{Summary}
Highlights
• All clades of the monkeypox virus (MPXV) continue to circulate.
- When mpox outbreaks are not rapidly contained and human-to-human transmission is not interrupted, there is a risk of sustained community transmission.
• In October 2025, 44 countries, across all WHO regions, reported a total of 2501 new confirmed mpox cases, including 12 deaths (case fatality ratio [CFR] 0.5%).
- About 75% of these cases were reported in the African Region.
- All regions, apart from the South-East Asia Region observed a decline in confirmed cases in October, compared to September 2025.
• Twenty-one countries in Africa have reported active transmission of mpox in the last six weeks (12 October – 23 November 2025), with 1734 confirmed cases, including 10 deaths (CFR 0.6%) reported during this period.
- Countries reporting the highest number of cases in this period are the Democratic Republic of the Congo, Liberia, Ghana, Kenya and Uganda; with all of them showing a downward trend in cases in recent weeks.
• One country, Mali, has reported mpox for the first time.
- The case reported a recent history of travel to Guinea.
- Genomic sequencing analysis is ongoing to determine the MPXV clade.
• Greece has reported detection of clade Ib MPXV for the first time.
• New imported cases of mpox due to clade Ib MPXV detected among travellers have been reported in Belgium, Germany, Greece, and the United Kingdom of Great Britain and Northern Ireland.
• Since the last report, at least 15 cases of mpox due to clade Ib MPXV have been detected among individuals who self-identify as men who have sex with men.
• Outside Africa, local transmission of clade Ib MPXV has been occurring in Italy, the Netherlands, Portugal and Spain, the United States of America and Malaysia.
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Source:
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