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#Transmission of #SARS-CoV-2 between #ferrets in presence of pre-existing #immunity

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By G.M.

 


ABSTRACT

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), is characterized by its high contagiousness. The COVID-19 pandemic has exerted profound impacts on human society. The persistent circulation of SARS-CoV-2 in human populations continues to pose re-exposure risks for both vaccinated individuals and those with prior natural infection. Against this epidemiological background, there is an urgent need to characterize the transmission dynamics of SARS-CoV-2 in the context of pre-existing immunity. Using a ferret infection model, this study systematically addresses critical scientific questions, including viral transmission efficiency, temporal patterns of transmissibility, and the ability of pre-existing immunity to mitigate reinfection and viral shedding. The findings provide robust experimental evidence for elucidating the transmission mechanisms of SARS-CoV-2 and offer scientific insights to inform the rational design of optimized antiviral strategies.

Source: Journal of Virology, https://journals.asm.org/doi/full/10.1128/jvi.01566-25?af=R

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