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Showing posts from July 22, 2025

#ACE2-like enzymatic activity in #COVID19 #convalescents with persistent pulmonary symptoms associated with #immunoglobulin

ABSTRACT Many difficult-to-understand clinical features characterize COVID-19 and post-acute sequelae of COVID-19 (PASC or long COVID [LC]). These can include blood pressure instability, hyperinflammation, coagulopathies , and neuropsychiatric complaints . The pathogenesis of these features remains unclear. The SARS-CoV-2 Spike protein receptor-binding domain (RBD) binds angiotensin converting enzyme 2 (ACE2) on the surface of host cells to initiate infection. We hypothesized that some people convalescing from COVID-19 may produce anti-RBD antibodies that resemble ACE2 sufficiently to have ACE2-like catalytic activity , that is, they are ACE2-like proteolytic abzymes that may help mediate the pathogenesis of COVID-19 and LC . In previous work, we showed that some people with acute COVID-19 had immunoglobulin-associated ACE2-like proteolytic activity , suggesting that some people with COVID-19 indeed produced ACE2-like abzymes . However, it remained unknown whether ACE2-like abzymes wer...

#China, two additional #human cases of #infections with #influenza A #H9N2 reported (#HK CHP, July 22 '25)

  {Excerpt} Avian influenza A(H9N2) :  -- Guangdong Province : - 1) An individual with onset on May 28, 2025.  -- Hubei Province :  - 2) An individual with onset on June 21, 2025.  (...) Source: Centre for Health Protection, Hong Kong PRC SAR,  https://www.chp.gov.hk/en/resources/29/332.html ____

#WHO #operations compromised following #attacks on warehouse and #facility sheltering #staff and #families in Deir al Balah, #Gaza

  WHO condemns in the strongest terms the attacks on a building housing WHO staff in Deir al Balah in Gaza, the mistreatment of those sheltering there, and the destruction of its main warehouse . Following intensified hostilities in Deir al Balah after the latest evacuation order issued by Israeli military, the WHO staff residence was attacked three times today.  Staff and their families, including children , were exposed to grave danger and traumatized after airstrikes caused a fire and significant damage.  Israeli military entered the premises , forcing women and children to evacuate on foot toward Al-Mawasi amid active conflict .  Male staff and family members were handcuffed, stripped, interrogated on the spot, and screened at gunpoint .  Two WHO staff and two family members were detained .  Three were later released , while one staff member remains in detention.  Thirty-two people , including women and children, were collected and evacuated to the...