (S) protein of multiple zoonotic sarbecoviruses . Mathematical simulations using these viruses show a significant reduction in their likelihood of emergence in populations with current levels of SARS-CoV-2 natural and vaccine-derived immunity, with the outcome determined by the extent of cross-protection and the R_0 of the novel virus. We also show that preventative vaccination programs agains...

  Am J Obstet Gynecol TAN YY, Loy EXH, Tan WZ, Tay AT, et al Long COVID-19 in pregnancy: increased risk but modest incidence following mild Omicron infection in a boosted obstetric cohort during endemicity. Am J Obstet Gynecol. 2025 Mar 10:S0002-9378(25)00147. PubMed           Abstract available BMJ IACOBUCCI G Covid-19: Gove tried to "circumvent" regulations to buy Dyson ventilators, inquiry hears. BMJ. 2025;388:r502. PubMed          Clin Infect Dis BARTOLETTI M, Mozaffari E, Amin AN, Doi Y, et al A systematic review and meta-analysis of the effectiveness of remdesivir to treat SARS-CoV-2 infection in hospitalized patients: have the guidelines evolved with the evidence? Clin Infect Dis. 2025 Mar 11:ciaf111. doi: 10.1093. PubMed           Abstract available COX SN, Roychoudhury P, Frivold C, Acker Z, et al Household Transmission and Genomic Diversity of Respiratory Syn...