Showing posts with label environmental pollution. Show all posts
Showing posts with label environmental pollution. Show all posts

Monday, March 30, 2026

#AI - guided multi-omics #analysis identifies NPC1-modulated susceptibility to #SARS-CoV-2 #infection under #PM2.5 exposure

 


Abstract

Exposure to airborne fine particulate matter (PM2.5) has been linked to increased risk of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, yet the underlying mechanisms remain unclear. Here, by leveraging a fine-tuned foundation model of single-cell transcriptomics, we uncover shared transcriptional signatures between PM2.5 exposure and SARS-CoV-2 infection. We further validate this association using population-level epidemiological analyses and perform genome-wide association studies (GWAS) to identify genetic variants that modulate infection risk under PM2.5 exposure. In addition, we identify NPC1 as a key modulator involved in SARS-CoV-2 infection efficiency under virus-laden PM2.5 exposure through integrative functional genomic analyses and in vitro experiments. Our findings suggest that PM2.5 facilitates viral entry through an NPC1-modulated endo-lysosomal pathway, providing a mechanistic explanation for observed pollution-related susceptibility. By integrating artificial intelligence (AI)-guided transcriptomics, epidemiology, GWAS, functional genomics, and in vitro verification, our study elucidates how environmental and genetic factors jointly influence SARS-CoV-2 susceptibility. This work highlights how AI-assisted multi-omics integration systematically decodes the health impacts of environmental exposures from molecular to population levels and informs air quality policy and infectious disease preparedness.

Source: 


Link: https://www.nature.com/articles/s41467-026-71196-3

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Thursday, March 5, 2026

#Dairy Sites with #Milk Exposure Are Most Likely to Have #Detection of #Influenza A Virus

 


Abstract

Highly pathogenic avian influenza virus of the H5N1 subtype has been infecting U.S. dairy cattle and spreading among dairy operations since March 2024. H5N1 surveillance systems for dairies are needed, but information on whether environmental sampling can inform these systems is lacking. To guide a surveillance framework, we determined the environmental sites with Influenza A virus (IAV) detection on H5N1-affected dairies (n = 25) in four states (California, Colorado, Michigan, and Ohio) and explored sample characteristics that may have influenced detection. A total of 581 samples from dairy environmental sites were characterized for IAV RNA via rRT-PCR, and classified into six categories. A total of 94 samples (16.2%) had IAV detected, and the Ct values measured from these samples were typically higher than those measured in bulk tank milk from a subset of sampled herds. A majority of IAV detections were made from the following site categories: milking equipment/personal protective equipment, parlor surfaces, and wastewater/lagoons/manure. These results suggest that environmental sites most likely to be contaminated with IAV on dairies are those with exposure to milk. Meanwhile, mixed effect logistic modeling showed that days into an outbreak that samples were collected was associated with IAV detection. These results provide a framework within which to continue the assessment of environmental sampling as a surveillance tool for dairy H5N1. This framework can be strengthened by studies that perform further IAV viral characterization and collect samples from sites prior to, during, and after H5N1 outbreak periods.

Source: 


Link: https://www.mdpi.com/2076-2607/14/3/584

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Friday, July 4, 2025

#IAEA #DG #Statement on #Situation in #Ukraine - #Update 300 (July 4 '25)

 


Ukraine’s Zaporizhzhya Nuclear Power Plant (ZNPP) has lost all off-site power for the ninth time during the military conflict and now relies on emergency diesel generators for the electricity it needs, underlining the extremely fragile nuclear safety situation at the site, IAEA Director General Rafael Mariano Grossi said today.

The plant’s connection to its last remaining 750 kilovolt (kV) power line was cut at 17:37 local time today. While the cause was not immediately known, it coincided with air raid alarms in the region, Director General Grossi said, citing information from the Ukrainian nuclear regulator.

It was the first time the ZNPP suffered a complete loss of off-site power since 2 December 2023.

The IAEA team based at the site, Europe’s largest nuclear power plant (NPP), reported that 18 emergency diesel generators immediately started operating to generate the electricity the plant needs to be able to cool the reactors and the spent fuel pools. The plant has diesel fuel for at least 10 days on-site, and arrangements in place to secure further supplies.

“What was once virtually unimaginable – that a major nuclear power plant would repeatedly lose all of its external power connections – has unfortunately become a common occurrence at the Zaporizhzhya Nuclear Power Plant. Almost three and a half years into this devastating war, nuclear safety in Ukraine remains very much in danger,” Director General Grossi said.

“Our team on the ground will continue to follow the situation very closely and report on further developments there. For now, the plant’s diesel generators are providing the necessary electricity,” he said.

The ZNPP’s six reactors have been in cold shutdown since 2024 but still require cooling water for their reactor cores and spent fuel pools. The ZNPP lost the connection to its last remaining 330 kV back-up power line on 7 May, leaving the plant dependent on its sole 750 kV line. Before the conflict, it had ten off-site power lines available, highlighting the extent to which nuclear safety has deteriorated since February 2022.

Source: International Atomic Energy Agency, https://www.iaea.org/newscenter/pressreleases/update-300-iaea-director-general-statement-on-situation-in-ukraine

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Friday, June 27, 2025

Seventh #Update on #Developments in #Iran (#War) (#IAEA, June 27 '25)

 


Radiation levels in the Gulf region remain normal following the 12-day conflict that severely damaged several nuclear facilities in Iran, Director General Rafael Mariano Grossi of the International Atomic Energy Agency (IAEA) said today.

Citing regional data reported regularly to the IAEA through the International Radiation Monitoring System (IRMIS), Director General Grossi noted that this 48-nation network would have detected an important radioactive release from any damaged nuclear power reactor.

“From a nuclear safety perspective, Iran’s Bushehr Nuclear Power Plant and the Tehran Research Reactor represented our main concern as any strike affecting those facilities – including their off-site power lines – could have caused a radiological accident with potential consequences in Iran as well as beyond its borders in the case of the Bushehr plant. It did not happen, and the worst nuclear safety scenario was thereby avoided,” Director General Grossi said.

Stressing again that nuclear facilities should never be attacked, he reiterated the IAEA’s current assessment – based on information received from Iran’s Nuclear Regulatory Authority – that this month’s Israeli and U.S. strikes on Iranian nuclear sites would have caused localized radioactive releases inside the impacted facilities and localized toxic effects, but there has been no report of increased off-site radiation levels.

The Director General also emphasised the need for IAEA inspectors to continue their verification activities in Iran, as required under its Comprehensive Safeguards Agreement (CSA) with the Agency.

Source: International Atomic Energy Agency, https://www.iaea.org/newscenter/pressreleases/update-on-developments-in-iran-7

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Tuesday, June 24, 2025

Sixth #Update on #Developments in #Iran (#War) (#IAEA, June 24 '25)

 


Director General Rafael Mariano Grossi has welcomed today’s announcements regarding the situation in Iran and stressed the need for a resumption of the IAEA’s indispensable safeguards verification work in the country following a 12-day military conflict that severely damaged several of its nuclear sites.

In a letter to Iranian Foreign Minister Dr Abbas Araghchi, Director General Grossi also proposed that they meet soon.

“Resuming cooperation with the IAEA is key to a successful diplomatic agreement to finally resolve the dispute over Iran’s nuclear activities. I’ve written to Foreign Minister Araghchi stressing the importance of us working together and proposing to meet soon,” he said.

IAEA inspectors have remained in Iran throughout the conflict and are ready to start working as soon as possible, going back to the country’s nuclear sites and verifying the inventories of nuclear material – including more than 400 kg of uranium enriched to 60% - which they last verified a few days before the Israeli air strikes began on 13 June.

Even though the conflict interrupted safeguards inspections in the country, the IAEA has been closely monitoring the impact of the military strikes on Iranian nuclear sites at Arak, Esfahan, Fordow and Natanz as well as the possible consequences for human health and the environment, based on relevant information received from Iran’s Nuclear Regulatory Authority.

“As I have repeatedly stated – before and during the conflict – nuclear facilities should never be attacked due to the very real risk of a serious radiological accident,” Director General Grossi said.

“During these attacks, we have seen extensive damage at several nuclear sites in Iran, including its uranium conversion and enrichment facilities. Our assessment is that there has been some localized radioactive as well as chemical release inside the affected facilities that contained nuclear material – mainly uranium enriched to varying degrees – but there has been no report of increased off-site radiation levels,” he said.  

Still, the IAEA is aware of concerns in the region regarding any radiological consequences as a result of the strikes on nuclear facilities.

“Based on the data available to us, the IAEA can provide assurances that there has been no radiological impact to the population and the environment in neighbouring countries. Crucially in terms of nuclear safety, Iran’s research and power reactors were not targeted,” Director General Grossi said.

In addition to the detailed assessment that Director General Grossi provided to the IAEA Board of Governors on Monday, the IAEA has identified additional impact points at nuclear sites at Fordow and Natanz as a result of strikes carried out before today’s announcements on the situation in Iran.

Regarding the additional strikes to Fordow that were reported early on Monday – after the U.S. bombing of the facility early on Sunday – the IAEA assesses that access roads close to the underground facility and one of its entrances were hit.

At Natanz, the IAEA has identified two impact holes from the U.S. strikes above the underground halls that had been used for enrichment as well as for storage. Based on its knowledge of what these halls contained, the IAEA assesses that this strike may have caused localized contamination and chemical hazards.

Source: International Atomic Energy Agency, https://www.iaea.org/newscenter/pressreleases/update-on-developments-in-iran-6

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Sunday, June 22, 2025

Fifth #Update on #Developments in #Iran {#War} (#IAEA, June 22 '25)

 


The International Atomic Energy Agency (IAEA) can confirm that the Iranian nuclear sites of Fordow, Natanz and Esfahan have been hit, following U.S. aerial attacks overnight, Director General Rafael Mariano Grossi said today.

Based on an analysis of the information available to it, the IAEA assessed that there has been extensive additional damage at the sprawling Esfahan site, which had already been struck several times by Israel since it began targeting Iran’s nuclear facilities on 13 June, Director General Grossi said.

The IAEA had previously reported that several buildings at the Esfahan complex were damaged, some of which may have contained nuclear material.

“The latest attacks early this morning damaged other buildings in Esfahan. In addition, we have established that entrances to underground tunnels at the site were impacted,” Director General Grossi said.

The extent of damage to the Fordow uranium enrichment facility – built deep inside a mountain in central Iran – was not immediately possible to assess in view of its underground location and the penetrating nature of the bombs used.

“It is clear that Fordow was also directly impacted, but the degree of damage inside the uranium enrichment halls can’t be determined with certainty,” Director General Grossi said.

Iran’s other enrichment site, Natanz, which has previously been extensively damaged, was again attacked during the strikes last night with ground-penetrating munitions.

The Director General said the IAEA has been informed by the Iranian regulatory authorities that there has been no increase in off-site radiation levels after the latest attacks on the three Iranian nuclear sites.

Director General Grossi stressed the paramount importance of the countries involved urgently embarking on a diplomatic path aimed at ending the hostilities.

This would also enable the IAEA to resume its crucial verification activities in Iran, including of its stockpile of more than 400 kg of highly enriched uranium, which Agency inspectors last verified a few days before the military conflict began.

“We need to try to go back to the negotiating table as soon as possible. We have to allow the IAEA inspectors to return. The IAEA is ready to play its indispensable role in this process. We have been talking to Iran, we have been talking to the United States. We have to work for peace,” Director General Grossi said.

Source: International Atomic Energy Agency, https://www.iaea.org/newscenter/pressreleases/update-on-developments-in-iran-5

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Fourth #Update on #Developments in #Iran [War] (#IAEA, June 22 '25)

 


Director General Rafael Mariano Grossi said he will call an emergency meeting of the IAEA Board of Governors on Monday in light of the “urgent situation” in Iran following the latest attacks on the country’s nuclear facilities.

“In view of the increasingly serious situation in terms of nuclear safety and security, the Board of Governors will meet in an extraordinary session tomorrow, which I will address,” Director General Grossi said.

The Director General said the IAEA has been informed by the Iranian regulatory authorities that there has been no increase in off-site radiation levels after the recent attacks on three Iranian nuclear facilities, including the Fordow uranium enrichment site.

“As of this time, we don’t expect that there will be any health consequences for people or the environment outside the targeted sites,” he said. “We will continue to monitor and assess the situation in Iran and provide further updates as additional information becomes available.”

According to the most recent information verified by the IAEA before the attacks on Iran began on 13 June, the three sites targeted by the United States – also including Esfahan and Natanz – contained nuclear material in the form of uranium enriched to different levels, which may cause radioactive and chemical contamination within the facilities that were hit.

As he did in his statement to the United Nations Security Council on Friday, Director General Grossi reiterated his call for military restraint and “indispensable work towards” a diplomatic solution.

“I have repeatedly stated that nuclear facilities should never be attacked,” he said.

There is a need for a cessation of hostilities so that the IAEA can resume its vital inspection work in the country, including the necessary verification of its stockpile of highly enriched uranium, he added.

Director General Grossi also stressed the importance of a continued and timely exchange of information with Iran regarding issues related to nuclear safety, security and safeguards.

Source: International Atomic Energy Agency, https://www.iaea.org/newscenter/pressreleases/update-on-developments-in-iran-4

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Third #Update on #Developments in #Iran {War} (June 22 '25)



A large nuclear complex in Esfahan has been targeted for a second time during Israel’s attacks on Iran over the past nine days, with several more buildings struck, Director General Rafael Mariano Grossi of the International Atomic Energy Agency (IAEA) said today.

The site in central Iran was first hit on 13 June when four buildings were damaged: the central chemical laboratory, a uranium conversion facility, a reactor fuel manufacturing plant, and an enriched uranium metal processing facility under construction. No increase of off-site radiation levels was reported.

Based on information available to the IAEA today, six other buildings at the same site have now also been attacked: a natural and depleted uranium metal production facility which had not yet begun operations, a fuel rod production facility, a building with low-enriched uranium pellet production as well as a laboratory and nuclear material storage, another laboratory building, a workshop handling contaminated equipment and an office building with no nuclear material.

The same Esfahan complex includes a centrifuge manufacturing workshop that the IAEA earlier today reported had also been hit by Israel.

The facilities targeted today either contained no nuclear material or small quantities of natural or low enriched uranium, meaning any radioactive contamination is limited to the buildings that were damaged or destroyed.

“This nuclear complex in Esfahan – one of the key sites of the Iranian nuclear programme – has repeatedly been attacked and extensively damaged. Based on our analysis of the nuclear material present, we don’t see any risk of off-site contamination. Nevertheless, as I have repeatedly stated, nuclear facilities should never be attacked,” Director General Grossi said.   

Source: International Atomic Energy Agency,  https://www.iaea.org/newscenter/pressreleases/update-on-developments-in-iran-3

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Friday, June 20, 2025

#IAEA #DG Grossi’s #Statement to #UNSC on #Situation in #Iran (June 20 '25)

 


Attacks on nuclear sites in the Islamic Republic of Iran have caused a sharp degradation in nuclear safety and security in Iran. Though they have not so far led to a radiological release affecting the public, there is a danger this could occur.

The International Atomic Energy Agency has been monitoring closely the situation at Iran’s nuclear sites since Israel began its attacks a week ago. As part of its mission, the IAEA is the global nerve centre for information on nuclear and radiological safety, and we can respond to any nuclear or radiological emergency.

Based on information available to the IAEA, the following is the current situation at Iran’s nuclear sites. Which I offer as a follow up to my most recent report to this Security Council.

The Natanz enrichment site contains two facilities. The first is the main Fuel Enrichment Plant. Initial attacks on the 13th of June targeted and destroyed electricity infrastructure at the facility, including an electrical sub-station, the main electric power supply building, and emergency power supply and back-up generators. On the same day, the main cascade hall appears to have been attacked using ground-penetrating munitions.

The second facility at Natanz is the Pilot Fuel Enrichment Plant. It consists of aboveground and underground cascade halls. On the 13th of June the above-ground part was functionally destroyed and the strikes on the underground cascade halls were seriously damaging.

The level of radioactivity outside the Natanz site has remained unchanged and at normal levels, indicating no external radiological impact on the population or the environment.

However, within the Natanz facility there is both radiological and chemical contamination. It is possible that Uranium isotopes contained in Uranium Hexafluoride, Uranyl Fluoride and Hydrogen Fluoride are dispersed inside the facility. The radiation, primarily consisting of alpha particles, poses a significant danger if inhaled or ingested. This risk can be effectively managed with appropriate protective measures, such as using respiratory devices. The main concern inside the facility is chemical toxicity.

Fordow is Iran’s main enrichment location for enriching uranium to 60%. The Agency is not aware of any damage at Fordow at this time.

At the Esfahan nuclear site, four buildings were damaged in last Friday’s attack: the central chemical laboratory, a uranium conversion plant, the Tehran reactor-fuel manufacturing plant, and the enriched uranium metal processing facility, which was under construction.

No increase of off-site radiation levels was reported. As in Natanz, the main concern is chemical toxicity.  

The Khondab Heavy Water Research Reactor under construction in Arak, was hit on the 19th of June. As the reactor was not operational and did not contain any nuclear material, no radiological consequence is expected. The nearby Heavy Water Production Plant is also assessed to have been hit, and similarly no radiological consequence is expected.

As stated in the IAEA’s update of the 18th of June, at the Tehran Research Center, one building, where advanced centrifuge rotors were manufactured and tested, was hit. At the Karaj workshop, two buildings, where different centrifuge components were manufactured, were destroyed. There was no radiological impact, internally or externally.

Let me now refer to the Bushehr Nuclear Power Plant. This is the nuclear site in Iran where the consequences of an attack could be most serious. It is an operating nuclear power plant and as such it hosts thousands of kilograms of nuclear material. Countries of the region have reached out directly to me over the past few hours to express their concerns, and I want to make it absolutely and completely clear: In case of an attack on the Bushehr Nuclear Power Plant a direct hit could result in a very high release of radioactivity to the environment.

Similarly, a hit that disabled the only two lines supplying electrical power to the plant could cause its reactor’s core to melt, which could result in a high release of radioactivity to the environment. In their worst-case, both scenarios would necessitate protective actions, such as evacuations and sheltering of the population or the need to take stable iodine, with the reach extending to distances from a few to several hundred kilometres. Radiation monitoring would need to cover distances of several hundred kilometres and food restrictions may need to be implemented.

Any action against the Tehran Nuclear Research Reactor could also have severe consequences, potentially for large areas of the city of Tehran and its inhabitants. In such a case, protective actions would need to be taken.

I will continue to provide public updates about the developments at all these sites and their possible health and environmental consequences.

The Agency is, as madame Undersecretary kindly reminded, and will remain present in Iran and inspections there will resume, as required by Iran’s safeguards obligations under its NPT Safeguards Agreement, as soon as safety and security conditions allow.

In this context, let me restate that the safety of our inspectors is of utmost importance. The host country has a responsibility in this regard, and we expect every effort to be made to ensure that their security and their communication lines with the IAEA headquarters will be maintained.

As stated in my most recent report to the Agency’s Board of Governors and based on inspections conducted at the relevant facilities since then, Iran’s uranium stockpiles remain under safeguards in accordance with Iran’s comprehensive safeguards agreement. You may recall that more than 400kg of this stockpile is uranium enriched up to 60% U-235. It is essential that the Agency resumes inspections as soon as possible to provide credible assurances that none of it has been diverted.

Importantly, any special measures by Iran to protect its nuclear materials and equipment must be done in accordance with Iran’s safeguards obligations and the Agency.  

Therefore, it is of paramount importance that the Agency’s inspectors are allowed to verify that all relevant materials, especially those enriched to 60%, are accounted for. Beyond the potential radiological risks, attacks on such materials would make this effort of course more difficult.

Madame President,

The IAEA has consistently underlined, as stated in its General Conference resolution, that armed attacks on nuclear facilities should never take place, and could result in radioactive releases with grave consequences within and beyond the boundaries of the State which has been attacked.

I therefore again call on maximum restraint. Military escalation threatens lives and delays indispensable work towards a diplomatic solution for the long-term assurance that Iran does not acquire a nuclear weapon.

Madame President,

The presence, support, analysis and inspections of technical experts are crucial to mitigating risks to nuclear safety and security – that is true during peacetime and even more so during military conflict.

For the second time in three years, we are witnessing a dramatic conflict between two UN and IAEA Member States in which nuclear installations are coming under fire and nuclear safety is being compromised. The IAEA, just as has been the case with the military conflict between the Russian Federation and Ukraine, will not stand idle during this conflict.

As I stated in this chamber just a few days ago, I am ready to travel immediately and to engage with all relevant parties to help ensure the protection of nuclear facilities and the continued peaceful use of nuclear technology in accordance with the Agency mandate, including by deploying Agency nuclear safety and security experts, in addition to our safeguards inspectors in Iran, wherever necessary.

For the IAEA to act, a constructive, professional dialogue is needed. I urge the Members of this Council to support us in making it happen sooner rather than later.

The IAEA must receive timely and regular technical information about affected nuclear facilities and their respective sites. I urge in this regard the Iranian regulatory authorities to continue a constructive dialogue with the IAEA Incident and Emergency Centre, which has been operating 24/7 since the beginning of this conflict.

Nuclear facilities and material must not be shrouded by the fog of war.

Yesterday there was an incorrect statement to the media by an Israeli military official that Bushehr Nuclear Power Plant had been attacked. Though the mistake was quickly identified and the statement retracted, the situation underscored the vital need for clear and accurate communication, and the Agency’s unique role in providing it in a technically accurate and politically impartial way is obvious.

Let me conclude by assuring the international community of the IAEA’s continued support at this very grave time.

A diplomatic solution is within reach if the necessary political will is there. Elements for an agreement have been discussed. The IAEA can guarantee, through a watertight inspections system, that nuclear weapons will not be developed in Iran.  They can form the basis of a long-standing agreement that brings peace and avoids a nuclear crisis in the Middle East. This opportunity should not be missed. The alternative would be a protracted conflict and a looming threat of nuclear proliferation that, while emanating from the Middle East, would effectively erode the NPT and the non-proliferation regime as a whole.

Source: IAEA, https://www.iaea.org/newscenter/statements/iaea-director-general-grossis-statement-to-unsc-on-situation-in-iran

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Saturday, June 14, 2025

#IAEA DG Grossi’s #Statement to #UNSC on #Situation in #Iran (June 14 '25)

Early this morning, the International Atomic Energy Agency (IAEA) was informed of the military operation launched by Israel which includes attacks on nuclear facilities in the Islamic Republic of Iran.

As I reported this morning to the IAEA Board of Governors, we have been in permanent contact with the Iran Nuclear Regulatory Authority, to ascertain the status of relevant nuclear facilities and to assess any wider impacts on nuclear safety and security.

Iran has confirmed that at present, only the Natanz Fuel Enrichment Plant site has been attacked in today’s strikes. This facility contains the Fuel Enrichment Plant and the Pilot Fuel Enrichment Plant.

At Natanz, the above-ground part of the Pilot Fuel Enrichment Plant, where Iran was producing uranium enriched up to 60% U-235, has been destroyed.

Electricity infrastructure at the facility (electrical sub-station, main electric power supply building, emergency power supply and back-up generators) has been destroyed.

There is no indication of a physical attack on the underground cascade hall containing part of the Pilot Fuel Enrichment Plant and the main Fuel Enrichment Plant. However, the loss of power to the cascade hall may have damaged the centrifuges there.

The level of radioactivity outside the Natanz site has remained unchanged and at normal levels indicating no external radiological impact to the population or the environment from this event.

However, due to the impacts, there is radiological and chemical contamination inside the facilities in Natanz. The type of radiation present inside the facility, primarily alpha particles, is manageable with appropriate radiation protection measures.

At present, the Iranian authorities are informing us of attacks on the other facilities, the Fordow Fuel Enrichment Plant; and Esfahan site, where a fuel plate fabrication plant, a fuel manufacturing plant, a uranium conversion facility and an enriched UO2 powder plant are located. However I have to inform that at this moment we do not have enough information beyond indicating that military activity has been taking place around these facilities as well which initially had not been part of military operation.

All these developments are deeply concerning. I have repeatedly stated that nuclear facilities must never be attacked, regardless of the context or circumstances, as it could harm both people and the environment.  Such attacks have serious implications for nuclear safety, security and safeguards, as well as regional and international peace and security.

In this regard, the IAEA recalls the numerous General Conference resolutions on the topic of military attacks against nuclear facilities, in particular, GC(XXIX)/RES/444 and GC(XXXIV)/RES/533, which provide, inter alia, that “any armed attack on and threat against nuclear facilities devoted to peaceful purposes constitutes a violation of the principles of the United Nations Charter, international law and the Statute of the Agency”. 

Furthermore, the IAEA has consistently underlined that armed attacks on nuclear facilities could result in radioactive releases with grave consequences within and beyond the boundaries of the State which has been attacked”, as was stated in GC(XXXIV)/RES/533.

As Director General of the International Atomic Energy Agency, and consistent with the objectives of the IAEA under the IAEA Statute, I call on all parties to exercise maximum restraint to avoid further escalation. I reiterate that any military action that jeopardizes the safety and security of nuclear facilities risks grave consequences for the people of Iran, the region, and beyond.

Madame Under Secretary General evoked that yesterday, the Board of Governors of the IAEA adopted an important resolution on Iran’s safeguards obligations. In addition to this, the Board resolution stressed its support for a diplomatic solution to the problems posed by the Iranian nuclear programme.

The IAEA continues to monitor the situation closely.  Our Incident and Emergency Center (IEC) has maintained continuous contact with Iranian authorities from the onset of the attack, regularly confirming the status of the facilities and will continue to do so in the coming days. Additionally, we have established a task force comprising several senior staff members to monitor the situation closely over the next few days, and they will be available 24/7at the disposal of the UNSC.

The IAEA stands ready to provide technical assistance, and remains committed to its nuclear safety, security and safeguards mandate in all circumstances. I stand ready to engage with all relevant parties to help ensure the protection of nuclear facilities and the continued peaceful use of nuclear technology in accordance with the Agency mandate, including, deploying Agency nuclear security and safety experts (in addition to our safeguards inspectors in Iran) wherever necessary to ensure that nuclear installations are fully protected and continue to be used exclusively for peaceful purposes.

As I informed today the IAEA Board of Governors, I have indicated to the respective authorities my readiness to travel at the earliest to assess the situation and ensure safety, security and non-proliferation in Iran.

I have also been in contact with our inspectors in Iran and Israel. The safety of our staff is of paramount importance. All necessary actions are being taken to ensure they are not harmed.

Despite the current military actions and heightened tensions, it is clear that the only sustainable path forward—for Iran, for Israel, the entire region, and the international community—is one grounded in dialogue and diplomacy to ensure peace, stability, and cooperation. 

The International Atomic Energy Agency, as the International technical institution entrusted with overseeing the peaceful use of nuclear energy, remains a unique and vital forum for dialogue, especially now. 

In accordance with its Statute and longstanding mandate, the IAEA provides the framework and natural platform where facts prevail over rhetoric and where engagement can replace escalation. 

I reaffirm the Agency’s readiness to facilitate technical discussions and support efforts that promote transparency, safety, security and the peaceful resolution of nuclear-related issues in Iran.

Source: IAEA, https://www.iaea.org/newscenter/statements/director-general-grossis-statement-to-unsc-on-situation-in-iran

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Tuesday, March 11, 2025

Independent and combined #effects of long-term #air #pollution #exposure and #genetic #predisposition on #COVID19 #severity: A population-based cohort study

Significance

To date, no study has investigated the relationships between air pollutants and the progression of COVID-19, nor the potential role of genetic susceptibility on the associations. This large population-based cohort study investigates the associations between air pollutants and genetic susceptibility, both individually and in combination, with the risk of COVID-19-related outcomes. It involves 458,396 participants from UK Biobank and demonstrates that air pollutants interact with host genetic susceptibility in both multiplicative and additive manners, thereby influencing the risk of COVID-19 severity. This study with cutting-edge methods provides robust evidence for the interplay between environmental and genetic factors on COVID-19 outcomes.


Abstract

The relationships between air pollution, genetic susceptibility, and COVID-19-related outcomes, as well as the potential interplays between air pollution and genetic susceptibility, remain largely unexplored. The Cox proportional hazards model was used to assess associations between long-term exposure to air pollutants and the risk of COVID-19 outcomes (infection, hospitalization, and death) in a COVID-19-naive cohort (n = 458,396). Additionally, associations between air pollutants and the risk of COVID-19 severity (hospitalization and death) were evaluated in a COVID-19 infection cohort (n = 110,216). Furthermore, this study investigated the role of host genetic susceptibility in the relationships between exposure to air pollutants and the development of COVID-19-related outcomes. Long-term exposure to air pollutants was significantly associated with an increased risk of COVID-19-related outcomes in the COVID-19 naive cohort. Similarly, in COVID-19 infection cohort, hazard ratios (HRs) for COVID-19 hospital admission were 1.23 (1.19, 1.27) for PM2.5 and 1.22 (1.17, 1.26) for PM10, whereas HRs for COVID-19 death were 1.28 (1.18, 1.39) for PM2.5 and 1.25 (1.16, 1.36) for PM10. Notably, significant interactions were found between PM2.5/PM10 and genetic susceptibility in COVID-19 death. In COVID-19 infection cohort, participants with both high genetic risk and high air pollutants exposure had 1.86- to 1.97-fold and 1.91- to 2.14-fold higher risk of COVID-19 hospitalization and death compared to those with both low genetic risk and low air pollutants exposure. Exposure to air pollution is significantly associated with an increased burden of severe COVID-19, and air pollution–gene interactions may play a crucial role in the development of COVID-19-related outcomes.

Source: Proceedings of the National Academy of Sciences of the United States of America, https://www.pnas.org/doi/abs/10.1073/pnas.2421513122?af=R

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