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#Risk #assessment of #SARS-CoV-2 #infection from external #surfaces and biological samples of #COVID19 corpses

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By G.M.

 


Highlights

• Infectious SARS-CoV-2 were detected in nasopharynx and on the surface of corpses

• Viral load and symptom-to-discovery time are linked to viral infectivity

• Infectious viruses were not found in the body fluids

• Our findings highlight strict infection control for COVID-19 corpse handling


Abstract

Objectives

The SARS-CoV-2 pandemic has resulted in millions of deaths worldwide. However, the risk of transmission from COVID-19 corpses remain unclear, posing challenges for forensic medicine in establishing effective infection control measures during autopsies. This study aimed to investigate the presence of infectious SARS-CoV-2 in corpses and identify factors affecting viral infectivity.

Methods

External examinations of 76 corpses with COVID-19 were performed, and nasopharyngeal, perioral, hand swabs, serum, cerebrospinal fluid (CSF), and urine samples were collected. Viral RNA was quantified by using digital PCR, and infectious viruses were assessed via isolation. Multivariate logistic regression analysis was used to identify factors associated with viral infectivity.

Results

Infectious viruses were isolated from the nasopharynx (51%), perioral region (10.3%), and hands (1.8%). Common predictive factors for nasopharyngeal and perioral viral infectivity were a higher viral load and shorter time from symptom onset. Detectable viral RNA in serum was also associated with nasopharyngeal infectivity. No infectious viruses were detected in serum, CSF, or urine samples.

Conclusions

Infectious SARS-CoV-2 was detected in the nasopharynx and on the surface of COVID-19 corpses. Viral infectivity correlated with viral load and time from symptom onset, highlighting the importance of strict infection control when handling COVID-19 corpses.

Source: 


Link: https://www.ijidonline.com/article/S1201-9712(25)00520-X/fulltext

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