Skip to main content

#Coronavirus Disease Research #References (by AMEDEO, August 30 '25)

 


    Br J Anaesth

  1. STEPHENS JR, Iki Y, Yasuda T, Brown E, et al
    Human neutrophil-derived extracellular vesicles induce renal endothelial inflammation in critical illness: an ex vivo investigation.
    Br J Anaesth. 2025 Aug 27:S0007-0912(25)00448-9. doi: 10.1016/j.bja.2025.
    PubMed         Abstract available


    Clin Infect Dis

  2. YONG MK, Thursky K, Crane M, Spelman T, et al
    Interferon-alpha Nasal Spray Prophylaxis Reduces COVID-19 in Cancer Patients: A Randomized, Double-Blinded, Placebo-Controlled Trial.
    Clin Infect Dis. 2025 Aug 28:ciaf409. doi: 10.1093.
    PubMed         Abstract available


    Emerg Infect Dis

  3. DRATCH AH, Le M, Zahn M
    Increased Incidence of Candida auris Colonization in Early COVID-19 Pandemic, Orange County, California, USA.
    Emerg Infect Dis. 2025;31:1747-1754.
    PubMed         Abstract available


    J Med Virol

  4. CHAUVEL C, Casalegno JS, Visseaux B, Vieillefond V, et al
    Community and Hospital-Based Laboratory Surveillance for Influenza, Respiratory Syncytial Virus, and SARS-CoV-2 During the 2023-2024 Season, Lyon, France.
    J Med Virol. 2025;97:e70549.
    PubMed         Abstract available

  5. FERREIRA AMS, Ferreira FELL, Alverga CCF, Nascimento JAD, et al
    Symptoms and Risk Factors for Long COVID: A Cross-Sectional Study in Primary Care.
    J Med Virol. 2025;97:e70579.
    PubMed         Abstract available

  6. MEYER J, Gosert R, Bingisser R, Nickel CH, et al
    Diagnostic Performance of a Combined Rapid Antigen Test for Detecting SARS-CoV-2, Influenza Virus, and Respiratory Syncytial Virus in Symptomatic Patients in Tertiary Care.
    J Med Virol. 2025;97:e70493.
    PubMed         Abstract available

  7. TORRES C, Jimenez A, Deulofeu M, Prenafeta A, et al
    Antibody and B-Cell Responses to PHH-1V81 XBB.1.16-Adapted SARS-CoV-2 Booster Vaccination Are Associated With Variant Neutralization.
    J Med Virol. 2025;97:e70583.
    PubMed         Abstract available

  8. OZDEMIRAL C, Esenboga S, Akarsu A, Cevik NN, et al
    Pediatric and Adult Inborn Errors of Immunity and COVID-19: A Comparative Study.
    J Med Virol. 2025;97:e70550.
    PubMed         Abstract available


    J Virol

  9. WANG Y, Peng D, Li M, Yao M, et al
    Organoids: physiologically relevant ex vivo models for viral disease research.
    J Virol. 2025 Aug 29:e0113225. doi: 10.1128/jvi.01132.
    PubMed         Abstract available

  10. VERMA A, Kamboj H, Kumar G, Khandelwal N, et al
    TGF-beta inhibitor SB431542 suppresses SARS-CoV-2 replication through multistep inhibition.
    J Virol. 2025 Aug 29:e0052925. doi: 10.1128/jvi.00529.
    PubMed         Abstract available

  11. GARTNER MJ, Smith ML, Dapat C, Liaw YW, et al
    Contemporary seasonal human coronaviruses display differences in cellular tropism compared to laboratory-adapted reference strains.
    J Virol. 2025 Aug 27:e0068425. doi: 10.1128/jvi.00684.
    PubMed         Abstract available


    JAMA

  12. ANDERER S
    COVID-19, Flu May Reawaken Dormant Cancer Cells.
    JAMA. 2025 Aug 29. doi: 10.1001/jama.2025.14772.
    PubMed        


    Science

  13. BERKLEY S
    Unraveling the arc of vaccine progress.
    Science. 2025;389:eaea7053.
    PubMed         Abstract available

  14. ZHANG H, Liu H, Xu Y, Huang H, et al
    Deep generative models design mRNA sequences with enhanced translational capacity and stability.
    Science. 2025 Aug 28:eadr8470. doi: 10.1126/science.adr8470.
    PubMed         Abstract available

Comments

Popular posts from this blog

#Neuroinvasive #Oropouche virus in a patient with #HIV from extra-Amazonian #Brazil

{Excerpt} A novel reassortant Oropouche virus (OROV) lineage (with medium [M], large [L], and small [S] RNA segments : M1L2S2) has driven Brazil's largest and most geographically widespread OROV epidemic , expanding beyond the endemic Amazon basin to establish local transmission across multiple Brazilian states and other previously unaffected Latin American countries . The rapid spread of this lineage underscores its evolutionary potential and reinforces its significance as a public health threat .1 Similar to chikungunya and Zika viruses, expanding arboviruses can exhibit unexpected clinical and epidemiological shifts , including vertical transmissions , neuroinvasive effects, and potentially fatal outcomes.2–4 Although OROV typically causes self-limited febrile illness, accumulating clinical and experimental evidence suggests neurotropic potential .5 This Correspondence describes the first confirmed case of neuroinvasive OROV infection caused by the emergent M1L2S2 lineage in ext...

No evidence of immune #exhaustion after repeated #SARS-CoV-2 #vaccination in vulnerable and healthy populations

Abstract Frequent SARS-CoV-2 vaccination in vulnerable populations has raised concerns that this may contribute to T cell exhaustion , which could negatively affect the quality of immune protection. Herein, we examined the impact of repeated SARS-CoV-2 vaccination on T cell phenotypic and functional exhaustion in frail older adults in long-term care (n = 23), individuals on immunosuppressive drugs (n = 10), and healthy adults (n = 43), in Canada . Spike-specific CD4+ and CD8+ T cell levels did not decline in any cohort following repeated SARS-CoV-2 vaccination, nor did the expression of exhaustion markers on spike-specific or total T cells increase. T cell production of multiple cytokines (i.e. polyfunctionality) in response to the spike protein of SARS-CoV-2 did not decline in any cohort following repeated vaccination. None of the cohorts displayed elevated levels of terminally differentiated T cells following multiple SARS-CoV-2 vaccinations. Thus, repeated SARS-CoV-2 vaccination was...

Chimeric #hemagglutinin and #M2 #mRNA #vaccine for broad #influenza subtype protection

Abstract Since multiple and unpredicted influenza viruses cause seasonal epidemics and even high-risk pandemics , developing a universal influenza vaccine is essential to provide broad protection against various influenza subtypes. Combined with the mRNA lipid nanoparticle-encapsulated (mRNA-LNP) vaccine platform and chimeric immunogen strategy , we developed a novel cocktail mRNA vaccine encoding chimeric HAs (cH5/1-BV, cH7/3) and intact M2 (termed Fluaxe), which confers broad protection against major circulating IAVs and IBVs , as well as highly pathogenic avian influenza . Two-dose intramuscular immunization of Fluaxe in mice elicited cross-reactive neutralizing antibodies , T cell responses, and long-lived immunity, resulting in robust protection against multiple lethal influenza virus infections and severe acute lung injuries . In particular, intramuscular administration stimulated systemic immunity together with a prominent lung tropism of memory cells . Moreover, Fluaxe immuniza...