A single–amino acid difference between #rodent and #human #Andes virus affects viral #glycoprotein trafficking

 

Abstract

Andes virus (ANDV) causes hantavirus pulmonary syndrome (HPS), with rare outbreaks involving person-to-person transmission. A human ANDV isolate from one such outbreak and a rodent isolate from the same region differ in lethality in Syrian golden hamsters. Genomic analysis revealed 25 nonsynonymous substitutions, including one leading to a T641I change in the human ANDV glycoprotein precursor near its cleavage site. Although the isolates differed in growth kinetics, strand-specific RT-qPCR did not support major differences in viral RNA synthesis, whereas virion release was delayed in the case of the human isolate. In human cell expression systems, a single I641T substitution in the human ANDV glycoprotein resulted in decreased Golgi retention and faster release of virion-like particles relative to wild-type glycoprotein. Since ANDV egress takes place at the Golgi, the T641I change present in the human ANDV isolate may represent a human adaptive mutation influencing glycoprotein trafficking and virus particle release.

Source: Science Advances Journal, https://doi.org/10.1126/sciadv.aek2522

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History of Mass Transportation: The Class 80 power car No. 69 in preservation at the Downpatrick and County Down Railway

 

{Click on Image to Enlarge}

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By Milepost98 - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=90062190

Source: Wikipedia, https://en.wikipedia.org/wiki/NIR_80_Class

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Six Recoveries and Eighteen Days Without a New #Ebola #Bundibugyo Virus Case As #Kenya Nears the Finish Lile (MoH, Nov. 6 '26)

 

Ministry of Health REPUBLIC OF KENYA | OFFICE OF THE DIRECTOR-GENERAL FOR  HEALTH | PRESS RELEASE

DAY 32: SIX RECOVERIES AND EIGHTEEN DAYS WITHOUT A NEW CASE AS KENYA NEARS THE FINISH LINE

Nairobi, 6 November 2026

    Today marks Day 32 since Kenya confirmed its first imported case of Ebola  (Bundibugyo Virus Disease) on 6th October 2026. 

    The Ministry of Health is pleased to report that the measures put in place  are working, and the country is firmly on the path to ending this outbreak.

    A sixth (6th) male patient has recovered and is being discharged today,  after testing negative and meeting all the criteria for discharge. 

    Only one (1) patient remains under care and continues to receive treatment  and close monitoring. 

    No new case has been recorded for eighteen (18) days, since 19th October  2026. 

    The total number of confirmed cases remains nine (9), all from one  known chain of transmission, and there has been no spread in the community. 

    Sixty-six (66) contacts have completed their 21 days of monitoring and  returned home, and the remaining fifty-two (52) are expected to complete their  quarantine by 11th November 2026.

    These results did not happen by chance. Kenya followed the proven steps  that stop Ebola: 

        ° find every case early, 

        ° isolate and treat the sick, 

        ° trace and monitor  everyone they came into contact with, 

        ° protect health workers, and 

        ° bury the dead  safely and with dignity. 

        ° Every person who fell ill after the first case was already  under quarantine, which meant the virus had nowhere to go.

    The outbreak will end in a clear, internationally agreed way. When the  last patient leaves the treatment centre free of the virus, Kenya will begin a 42- day countdown, twice the longest time it takes for the illness to appear. If no new  case is recorded in those 42 days, the outbreak will be declared over. Until that  day, we must not let down our guard. 

    The Ministry sincerely thanks everyone who has made this progress possible: 

        ° our doctors, nurses, laboratory, surveillance and burial teams, who worked  at great personal risk; 

        ° Community Health Promoters, Public Health Officers and county  governments; 

        ° the Kenyatta National Hospital and The Nairobi Hospital; the security agencies; religious and

        ° community leaders; and 

        ° the media, for sharing accurate information. 

    We are grateful to the patients and their families, and to the contacts who  stayed in quarantine for the sake of their neighbors and the entire country. We  also thank our partners, including WHO, Africa CDC, UNICEF, IGAD and friendly  governments, for standing with Kenya. 

    Staying free of Ebola, and of any other outbreak, is everyone's responsibility.  

    We ask every Kenyan to: 

        ° know the signs (fever, weakness, muscle  pain, vomiting, diarrhea or  unexplained bleeding) and seek care early; 

        ° report any sick person or unexplained death in the community; 

        ° avoid touching the blood or body fluids of a sick person, or the body of anyone who has died of an unexplained illness; 

        ° wash hands regularly with soap and water; 

        ° avoid handling sick or dead wild animals or their meat; and 

        ° welcome recovered patients and released contacts without stigma.

    Ebola is still active in the region, and outbreaks in one country can quickly  reach another. Kenya will keep screening travelers at all twenty-six (26) points of  entry, where to date more than 760,000 travelers have been screened, and will  keep its emergency operations centers and rapid response teams on alert in every  county. 

    Travelers should truthfully complete the electronic traveler surveillance form on the UHAI Chatbot before arrival, declare any symptoms  honestly, and report any illness within 21 days of arrival. 

    Health workers should ask every patient with fever about travel and  contact history and always keep up infection prevention and control measures. 

    We  will continue to work with our neighbors, the East African Community  and Africa CDC, because no country is safe until the whole region is safe.

    Kenya remains open, with no restrictions on travel, trade or public gatherings. To report a suspected case or seek information, call 719 free of charge  or use the Jali WhatsApp chatbot on 0700 719 719.

    We are close to the finish line. Let us stay alert, report early and keep  working together until Kenya is declared Ebola-free and stays that way.

Dr. Patrick Amoth, CBS | DIRECTOR-GENERAL FOR HEALTH

Source: Facebook Page of Kenya's Ministry of Health, https://www.facebook.com/MinstryofHealthKE

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Yellow fever - #WHO #African Region, 6 November 2026 (WHO D.O.N., summary)

 

{Summary}

Situation at a glance

    Yellow fever transmission continues in the WHO African Region, with recent outbreak activity concentrated in parts of West Africa. 

    Between 1 January and 12 October 2026, 67 confirmed cases, including 18 deaths, were recorded in nine countries in the Region: Burkina Faso, Cameroon, the Central African Republic, Côte d’Ivoire, Ghana, Guinea, Liberia, Nigeria and Togo. 

    The most recent outbreak activity has been concentrated in Burkina Faso, Côte d’Ivoire, Ghana and Liberia, including in areas close to international borders. 

    Occupational and environmental exposures, including work in or near forested areas, mining activities, and other outdoor occupations, are important risk factors for yellow fever infection. 

    Frequent cross-border population movement, the presence of competent mosquito vectors, and uneven vaccination coverage increase the risk of further transmission and geographic spread. 

    Countries in the Region, supported by WHO and partners, are implementing response activities including enhanced surveillance and case investigation, laboratory testing, active case finding, risk communication and community engagement, and vaccination activities in affected and at-risk areas. 

    On 27 October 2026, WHO assessed the overall public health risk associated with the current yellow fever situation as moderate at the regional level. 

    The global risk remains low.

(...)

Source: World Health Organization, https://www.who.int/emergencies/disease-outbreak-news/item/2026-DON624

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#Ebola disease caused by #Bundibugyo virus - #DRC, #Kenya and #Nigeria, 6 November 2026 (WHO D.O.N., Summary)

 

{Summary}

Situation at a glance

    Since the publication of the previous Disease Outbreak News on 23 October 2026, the Bundibugyo virus disease (BVD) outbreak has expanded geographically in the Democratic Republic of the Congo. 

    While some areas have seen a slight decline in cases, sustained, high-level transmission continues overall in the Democratic Republic of the Congo. 

    As of 3 November 2026, a total of 10 668 confirmed cases, including 5198 deaths (crude case fatality ratio: 48.7%), have been reported across 67 health zones in eight provinces, with active transmission ongoing in 51 health zones. 

    The high proportion of deaths occurring in communities, especially among young children, continues to highlight challenges in early case detection and timely access to appropriate care. 

    Of the 512 deaths reported since 21 October, 335 occurred in communities and 177 in treatment centres. 

    Since the last Disease Outbreak News, no new cases have been reported from Kenya or Nigeria. 

    However, the high-level transmission in the Democratic Republic of the Congo indicates a continued need for readiness in the region, including cross-border surveillance, points of entry monitoring, timely case detection and coordinated preparedness and response measures. 

    No new country has reported cases since the last Disease Outbreak News was published, however, two countries have medically evacuated confirmed cases among citizens: Switzerland and the United Kingdom of Great Britain and Northern Ireland. 

    Based on the currently available information, WHO advises against any restriction of travel to, or trade with, States Parties experiencing and/or responding to the public health event.

(...)

Source: World Health Organization, https://www.who.int/emergencies/disease-outbreak-news/item/2026-DON625

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#Bundibugyo Virus Disease #Outbreak - #DRC, #Kenya, #Nigeria - Sit. #Report No. 24, Data as of 1 Nov. '26 (WHO, summary): 10,532 cases & 5,126 deaths in DRC

  

{Summary}

(...)

{Click on Image to Enlarge}

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Event description

    The Bundibugyo virus disease (BVD) outbreak in the Democratic Republic  of the Congo passed 10 000 confirmed cases during the reporting period and  continues at a high, sustained level of transmission, driven increasingly by  Nord-Kivu while Ituri remains the largest contributor. 

    The importation events in Kenya and Nigeria have so far remained  contained: no new case has been reported in Kenya since 19 October and all  secondary cases occurred among contacts already in quarantine, while no  secondary case has been identified in Nigeria. 

    However, a one new death was reported in Kenya, bring the total number of  deaths to two. 

    In the Democratic Republic of the Congo, insecurity, health-worker strikes  in Bas-Uélé and Tshopo and the suspension of response activities in Bafwasende  Health Zone continue to constrain surveillance and response operations.

Democratic Republic of the Congo

    As of 1 November 2026, the BVD outbreak in the Democratic Republic of  the Congo has affected 67 health zones across eight provinces; Yakoma  Health Zone in Nord-Ubangi Province was added to the list of affected zones on 28  October.

    Since External Situation Report #23, an additional 895 confirmed cases and 480 confirmed deaths have been reported, bringing the cumulative total to  10 532 confirmed cases, including 5 126 confirmed deaths [crude case fatality  ratio (CFR) 48.7%]. 

    Transmission remains highly heterogeneous across affected areas. Ituri  continues to account for the largest proportion of cumulative confirmed cases  (70.6%), although its relative contribution is declining, while Nord-Kivu (23.9% of cumulative cases; CFR 55.4%) accounted for 60.0% of the cases reported on 1 November. 

    Transmission persists at lower levels in Haut-Uélé and Tshopo.

    National daily incidence rose steadily from May to its highest levels in late  July and mid-August, declined through late September and has fluctuated at  a high plateau since early October. 

    The seven-day moving average ranged between 67 and 76 confirmed  cases per day during the reporting period, peaking at 76 cases per day on 29–30  October before easing to 67 on 1 November, still below the mid-August peak of  94. 

    Provincial trends diverge. Ituri continues its gradual decline from the late- July peak (seven-day average of 31 cases per day on 1 November, down from 38  on 19 October), while Nord-Kivu is rising again (30 cases per day, up from 26)  and now reports almost as many cases as Ituri each day. HautUélé remains stable  at four to five cases per day, Tshopo shows low-level but sustained transmission,  and Nord-Ubangi reported its first cases in October. Bas-Uélé, Sud-Kivu and Sud-Ubangi have reported no case in the last 21 days (Figures 1 and 2).

{Click on Image to Enlarge}

___

(...)

Trend Analysis (21-day comparison):

    During the most recent 21-day period (12 October – 1 November 2026), a  total of 1 466 confirmed cases were reported nationally, compared with 1 333  cases during the preceding 21 days (21 September – 11 October), representing  an increase of 133 cases (+10.0%). 

    Provincial trends remain heterogeneous. Cases in Ituri decreased slightly  from 748 to 736 (−1.6%), accounting for 50.2% of national cases during the  latest period. 

    In Nord-Kivu, cases increased from 486 to 607 (+24.9%), accounting for  41.4% of national cases, while in Haut-Uélé cases increased from 72 to 84  (+16.7%), accounting for 5.7% of national cases. Tshopo reported 33 cases  compared with 20 in the preceding period (+65.0%), and Nord-Ubangi reported  its first six cases. Bas-Uélé and Sud-Ubangi, which reported six and one cases  respectively in the preceding period, reported none.

    During the same period, a total of 745 confirmed deaths were reported  nationally, compared with 649 deaths during the preceding 21 days (21  September – 11 October), representing an increase of 96 deaths (+14.8%). 

    Deaths increased from 377 to 393 (+4.2%) in Ituri, from 230 to 303  (+31.7%) in Nord-Kivu and from 34 to 43 (+26.5%) in Haut-Uélé and decreased  from eight to five in Tshopo; Nord-Ubangi reported its first death. The rise in  deaths, concentrated in NordKivu, outpaced the rise in cases, reflecting a  worsening mortality burden in the province where transmission is now intensifying.

(...)

    Transmission remained active in two-thirds of all health zones affected  since the start of the outbreak. Of the 67 health zones affected to date,  45 (67.2%) reported at least one new confirmed case during the most recent 21  days(12 October – 1 November 2026). 

    Case incidence increased in 26 health zones, decreased in 27 and was  unchanged in one when the two periods are compared. 

    

    The largest absolute increase occurred in Beni, Nord-Kivu (177 to 262  cases; +48.0%), followed by Mambasa, Ituri (22 to 62; +181.8%), Mandima,  Ituri (199 to 233; +17.1%), Mutwanga, Nord-Kivu (14 to 43; +207.1%), Oicha,  Nord-Kivu (28 to 51; +82.1%) and Wamba, Haut-Uélé (26 to 49; +88.5%).  Bafwasende in Tshopo (11 cases), Wapinda and Yakoma in Nord-Ubangi (three  cases each) and Damas and Mahagi in Ituri (one case each) reported cases after  none in the preceding period (Figure 4).

    There were also 22 health zones without a new case in the last 21 days.  These include Adja, Ariwara, Aungba, Boga, Drodro, Fataki, Gety, Kambala and  Logo in Ituri; Goma and Kayna in Nord-Kivu; Dungu and Gombari in Haut-Uélé;  Lubunga, Mangobo and Wanie-Rukula in Tshopo; Miti-Murhesa in Sud-Kivu; Buta, Dakwa, Ganga and Viadana in BasUélé; and Bulu in Sud-Ubangi.

(...)

    Weekly confirmed deaths (Figure 6) rose to 286 during 19–25 October 2026,  the highest weekly total since late August, before declining by 16.4% to  239 during 26 October – 1 November. Community deaths decreased from 184 to  155 (−15.8%) and deaths in treatment facilities from 102 to 84 (−17.6%), so  that the proportion of deaths occurring in the community was essentially  unchanged at 64.9% (64.3% the previous week). 

    On 1 November alone, 20 of the 23 confirmed deaths (87.0%) occurred in  the community. Close to two-thirds of confirmed deaths continue to occur outside treatment facilities, highlighting persistent challenges in early case  detection, timely referral and access to treatment.

(...)

Kenya

    Since the previous report, Kenya has reported no new confirmed case of BVD. The cumulative total remains nine confirmed cases, including two deaths (CFR 22.2%): the imported index case, who died on 5 October, and a  65-year-old family member who died on 23 October. All eight secondary cases  (four family members and four hospital staff) were epidemiologically linked to the  index case and were already under quarantine when they developed symptoms. 

    The last confirmed case was reported on 19 October 2026; the 42-day  countdown to the end of the outbreak will start once the last confirmed patient  has been discharged after two negative tests.

    Of the nine confirmed cases, seven were male and two were female, with  ages ranging from 24 to 65 years. Seven patients remain under treatment in  isolation at designated facilities, which have 211 isolation beds (scalable to 241), 

corresponding to a bed occupancy of 3.3%.

    A total of 135 contacts have been listed, comprising 46 airport staff, 45  hospital staff, 26 passengers, 14 relatives and four flight crew members. Of these,  eight (5.9%) tested positive for BVD during quarantine (four relatives and  four hospital staff), one of whom has died. 

    As of 28 October, 98 contacts remained  in quarantine in Kenya (41 hospital staff, 33 airport staff, 14 passengers  and 10 family members), all of whom were followed up in the  previous 24 hours (100%); 20 contacts (13 airport staff, four flight crew and three  passengers) had completed follow-up and been discharged from quarantine; and nine passengers who travelled outside Kenya are being  followed up through bilateral engagement with their Countries of destination.

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Nigeria

    Nigeria reported a single confirmed case of BVD, announced by the  Federal Ministry of Health on 20 October 2026 in the Federal Capital Territory,  Abuja. The case, a 42-year-old woman, arrived in Abuja from Uganda via Addis  Ababa on 3 October, developed symptoms on 7 October and was admitted to a  private health facility on 11October. 

    The patient was clinically stable and received supportive care before  being medically evacuated to Switzerland on 26 October 2026. 

    As of 31 October, no additional confirmed cases had been reported. As of  29 October, 62 contacts had been identified in Abuja Municipal Area Council, none  of whom had developed symptoms, and 18 samples had been tested, of which one  was positive. 

    No secondary transmission has been detected; the 12-day  interval  between symptom onset and notification, eight days of which were spent in  private-facility care, remains the main concern for undetected exposures.

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Situation interpretation

    The BVD outbreak remains at a critical juncture. In the Democratic  Republic of the Congo, transmission is not declining:  the cumulative count  passed 10 000 confirmed cases, the national seven-day average has held between  67 and 76 cases per day for three weeks, and the epicentre is shifting  towards Nord-Kivu, where cases rose by a quarter and deaths by a third over the  last 21-day period, where one in three patients is managed outside dedicated  treatment centres, and where contact follow-up and safe burial performance are  the weakest. 

    Health-worker strikes in Bas-Uélé and Tshopo, insecurity in Beni and Nizi and  the suspension of activities in Bafwasende further increase the risk of  undetected transmission. 

    The absence of new cases in Kenya since 19 October and of secondary  transmission in Nigeria is encouraging and indicates that the exported chains have  so far been contained, although continued surveillance is essential until the  end-of-outbreak criteria are met. 

    Priorities should focus on reinforcing response capacity in NordKivu,  particularly in Beni, Mutwanga, Oicha and Mabalako, restoring operational access  in insecure and strike-affected areas, improving the timeliness of isolation of  suspected cases and the completion of safe burials, and maintaining coordinated  cross-border surveillance and information sharing to prevent further international  spread.

Source: World Health Organization, https://www.afro.who.int/countries/nigeria/publication/bundibugyo-virus-disease-outbreak-democratic-republic-congo-kenya-nigeria-weekly-external-situation

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#Germany - High pathogenicity avian #influenza #H5N1 viruses (Inf. with) ( #poultry ) - Immediate notification

 

{Extract}

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A Turkeys for Fatteing Farm in the Mecklenburg-Vorpommern Region.

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Source: World Animal Health Organization, https://wahis.woah.org/#/in-review/7963

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Weekly #US #Influenza #Surveillance #Report: Key Updates for Week 43, ending October 31, 2026 (CDC, Summary): #H1N1pdm09 vastly predominated

{Extract, Summary}

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Key Points

    ° Multiple seasonal influenza surveillance indicators continue to increase in many parts of the country.

    ° This early-season influenza activity is currently higher than typically observed at this time of year, but an earlier increase in activity does not necessarily lead to a higher seasonal peak or greater overall severity.

    ° During Week 43 (the week ending October 31, 2026), of the 513 influenza viruses reported by public health laboratories, 502 were influenza A and 11 were influenza B. Of the 388 influenza A viruses subtyped during Week 43, 379 (97.7%) were influenza A(H1N1)pdm09, 7 (1.8%) were A(H3N2) and 2 (0.5%) were influenza A(H5).

    ° Since Week 21 (the week ending May 30, 2026), 83.4% of the influenza A viruses reported have been A(H1N1)pdm09 and among these, the majority have been D.3.1.1 HA subclade.

    ° The influenza A(H1N1) viruses detected this season are still A(H1N1)pdm09 viruses, which emerged in 2009 and have caused seasonal epidemics globally since then. Influenza viruses are constantly changing, often requiring updates to influenza vaccine viruses each season.

    ° Historically, influenza A(H1N1)pdm09 viruses have changed less often than A(H3N2) viruses. Recently circulating influenza A(H1N1)pdm09 viruses (which are in an HA subclade called "D.3.1.1") have divided into distinct groups with different genetic changes in their HA genes. We are seeing more genetic diversity among co-circulating A(H1N1)pdm09 viruses than we have before.

    ° It is too early to know what viruses may predominate or to say whether there might be implications on flu vaccine effectiveness this season.

    ° Two pediatric deaths associated with season influenza virus infection and occurring during the 2026-27 influenza season were reported to CDC this week.

    ° Because case investigation takes time, flu-associated deaths in children may be reported to CDC weeks after they occur; counts are preliminary and may increase. All reported cases meet the influenza-associated pediatric mortality case definition.

    ° The preliminary in-season severity assessment has classified the severity of influenza activity at this point in the season as low across all ages and for children (0-17years), adults (18-64 years) and older adults (65+ years). The severity assessment for the season may change as flu activity is currently increasing.

    ° CDC estimates that there have been at least 1,700,000 illnesses, 25,000 hospitalizations, and 1,400 deaths from flu so far this season.

    ° CDC’s FluSight forecasts predict a likely increase nationally in both flu hospital admissions and the percentage of emergency department visits due to flu for the week ending November 21. The number of new flu hospital admissions is forecast to range from 6,900 to 30,100 admissions, while the national percentage of emergency department visits due to flu is forecast to range from 1.6% to 6.7%.

    ° Annual seasonal influenza (flu) vaccination is recommended. Influenza vaccines are available for persons aged 6 months and older. People who are recommended for influenza vaccination but have not been vaccinated yet this season are encouraged to be vaccinated now.

    ° There are prescription flu antiviral drugs that can treat flu illness; those should be started as early as possible and are especially important for patients at higher risk for influenza complications.1

    ° Two confirmed cases of avian influenza A(H5) virus infection were reported to CDC this week, including one death. To date, human-to-human transmission of avian influenza A(H5) virus (H5 bird flu) has not been identified in the United States.

    ° Influenza viruses are among several viruses contributing to respiratory disease activity. CDC is providing updated, integrated information about COVID-19, flu, and respiratory syncytial virus (RSV) activity on a weekly basis.

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Novel Influenza A Virus Infections

    ° Two confirmed human infections with avian influenza A(H5) virus were reported to CDC this week, including one death. To date, human-to-human transmission of avian influenza A(H5) virus has not been identified in the United States.

    ° Both cases were reported by the Washington State Department of Health and occurred in adults aged ≥18 years who worked at commercial dairy cattle farms where highly pathogenic avian influenza (HPAI) A(H5N1) virus has been detected in cows.

    ° One individual developed respiratory symptoms during the week ending October 24, 2026 (Week 42). The patient presented to an emergency department the following week, was hospitalized, and has died. A respiratory specimen collected at the healthcare facility tested positive for influenza A and was presumptive positive for influenza A(H5) at the University of Washington. The specimen was sent to the Washington State Public Health Laboratory where influenza A(H5) was confirmed using the CDC influenza A(H5) assay. Additional testing conducted by the University of Washington determined this was an avian influenza A(H5N1) virus.

    ° The second individual developed conjunctivitis and sought healthcare. Specimens were collected from the individual and tested at the state public health laboratory using the CDC influenza A(H5) assay during the week ending October 31, 2026 (Week 43). Influenza A(H5) virus was confirmed by the state public health laboratory. The specimen has been shipped to CDC for additional testing.

    ° There has been a total of three influenza A(H5) cases in dairy workers in Washington.

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Source: US Centers for Disease Control and Prevention, https://www.cdc.gov/fluview/surveillance/2026-week-43.html

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#USA, #Wastewater Data for Avian #Influenza #H5 (CDC, Nov. 6 '26)

 

{Extract}

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A(H5) detections in the past week

Time Period: October 25, 2026 - October 31, 2026

    -- A(H5) Detection: 11 site(s) (2.4%)

    -- No Detection: 447 site(s) (97.6%)

    -- No samples: 115 site(s)

{Click on Image to Enlarge}

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Source: US Centers for Disease Control and Prevention, https://www.cdc.gov/wastewater/emerging-viruses/h5.html?

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#Mexico - High pathogenicity avian #influenza #H5N1 viruses (Inf. with) ( #poultry ) - Immediate notification

 

{Extract}

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{Yucatán State}

    As part of efforts to promote reporting, a suspicion of avian influenza at a commercial poultry production facility in the state of Yucatán was reported. 

    Laboratory results confirmed the presence of the high pathogenicity influenza A H5N1 virus through sequencing. 

    The production facility was placed under quarantine to carry out anti-epidemic measures and epidemiological surveillance of poultry and wild birds in the area.

(...)

Source: World Animal Health Organization, https://wahis.woah.org/#/in-review/7960

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#Korea (Rep. of) - High pathogenicity avian #influenza #H5N9 viruses (Inf. with) ( #poultry ) - Immediate notification

 

{Extract}

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A Poultry Farm in the Gyeonggi-do Region.

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Source: World Animal Health Organization, https://wahis.woah.org/#/in-review/7961

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#Influenza virus characteristics, week 40 2025 to week 33 2026, #EU/EEA (ECDC, Nov. 6 '26)

 

{Summary}

Surveillance and monitoring | 6 November 2026

This report summarises influenza virological surveillance data from all 30  European Union and European Economic Area (EU/EEA) countries from week 40  2025 to week 33 2026, as reported by National Reference Laboratories (NRLs) to  The European Surveillance System (TESSy) at the European Centre for Disease  Prevention and Control.

Executive summary

Detections

    Within the reporting period, 256 967 influenza virus detections (sentinel and non-sentinel combined) were reported, of which 249 514 (97.1 %) were type A and 3 292 (1.3 %) were type B viruses; another 4 161 viruses were reported untyped. 

    Of the 56 946 subtyped influenza A viruses (23 % of type A viruses), 20 072 (35 %) were A(H1)pdm09 and 36 874 (65 %) were A(H3). 

    Of the 3 292 reported influenza type B viruses, the lineage for 372 (11 %) was determined as all falling into the B/Victoria/2/87-lineage (B/Victoria).

A(H1N1)pdm09

    For A(H1N1)pdm09 viruses, 25 countries reported 6 636 haemagglutinin (HA) sequences. 

    Of all A(H1N1)pdm09 viruses, the majority belonged to clade 5a.2a.1, newly emerged subclade D.3.1.1 (6 270, 95 %), defined by HA substitutions R113K, A139D, E283K and K302E and which was not represented by any reporting category or reference strain defined for this season. 

    Within the genetic diversification of 5a.2a.1 clade, 340 (5 %) viruses belonged to subclade D.3.1, carrying HA substitutions T216A, T120A, I372V, I460T, V520A and was represented by A/Missouri/11/2025 egg- and cell-based vaccine strains for northern hemisphere 2026-2027 influenza season.

    Among the 838 antigenically characterised A(H1)pdm09 viruses, the main reported categories were A/Missouri/11/2025-like, clade 5a.2a.1(D.3.1) and A/Victoria/4897/2022-like, clade 5a.2a.1(D), representing 44.2 % and 51.1 %, respectively.

    In total, 6 612 A(H1N1)pdm09 viruses were assessed for antiviral susceptibility to oseltamivir and/or zanamivir and/or baloxavir marboxil by 25 countries. 

    Phenotypically assessed reduced and highly reduced inhibition by Oseltamivir was observed for ten (2.3 %) and three (0.7 %) of the 437 tested A(H1N1)pdm09 viruses. 

    Genetic substitutions associated with reduced and highly reduced inhibition by Oseltamivir were observed for 147 (2.4 %, associated with neuraminidase (NA) gene substitutions I223V and S247N mainly, or NA_I223M/T or NA_S247R) and 15 (0.2 %, associated with NA_H275Y or NA_N295S) of the 6 088 assessed viruses, respectively. 

    For Zanamivir, substitutions associated with reduced and highly reduced inhibition were observed for one (<0.1 %, associated with NA_S247R) and one (<0.1%, associated with NA_Q136K) of the 6 089 assessed viruses, respectively. 

    Out of the 4 020 assessed A(H1N1)pdm09 viruses for baloxavir marboxil, substitutions associated with reduced susceptibility were observed for four (0.1 %, associated with polymerase acidic (PA) protein gene substitutions E23G or PA_A37T or PA_E199G/K) viruses.

A(H3N2)

    For A(H3N2) viruses, 25 countries reported 9 538 HA sequences. 

    All A(H3) HA sequences fell into clade 2a.3a.1 and there to seven different subclades. 

    Most viruses (8 808, 92%) fell into newly emerged subclade K (former J.2.4.1) characterised by K2N, S144N (a potential addition of an N-glycosylation site), N158D, I160K, Q173R, T328A and S378N and represented by A/Norway/8765/2025. 

    The remaining 719 A(H3N2) viruses belonged to subclades J.2 (83, 0.9%; which is the NH 2025-26 season vaccine strain represented by A/Croatia/10136RV/2023), J.2.2 (47, 0.5%), J.2.3 (235, 2.5%), J.2.4 (47, 0.5%) and J.2.4.2 (307, 3.2%).

    Among the 1 137 antigenically characterised A(H3) viruses, the main reported categories were A/Croatia/10136RV/2023-like, subclade J.2, A/Singapore/GP20238/2024-like, subclade J.2.4 and A/Norway/8765/2025-like, subclade K, representing 43.3 %, 34.7 % and 10.6 %, respectively.

    In total, 9 441 A(H3N2) viruses were assessed for antiviral susceptibility to oseltamivir and/or zanamivir and/or baloxavir marboxil by 25 countries. 

    Phenotypically assessed reduced inhibition to Oseltamivir was observed for one (0.2%) of the 505 tested A(H3N2), and reduced inhibition to Zanamivir was observed for one (0.2%) of 491 tested A(H3N2) viruses. 

    Genetic substitutions associated with reduced and highly reduced inhibition by Oseltamivir were observed for 19 (0.2%, associated with NA_S331R mainly or NA_K249E or NA_N329R) and three (<0.1%, associated with NA_E119V or NA_del245-248/247-250), respectively, of the 8 869 viruses that could be assessed. 

    Reduced inhibition by Zanamivir was observed for 17 (0.2%, associated with NA_S331R mainly or NA_del245-248/247-250) among the 8 883 viruses that could be assessed. 

    Out of the 5 397 assessed A(H3N2) viruses, substitutions associated with reduced susceptibility for baloxavir marboxil were observed for seven (0.1%, associated with PA_I38L) A(H3N2) viruses.

B/Victoria

    For B/Victoria viruses, 14 countries reported 318 HA sequences. 

    The majority (288, 91%) of the viruses fell in the branch of subclade C.5 defined by D197E, compared with NH 2025-26 vaccine virus B/Austria/1359417/2021_Egg. 

    In that clade, the B/Victoria viruses fell into subclades C.5.6 (126, 40%), C.5.6.1 (89, 28%), C.5.1 (54, 17%) and C.5.7 (18, 6%). 

    Twenty-eight (9%) viruses represented the subclade C.3, where half of them belonged to subclade C.3.1 and half to C.3.3.

    The 21 antigenically characterised B/Victoria viruses were all reported as B/Austria/1359417/2021-like, subclade C.

    None of the 298 genotypically and 14 phenotypically tested B/Victoria viruses showed reduced susceptibility to neuraminidase inhibitors or baloxavir marboxil (when 250 viruses were tested for baloxavir).

Source: European Centre for Disease Control and Prevention, https://www.ecdc.europa.eu/en/publications-data/influenza-virus-characteristics-week-40-2025-week-33-2026-eueea

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#Australia, #H5 avian #influenza events in #wildlife (Dept. of Agriculture, Nov. 6 '26)

 

{Extract}

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Event data

    As of 4pm AEST, 5 November 2026, Australia has 737 confirmed events of H5 bird flu in wildlife.

        § 10 in Western Australia (WA)

        § 342 in South Australia (SA)

        § 80 in New South Wales (NSW)

        § 2 in Queensland (QLD)

        § 249 in Victoria (VIC)

        § 53 in Tasmania (TAS)^

        § 1 in Other Territories#

    {^} Includes events on Macquarie Island

    {#} Jervis Bay Territory (Commonwealth jurisdiction)

{Click on Image to Enlarge}

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Source: Australian Department of Agriculture, https://www.agriculture.gov.au/campaigns/birdflu/latest-data#h1_bird_flu

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