Independent and combined #effects of long-term #air #pollution #exposure and #genetic #predisposition on #COVID19 #severity: A population-based cohort study
Significance To date, no study has investigated the relationships between air pollutants and the progression of COVID-19 , nor the potential role of genetic susceptibility on the associations. This large population-based cohort study investigates the associations between air pollutants and genetic susceptibility, both individually and in combination, with the risk of COVID-19-related outcomes. It involves 458,396 participants from UK Biobank and demonstrates that air pollutants interact with host genetic susceptibility in both multiplicative and additive manners, thereby influencing the risk of COVID-19 severity. This study with cutting-edge methods provides robust evidence for the interplay between environmental and genetic factors on COVID-19 outcomes. Abstract The relationships between air pollution, genetic susceptibility, and COVID-19-related outcomes, as well as the potential interplays between air pollution and genetic susceptibility, remain largely unexplored. The Cox proportio...