#Host #cell entry and #neutralisation sensitivity of the emerging #SARS-CoV-2 #variant #LP.8.1

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Novel SARS-CoV-2 variants continue to emerge, driving waves of COVID-19. The evolution of SARS-CoV-2 took a surprising turn in 2023 with the emergence of BA.2.86, a BA.2-descendant harbouring multiple spike (S) protein mutations, enhancing antibody evasion. Subsequently, several BA.2.86-derived lineages emerged, with JN.1 dominating early and the JN.1-derived variants KP.3.1.1 and XEC dominating late in 2024. Currently, LP.8.1 is on the verge of becoming dominant. This study provides a preliminary virological characterisation of LP.8.1 and its sublineage LP.8.1.1.

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Source: Lancet Infectious Diseases, https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00113-6/fulltext?rss=yes

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