#Coronavirus Disease Research #References (by AMEDEO, September 13 '25)

Am J Respir Crit Care Med

GORDHAN BG, Sewcharran A, Waja Z, Martinson N, et al
Oral Rinse as an Alternative Diagnostic Specimen for Detection of Tuberculosis.
Am J Respir Crit Care Med. 2025 Sep 12. doi: 10.1164/rccm.202503-0723.
PubMed
CRESCIOLI E, Klitgaard TL, Riis JO, Weinreich UM, et al
Oxygenation Targets and Long-Term Cognitive and Pulmonary Functions in Hypoxemic Respiratory Failure.
Am J Respir Crit Care Med. 2025 Sep 8. doi: 10.1164/rccm.202412-2499.
PubMed Abstract available

Clin Infect Dis
NADIG N, Bhimraj A, Cawcutt K, Chiotos K, et al
2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Abatacept.
Clin Infect Dis. 2025 Sep 9:ciaf354. doi: 10.1093.
PubMed Abstract available

Infect Control Hosp Epidemiol
WILLIAMS V, Volpentesta K, Avaness M, Chan C, et al
Risk of viral respiratory infection associated with shared washroom between adjoining rooms: a test-negative study.
Infect Control Hosp Epidemiol. 2025 Sep 10:1-3. doi: 10.1017/ice.2025.10262.
PubMed Abstract available
MITCHELL R, Lee D, Bartoszko J, Lybeck C, et al
Trends in healthcare-associated infections and antimicrobial-resistant organisms among adults in Canadian acute care hospitals: findings from four point prevalence surveys, 2002 to 2024.
Infect Control Hosp Epidemiol. 2025 Sep 10:1-8. doi: 10.1017/ice.2025.10259.
PubMed Abstract available
SILVA A, Bartoszko JJ, Cayen J, Choi KB, et al
An interrupted time-series analysis assessing the association of the COVID-19 pandemic on healthcare-associated infections and antimicrobial-resistant organisms in Canadian acute care hospitals, 2018-2022.
Infect Control Hosp Epidemiol. 2025 Sep 10:1-5. doi: 10.1017/ice.2025.10247.
PubMed
WILLIAMS V, Schwartz KL, Brown K, Muller M, et al
Risk mitigation of shared room ventilation and filtration on SARS-CoV-2 transmission: a multicenter test-negative study.
Infect Control Hosp Epidemiol. 2025 Sep 10:1-7. doi: 10.1017/ice.2025.10256.
PubMed Abstract available

Int J Infect Dis
PASQUINI Z, Toschi A, Gibertoni D, Amicucci A, et al
Risk Factors for Persisting SARS-CoV-2 Infection in Patients with B-Cell Malignancies in the Omicron Era: A Multicenter Cohort Study.
Int J Infect Dis. 2025 Sep 8:108053. doi: 10.1016/j.ijid.2025.108053.
PubMed Abstract available
ROWE SL, Sullivan SG, Koerber JJ, Munoz FM, et al
Adverse events associated with COVID-19 vaccination or diagnosis among pregnant and non-pregnant women in the United States, 2021-2022.
Int J Infect Dis. 2025 Sep 5:108050. doi: 10.1016/j.ijid.2025.108050.
PubMed Abstract available

J Med Virol
GONZALEZ-VAZQUEZ LD, Iglesias-Rivas P, Ferreiro D, Arenas M, et al
Heterogeneous Evolution Among SARS-CoV-2 Genes and Variants of Concern.
J Med Virol. 2025;97:e70604.
PubMed Abstract available

J Virol
KASLE G, Sharma M, Kumar S, Das P, et al
Phenylbutyrate restricts murine beta-coronavirus infectivity and limits virus-induced demyelination in vivo.
J Virol. 2025 Sep 8:e0081925. doi: 10.1128/jvi.00819.
PubMed Abstract available
JIAO Z, Li J, Wang P, Yan Y, et al
Mutations in feline infectious peritonitis virus nonstructural protein 14/16 methyltransferase attenuate the pathogenicity of the virus in cats.
J Virol. 2025 Sep 9:e0083925. doi: 10.1128/jvi.00839.
PubMed Abstract available
LIZCANO-PERRET B, Wavreil F, Veinstein M, Duflos C, et al
The leader proteins of Theiler's virus and Boone cardiovirus use a combination of short linear motifs (SLiMs) to target RSK kinases to the nuclear pore complex.
J Virol. 2025 Sep 10:e0127525. doi: 10.1128/jvi.01275.
PubMed Abstract available
WESTON S, Baracco L, Taylor L, Scott AJ, et al
The mammalian SKI complex is a broad-spectrum antiviral drug target that upregulates cellular cholesterol to inhibit viral replication.
J Virol. 2025 Sep 10:e0132325. doi: 10.1128/jvi.01323.
PubMed Abstract available

JAMA
RUDMAN SPERGEL AK, Callendret B, Kostanyan L
Influenza and COVID-19 Multicomponent Vaccine in Adults-Reply.
JAMA. 2025 Sep 8. doi: 10.1001/jama.2025.12225.
PubMed
LIU Z, Zhang L, Jiang M
Influenza and COVID-19 Multicomponent Vaccine in Adults.
JAMA. 2025 Sep 8. doi: 10.1001/jama.2025.12222.
PubMed

Lancet Infect Dis
WILHELM F, Cadamuro J, Mink S
Autoantibodies in long COVID: a systematic review.
Lancet Infect Dis. 2025 Sep 8:S1473-3099(25)00411.
PubMed Abstract available

#Neuroinvasive #Oropouche virus in a patient with #HIV from extra-Amazonian #Brazil

{Excerpt} A novel reassortant Oropouche virus (OROV) lineage (with medium [M], large [L], and small [S] RNA segments : M1L2S2) has driven Brazil's largest and most geographically widespread OROV epidemic , expanding beyond the endemic Amazon basin to establish local transmission across multiple Brazilian states and other previously unaffected Latin American countries . The rapid spread of this lineage underscores its evolutionary potential and reinforces its significance as a public health threat .1 Similar to chikungunya and Zika viruses, expanding arboviruses can exhibit unexpected clinical and epidemiological shifts , including vertical transmissions , neuroinvasive effects, and potentially fatal outcomes.2–4 Although OROV typically causes self-limited febrile illness, accumulating clinical and experimental evidence suggests neurotropic potential .5 This Correspondence describes the first confirmed case of neuroinvasive OROV infection caused by the emergent M1L2S2 lineage in ext...

No evidence of immune #exhaustion after repeated #SARS-CoV-2 #vaccination in vulnerable and healthy populations

Abstract Frequent SARS-CoV-2 vaccination in vulnerable populations has raised concerns that this may contribute to T cell exhaustion , which could negatively affect the quality of immune protection. Herein, we examined the impact of repeated SARS-CoV-2 vaccination on T cell phenotypic and functional exhaustion in frail older adults in long-term care (n = 23), individuals on immunosuppressive drugs (n = 10), and healthy adults (n = 43), in Canada . Spike-specific CD4+ and CD8+ T cell levels did not decline in any cohort following repeated SARS-CoV-2 vaccination, nor did the expression of exhaustion markers on spike-specific or total T cells increase. T cell production of multiple cytokines (i.e. polyfunctionality) in response to the spike protein of SARS-CoV-2 did not decline in any cohort following repeated vaccination. None of the cohorts displayed elevated levels of terminally differentiated T cells following multiple SARS-CoV-2 vaccinations. Thus, repeated SARS-CoV-2 vaccination was...

Chimeric #hemagglutinin and #M2 #mRNA #vaccine for broad #influenza subtype protection

Abstract Since multiple and unpredicted influenza viruses cause seasonal epidemics and even high-risk pandemics , developing a universal influenza vaccine is essential to provide broad protection against various influenza subtypes. Combined with the mRNA lipid nanoparticle-encapsulated (mRNA-LNP) vaccine platform and chimeric immunogen strategy , we developed a novel cocktail mRNA vaccine encoding chimeric HAs (cH5/1-BV, cH7/3) and intact M2 (termed Fluaxe), which confers broad protection against major circulating IAVs and IBVs , as well as highly pathogenic avian influenza . Two-dose intramuscular immunization of Fluaxe in mice elicited cross-reactive neutralizing antibodies , T cell responses, and long-lived immunity, resulting in robust protection against multiple lethal influenza virus infections and severe acute lung injuries . In particular, intramuscular administration stimulated systemic immunity together with a prominent lung tropism of memory cells . Moreover, Fluaxe immuniza...

ETIDIOH - NEW

Search This Blog