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On Sept 4, 2025, the DR Congo Government and Ministry of Health announced a new Ebola virus disease outbreak in the Bulape health zone (Kasai province), marking the end of over 15 years without any reported cases of Ebola virus disease in this region. As of Sept 14, 2025, there were 35 confirmed Ebola virus disease cases and 16 deaths, representing a case fatality rate of 45·7%.1,2 This unexpected resurgence in a region with insufficient preparedness capacity raises serious concerns about potential regional spread, including towards neighbouring Angola.
At the same time, DR Congo is experiencing one of the most severe cholera outbreaks of the past decade, with a total of 48 139 cases and 1443 deaths reported between Jan 1 and Aug 24, 2025, resulting in a case fatality rate of 3%.3 By epidemiological week 33, high case fatality rates were reported in the provinces of Kwilu (76 cases, 26 deaths; 44%), Sankuru (42 cases, 6 deaths; 14%), and Equateur (224 cases, 19 deaths; 8%).3
DR Congo also continues to be the global epicentre of mpox. Between Jan 1 and Sept 14, 2025, DR Congo has reported 16 879 confirmed mpox cases and 43 deaths.4 Response efforts have been challenged by factors such as persistent endemic conditions, gaps in surveillance, and poor access to vaccines.
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Source: The Lancet, https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02100-2/fulltext?rss=yes
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