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  Ukraine’s Zaporizhzhya Nuclear Power Plant (ZNPP) has lost all off-site power for the ninth time during the military conflict and now relies on emergency diesel generators for the electricity it needs, underlining the extremely fragile nuclear safety situation at the site , IAEA Director General Rafael Mariano Grossi said today. The plant’s connection to its last remaining 750 kilovolt (kV) power line was cut at 17:37 local time today. While the cause was not immediately known, it coincided with air raid alarms in the region, Director General Grossi said, citing information from the Ukrainian nuclear regulator. It was the first time the ZNPP suffered a complete loss of off-site power since 2 December 2023. The IAEA team based at the site , Europe’s largest nuclear power plant (NPP), reported that 18 emergency diesel generators immediately started operating to generate the electricity the plant needs to be able to cool the reactors and the spent fuel pools . The plant has diesel f...

Abstract The emergence of highly pathogenic avian influenza (HPAI) A(H5N1), clade 2.3.4.4b, genotype B3.13 in U.S. dairy cattle marks a significant shift in the virus' host range and epidemiological profile. Infected cattle typically exhibit mild clinical signs, such as reduced milk production, mastitis and fever, with morbidity generally below 20% and mortality averaging 2%. Transmission within farms is primarily driven by contaminated milk and milking procedures , while farm‐to‐farm spread is mainly linked to cattle movement and shared equipment . The virus demonstrates high replication in mammary glands , with infected cows shedding large quantities of virus in milk for up to 3 weeks, even in the absence of clinical signs. Shedding through other routes appears limited. Infected cattle develop virus‐specific antibodies within 7–10 days , offering short‐term protection, though the duration and robustness of immunity remain unclear. Between March 2024 and May 2025, the virus was co...

Abstract On 08 December 2024, the World Health Organization (WHO) reported an outbreak of Disease X in the Panzi Health Zone, Kwango province, Democratic Republic of the Congo (DRC). This unknown pathogen , with 406 cases and 31 deaths at the time of its declaration, predominantly affects children under 5 years. Disease X, hypothesised to be a zoonotic ribonucleic acid (RNA) virus , poses significant challenges because of limited healthcare infrastructure, gaps in risk communication and ineffective community engagement . This opinion article aims to explore these challenges and advocate for the urgent need for culturally tailored, inclusive communication strategies that foster trust and empower local communities in responding to outbreaks. Key approaches highlighted include mobilising local leaders, utilising mobile laboratories for decentralised diagnostics and improving sample collection techniques. Drawing on lessons from previous epidemics, such as COVID-19 and Ebola, this article ...

Summary Background Clade I monkeypox virus is endemic in DR Congo. We aim to describe the epidemiological trends of the cocirculating subclades Ia and Ib mpox outbreaks in Kinshasa, DR Congo. Methods This retrospective observational study included suspected and laboratory-confirmed mpox cases reported between Jan 1, 2023, and Oct 31, 2024, in Kinshasa. Skin lesion swabs or blood samples were collected as part of a routine countrywide mpox surveillance programme. To confirm the diagnosis of mpox, all samples were tested at the Institut National de Recherche Biomédicale (INRB) using real-time PCR. Whole-genome sequencing was conducted for phylogenomic analysis and assessment of APOBEC3 type mutations. Samples that remained unassigned to subclade Ia or Ib after whole-genome sequencing and real-time PCR were labelled as an unknown subclade. Findings As part of routine disease surveillance, 1479 suspected mpox cases were reported in Kinshasa. Samples were collected from 1314 suspected mpox ...

Abstract As of 20 May, the US Department of Agriculture (USDA) has confirmed highly pathogenic avian influenza (HPAI) in more than 173.1 million birds since the outbreak began in January 2022. The secretary of the US Department of Health and Human Services, Robert Kennedy Jr., has suggested allowing the unmitigated spread of HPAI in turkeys and chickens to identify surviving birds—a sentiment supported by Brooke Rollins, secretary of the USDA , which, along with state-level departments of agriculture, has jurisdiction over animal disease outbreaks (1). This approach would be dangerous and unethical . Allowing a highly lethal, rapidly evolving, and contagious virus to run a natural course of infection in poultry would lead to unnecessary suffering of poultry and put other susceptible animals on and near affected farms at risk . It would prolong exposure for farmworkers , which could increase viral adaptation and transmission risks for poultry, other peridomestic animals, and humans. Sou...

Abstract Background Avian influenza is an infectious disease of birds caused by the influenza A virus, which can infect a variety of domestic,wild birds and even cross the species barrier and infect humans.To understand the contamination of avian influenza virus in the external environment of poultry in Huzhou City from 2017 to 2023 and to assess the risk of human infection with avian influenza. Methods A total of 3,400 environmental specimens from five types of venues in Huzhou City were collected and tested for influenza A virus nucleic acid using fluorescent reverse transcription polymerase chain reaction (RT-PCR). Results From 2017 to 2023, with 15.44% overall positive rate of influenza A virus . The predominant subtype of avian influenza virus was H9 (accounting for 54.67%). The peak of positive influenza virus detection rates occurred in winter and spring seasons every year. The venue with highest positive rate was poultry slaughtering and processing plants (41.83%), followed by ...