Saturday, August 1, 2026

#Ebola disease caused by #Bundibugyo virus - #DRC (WHO D.O.N., August 1 '26): 3605 cases and 1587 deaths, CFR: 44% in DRC





Situation at a glance

    The Bundibugyo virus disease (BVD) outbreak in the Democratic Republic of the Congo is intensifying, with sustained transmission and continued increases in reported cases and deaths
    
    Initially confined to the Mongbwalu health zone in Ituri Province, over the last two months, the outbreak has expanded to five provinces (Ituri, North Kivu, South Kivu, Haut-Uélé and Tshopo), now affecting 49 health zones

    The outbreak is now the largest Ebola outbreak ever reported in the Democratic Republic of the Congo

    As of 30 July 2026, a total of 3605 confirmed cases, including 1587 deaths, have been reported, corresponding to a crude case fatality ratio (CFR) of 44%. 

    The continued increase in cases, expanding geographic spread, and persistently high mortality underscore the rapidly evolving nature of this public health emergency. 

    During the most recent complete reporting week (epidemiological week 30), the highest weekly number of reported cases (567) and deaths (296) to date were recorded, underscoring the exceptional pace of transmission

    The convergence of insecurity, population displacement and mobility, and cross-border movements complicate response operations and increase the risk of further geographical spread. 

    National authorities in the Democratic Republic of the Congo, in collaboration with WHO and partners, continue to implement extensive response measures, however, a substantial scaling up of response activities is needed to get ahead of the outbreak. 

    A regional preparedness and prioritization framework continues to guide readiness and response activities across the African Region. 

    On 28 July, the Ministry of Health of Uganda declared the end of the BVD outbreak in the country, following 42 days without a new confirmed locally transmitted case after the last confirmed case was discharged from care on 16 June 2026. 

    The most recent imported case was discharged from a treatment centre on 16 July after two negative tests results. 

    Following international guidance WHO will be monitoring the situation for 42 days from this date to ensure no chains of transmission have been missed. 

    Uganda remains at risk of imported cases and re-introduction of BVD, due to ongoing transmission in neighbouring Democratic Republic of the Congo. 

    WHO reiterates the need to maintain heightened surveillance, preparedness and control measures, particularly in view of continued population movement and the risk of cross-border transmission.


Description of the situation

    Since the previous Disease Outbreak News was published on 17 July 2026, additional confirmed cases and deaths have been reported only in the Democratic Republic of the Congo.

    Cumulatively, 3626 confirmed cases have been reported: 3605 in the Democratic Republic of the Congo (including two cases diagnosed in the Democratic Republic of the Congo and subsequently treated in Germany), 20 in Uganda and one in France
    
    A total of 1589 deaths have been reported, including two in Uganda. 

    As of 30 July, at least 651 people in the Democratic Republic of the Congo, and 18 from Uganda have recovered.

    This outbreak is now the largest recorded Ebola virus disease outbreak in the country, surpassing the previous largest outbreak, which occurred from 2018 to 2020, and resulted in 3317 confirmed cases. 

(...)


Democratic Republic of the Congo

    Since 17 July 2026 when the last Disease Outbreak News was published, an additional 1481 confirmed cases, including 759 confirmed deaths, have been reported in the Democratic Republic of the Congo. 

    The increase is in part due to expansion of surveillance activities, enhanced laboratory testing, and diagnostic capacity. However, most of the increase reflects the expansion of the outbreak.

    As of 30 July 2026, a total of 3605 confirmed cases, including 1587 deaths (CFR 44%), have been reported in the Democratic Republic of the Congo. 

    To date, 651 patients have recovered.

    Cases have been reported from 49 health zones (HZ) across five provinces: Ituri (28/36 HZ), North Kivu (11/34 HZ), South Kivu (1/34 HZ), Haut- Uélé (5/13 HZ) and Tshopo (4/23 HZ).[1] An additional HZ, Wanie-Rukula in Tshopo, is awaiting data harmonisation at the health province level.

    Of the 49 affected health zones, the outbreak remains active in 33, with confirmed cases reported within the past seven days. During this period, 641 confirmed cases, including 282 confirmed deaths, were reported.

    Ituri remains the most affected province, accounting for 88% (3176/3605) of all confirmed cases and 82.6% (1311/1587) of reported deaths nationwide. Within the province, the highest number of confirmed cases have been reported from Bunia (880 cases), Rwampara (627 cases), Mongbwalu (541 cases), Nizi (377 cases), Lita (131 cases), and Nyankunde (114 cases) health zones.

    As of 30 July, 17 863 contacts have been identified and are under follow-up across Ituri (11 638), North Kivu (5667), Haut-Uélé (458) and 65 in Tshopo. Of these, 13 455 contacts were under active follow-up, corresponding to follow-up rates of 75.5% in Ituri, 74.6% in North Kivu, 80.6% in Haut-Uélé, and 66.2% in Tshopo. Previously identified contacts in South Kivu have completed the required 21-day follow-up period.

    Infections among health workers continue, with 151 confirmed cases, including 44 deaths (CFR: 29%) and 68 recoveries. These infections highlight ongoing occupational exposure risks, persistent challenges in implementing infection prevention and control (IPC) in health-care facilities, and continued exposure risk in the community.

    The outbreak is occurring in a complex humanitarian and conflict-affected setting, characterized by population displacement, high population mobility, and limited access to essential services, including health care, clean water, food, shelter, and protection.  These conditions increase the risk of disease transmission, including in overcrowded sites for internally displaced persons (IDPs).

    Insecurity and attacks affecting health facilities have hampered response operations in affected provinces, by restricting access for response teams, disrupting surveillance and response activities and increasing the risk of undetected transmission. These challenges underscore the importance of community-centred response efforts led by local authorities and trusted community leaders. 


Figure 2: Number of confirmed cases (n = 3605), in the Democratic Republic of the Congo, by date of reporting, as of 30 July 2026


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{*} Note that the large number of reported cases on 22 July represents the completion of a data reconciliation exercise, including cases that occurred earlier in the outbreak, rather than newly recorded cases.

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Figure 3: Number of deaths among confirmed cases (n = 1587), in the Democratic Republic of the Congo, by date of reporting, as of 30 July 2026


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{*} Note that the large number of reported deaths on 22 July represents the completion of a data reconciliation exercise, including deaths that occurred earlier in the outbreak, rather than newly recorded deaths.


Epidemiology

    Bundibugyo virus disease (BVD) is a severe Ebola disease caused by the Bundibugyo virus, one of the Orthoebolavirus species. It is a zoonotic disease, with fruit bats suspected to be the natural reservoir.

    Human infection is thought to occur through close contact with the blood or secretions of infected wildlife, such as bats or non-human primates, and it subsequently spreads from person-to-person through direct contact with the blood, secretions, organs, or other bodily fluids of infected individuals or contaminated surfaces and materials. Transmission is particularly amplified in health-care settings when IPC measures are inadequate and during unsafe burial practices involving direct contact with deceased individuals.

    The incubation period for BVD ranges from two to 21 days, and infected individuals are not infectious until symptom onset. Early symptoms such as fever, fatigue, muscle pain, headache, and sore throat are non-specific, which complicates clinical diagnosis and can delay detection. These symptoms then progress to gastrointestinal symptoms, organ dysfunction, and, in some cases, haemorrhagic manifestations.

    CFRs in the past two BVD outbreaks, reported in Uganda and in the Democratic Republic of the Congo in 2007 and 2012, were 30% and 50%, respectively.

    Differentiating BVD from other endemic febrile illnesses such as malaria is challenging without laboratory confirmation using PCR or antigen- or antibody-based assays. Outbreak control relies on rapid case identification, isolation and care, contact tracing, safe burials and strong community engagement, as no approved vaccines or specific treatments currently exist for BVD.


Public health response

    Health authorities in the Democratic Republic of the Congo, in collaboration with WHO and partners, continue to implement extensive public health measures, including implementing the continental preparedness and response plan a strategic six-month framework plan designed to guide coordinated efforts to strengthen outbreak response measures, including emergency coordination, disease surveillance, laboratory testing, infection prevention and control, clinical care, community engagement, research, logistics and support for essential health services, engaging donors and mobilizing additional resources to address critical funding gaps and sustain response operations across affected and at-risk areas. A substantial scale-up will be needed in all pillars to get ahead of the outbreak.

    For further information about public health response actions by the respective Ministry of Health, WHO and partners, please refer to the latest situation reports published by the WHO Regional Office for Africa: Ebola Bundibugyo Virus Disease Outbreak Democratic Republic of the Congo | Uganda Weekly External Situation Report | WHO | Regional Office for Africa 


WHO risk assessment

    On 6 June 2026, WHO reassessed the risk of the outbreak of BVD to incorporate newly available information and align with the WHO Temporary Recommendations. The risk for countries sharing land borders with countries with documented Bundibugyo virus detection, the Democratic Republic of the Congo and Uganda at the time of assessment, was separated from the risk for other countries in the African Region.

    The risk in the Democratic Republic of the Congo was assessed as very high due to ongoing transmission and the continued expansion of the outbreak into new health zones, increasing the potential for further national and regional spread.

    The risk in Uganda was assessed as high due to confirmed cross-border spread through imported cases and ongoing epidemiological links along the eastern Democratic Republic of the Congo–western Uganda corridor, which has historically been affected by Ebola outbreaks, including Bundibugyo virus and Sudan virus disease.

    The risk for countries sharing land borders with countries reporting BDBV detection was assessed as high due to sustained population mobility linked to cross-border trade and mining activities, variation in capacities and experience of BVD response, and variable levels of readiness.

    The risk for the rest of the African region and at the global level was assessed as low.

    For further information, please see the WHO Rapid Risk Assessment – Ebola disease caused by Bundibugyo virus, Democratic Republic of the Congo, Uganda and countries with land borders adjoining countries with documented BDBV detection v3.

    An updated Rapid Risk Assessment is currently being developed in advance of the upcoming IHR Emergency Committee meeting regarding the epidemic of Ebola Bundibugyo virus disease scheduled for 18 August. 

(...)

Source: 


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Synergistic #antiviral effect of #Asunaprevir and #Ribavirin in combination against Murray Valley #Encephalitis Virus replication

 


Highlights

    • Renilla luciferase-based MVEV sub-genomic replicon was constructed and applied in antiviral drug evaluation.

    • Removal of Stem Loop I from 3’UTR impairs viral genome replication.

    • Asunaprevir and ribavirin exhibit synergistic antiviral activity against MVEV.

    • A single-round MVEV infectious particle platform was developed.


Abstract

Murray Valley encephalitis virus (MVEV) is a mosquito-borne flavivirus known for causing severe neurological diseases in humans. Despite the rising number of reported infections and high mortality rate among hospitalized patients, no antiviral therapies or licensed vaccines are available. To strengthen preparedness against this reemerging virus, we establish a subgenomic replicon (SGR) platform and a complementary single-round infectious particles (SRIPs) production system, using widely circulating genotype 1 (G1) MVEV as backbone. Stem-loop I(SLI) from 3’UTR stands for the major difference among 4 MVEV genotypes and removal of SLI resulted in mild decrease of genome replication. Through screening a mini anti-flavivirus drug library, we identified that asunaprevir (ASV) and ribavirin (RBV) inhibit MVEV infection independently. Combination of ASV and RBV also showed synergistic activity against MVEV. These results underscore the value of the MVEV replicon system as a versatile tool for evaluating antiviral compounds, supporting the potential of ASV and RBV as a combinatorial therapeutic approach.

Source: 


Link: https://www.sciencedirect.com/science/article/abs/pii/S0166354226001567?via%3Dihub

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A #review of #Bundibugyo virus and the 2026 #outbreak: lessons for #epidemic #preparedness

 


Summary

The ongoing 2026 outbreak of Ebola virus disease caused by Bundibugyo virus (BDBV) in the Democratic Republic of the Congo and Uganda has renewed attention to one of the least studied human-pathogenic orthoebolaviruses. Since its discovery in western Uganda in 2007, only two recognised outbreaks of BDBV had been reported, limiting opportunities to define the epidemiology, pathogenesis, diagnosis, clinical spectrum, and optimal management of BDBV or to develop species-specific countermeasures. The current outbreak, declared a Public Health Emergency of International Concern by WHO on May 17, 2026, has also exposed the gap between scientific innovation and operational readiness. Although pan-filovirus diagnostics, investigational vaccines, therapeutics, and adaptive clinical trial platforms are now available, their deployment has been constrained by delayed diagnosis, limited access to species-inclusive diagnostics, insecurity due to conflict, population displacement, and fragile health systems. In this Review, we synthesise evidence on BDBV from its discovery to the current 2026 outbreak, highlighting advances in epidemiology, clinical management, diagnostics, vaccines, therapeutics, and preparedness. More broadly, the outbreak shows that scientific innovation alone is insufficient; its public health impact depends on integrated, species-inclusive systems capable of rapidly detecting, evaluating, and responding to outbreaks caused by any human-pathogenic Orthoebolavirus spp.

Source: 


Link: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(26)00414-7/fulltext

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History of Mass Transportation: Electroputere V54 Tram in Bucharest


 {Click on Image to Enlarge}

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By Șerban Lăcrițeanu - https://bucurestiulmeudrag.ro/profil/slacriteanu/, Public Domain, https://commons.wikimedia.org/w/index.php?curid=125584381

Source: 


Link: https://en.wikipedia.org/wiki/Electroputere#/media/File:Electroputere_V54_on_Pantelimon_Avenue.jpg

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#USA, #Hawaii: Dept. of Health Confirms Fourth Case Of #Cyclosporiasis (DOH, August 1 '26)

 


    HONOLULU — The Hawaiʻi Department of Health (DOH) has confirmed a case of cyclosporiasis in a member of the military based in Hawaiʻi.

    The individual traveled internationally before returning to Hawaiʻi prior to getting sick

    Based on their travel history, symptom onset and the known incubation period it is not known at this time if the infection was acquired in Hawaiʻi or while traveling. 

    However, at this point in the DOH investigation, there is no evidence that this case changes the risk of cyclosporiasis in Hawaiʻi. 

    The assessment of risk of cyclosporiasis to the public in Hawaiʻi remains low.

    This case brings the total number of confirmed cyclosporiasis cases reported in Hawaiʻi in 2026 to four

    The first case involved a non-resident visitor whose infection also was acquired outside of Hawaiʻi. The next two cases involved two Hawaiʻi residents who traveled internationally.

    Cyclosporiasis is an intestinal illness caused by the microscopic parasite Cyclospora cayetanensis. Eggs of the parasite shed in the feces of infected persons must mature outside the host, in the environment, before they become infectious to another person. 

    People become infected by consuming food or water contaminated with the parasite. In the United States, outbreaks have most often been linked to certain fresh produce items. The illness is not typically spread directly from person to person.

    Symptoms usually begin about one week after exposure but can appear anywhere from two days to two weeks later. 

    The most common symptom is frequent, watery diarrhea. Other symptoms may include loss of appetite, weight loss, stomach cramps or bloating, nausea, increased gas, fatigue and, less commonly, vomiting or low-grade fever. Without treatment, symptoms may last for several weeks or longer and can come and go.

    The DOH routinely investigates reportable diseases to identify potential sources of infection and monitors for any signs of local transmission.

    People can help reduce their risk of cyclosporiasis by:

        ° Washing hands thoroughly with soap and water before preparing or eating food and after using the restroom.

        ° Washing fresh fruits and vegetables under running water before eating, cutting or cooking them.

        ° Following safe food handling practices when preparing meals.

        ° Seeking medical care if they experience prolonged or severe diarrhea, particularly after recent travel or eating fresh produce from an area associated with an outbreak.

    Cyclosporiasis is treatable with prescription antibiotics. Individuals experiencing persistent diarrhea should contact their healthcare provider. Healthcare providers who suspect cyclosporiasis are encouraged to report cases to the DOH and submit appropriate specimens to commercial laboratories for testing.

    The DOH will continue to monitor for additional cases and work closely with healthcare providers and public health partners to protect the health of Hawaiʻi residents and visitors.

(...)

Source: 


Link: https://health.hawaii.gov/news/newsroom/doh-confirms-fourth-case-of-cyclosporiasis/

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Friday, July 31, 2026

#Thrombotic and #cerebrovascular events following #SARS-CoV-2 #vaccination: an umbrella #review of systematic reviews and meta-analyses

 


Abstract

Rare thrombotic and cerebrovascular events have been reported after SARS-CoV-2 vaccination, raising safety concerns. This umbrella review synthesizes evidence from 19 systematic reviews and meta-analyses examining thrombotic outcomes, including acute ischemic stroke and cerebral venous sinus thrombosis, across different vaccine platforms. Methodological quality was assessed using AMSTAR-2, and findings were synthesized by outcome and platform. Evidence consistently shows that thrombotic and cerebrovascular events following vaccination are rare. mRNA vaccines (BNT162b2, mRNA-1273) were not associated with increased risk beyond background population rates. Adenoviral vector vaccines (ChAdOx1 nCoV-19, Ad26.COV2.S) were linked to a rare syndrome of vaccine-induced immune thrombotic thrombocytopenia, most commonly presenting as cerebral venous sinus thrombosis in younger adults. Evidence for whole-virus vaccines was limited but did not indicate consistent safety concerns. Across all platforms, thrombotic risk was substantially lower than that from SARS-CoV-2 infection. Overall, vaccination benefits outweigh risks, highlighting the importance of ongoing surveillance and transparent communication.

Source: 


Link: https://www.nature.com/articles/s41541-026-01550-5

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Expedition #cruises, island hopping, and #zoonotic #risk: #governance and operational lessons from the MV #Hondius #Andes hantavirus outbreak

 


Abstract

The Andes orthohantavirus outbreak linked to the MV Hondius expedition cruise illustrates how a probable land-based zoonotic exposure can become a multinational public health event when it intersects with enclosed shipboard environments, delayed clinical recognition, remote navigation, medical evacuation, and international passenger dispersal. Although hantavirus infection is classically associated with exposure to infected rodents or contaminated environments, Andes virus is exceptional among orthohantaviruses because limited person-to-person transmission has been documented, particularly after close and prolonged contact. This Perspective uses the MV Hondius outbreak as an analytical case study to identify governance and operational gaps in expedition-era travel medicine. Existing International Health Regulations, WHO ship-event guidance, and ECDC recommendations provide essential foundations for coordination, notification, isolation, and contact tracing; however, this outbreak exposed expedition-specific gaps in safe port access, medical evacuation, onboard recognition of nonspecific febrile illness, diagnostic escalation, passenger traceability, and post-disembarkation monitoring. We therefore propose an accountability-oriented One Health preparedness model that operationalizes existing guidance through route-level risk assessment, exposure-history assessment, onboard syndromic surveillance, isolation and telemedicine triggers, reference-laboratory pathways, port-of-call agreements, auditable passenger and excursion records, and cross-border post-travel monitoring. The central lesson is not that expedition cruises, birdwatching, or ecological tourism are inherently unsafe, but that their expanding geographic reach requires binding, auditable, and expedition-specific outbreak protocols before passengers embark.

Source: 


Link: https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1892006/full

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#USA, #Wastewater Data for Avian #Influenza #H5 (CDC, July 31 '26)

 


{Excerpt}

(...)

A(H5) detections in the past week

Time Period: July 19, 2026 - July 25, 2026

    -- A(H5) Detection4 site(s) (0.9%)

    -- No Detection427 site(s) (99.1%)

    -- No samples81 site(s)


{Click on Image to Enlarge}

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(...)

Source: 


Link: https://www.cdc.gov/wastewater/emerging-viruses/h5.html?

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#USA, #Oregon: Avoid #contact with #bats to reduce #rabies exposure risk (Dept. of Health, July 31 '26)

 


July 30, 2026


    PORTLAND, Ore.—Oregon Health Authority (OHA) and the Oregon Department of Fish and Wildlife (ODFW) are urging people to prevent exposure to rabies while highlighting the importance of bats and other wildlife to the state’s ecosystems.

    So far, 22 bats have tested positive for rabies in 2026, according to OHA data. That means the state has matched – and is poised to surpass – its record for the number of bats that test positive for rabies in a single year. Bats have carried the rabies virus in their populations for thousands of years and are well known to carry rabies today, but generally at a very low level. Nevertheless, they account for the most human exposures to the virus more than any other species in the U.S.

    The highest number of animals testing positive for rabies since 2000 was in 2006, when 22 bats and two foxes were found to be carrying the disease. In 2023, 20 bats tested positive for the virus.

    Emilio DeBess, DVM, public health veterinarian at OHA’s Public Health Division, said the more contact someone has with bats, the higher the risk of exposure to rabies.

    “Unfortunately, when people find a dead or dying bat, they may pick it up with their hands because they want to help it, or maybe they’re just curious,” DeBess said. “When a bat or other wild animal is sick or dying with rabies, there’s an increased chance they will bite or transmit the virus in other ways.”

    Colin Gillin, DVM, ODFW state wildlife veterinarian, agrees that bats and other wildlife rarely bite people but may do so if they are sick or feel threatened. Oregon bats, in particular, eat only insects—about 1,000 insects every hour—and avoid people.

    “Bats provide important ecosystem services in Oregon, but also globally with insect control, seed dispersal, and pollination of specific plants, supporting agriculture and forest systems,” Gillin said. “And like many animals that can carry disease, bats can also prevent or suppress disease by reducing mosquitoes and other vectors that carry human and animal pathogens.”


    ° What to do if you find a bat

        § Bats are protected wildlife, which makes it illegal to harm or keep them. If you see a bat that appears to be sick:

            * Stay calm, do not touch it, and keep people and pets away.

            * When the sick or dead bat is indoors, do not release the bat. It may have exposed someone or a pet to rabies. If it is safe to do so, place a container or box over the bat.

           * When the sick or dead bat is outdoors and may have exposed someone to rabies, cover it with a box or bucket to keep it in place, if safe to do so. Finding a dead bat does not require any action unless someone was bitten or scratched before the bat died.

            * Contact your local health authority or veterinarian for your area right away to discuss potential exposures to humans or pets.

            * If there are multiple sick or dead bats observed in an area, report it to ODFW.

        § When a person or pet has been bitten or scratched by an animal that may have rabies, report this exposure immediately to your local animal regulation services or local public health authority. Seek medical care immediately from a medical provider or veterinarian.

            * Teach children to avoid all contact with bats and other wildlife.

            * Avoid bats seen in the wild, such as while hiking.

            * Make sure your dog or cats' vaccinations are up to date, whether they are indoor or outdoor pets.

            * Unvaccinated pets that come into contact with a bat may be quarantined for up to four months, or euthanized.

            * Protect your home from bats by covering vents, chimneys, and other entry points with screens.

            * If you have roosting (nesting) bats living in your attic or other areas of your house, call a wildlife control operator (WCO). ODFW is unable to respond to homeowner requests for bat removal.

(...)

Source: 


Link: https://www.oregon.gov/oha/ERD/Pages/Avoid-contact-with-bats-to-reduce-rabies-exposure-risk.aspx

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#UK, Sharp rise in #cyclospora #infections linked to #Mexico #travel (UKHSA, July 31 '26)

 


    The UK Health Security Agency (UKHSA) has published new data showing a sharp rise in cyclospora infections among travellers returning from Mexico.

    UKHSA is advising all travellers to take precautions when travelling abroad including maintaining good food and water hygiene to reduce their risk of infection.

    Cyclospora is a parasite that causes explosive diarrhoea. Contaminated food specifically herbs, salad and soft fruit are common sources of outbreaks and infections. Infection is acquired via consumption of contaminated food. Cyclospora doesn’t naturally occur in the UK and there is no risk of spread from person to person.

    Symptoms of infection can include frequent watery diarrhoea, abdominal cramping, bloating, nausea, flatulence, low-grade fever, loss of appetite and weight loss. While cyclosporiasis is usually mild and most people improve typically in a few days without any treatment, infections can be more serious or prolonged in people who are immunocompromised and antibiotics may be prescribed.

    The latest data, published today, shows that 67 cases have been reported in returning travellers in England (30 cases) Wales and (10 cases) Scotland (27 cases) between 30 April and 15 July 2026; a sharp rise this year when compared to the annual average of 93 cases recorded between 2022 and 2025.

    Travel information is available for 52 out of the 67 cases; of these, 48 reported travel to Mexico, with one also reporting travel to the USA. One further case reported travel to the USA only, and one to Kenya.

    Among those who travelled to Mexico, cases reported staying at a range of different hotels in the Riviera Maya and Cancún regions and consuming a variety of food and drink as part of all-inclusive holiday packages. Further investigations around the cases are ongoing.

    UKHSA anticipates a continued rise in travel-associated cases linked to increased summer travel to Mexico and a potential increase in cases linked to travel to the USA, where a widespread outbreak has been reported.

    Dr Philip Veal, Consultant in Travel Health at UKHSA, said:

        ''We have recently detected a rise in Cyclospora infections among travellers returning from Mexico. These infections are caused by a parasite and can affect the stomach and intestines.

        ''Travellers to Mexico and other areas where the infection is more common can reduce their risk by following good food and water hygiene measures, including drinking bottled water and eating thoroughly cooked food, even when staying in high-end all-inclusive resorts. We also advise avoiding certain foods such as fresh uncooked berries and herbs, unpeeled fruit and salad items.

        ''If you develop symptoms after returning from travel, such as watery diarrhoea, loss of appetite, weight loss, stomach cramps or pain, bloating, increased wind, nausea, fatigue or other flu-like symptoms, please seek medical attention and inform your healthcare professional of your travel history.

        ''The TravelHealthPro website has more information on the steps you can take to keep yourself and your family well.

(...)

Source: 


Link: https://www.gov.uk/government/news/sharp-rise-in-cyclospora-infections-linked-to-mexico-travel

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Seasonal #surveillance in #humans in 2026 for West Nile virus (#WNV) (ECDC, July 31 '26): 158 cases so far of which 94 from #Italy

 


{Summary}

Week 31, 2026 | Produced on 30 July 2026 at 12:00, based on data submitted up until and including 29 July 2026.


Current situation

    ° Since the beginning of the 2026 transmission season, and as at 29 July, 49 areas affected by West Nile virus (WNV) have been identified in seven countries across Europe.

    ° These areas are located in: 

        § Italy (30), 

        § Greece (eight), 

        § Romania (four), 

        § France (two), 

        § North Macedonia (two), 

        § Spain (two) and 

        § Germany (one).

    ° The seven countries have reported 158 locally acquired human cases of WNV infection: 

        § Italy has reported 94

        § Greece 42

        § North Macedonia seven

        § Spain seven

        § Romania five

        § France two and 

        § Germany one case.

    ° This week, 14 areas are reported as affected for the first time this season. The affected areas identified as at 29 July 2026 are listed in Table 1 and shown in Map 1 below.

(...)


{Click on Image to Enlarge}

__

{In Yellow, areas already affected since the beginning of the season.}

{In Red, areas newly affected this week.}

__

Source: 


Link: https://www.ecdc.europa.eu/en/west-nile-fever/surveillance-and-disease-data/disease-data-ecdc

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Pre-existing and Cross-Reactive #Immunity to Avian #Influenza #H5N1 in #Humans: Implications for #Pandemic #Risk and Vaccine Strategies

 


Highlights

    ° Evidence of cross-reactive antibodies to H5N1 in humans.

    ° Seasonal influenza may induce partial H5N1 cross-protection.

    ° H5N1 clade 2.3.4.4b shows expanded host range and spread.

    ° Role of viral glycoproteins in immune cross-reactivity.

    ° Implications of baseline immunity for H5N1 pandemic risk.


Abstract

Due to the continuous evolution of Influenza A viruses (IAVs), novel strains with efficient human-to-human transmission may emerge and cause future pandemics. Among these, highly pathogenic avian influenza (HPAI) H5N1 remains a major concern because of its impact on wildlife, livestock, and human health. The widespread circulation of H5N1 clade 2.3.4.4b, detected in hundreds of bird species and numerous mammals worldwide, highlights important changes in viral ecology and transmission, increasing its zoonotic and pandemic potential. This review summarizes current evidence on cross-reactive and cross-protective immunity to H5N1 in humans, focusing primarily on humoral immune responses. We examine the presence of pre-existing H5N1-reactive antibodies in individuals without known exposure and discuss how previous seasonal influenza infection or vaccination may contribute to their development. Particular attention is given to antibodies targeting conserved regions of hemagglutinin (HA), especially the stalk domain, as well as neuraminidase (NA), which may provide heterosubtypic protection. We also evaluate the ability of seasonal influenza vaccines and infections to induce cross-reactive responses against H5N1 and their potential role in partial protection or immune priming. Finally, we review current and emerging H5N1 vaccination strategies, including adjuvanted and mRNA-based platforms, and identify priorities for surveillance, population immunity assessment, and the development of broadly protective influenza vaccines.

Source: 


Link: https://www.journalofinfection.com/article/S0163-4453(26)00148-9/fulltext

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