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#Thermal #tolerance and #inactivation of #Ebola virus

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By G.M.

{Summary}

HIGHLIGHTS

• The investigation demonstrated a high level of tolerance of EBOV to thermal disinfection.

• A water-bath is recommended and the tubes should be fully submerged during the process.

• The established inactivation guidelines should be followed very strictly.


Dear Editor,

Viruses of the genus Orthoebolavirus cause sporadic outbreaks of severe haemorrhagic fever, with case fatality rates ranging from 25% to 90% (Mahanty and Bray, 2004). Six species of the virus (Orthoebolavirus zairense, sudanense, bundibugyoense, taiense, restonense, and bombaliense) have so far been identified (Biedenkopf et al., 2023). Among these, Orthoebolavirus zairense, commonly known as Ebola virus (EBOV), stands out as the most virulent. Given its high contagiousness and lethality, EBOV must be manipulated under biosafety level 4 (BSL-4) conditions, as stipulated by the National Health Commission of the People's Republic of China's list of human pathogenic microorganisms. Prior to being removed from a BSL-4 laboratory, it is imperative that infectious EBOV undergoes complete inactivation. Here we systematically evaluate viral thermostability under BSL-4 containment conditions, demonstrating EBOV’s marked thermotolerance.

(...)

Source: Virologica Sinica, https://www.sciencedirect.com/science/article/pii/S1995820X25000975

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