ETIDIOH - NEW

 {Excerpt} KINSHASA, Dec. 21 (Xinhua) -- The Democratic Republic of the Congo (DRC) is grappling with a deadly illness of unknown origin that has claimed dozens of lives in a province, prompting investigations and heightened alertness as test results are awaited. "This is, therefore, influenza, which has been formally identified," Patrick Muyaya, spokesperson for the DRC government, announced at a national television broadcast late Friday as he read the minutes of the Council of Ministers meeting chaired by President Felix Tshisekedi in Kinshasa, the country's capital, earlier that day. During the meeting, Public Health Minister Roger Kamba said that since October, 592 cases of the illness have been recorded in the Panzi health zone of the southwestern Kwango province . Symptoms exhibited by patients are "similar to the flu," according to Kamba, who noted that the outbreak coincides with the seasonal flu period, which peaks in December. Laboratory analysis revea...

 {Excerpt} The outbreak of an undiagnosed disease in DR Congo, reported by WHO on Dec 8, 2024,1 is a pressing global health concern that demands swift and coordinated action. As of Dec 5, 406 cases and 31 deaths have been reported in the Panzi health zone in Kwango province, with influenza-like symptoms and anaemia. Most affected individuals are children aged younger than 5 years , many of whom are severely malnourished . The remoteness of the region and poor infrastructure complicate the identification of the pathogen, with suspicions that multiple diseases could be contributing to these cases . Furthermore, the outbreak has the potential to transcend regional boundaries, particularly as DR Congo shares porous borders with Angola , where provinces such as Uige are vulnerable to cross-border transmission. Mobility between these regions could facilitate the spread of the disease to neighbouring African countries, raising the potential for a Public Health Emergency of International C...

Abstract On 30 January 2024, China announced the first human case of H10N5 influenza infection . Prior to this, human cases of H10N7 and H10N8 had been reported. It is now appropriate to re-examine the evolution and future epidemiological trends of the H10 and N5 subtypes of avian influenza viruses (AIVs). In this study, we analyzed the reassortment characteristics of the first human-derived H10N5 AIV (A/Zhejiang/ZJU01/2023), as well as the evolutionary dynamics of the wild bird-derived H10 and N5 subtypes of AIVs over the past decade. Our findings indicate that the human-derived H10N5 AIV exhibited low pathogenicity . A/bean_goose/Korea/KNU-10/2022(H10N7) and A/mallard/Novosibirsk_region/962k/2018(H12N5) were identified as the potential reassortment parents. The virus has existed since 2022 and several isolations have been reported in Bangladesh . Phylogenetic analysis showed that H10Ny and HxN5 AIVs in China are clustered differently based on the East Asian-Australian (eastern) and C...

  Source: WikiArt,  https://www.wikiart.org/en/pieter-bruegel-the-elder/yawning-man-disputed-attribution-1563 {Public Domain} _____

Abstract Central nervous system (CNS) infections caused by SARS-CoV-2 are uncommon. This case report describes the clinical progression of a 92-year-old female who developed a persistent neuroinfection associated with SARS-CoV-2. The patient initially presented with progressive fatigue , catarrhal symptoms , and a fever (38.6 °C). Initial laboratory findings revealed hypoxemia (O2 saturation 79.8%), acidosis (pH 7.3), an elevated C-reactive protein (CRP) level of 14.8 mg/L, and a high D-dimer level (2.15 µg/mL). Nasopharyngeal (NP) antigen and RT-PCR tests confirmed SARS-CoV-2 infection, and an NP swab also detected penicillin- and ampicillin-resistant Staphylococcus aureus . She was admitted for conservative management , including oxygen supplementation , IV fluids, and prophylactic anticoagulation. Subsequently, she developed neurological symptoms — lethargy, discoordination, and impaired communication —without signs of meningism . Cerebrospinal fluid (CSF) analysis identified SARS-C...

Abstract The repeated emergence of pandemic viruses underscores the linkages between land-use change and wildlife disease , and urban-adapted wildlife are of special interest due to their close proximity to humans . However, viral diversity within urban-adapted species and their zoonotic potential remain largely unexplored. We compiled a large dataset on seven priority urban-adapted mammal species and their viruses covering over 115 countries from 1574 to 2023. These urban-adapted species host 286 virus species spanning 24 orders and 38 families , 14 of which are potentially high risk for human infection. Raccoons carried the most high-risk viruses, while raccoon dogs had increased viral positivity in urban habitats compared to raccoons, wild boars , and red foxes . Many viruses in urban-adapted species were phylogenetically related to those found in humans, and we also observed evidence of possible viral spillback . These results highlight zoonotic risks associated with urban-adapted ...

Abstract Since late 2021, a panzootic of highly pathogenic H5N1 avian influenza virus has driven significant morbidity and mortality in wild birds, domestic poultry, and mammals. In North America , infections in novel avian and mammalian species suggest the potential for changing ecology and establishment of new animal reservoirs . Outbreaks among domestic birds have persisted despite aggressive culling, necessitating a re-examination of how these outbreaks were sparked and maintained. To recover how these viruses were introduced and disseminated in North America, we analyzed 1,818 Hemagglutinin (HA) gene sequences sampled from North American wild birds, domestic birds and mammals from November 2021-September 2023 using Bayesian phylodynamic approaches. Using HA, we infer that the North American panzootic was driven by ~8 independent introductions into North America via the Atlantic and Pacific Flyways , followed by rapid dissemination westward via wild, migratory birds. Transmission w...

Abstract Influenza A viruses (IAVs) initially infect a few host cells , and the infection subsequently spreads to neighboring cells . However, the molecular mechanisms underlying this expansion remain unclear. Here, we show that IAV infection upregulates the frequency of intercellular calcium wave propagations (iCWPs) that mediate the spread of IAVs. ADP released from initially infected cells mediated iCWPs via the P2Y1 receptor. The generation of iCWPs and spread of viral infection were inhibited by a P2Y1 antagonist. Enhanced endocytosis in the surrounding cells that received ADP signaling upregulated viral entry. Expression of IAV matrix protein 2 (M2) in initially infected cells triggered iCWPs through ADP diffusion, thereby increasing infection, whereas an ion permeability-deficient mutation of M2 or inhibition of its ion channel activity suppressed iCWPs. Therefore, intercellular calcium signaling is essential for early expansion and potential establishment of IAV infection, whic...

The Iowa Department of Health and Human Services (Iowa HHS) is reporting the first human case of avian influenza A(H5) in the state .  The individual was exposed to infected poultry while working with a commercial flock in northwest Iowa .  The individual reported mild symptoms , has received appropriate treatment and is recovering .  The case was identified through testing at the State Hygienic Laboratory and confirmed by the Centers for Disease Control and Prevention (CDC). As of December 20, 2024, the CDC has reported 64 confirmed human cases of H5 HPAI across nine states. The majority of the exposures are linked to infected poultry or dairy cows.  There is no evidence that human-to-human transmission of influenza A(H5) is occurring in the U.S. Although human infections are rare{!} , the virus is spread through prolonged exposure around infected flocks and herds, through the eyes, nose or mouth. Any individuals with direct contact who develop flu-like symptoms or ...

Exposure Source [ State -  Exposure Associated with Commercial Agriculture and Related Operations: Dairy Herds (Cattle) - Poultry Farms and Culling Operations - Other Animal Exposure† - Exposure Source Unknown‡ - State Total ] 1) California -  35 - 0 - 0 - 1 -  36 {+2} 2)  Colorado -  1 - 9 - 0 - 0 -  10 3) Louisiana -  0 - 0 - 1 - 0 -  1 {+1}  4) Michigan -  2 - 0 - 0 - 0 -  2 5) Missouri -  0 - 0 - 0 - 1 -  1 6) Oregon -  0 - 1 - 0 - 0 -  1 7) Texas -  1 - 0 - 0 - 0 -  1 8) Washington -  0 - 11 - 0 - 0 -  11 9) Wisconsin -  0 - 1 - 0 - 0 -  1 {+1} --  Source Total -  39 - 22 - 1 - 2 -  64 {+3} NOTE : One additional case was previously detected in a poultry worker in Colorado in 2022. † Exposure was related to...

Summary The purpose of this guidance is to outline CDC's recommendations for preventing exposures to highly pathogenic avian influenza (HPAI) A(H5N1) viruses, infection prevention and control measures including the use of personal protective equipment , testing, antiviral treatment , patient investigations , monitoring of exposed persons (including persons exposed to sick or dead wild and domesticated animals and livestock with suspected or confirmed infection with highly pathogenic avian influenza (HPAI) A(H5N1) virus), and antiviral chemoprophylaxis of exposed persons. These recommendations are based on available information and will be updated as needed when new information becomes available. (...) Source: US Centers for Disease Control and Prevention,  https://www.cdc.gov/bird-flu/prevention/hpai-interim-recommendations.html _____

Abstract During the 2023–2024 winter, 11 high pathogenicity avian influenza (HPAI) outbreaks caused by clade 2.3.4.4b H5N1 and H5N6 HPAI viruses were confirmed in Japanese domestic poultry among 10 prefectures (n = 10 and 1, respectively). In this study, we aimed to genetically and pathologically characterize these viruses. Phylogenetic analysis revealed that H5N1 viruses were classified into the G2d-0 genotype , whereas the H5N6 virus was a novel genotype in Japan, designated as G2c-12. The G2c-12 virus shared PB2, PB1, PA, HA, and M genes with previous G2c viruses , but had NP and NS genes originating from avian influenza viruses in wild birds abroad. The N6 NA gene was derived from an H5N6 HPAI virus that was different from the viruses responsible for the outbreaks in Japan in 2016–2017 and 2017–2018. Experimental infections in chickens infected with H5N1(G2d-0) and H5N6(G2c-12) HPAI viruses showed no significant differences in the 50% chicken lethal dose, mean death time, or virus ...

ABSTRACT Neutralizing antibodies (nAbs) are important for the treatment of emerging viral diseases and for effective vaccine development. In this study, we generated and evaluated three nAbs (1H9, 2D7, and C4H4) against H7N9 influenza viruses and found that they differ in their ability to inhibit viral attachment, membrane fusion, and egress . We resolved the cryo-electron microscopy (cryo-EM) structures of H7N9 hemagglutinin (HA) alone and in complex with the nAb antigen-binding fragments (Fabs) and identified the HA head-located epitope for each nAb, thereby revealing the molecular basis and key residues that determine the differences in these nAbs in neutralizing H7N9 viruses. Moreover, we found that the humanized nAb CC4H4 provided complete protection in mice against death caused by a lethal H7N9 virus infection, even when nAb was given 3 days after the mice were infected. These findings provide new insights into the neutralizing mechanism and structural basis for the rational desi...

 {Summary} Situation at a glance On 20 December 2024, after two consecutive incubation periods (total of 42 days) since the second negative PCR test was conducted on 7 November for the last confirmed Marburg case, and without a new confirmed case reported , the Ministry of Health of Rwanda declared the end of the Marburg virus disease (MVD) outbreak , as per the WHO recommendations.  The outbreak had been declared on 27 September 2024 .  As of 19 December 2024, 66 confirmed cases,15 deaths with a case fatality ratio ( CFR) of 23%, and 51 recovered cases have been reported.  The last confirmed case was reported on 30 October 2024 .  WHO through its country office and development partners provided technical and financial support to the government to contain this outbreak.  The risk of re-emergence of MVD still remains even after the official declaration of the end of the outbreak, linked to viral persistence in body fluids (mostly semen) of recovered patients...

 {Excerpt} Influenza at the human-animal interface   Summary and risk assessment, from 2 November to 12 December 2024   • New human cases : From 2 November to 12 December 2024, the detection of influenza A(H5) virus in 16 humans and influenza A( H9N2 ) virus in nine humans were reported officially.   • Circulation of influenza viruses with zoonotic potential in animals: High pathogenicity avian influenza (HPAI) events in poultry and non-poultry continue to be reported to the World Organisation for Animal Health (WOAH). The Food and Agriculture Organization of the United Nations (FAO) also provides a global update on avian influenza viruses with pandemic potential.   • Risk assessment : Based on information available at the time of the risk assessment, the overall public health risk from currently known influenza viruses at the human-animal interface has not changed remains low . Sustained human to human transmission has not been reported from these eve...

Assessment based on data as of 18 November 2024   12 December 2024  Key points   At the present time , based on available information , FAO-WHO-WOAH assess the global public health risk of influenza A(H5N1) viruses to be low , while the risk of infection for occupationally exposed persons is low to moderate depending on the risk mitigation measures in place and the local avian influenza epidemiological situation.  Transmission between animals continues to occur and, to date, a growing yet still limited number of human infections are being reported.  Although additional human infections associated with exposure to infected animals or contaminated environments are expected to occur, the overall public health impact of such infections at a global level, at the present time, is minor .  This risk assessment from FAO, WHO, and WOAH updates the assessment of the risk of zoonotic transmission (for example, animal to human) considering additional information made a...

 {Excerpt} Time Period: December 08 - December 14, 2024 H5 Detection : 49 sites (14.5%) No Detection : 288 sites (85.5%) No samples in last week : 35 sites (...) Source: US Centers for Disease Control and Prevention,  https://www.cdc.gov/bird-flu/h5-monitoring/index.html _____

{Excerpt} Three confirmed cases and one probable influenza A(H5) case were reported to CDC this week .  To date, human-to-human transmission of influenza A(H5) virus has not been identified in the United States . Two of these confirmed cases were reported by the California Department of Public Health. The cases occurred in a workers aged ≥18 years at a commercial dairy cattle farm in an area where highly pathogenic avian influenza (HPAI) A(H5N1) viruses had been detected in cows. The individuals had mild symptoms , which they reported to local health department officials. There have now been 34 total confirmed cases and one probable case in California. The other confirmed case was reported by the Louisiana Department of Health. This case occurred in an individual aged ≥18 years . This individual developed respiratory symptoms during week 48 and was hospitalized with their illness. A respiratory specimen was collected at the healthcare facility and tested positive for influenza A, b...

 A wild Eurasian Lynx in Troms Og Finnmark. Source: WOAH,  https://wahis.woah.org/#/in-review/6117 _____

 Forty Southern elephant seal (WILD), Sealion Island. Source: WOAH,  https://wahis.woah.org/#/in-review/6118 _____