ETIDIOH - NEW

  Clin Infect Dis BIEBELBERG B, Chen T, McKenna C, Kanjilal S, et al Associations between antibiotic use and outcomes in patients hospitalized with community-acquired pneumonia and positive respiratory viral assays. Clin Infect Dis. 2025 Dec 11:ciaf687. doi: 10.1093. PubMed           Abstract available Emerg Infect Dis BRAUNFELD JB, Traub E, Chiou H, Amoon AT, et al Community-Driven, Text Message-Based COVID-19 Surveillance System, Los Angeles County, California, USA, 2020-2024. Emerg Infect Dis. 2025;31:2109-2117. PubMed           Abstract available Int J Infect Dis LI H, LiuPhD J, Fang Q, Li Z, et al Pathogen-specific immunity debt in children after prolonged nonpharmaceutical interventions: a cross-sectional study in China. Int J Infect Dis. 2025 Dec 3:108278. doi: 10.1016/j.ijid.2025.108278. PubMed           Abstract available JIANG Z, Shan T, Li Y, Han F, et ...

  Biochem Biophys Res Commun HU J, Li J, You W, Liu L, et al Disruption of the local vRNA structure at the end of HA encoding region interferes with the selective packaging of influenza A virus genome. Biochem Biophys Res Commun. 2025;795:153082. PubMed           Abstract available BANGARU MLY, Raghavendra NK Helix alpha1 of human ACE2 mimics dsDNA and Spike of SARS-CoV-2 binds DNA. Biochem Biophys Res Commun. 2025;793:153020. PubMed           Abstract available Cell WASDIN PT, Johnson NV, Janke AK, Held S, et al Generation of antigen-specific paired-chain antibodies using large language models. Cell. 2025;188:7206-7221. PubMed           Abstract available YAN L, Huang Y, Liu Y, Ge J, et al Structural basis for the concurrence of template recycling and RNA capping in SARS-CoV-2. Cell. 2025;188:7194-7205. PubMed           Abs...

  Abstract SARS-CoV-2 rapidly adapts to new hosts following cross-species transmission; this is highly relevant as unique within-host variants have emerged following infection of susceptible wild and domestic animal species . Furthermore, SARS-CoV-2 transmission from animals (e.g., white-tailed deer, mink, domestic cats, and others) back to humans has been observed , documenting the potential of animal-derived variants to infect humans. Here, we investigate SARS-CoV-2 evolution and host-specific adaptation during an outbreak in Amur tigers (Panthera tigris altaica), African lions (Panthera leo), and spotted hyenas (Crocuta crocuta) at Denver Zoo in 2021 . SARS-CoV-2 genomes from longitudinal samples from 16 individuals are evaluated for within-host variation and genomic signatures of selection, and we determine that the outbreak was likely initiated by a single spillover of a rare Delta sublineage . Within-host virus populations rapidly expand and diversify, and we detect signature...

  Highlights •  Infectious SARS-CoV-2 were detected in nasopharynx and on the surface of corpses •  Viral load and symptom-to-discovery time are linked to viral infectivity •  Infectious viruses were not found in the body fluids •  Our findings highlight strict infection control for COVID-19 corpse handling Abstract Objectives The SARS-CoV-2 pandemic has resulted in millions of deaths worldwide . However, the risk of transmission from COVID-19 corpses remain unclear, posing challenges for forensic medicine in establishing effective infection control measures during autopsies . This study aimed to investigate the presence of infectious SARS-CoV-2 in corpses and identify factors affecting viral infectivity. Methods External examinations of 76 corpses with COVID-19 were performed, and nasopharyngeal, perioral, hand swabs, serum, cerebrospinal fluid (CSF), and urine samples were collected. Viral RNA was quantified by using digital PCR, and infectious viruses were as...

  Am J Respir Crit Care Med SARMA A, Christenson SA, Shoshana BZ, Oliveira AP, et al Acute Respiratory Distress Syndrome Molecular Phenotypes Have Distinct Lower Respiratory Tract Transcriptomes. Am J Respir Crit Care Med. 2025;211:2352-2362. PubMed           Abstract available Ann Intern Med SOUMARE A, Kapfer T, Botrel T, Adda L, et al Systemic Corticosteroids, Mortality, and Infections in Pneumonia and Acute Respiratory Distress Syndrome : A Systematic Review and Meta-analysis. Ann Intern Med. 2025 Dec 2. doi: 10.7326/ANNALS-25-03055. PubMed           Abstract available BMJ LOGAN M FDA claims 10 child deaths caused by covid-19 vaccine, vows to tighten vaccine approvals. BMJ. 2025;391:r2546. PubMed          Graefes Arch Clin Exp Ophthalmol NEO YN, Martinez-Alvarez L, Davagnanam I, Girafa G, et al Treatment of post-vaccination optic neuritis: implications from the glob...

  Antiviral Res XIONG R, Wu Y, Wang Y, Qu Z, et al Rapid generation of a murine RSV infectious model by transducing a conditional knock-in mouse harboring human IGF1 receptor with adenoviral vector. Antiviral Res. 2025;244:106304. PubMed           Abstract available SUTTO-ORTIZ P, Selisko B, Ferron F, Sommadossi JP, et al Mapping the impact of 1'-, 2'- and 4'-nucleotide modifications on the Respiratory Syncytial Virus RNA-dependent RNA polymerase. Antiviral Res. 2025;244:106298. PubMed           Abstract available Biochem Biophys Res Commun MOHAMMED A, Ibrahim NA, Basher NS Innovations and challenges in vaccine development: Lessons from the SARS-CoV-2 pandemic and prospects. Biochem Biophys Res Commun. 2025;792:152947. PubMed           Abstract available J Gen Virol METAXAKI M, Ram R, Perera M, Wills M, et al Robust antibody and T cell responses tracked longitudin...

  ABSTRACT The secondary thrombotic/vascular clinical syndrome of COVID-19 suggests that SARS-CoV-2 infects the endothelium ; however, robust in vitro infection of endothelial cells by various strains of SARS-CoV-2 remains to be demonstrated and continues to be debated. Here, we revisit the question of endothelial cell permissiveness to SARS-CoV-2 using isolated endothelial cells ( from the lung, aorta, and endothelial cell progenitors ), and additionally, to overcome limitations associated with cultured cells , using native endothelial cells within living precision cut human lung slices and single-cell RNA sequencing to track viral presence. Cellular infection in endothelial monocultures was determined using fluorescence imaging. Mediator release was measured by ELISA, and gene expression was assessed by RT-qPCR. Infection in lung slices was determined using single-cell RNA sequencing, capturing molecular identifiers that aligned to the SARS-CoV-2 viral genome (for lung slices). E...

{Summary} Context   Over five years since the detection of the first COVID-19 cases , SARS-CoV-2 continues to circulate globally, causing acute illness, hospitalization, and death , alongside prolonged negative impacts on individuals, health systems , and economies , including post-COVID-19 condition (PCC or Long COVID).  While global population-level immunity has increased significantly through both infection and vaccination, the virus continues to evolve, challenging control efforts and underscoring the need for long-term, sustainable disease management .  Confirming earlier warnings from MERS-CoV and SARS-CoV-1 , SARS-CoV-2 has demonstrated the pandemic potential of coronaviruses , which remain one of the most consequential infectious disease threats of our time .  Purpose of the strategic plan   This plan sets out WHO’s strategic framework to support Member States in the sustained, integrated, evidence-based management of coronavirus disease threats , includ...

  BMJ Analysis of peer reviewers' response to invitations by gender and geographical region: cohort study of manuscripts reviewed at 19 biomedical journals before and during covid-19 pandemic. BMJ. 2025;391:r2507. PubMed          Clin Infect Dis NGUYEN VAN JC, Pilmis B, El Helali N, Azria E, et al Implementing POCT in infectious diseases. Clin Infect Dis. 2025 Nov 27:ciaf650. doi: 10.1093. PubMed           Abstract available PANAGIOTOPOULOS AP, Anastassopoulou C, Tsakris A, Ioannidis JPA, et al Effective Antivirals in Pandemic Preparedness: Past Mistakes, Future Needs. Clin Infect Dis. 2025 Nov 25:ciaf648. doi: 10.1093. PubMed           Abstract available Int J Infect Dis HEMPEL H, Xue H, La Shu S, Jain S, et al Cancer and COVID-19: A review of Immune Insights and Partnerships to Inform Public Health Strategy. Int J Infect Dis. 2025 Nov 24:108252. doi: 10.1016/j.ijid.2...