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Swine acute #diarrhea syndrome #coronavirus-related viruses from #bats show potential #interspecies infection

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By G.M.

 


ABSTRACT

Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a bat-originated virus causing severe diseases in piglets. Since the 2016 outbreak, diverse SADS-related CoVs (SADSr-CoVs) have been detected in Rhinolophus bats in China and Southeast Asia, but their potential interspecies infection and pathogenicity remain unknown. Herein, we sequenced the spike (S) genes of bat SADSr-CoVs and classified them into four genotypes. We constructed an infectious SADS-CoV cDNA clone (rSADS-CoV) and nine recombinant viruses by replacing the SADS-CoV S gene with that of bat SADSr-CoVs. Recombinant SADSr-CoVs could replicate efficiently in respiratory and intestinal cell lines and human- and swine-derived organoids and caused varying tissue damage and mortality in suckling mice. These viruses can be classified into at least five serotypes based on cross-neutralization assays. Our findings highlight the potential risk of interspecies infection and provide important information for future surveillance of these bat viruses.

Source: Journal of Virology, https://journals.asm.org/doi/full/10.1128/jvi.02240-24?af=R

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