Skip to main content

#Coronavirus Disease Research #References (by AMEDEO, April 5 '25)

Image
By G.M.

 


    Ann Intern Med

  1. DACSO CC
    Coadministration of RSV + influenza or COVID-19 vaccines was noninferior to separate administration for immune responses in adults aged >/=50 y.
    Ann Intern Med. 2025 Apr 1. doi: 10.7326/ANNALS-25-00904.
    PubMed         Abstract available

  2. AMAN M, Jeevananthan A, Martinez-Cruz M, Namasingh N, et al
    Endocrinology: What You May Have Missed in 2024.
    Ann Intern Med. 2025 Apr 1. doi: 10.7326/ANNALS-25-00990.
    PubMed         Abstract available

  3. HAMED HKA, Nachman A, Riopel N, Schuster M, et al
    Infectious Diseases: What You May Have Missed in 2024.
    Ann Intern Med. 2025 Apr 1. doi: 10.7326/ANNALS-25-00925.
    PubMed         Abstract available

  4. CORONADO GD, Petrik AF, Thompson JH, Leo MC, et al
    Patient Navigation to Improve Colonoscopy Completion After an Abnormal Stool Test Result : A Randomized Controlled Trial.
    Ann Intern Med. 2025 Apr 1. doi: 10.7326/ANNALS-24-01885.
    PubMed         Abstract available


    Antiviral Res

  5. ZHU Y, Gao Z, Feng X, Hu Y, et al
    Comprehensive preclinical characterization of IPB29, a pan-coronavirus fusion inhibitor under clinical trials.
    Antiviral Res. 2025;237:106154.
    PubMed         Abstract available


    BMJ

  6. VANDERSLOTT S
    Confronting the shortcomings of covid-19 vaccination will help us in future pandemics.
    BMJ. 2025;388:r590.
    PubMed        


    Clin Infect Dis

  7. ADAMS K, Garg S, Tartof SY, Irving SA, et al
    Patterns in prescribing and dispensing of influenza antivirals among adults with influenza presenting to urgent care and emergency department settings, VISION Network, 2023-2024.
    Clin Infect Dis. 2025 Apr 4:ciaf178. doi: 10.1093.
    PubMed         Abstract available

  8. DORAIVELU K, Williams S, Hazell M, Smith S, et al
    The dynamic impact of community social vulnerability on COVID-19 outcomes: A census tract-level analysis of Fulton County, GA.
    Clin Infect Dis. 2025 Apr 3:ciaf177. doi: 10.1093.
    PubMed         Abstract available


    Int J Infect Dis

  9. FANG S, Zhu L, Bai S, Tian W, et al
    Year-round infectome profiling of acute febrile respiratory illness unveiled complex epidemiological dynamics post-lifting of COVID-19 restrictions.
    Int J Infect Dis. 2025 Mar 29:107896. doi: 10.1016/j.ijid.2025.107896.
    PubMed         Abstract available


    J Med Virol

  10. LAI C, Lu S, Yang Y, You X, et al
    Myeloid-Driven Immune Suppression Subverts Neutralizing Antibodies and T Cell Immunity in Severe COVID-19.
    J Med Virol. 2025;97:e70335.
    PubMed         Abstract available

  11. KUMAR R, Verma A, Kamboj H, Bhattacharya TK, et al
    H3K27-me3 Inhibition Induces YTHDF2-Mediated Decay of m6A-Marked Severe Acute Respiratory Syndrome Coronavirus 2 Transcripts.
    J Med Virol. 2025;97:e70332.
    PubMed         Abstract available

  12. REUS P, Torbica E, Rothenburger T, Bechtel M, et al
    Papaverine Targets STAT Signaling: A Dual-Action Therapy Option Against SARS-CoV-2.
    J Med Virol. 2025;97:e70319.
    PubMed         Abstract available


    J Virol

  13. XIAO X, Li S, Zheng Z, Ji Y, et al
    Targeting USP22 to promote K63-linked ubiquitination and degradation of SARS-CoV-2 nucleocapsid protein.
    J Virol. 2025 Apr 4:e0223424. doi: 10.1128/jvi.02234.
    PubMed         Abstract available

  14. GHIMIRE R, Shrestha R, Amaradhi R, Liu L, et al
    Toll-like receptor 7 (TLR7)-mediated antiviral response protects mice from lethal SARS-CoV-2 infection.
    J Virol. 2025 Mar 31:e0166824. doi: 10.1128/jvi.01668.
    PubMed         Abstract available


    Lancet

  15. GOSTIN LO, Friedman EA, Dhai A, Zia-Zarifi S, et al
    COVID-19: border closures violate human rights - Authors' reply.
    Lancet. 2025;405:1054.
    PubMed        

  16. SILVA DS, Razum O
    COVID-19: border closures violate human rights.
    Lancet. 2025;405:1053-1054.
    PubMed        


    MMWR Morb Mortal Wkly Rep

  17. JOBE NB, Rose E, Winn AK, Goldstein L, et al
    Human Metapneumovirus Seasonality and Co-Circulation with Respiratory Syncytial Virus - United States, 2014-2024.
    MMWR Morb Mortal Wkly Rep. 2025;74:182-187.
    PubMed         Abstract available


    Science

  18. COHEN J
    NIH cancels research grants for COVID-19 and future pandemics.
    Science. 2025;388:16.
    PubMed         Abstract available
Labels:

Comments

Post a Comment

Popular posts from this blog

#Neuroinvasive #Oropouche virus in a patient with #HIV from extra-Amazonian #Brazil

By G.M.
{Excerpt} A novel reassortant Oropouche virus (OROV) lineage (with medium [M], large [L], and small [S] RNA segments : M1L2S2) has driven Brazil's largest and most geographically widespread OROV epidemic , expanding beyond the endemic Amazon basin to establish local transmission across multiple Brazilian states and other previously unaffected Latin American countries . The rapid spread of this lineage underscores its evolutionary potential and reinforces its significance as a public health threat .1 Similar to chikungunya and Zika viruses, expanding arboviruses can exhibit unexpected clinical and epidemiological shifts , including vertical transmissions , neuroinvasive effects, and potentially fatal outcomes.2–4 Although OROV typically causes self-limited febrile illness, accumulating clinical and experimental evidence suggests neurotropic potential .5 This Correspondence describes the first confirmed case of neuroinvasive OROV infection caused by the emergent M1L2S2 lineage in ext...
Post a Comment
Read more »

No evidence of immune #exhaustion after repeated #SARS-CoV-2 #vaccination in vulnerable and healthy populations

By G.M.
Abstract Frequent SARS-CoV-2 vaccination in vulnerable populations has raised concerns that this may contribute to T cell exhaustion , which could negatively affect the quality of immune protection. Herein, we examined the impact of repeated SARS-CoV-2 vaccination on T cell phenotypic and functional exhaustion in frail older adults in long-term care (n = 23), individuals on immunosuppressive drugs (n = 10), and healthy adults (n = 43), in Canada . Spike-specific CD4+ and CD8+ T cell levels did not decline in any cohort following repeated SARS-CoV-2 vaccination, nor did the expression of exhaustion markers on spike-specific or total T cells increase. T cell production of multiple cytokines (i.e. polyfunctionality) in response to the spike protein of SARS-CoV-2 did not decline in any cohort following repeated vaccination. None of the cohorts displayed elevated levels of terminally differentiated T cells following multiple SARS-CoV-2 vaccinations. Thus, repeated SARS-CoV-2 vaccination was...
Post a Comment
Read more »

Chimeric #hemagglutinin and #M2 #mRNA #vaccine for broad #influenza subtype protection

By G.M.
Abstract Since multiple and unpredicted influenza viruses cause seasonal epidemics and even high-risk pandemics , developing a universal influenza vaccine is essential to provide broad protection against various influenza subtypes. Combined with the mRNA lipid nanoparticle-encapsulated (mRNA-LNP) vaccine platform and chimeric immunogen strategy , we developed a novel cocktail mRNA vaccine encoding chimeric HAs (cH5/1-BV, cH7/3) and intact M2 (termed Fluaxe), which confers broad protection against major circulating IAVs and IBVs , as well as highly pathogenic avian influenza . Two-dose intramuscular immunization of Fluaxe in mice elicited cross-reactive neutralizing antibodies , T cell responses, and long-lived immunity, resulting in robust protection against multiple lethal influenza virus infections and severe acute lung injuries . In particular, intramuscular administration stimulated systemic immunity together with a prominent lung tropism of memory cells . Moreover, Fluaxe immuniza...
Post a Comment
Read more »