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High pathogenicity avian #influenza in #pinniped #conservation

By G.M.
  Abstract Since 2020, H5Nx high pathogenicity avian influenza viruses (HPAIVs) have caused widespread disruptions not only to global agriculture and trade but also to the health of free-ranging wildlife . Pinnipeds have experienced greater mortality from H5Nx HPAIV than any other mammalian taxa . Emergent virus strains, persisting over long time periods and vast geographic distances , have repeatedly triggered large-scale mortality events in pinniped populations. Of particular concern is the spread of H5Nx HPAIV to the Southern Hemisphere —including the emergence of a marine mammal-adapted clade in South America and detections in the sub-Antarctic and Antarctic —and to other remote locations such as the Hawaiian Islands . These developments elevate concern for the world’s endangered, isolated and endemic pinnipeds . While managing HPAIV in any animal population is a formidable task, working with free-ranging marine mammals poses unique challenges. In this review and perspective pi...
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#Coronavirus Disease Research #References (by AMEDEO, March 7 '26)

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By G.M.

 


    Ann Intern Med

  1. LIM SY, Lee J, Chang E, Kwon JS, et al
    Neither Metformin nor Ursodeoxycholic Acid Effectively Treats Postacute Sequelae of COVID-19 : A Randomized Clinical Trial.
    Ann Intern Med. 2026 Mar 3. doi: 10.7326/ANNALS-25-04883.
    PubMed         Abstract available


    Antiviral Res

  2. ZUO X, Xiao X, Dong X, Wang J, et al
    Direct-acting antivirals and beyond: emerging approaches to targeting viral RNA and ribonucleoprotein complexes.
    Antiviral Res. 2026;249:106383.
    PubMed         Abstract available

  3. RUDRAMURTHY GR, Gudla CS, Harisha R, Selvam V, et al
    FNDR-11124, a broad-spectrum small molecule inhibitor of viral RNA polymerase, restricts replication of SARS-CoV-2 and Influenza virus in vitro and in vivo.
    Antiviral Res. 2026 Mar 2:106382. doi: 10.1016/j.antiviral.2026.106382.
    PubMed         Abstract available


    Clin Infect Dis

  4. RIERA MT, Prato R, Perez-Rubio A, Echave-Sustaeta JM, et al
    Burden of respiratory syncytial virus among older adults with an acute respiratory infection: a prospective study in six European countries.
    Clin Infect Dis. 2026 Mar 6:ciag146. doi: 10.1093.
    PubMed         Abstract available

  5. TAN CS, Anjan S, Ariza-Heredia EJ, Magana F, et al
    IDSA 2025 Guidelines on the use of vaccines for the prevention of seasonal RSV infections in immunocompromised patients.
    Clin Infect Dis. 2026 Mar 2:ciag117. doi: 10.1093.
    PubMed         Abstract available

  6. NELLORE A, Goepfert P, Tan CS, Bajema K, et al
    IDSA 2025 Guidelines on the use of vaccines for the prevention of seasonal COVID-19, Influenza, and RSV infections in immunocompromised patients.
    Clin Infect Dis. 2026 Mar 2:ciag114. doi: 10.1093.
    PubMed         Abstract available

  7. GOEPFERT P, Katz MJ, Kaul D, Sharma T, et al
    IDSA 2025 Guidelines on the use of vaccines for the prevention of seasonal Influenza infections in immunocompromised patients.
    Clin Infect Dis. 2026 Feb 28:ciag116. doi: 10.1093.
    PubMed         Abstract available


    Int J Infect Dis

  8. NYGREN M, Dahlgren HM, Gustavsson L, Snygg-Martin U, et al
    Temporal association and seasonal variation of respiratory viruses and invasive group A streptococcal infections in Western Sweden, a 15-year analysis across pre- and postpandemic periods.
    Int J Infect Dis. 2026 Mar 3:108517. doi: 10.1016/j.ijid.2026.108517.
    PubMed         Abstract available

  9. YEZLI S, Bonanni P, Dinleyici EC, Divyesh T, et al
    Invasive Meningococcal Disease Rebound in Older Adults Post-COVID-19 Pandemic: A Targeted Literature and Surveillance Review.
    Int J Infect Dis. 2026 Feb 27:108502. doi: 10.1016/j.ijid.2026.108502.
    PubMed         Abstract available


    J Virol

  10. LI S, Liu DX
    Interaction of coronavirus E protein with BRD2 plays important regulatory roles in viral replication and induction of pro-inflammatory response.
    J Virol. 2026 Mar 3:e0220125. doi: 10.1128/jvi.02201.
    PubMed         Abstract available


    N Engl J Med

  11. GABET A, Bernard C, Zureik M
    Updated Evidence Base for Covid-19, RSV, and Influenza Immunizations.
    N Engl J Med. 2026;394:10.
    PubMed        
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