#Coronavirus Disease Research #References (by AMEDEO, Jan. 3 '26)

Antiviral Res

RODRIGUEZ L, Hu Y, Li J, Han D, et al
SARS-CoV-2 Resistance Analyses From the Phase 3 OAKTREE Study of Obeldesivir in Low-Risk Nonhospitalized Participants With COVID-19.
Antiviral Res. 2025 Dec 29:106339. doi: 10.1016/j.antiviral.2025.106339.
PubMed Abstract available

Eur J Radiol
YAO J, Zhang L, Huang S, Cao S, et al
Changes in the cerebral glymphatic system after rehabilitation of COVID-19 patients: A five-year follow-up study.
Eur J Radiol. 2025;195:112615.
PubMed Abstract available

Int J Infect Dis
DAVIDO B, Mamona C, Gault E, Annane D, et al
"Three of a Kind?" Unmasking the Clinical Burden of Human Metapneumovirus and Parainfluenza Virus Compared to Respiratory Syncytial Virus in Hospitalized Adults: A Pre-COVID-19 Multicenter Cohort Study.
Int J Infect Dis. 2025 Dec 26:108353. doi: 10.1016/j.ijid.2025.108353.
PubMed Abstract available
ZWAWI A, Sward P, Wandell P, Carlsson AC, et al
Objective Family Burden of Diabetes Is Associated with Increased Risk of Hospital Diagnosis of COVID-19: A Prospective Cohort Study from the Malmo Diet and Cancer Study.
Int J Infect Dis. 2025 Dec 25:108333. doi: 10.1016/j.ijid.2025.108333.
PubMed
ZHANG X, Yang J
Caution is warranted regarding the association between heavy familial diabetes burden and COVID-19 hospitalization.
Int J Infect Dis. 2025 Dec 25:108332. doi: 10.1016/j.ijid.2025.108332.
PubMed
MITSUSHIMA S, Horiguchi H, Taniguchi K
Response to the Letter to the Editor by Zeng.
Int J Infect Dis. 2025 Dec 23:108341. doi: 10.1016/j.ijid.2025.108341.
PubMed
ZENG G
Effectiveness of remdesivir and dexamethasone for confirmed COVID-19 patients: benefit from rational use.
Int J Infect Dis. 2025 Dec 23:108342. doi: 10.1016/j.ijid.2025.108342.
PubMed
HAUSER-VAN WESTRHENEN E, Guinovart LJ, Schuurman R, van Boven M, et al
Associations between virus single or coinfections and respiratory symptoms in young children; a community-based cohort study.
Int J Infect Dis. 2025 Dec 19:108317. doi: 10.1016/j.ijid.2025.108317.
PubMed Abstract available

J Med Virol
VINGELIENE S, Li H, Backman H, Udumyan R, et al
SARS-CoV-2 Infection Is Associated With an Increased Risk of Hospital-Treated Infectious Mononucleosis due to EBV: National Register-Based Cohort Study.
J Med Virol. 2026;98:e70787.
PubMed Abstract available
HUANG X, He H, Yang W, Lin B, et al
A Multicenter Clinical Evaluation of Polymerase Chain Reaction Coupled With Quantum Dot Fluorescence Analysis and Quantitative Real-Time Reverse Transcription Polymerase Chain Reaction in the Diagnosis of Pathogens in Patients With Suspected Respirato
J Med Virol. 2026;98:e70759.
PubMed Abstract available
LIU F, Cui F, Quilty BJ, Song Y, et al
Estimating the Uptake of and Factors Associated With a New Vaccine Outside of the National Immunisation Programme: A Case Study of the EV-A71 Vaccine Against Hand, Foot, and Mouth Disease.
J Med Virol. 2026;98:e70776.
PubMed Abstract available
LIN HJ, Su WC, Wen HY, Hung CH, et al
Evaluation of the GeneTex U-OK SARS-CoV-2 Neutralizing Antibody Detection Assay: Comparison With GenScript cPass and Viral Neutralization Assays.
J Med Virol. 2026;98:e70771.
PubMed Abstract available
HENNEMANN AK, Mahmoudi N, Doring K, Lanfermann H, et al
Evidence of Impaired Neuroimmune System in Post-COVID Syndrome-A Whole Brain Magnetic Resonance Spectroscopy Study.
J Med Virol. 2025;97:e70762.
PubMed Abstract available

J Virol
CHEN J, Lin S, Liu Q, Gao M, et al
N6-methyladenosine within transmissible gastroenteritis virus genomic RNA inhibits its replication via efficient recognition by RNA sensor RIG-I.
J Virol. 2025 Dec 31:e0137325. doi: 10.1128/jvi.01373.
PubMed Abstract available
LI Y, Chen W, Zhang X, Zhou J, et al
STING agonist diABZI confers protection against swine acute diarrhea syndrome coronavirus in neonatal mice by activating antiviral immunity.
J Virol. 2025 Dec 29:e0170325. doi: 10.1128/jvi.01703.
PubMed Abstract available
LI Z, Ma Z, Li Y, Zhao X, et al
The glycosylation variant at residue 381 of the spike protein contributes to virulence shifts in porcine epidemic diarrhea virus during both natural field transmission and laboratory cell passaging with poor cross-protection.
J Virol. 2025;99:e0156125.
PubMed Abstract available

JAMA
ANDERER S
COVID-19 in Pregnancy Linked With Risk of Neurodevelopmental Disorders in Early Childhood.
JAMA. 2026 Jan 2. doi: 10.1001/jama.2025.23090.
PubMed

#Neuroinvasive #Oropouche virus in a patient with #HIV from extra-Amazonian #Brazil

{Excerpt} A novel reassortant Oropouche virus (OROV) lineage (with medium [M], large [L], and small [S] RNA segments : M1L2S2) has driven Brazil's largest and most geographically widespread OROV epidemic , expanding beyond the endemic Amazon basin to establish local transmission across multiple Brazilian states and other previously unaffected Latin American countries . The rapid spread of this lineage underscores its evolutionary potential and reinforces its significance as a public health threat .1 Similar to chikungunya and Zika viruses, expanding arboviruses can exhibit unexpected clinical and epidemiological shifts , including vertical transmissions , neuroinvasive effects, and potentially fatal outcomes.2–4 Although OROV typically causes self-limited febrile illness, accumulating clinical and experimental evidence suggests neurotropic potential .5 This Correspondence describes the first confirmed case of neuroinvasive OROV infection caused by the emergent M1L2S2 lineage in ext...

No evidence of immune #exhaustion after repeated #SARS-CoV-2 #vaccination in vulnerable and healthy populations

Abstract Frequent SARS-CoV-2 vaccination in vulnerable populations has raised concerns that this may contribute to T cell exhaustion , which could negatively affect the quality of immune protection. Herein, we examined the impact of repeated SARS-CoV-2 vaccination on T cell phenotypic and functional exhaustion in frail older adults in long-term care (n = 23), individuals on immunosuppressive drugs (n = 10), and healthy adults (n = 43), in Canada . Spike-specific CD4+ and CD8+ T cell levels did not decline in any cohort following repeated SARS-CoV-2 vaccination, nor did the expression of exhaustion markers on spike-specific or total T cells increase. T cell production of multiple cytokines (i.e. polyfunctionality) in response to the spike protein of SARS-CoV-2 did not decline in any cohort following repeated vaccination. None of the cohorts displayed elevated levels of terminally differentiated T cells following multiple SARS-CoV-2 vaccinations. Thus, repeated SARS-CoV-2 vaccination was...

Chimeric #hemagglutinin and #M2 #mRNA #vaccine for broad #influenza subtype protection

Abstract Since multiple and unpredicted influenza viruses cause seasonal epidemics and even high-risk pandemics , developing a universal influenza vaccine is essential to provide broad protection against various influenza subtypes. Combined with the mRNA lipid nanoparticle-encapsulated (mRNA-LNP) vaccine platform and chimeric immunogen strategy , we developed a novel cocktail mRNA vaccine encoding chimeric HAs (cH5/1-BV, cH7/3) and intact M2 (termed Fluaxe), which confers broad protection against major circulating IAVs and IBVs , as well as highly pathogenic avian influenza . Two-dose intramuscular immunization of Fluaxe in mice elicited cross-reactive neutralizing antibodies , T cell responses, and long-lived immunity, resulting in robust protection against multiple lethal influenza virus infections and severe acute lung injuries . In particular, intramuscular administration stimulated systemic immunity together with a prominent lung tropism of memory cells . Moreover, Fluaxe immuniza...

ETIDIOH - NEW

Search This Blog