Skip to main content

Clinical #Features of #Human #Parvovirus B19-Associated #Encephalitis Identified in the #Dakar Region, #Senegal, and Viral Genome Characterization

Image
By G.M.

Abstract

Neurological manifestations associated with human parvovirus B19 (B19V) infections are rare and varied. Acute encephalitis and encephalopathy are the most common, accounting for 38.8% of all neurological manifestations associated with human B19V. Herein, we report on the clinical features of 13 laboratory-confirmed human cases of B19V-associated encephalitis in Senegal in the framework of a hospital-based surveillance of acute viral encephalitis conducted from 2021 to 2023. Overall, B19V was detected from 13 cerebrospinal fluid samples using specific real time PCR. The mean age was 16.7 years among B19V-positive patients, with a higher prevalence in 0–5-year-old children and the sex ratio (male/female) was 2.25. The B19V-positive patients mainly exhibited hypoleukocytosis, normal glycorrhachia, and normal proteinorrachia in the cerebrospinal fluid. While the main neurological symptoms included meningeal and infectious syndromes. Furthermore, three complete B19V genome sequences were successfully characterized using next-generation sequencing. The newly characterized sequences belonged to the genotype 1a and represent, to date, the first complete B19V genome sequences from Senegal. These sequences could be useful not only in future phylodynamic studies of B19V but also in the development of prevention or treatment countermeasures. Our study is noteworthy for the identification of acute B19V-associated encephalitis in Senegal More investigations on the risk factors associated with B19V transmission in Africa are warranted.

Source: Viruses, https://www.mdpi.com/1999-4915/17/1/111

_____

Labels:

Comments

Post a Comment

Popular posts from this blog

#USA, Two more #human cases of #H5N1 #birdflu reported in #California

By G.M.
Two cases of bird flu have been reported in San Joaquin County, California, local health officials said. According to a press release issued Friday and reported by the Sacramento Bee , health officials with San Joaquin County Public Health Services said both cases were farm workers who were exposed to infected animals . Both people are showing mild symptoms and are recovering, officials said, adding that there are 34 total confirmed cases across California. In a warning posted on Facebook, health officials said bird flu was “spreading in several farms such as poultry and cattle” and urged residents to take precautions to prevent the spread of the disease. Precautions include the use of protective equipment when handling poultry, dairy cattle or other animals that may be infected, and when handling raw and unpasteurized milk. (...) There are currently 60 confirmed cases of bird flu in the country . While most of the cases are in California , other states with confirmed cases include Col...
Post a Comment
Read more »

Viral #sepsis: #diagnosis, clinical #features, #pathogenesis, and #clinical considerations

By G.M.
Abstract Sepsis , characterized as life-threatening organ dysfunction resulting from dysregulated host responses to infection , remains a significant challenge in clinical practice . Despite advancements in understanding host-bacterial interactions , molecular responses, and therapeutic approaches, the mortality rate associated with sepsis has consistently ranged between 10 and 16%. This elevated mortality highlights critical gaps in our comprehension of sepsis etiology. Traditionally linked to bacterial and fungal pathogens, recent outbreaks of acute viral infections , including Middle East respiratory syndrome coronavirus ( MERS-CoV ), influenza virus, and severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ), among other regional epidemics, have underscored the role of viral pathogenesis in sepsis, particularly when critically ill patients exhibit classic symptoms indicative of sepsis. However, many cases of viral-induced sepsis are frequently underdiagnosed because standar...
Post a Comment
Read more »