#LongCOVID associated with #SARS-CoV-2 #reinfection among #children and adolescents in the #omicron era (RECOVER-EHR): a retrospective cohort study
Summary Background Post-acute sequelae of SARS-CoV-2 infection (PASC) remain a major public health challenge . Although previous studies have focused on characterising PASC in children and adolescents after an initial infection , the risks of PASC after reinfection with the omicron variant remain unclear. We aimed to assess the risk of PASC diagnosis (U09.9) and symptoms and conditions potentially related to PASC in children and adolescents after a SARS-CoV-2 reinfection during the omicron period. Methods This retrospective cohort study used data from 40 children's hospitals and health institutions in the USA participating in the Researching COVID to Enhance Recovery (RECOVER) Initiative. We included patients younger than 21 years at the time of cohort entry; with documented SARS-CoV-2 infection after Jan 1, 2022; and who had at least one health-care visit within 24 months to 7 days before the first infection. The second SARS-CoV-2 infection was confirmed by positive PCR, antigen...