Key Points -- Question: Is regular application of azelastine nasal spray associated with reduced risk of SARS-CoV-2 infections? - Findings: In this randomized placebo-controlled clinical trial that included 450 participants , the incidence of laboratory-confirmed SARS-CoV-2 infections was significantly lower with application of azelastine nasal spray compared with placebo treatment. -- Meaning: The use of azelastine nasal spray may help to reduce the risk of SARS-CoV-2 infections. Abstract Importance Limited pharmaceutical options exist for preexposure prophylaxis of COVID-19 beyond vaccination. Azelastine, an antihistamine nasal spray used for decades to treat allergic rhinitis, has in vitro antiviral activity against respiratory viruses, including SARS-CoV-2. Objective To determine the efficacy and safety of azelastine nasal spray for prevention of SARS-CoV-2 infections in healthy adults. Design, Setting, and Participants ...
Media Monitoring for Signals about Emerging Threats