ETIDIOH - NEW

  Radiation levels in the Gulf region remain normal following the 12-day conflict that severely damaged several nuclear facilities in Iran , Director General Rafael Mariano Grossi of the International Atomic Energy Agency (IAEA) said today. Citing regional data reported regularly to the IAEA through the International Radiation Monitoring System (IRMIS), Director General Grossi noted that this 48-nation network would have detected an important radioactive release from any damaged nuclear power reactor. “From a nuclear safety perspective, Iran’s Bushehr Nuclear Power Plant and the Tehran Research Reactor represented our main concern as any strike affecting those facilities – including their off-site power lines – could have caused a radiological accident with potential consequences in Iran as well as beyond its borders in the case of the Bushehr plant. It did not happen, and the worst nuclear safety scenario was thereby avoided,” Director General Grossi said. Stressing again that nuc...

Abstract Background/Objectives : H5N1 influenza viruses are spreading worldwide and threaten global public health. Preparedness is necessary to mitigate the worst-case scenario should an H5N1 influenza pandemic occur and justify the development of vaccines against circulating H5N1 viruses of concern.  Methods :  The production and characterization of egg-based split and inactivated H5Nx of three distinct monovalent antigens from clades 2.3.4.4b, 2.3.2.1c, and 2.3.4 were performed at an industrial scale. These antigens were formulated and their immune responses, when combined or not with IB160 squalene-based oil-in-water emulsion adjuvant in a rat model, were evaluated in a one- or two-dose immunization schedule. IgG antibodies, hemagglutination inhibitions, and microneutralization titers were measured for vaccine-induced immunity and cross-reactivity.  Results :  Three monovalent vaccines from clades 2.3.4.4b, 2.3.2.1c, and 2.3.4 were produced at an industrial scale ...

{Summary) KEY FIGURES   {Area - Number of reported confirmed cases - Number of deaths among confirmed cases - Number of reporting countries} -- Global (1 Jan – 31 May 2025)* - 24 672 - 82 - 75  Key countries (01 Jan – 22 June 2025) - Democratic Republic of the Congo - 12 208 - 22 - ... - Uganda - 5636 - 31  - ... - Sierra Leone - 4294 - 28 - ... - Burundi - 1079 - 0 - ... {*} Most recent global surveillance data available. Highlights • In May 2025, a total of 6823 confirmed mpox cases and 16 deaths (Case Fatality Ratio: 0.2%) were reported from 49 countries across all WHO regions. • The majority of mpox cases continue to be reported from the WHO African Region , with 18 countries currently experiencing active ongoing transmission. • Since the last report, Ethiopia and Italy have reported their first cases of mpox due to clade Ib monkeypox virus (MPXV). In addition, North Macedonia, the Republic of the Congo, and Togo have reported their first cases of mpox clade IIb MPXV ...

Abstract The ongoing spread of highly pathogenic avian influenza H5N1 clade 2.3.4.4b virus in animals and occasional spillover to humans have raised concerns about a potential H5N1 pandemic. Although recent studies have shown that pre-existing human antibodies can recognize H5N1 neuraminidase , there is a lack of molecular understanding of how this cross-reactivity develops. Using a phage display antibody library derived from 245 healthy donors , this study isolates an antibody, known as HB420 , that cross-reacts with the neuraminidases of human H3N2 and avian H5N1 clade 2.3.4.4b viruses and confers protection in vivo. Cryo-EM analysis shows that HB420 targets the neuraminidase active site by mimicking sialic acid binding through a single Asp residue. Additionally, the inferred germline of HB420 is N2-specific but acquires cross-reactivity to H5N1 neuraminidase through somatic hypermutations . Overall, our findings provide insights into how neuraminidase antibody evolves breadth, which...

  {Excerpts} Time Period: June 15, 2025 - June 21, 2025 - H5 Detection :  3 sites ( 0.8% ) - No Detection :  367 sites ( 99.2% ) - No samples in last week :  55 sites (...) Source: US Centers for Disease Control and Prevention,  https://www.cdc.gov/bird-flu/h5-monitoring/index.html ____

Highlights •  Antiviral susceptibility to NA inhibitors and PA inhibitor baloxavir was determined for seasonal and zoonotic influenza viruses circulating globally during 2020–2023. •  Low global frequencies (0.1-0.2%) of seasonal influenza viruses with reduced or highly reduced inhibition by NAI inhibitors were observed as in previous years. •  Low global frequencies of seasonal influenza viruses (∼ 0.1%) with reduced susceptibility to baloxavir were observed, with the rate in Japan elevated (3.3%) in 2022–2023, as has been seen previously. •  For zoonotic viruses, 2.7% contained genetic markers associated with reduced or highly reduced inhibition to NA inhibitors and none contained markers associated with reduced susceptibility for baloxavir. •  For the treatment of influenza , NA inhibitors and baloxavir remain suitable. ABSTRACT Antiviral susceptibility of influenza viruses is monitored by the World Health Organization Global Influenza Surveillance and Respon...