ETIDIOH - NEW

Situation at a glance On 30 January 2025, the Ministry of Health of Uganda declared an outbreak of Sudan virus disease (SVD) following confirmation from three national reference laboratories.  The case presented with signs and symptoms between 20 and 21 January and died on 29 January at the National Referral Hospital in Kampala.  As of 30 January 2025, 45 contacts have been identified , including 34 healthcare workers and 11 family members.  Sudan virus disease belongs to the same family as Ebola virus disease. It is caused by Sudan virus (SUDV). It is a severe disease with high case fatality from 41% to 70% in past outbreaks.  In the absence of licensed vaccines and therapeutics for the prevention and treatment of SVD, the risk of potential serious public health impact is high.  Early supportive patient care and treatment may increase the chance of survival from severe disease. Description of the situation On 30 January 2025, the Ministry of Health of Uganda de...

  Antiviral Res WU Q, Wu H, Hu Y, Zheng X, et al Immune evasion of Omicron variants JN.1, KP.2, and KP.3 to the polyclonal and monoclonal antibodies from COVID-19 convalescents and vaccine recipients. Antiviral Res. 2025 Jan 24:106092. doi: 10.1016/j.antiviral.2025.106092. PubMed           Abstract available Infect Control Hosp Epidemiol HANKINS RJ, Handke L, Fey PD, Cavalieri RJ, et al Prospective, crossover, comparative study of two methods of chlorhexidine bathing. Infect Control Hosp Epidemiol. 2025 Jan 30:1-6. doi: 10.1017/ice.2024. PubMed           Abstract available PISCHEL L, Aguolu OG, Ahmed N, Campbell MM, et al Social mixing patterns of United States healthcare personnel at a quaternary health center: a prospective observational study. Infect Control Hosp Epidemiol. 2025 Jan 30:1-9. doi: 10.1017/ice.2024. PubMed           Abstract availab...

  Biochemistry (Mosc) KOROLEVA ON, Kuzmina NV, Tolstova AP, Dubrovin EV, et al Effect of C- and N-Terminal Polyhistidine Tags on Aggregation of Influenza A Virus Nuclear Export Protein. Biochemistry (Mosc). 2024;89:2238-2251. PubMed           Abstract available BMC Pediatr ZHANG P, Xin M, Bai Y, Ren X, et al Severe central nervous system injury in 9 children with COVID-19. BMC Pediatr. 2025;25:63. PubMed           Abstract available Epidemiol Infect BEDNARSKA NG, Smith S, Bardsley M, Loveridge P, et al Trends in general practitioner consultations for hand foot and mouth disease in England between 2017 and 2022. Epidemiol Infect. 2025;153:e22. PubMed           Abstract available J Virol KIRKPATRICK ROUBIDOUX E, Meliopoulos V, Livingston B, Brigleb PH, et al Intraductal infection with H5N1 clade 2.3.4.4b influenza virus. J Virol. 2025 Jan 31:e0192724....

ABSTRACT Reassortant highly pathogenic avian influenza A(H5N2) clade 2.3.4.4.b viruses were detected from ducks and environmental samples in Egypt , June 2024. Genomic and phylogenetic analyses revealed a novel genotype produced by the reassortment of an A( H5N1 ) clade 2.3.3.4b virus with an A( H9N2 ) G1-like virus. Monitoring the spread of this virus is important. Source: Emerging Microbes and Infections,  https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2455601#abstract _____

Abstract Following reports of HPAI H5N1 infections of dairy cattle in the United States (US) in March 2024, we established a Pan-Canadian Milk network to monitor retail milk in Canada. Milk samples from across Canada that had previously tested negative for influenza A virus (IAV) RNA were tested for the presence of anti-IAV nucleoprotein (NP) antibodies , as an indicator of past infection of dairy cattle. None of the 109 milk samples tested had evidence of anti-IAV NP antibodies. This is consistent with previous findings from our academic group as well as others including federal testing initiatives that have not found any IAV RNA in milk. Although not surprising given that no cases of H5N1 in cattle have been reported in Canada to date, this work further supports that the extensive outbreak in dairy cattle in the US has not extended northward into Canada, and the integrity of the Canadian milk supply remains intact. Source: MedRxIV,  https://www.medrxiv.org/content/10.1101/2025.01...