Significance Middle East respiratory syndrome coronavirus (MERS-CoV) remains the most lethal human coronavirus , with continued zoonotic transmission from wild naturally infected dromedary camels , posing a persistent risk of spillover to humans. Despite this ongoing threat , no specific antiviral treatment has been approved. In this study, we characterize the antibody response to MERS-CoV in naturally infected dromedaries, the primary animal reservoir, and identify a panel of nanobodies (Nbs) exhibiting potent neutralizing activity . These Nbs recognize a previously unreported binding and neutralizing site on the virus spike receptor-binding domain (RBD). Their distinctive genetic, structural, and functional properties make them promising candidates for the development of effective and therapeutic interventions against MERS-CoV, as strongly advocated by global health authorities. Abstract Wild dromedary camels in the Arabian Peninsula and Africa have harbored antibodies against ...
Media Monitoring for Signals about Emerging Threats