Skip to main content

#Coronavirus Disease Research #References (by AMEDEO, June 21 '25)

 


    Am J Obstet Gynecol

  1. KOENIG LR, Raymond EG, Upadhyay UD, Frye LJ, et al
    Effectiveness and safety of medication abortion with vs. without screening ultrasonography or pelvic exam.
    Am J Obstet Gynecol. 2025 Jun 11:S0002-9378(25)00387.
    PubMed         Abstract available


    J Med Virol

  2. YIN L, He H, Zhang H, Shang Y, et al
    Revolution of AAV in Drug Discovery: From Delivery System to Clinical Application.
    J Med Virol. 2025;97:e70447.
    PubMed         Abstract available

  3. TANG X, Zhou Y, Sun Y, Ding T, et al
    Proteomics and Phosphoproteomics Characteristics of the Rhesus Macaque Lung Infected With Original SARS-CoV-2, Delta, and Omicron Variants.
    J Med Virol. 2025;97:e70446.
    PubMed         Abstract available

  4. WU F, Zhang Z, Lun Q, Hong X, et al
    Papain-Like Protease of SARS-CoV-2 Induces Intestinal Inflammation via the ISG15 Pathway: Identification of Natural Compound Inhibitors.
    J Med Virol. 2025;97:e70448.
    PubMed         Abstract available

  5. LEMAITRE F, Chivasso C, Debaisieux L, Jurion MH, et al
    Molecular Characterization of Parvovirus B19 in Pregnant Women During the 2024 Outbreak in Belgium.
    J Med Virol. 2025;97:e70443.
    PubMed         Abstract available

  6. OKITSU S, Khamrin P, Hikita T, Onda Y, et al
    Molecular Epidemiology of Sapovirus Infection in Japanese Children With Acute Gastroenteritis Before and After the COVID-19 Pandemic.
    J Med Virol. 2025;97:e70450.
    PubMed         Abstract available


    J Virol

  7. POWELL BH, Witwer KW, Meffert MK
    Cellular miRNAs and viruses: trends in miRNA sequestering and target de-repression.
    J Virol. 2025 Jun 18:e0091425. doi: 10.1128/jvi.00914.
    PubMed         Abstract available

  8. CHEN Y, Shi Y, Zuo X, Dong X, et al
    UNC0638 inhibits SARS-CoV-2 entry by blocking cathepsin L maturation.
    J Virol. 2025 Jun 18:e0074125. doi: 10.1128/jvi.00741.
    PubMed         Abstract available

  9. MATSUGO H, Kitamura T, Takahashi N, Chambers J, et al
    In vitro and in vivo characterization of a bat merbecovirus with ACE2- and DPP4-independent cell entry.
    J Virol. 2025 Jun 17:e0072725. doi: 10.1128/jvi.00727.
    PubMed         Abstract available


    N Engl J Med

  10. SCHWARTZ JL
    Revised Recommendations for Covid-19 Vaccines - U.S. Vaccination Policy under Threat.
    N Engl J Med. 2025 Jun 18. doi: 10.1056/NEJMp2507766.
    PubMed        


    Science

  11. ENSERINK M, Wadman M
    New vaccine panelists have published little on vaccines.
    Science. 2025;388:1253-1254.
    PubMed         Abstract available

Comments

Popular posts from this blog

#Neuroinvasive #Oropouche virus in a patient with #HIV from extra-Amazonian #Brazil

{Excerpt} A novel reassortant Oropouche virus (OROV) lineage (with medium [M], large [L], and small [S] RNA segments : M1L2S2) has driven Brazil's largest and most geographically widespread OROV epidemic , expanding beyond the endemic Amazon basin to establish local transmission across multiple Brazilian states and other previously unaffected Latin American countries . The rapid spread of this lineage underscores its evolutionary potential and reinforces its significance as a public health threat .1 Similar to chikungunya and Zika viruses, expanding arboviruses can exhibit unexpected clinical and epidemiological shifts , including vertical transmissions , neuroinvasive effects, and potentially fatal outcomes.2–4 Although OROV typically causes self-limited febrile illness, accumulating clinical and experimental evidence suggests neurotropic potential .5 This Correspondence describes the first confirmed case of neuroinvasive OROV infection caused by the emergent M1L2S2 lineage in ext...

No evidence of immune #exhaustion after repeated #SARS-CoV-2 #vaccination in vulnerable and healthy populations

Abstract Frequent SARS-CoV-2 vaccination in vulnerable populations has raised concerns that this may contribute to T cell exhaustion , which could negatively affect the quality of immune protection. Herein, we examined the impact of repeated SARS-CoV-2 vaccination on T cell phenotypic and functional exhaustion in frail older adults in long-term care (n = 23), individuals on immunosuppressive drugs (n = 10), and healthy adults (n = 43), in Canada . Spike-specific CD4+ and CD8+ T cell levels did not decline in any cohort following repeated SARS-CoV-2 vaccination, nor did the expression of exhaustion markers on spike-specific or total T cells increase. T cell production of multiple cytokines (i.e. polyfunctionality) in response to the spike protein of SARS-CoV-2 did not decline in any cohort following repeated vaccination. None of the cohorts displayed elevated levels of terminally differentiated T cells following multiple SARS-CoV-2 vaccinations. Thus, repeated SARS-CoV-2 vaccination was...

Chimeric #hemagglutinin and #M2 #mRNA #vaccine for broad #influenza subtype protection

Abstract Since multiple and unpredicted influenza viruses cause seasonal epidemics and even high-risk pandemics , developing a universal influenza vaccine is essential to provide broad protection against various influenza subtypes. Combined with the mRNA lipid nanoparticle-encapsulated (mRNA-LNP) vaccine platform and chimeric immunogen strategy , we developed a novel cocktail mRNA vaccine encoding chimeric HAs (cH5/1-BV, cH7/3) and intact M2 (termed Fluaxe), which confers broad protection against major circulating IAVs and IBVs , as well as highly pathogenic avian influenza . Two-dose intramuscular immunization of Fluaxe in mice elicited cross-reactive neutralizing antibodies , T cell responses, and long-lived immunity, resulting in robust protection against multiple lethal influenza virus infections and severe acute lung injuries . In particular, intramuscular administration stimulated systemic immunity together with a prominent lung tropism of memory cells . Moreover, Fluaxe immuniza...