ETIDIOH - NEW

Abstract Objective :  The objective is to examine the epidemiology and clinical features of human cases infected with H5N6 avian influenza in Sichuan Province from 2014 to 2024, and to offer guidance for the prevention and management of human infections with H5N6 avian influenza. Methods :  Epidemiological survey reports of H5N6 avian influenza cases in Sichuan Province from 2014 to 2024 were compiled, and the epidemiological context and characteristics of 16 human cases infected with H5N6 avian influenza in the province were summarized and analyzed using descriptive epidemiological methods. Results :  From 2014, when the initial human case of H5N6 infection was documented in Sichuan Province, to 2024, there have been 16 human cases of H5N6 avian influenza in the region, resulting in 12 fatalities and a case fatality rate of 75%. The instances were predominantly located in the Chengdu Plain, eastern Sichuan, and southern Sichuan. Conclusion :  Human instances of H5N6...

  Director General Rafael Mariano Grossi has welcomed today’s announcements regarding the situation in Iran and stressed the need for a resumption of the IAEA’s indispensable safeguards verification work in the country following a 12-day military conflict that severely damaged several of its nuclear sites . In a letter to Iranian Foreign Minister Dr Abbas Araghchi , Director General Grossi also proposed that they meet soon. “Resuming cooperation with the IAEA is key to a successful diplomatic agreement to finally resolve the dispute over Iran’s nuclear activities. I’ve written to Foreign Minister Araghchi stressing the importance of us working together and proposing to meet soon,” he said. IAEA inspectors have remained in Iran throughout the conflict and are ready to start working as soon as possible, going back to the country’s nuclear sites and verifying the inventories of nuclear material – including more than 400 kg of uranium enriched to 60% - which they last verified a few da...

{Excerpt} Epi-Week 25 2025 Avian influenza A(H9N2) :  - Henan Province :  -- 1) A 52-year-old woman with onset on May 10, 2025.  - Hunan Province :  -- 2) A 72-year-old woman with onset on May 14, 2025.  - Sichuan Province :  --3) A six-year-old boy with onset on May 14, 2025. Avian influenza A(H10N3) :  - Shaanxi Province :  -- 1) A 70-year-old woman with onset on April 21, 2025.  (...) Source: Centre for Health Protection, Hong Kong PRC SAR,  https://www.chp.gov.hk/files/pdf/2025_avian_influenza_report_vol21_wk25.pdf ____

Abstract The ongoing outbreak of highly pathogenic avian influenza virus (HPAIV) subtype H5N1 in the U.S. poses a significant public health threat. To date, 70 human cases have been confirmed in the United States , including two severe cases and one fatality. While suitable animal models are crucial for predicting the potential pandemic risk of newly emerging pathogens in humans, studies investigating contemporary HPAIV H5N1 transmission dynamics remain limited. Here, we investigated the pathogenicity and transmission efficiency of three recent clade 2.3.4.4b H5N1 viruses isolated from a bovine, mountain lion, and a human case using Syrian hamsters . Intranasal inoculation with 104 TCID50 resulted in productive virus replication in the respiratory tract and shedding for all three isolates. Transmission studies showed limited efficiency via direct contact and airborne routes for all three isolates. Although overall transmission was inefficient , the human H5N1 isolate demonstrated relat...

  PHNOM PENH, June 24 (Xinhua) -- A 41-year-old woman from northwestern Cambodia's Siem Reap province has been confirmed for H5N1 human avian influenza, raising the number of cases to seven so far this year , the Ministry of Health said in a statement Monday night. "A laboratory result from the National Institute of Public Health showed on June 23 that the woman was positive for H5N1 virus," the statement said. "The patient has the symptoms of fever, cough, and dyspnea , and she is currently in critical condition ," it added. According to queries, there were sick and dead chickens at the patient's home and her neighbor's homes, and the patient had been in contact with sick and dead chickens and cooked them for food five days before she felt ill. Health authorities are looking into the source of the infection and are examining any suspected cases or people who have been in contact with the victim in order to prevent an outbreak in the community. Tamiflu (...