#Coronavirus Disease Research #References (by AMEDEO, June 14 '25)

Antiviral Res

CHANG CW, Oswal N, Murugan M, Goldgirsh K, et al
A novel cellular tool for screening human pan-coronavirus antivirals.
Antiviral Res. 2025 Jun 10:106212. doi: 10.1016/j.antiviral.2025.106212.
PubMed Abstract available

Clin Infect Dis

LEE R, Kim N, Kim WB, Im KI, et al
Effectiveness and safety of Autologous Virus-Specific T Cell Therapy for Persistent COVID-19 in People with Immunocompromise: A Clinical Trial Study.
Clin Infect Dis. 2025 Jun 10:ciaf302. doi: 10.1093.
PubMed Abstract available

SUDNIK P, Walsh EE, Branche AR, Islam M, et al
Comprehensive Analysis of Cardiovascular Events and Risk Factors in Patients Hospitalized with RSV.
Clin Infect Dis. 2025 Jun 12:ciaf310. doi: 10.1093.
PubMed Abstract available

Int J Infect Dis

WEE LE, Ho RWL, Lim JT, Chiew CJ, et al
Long-term multi-systemic sequelae post-hospitalization for Omicron COVID-19 versus influenza: a retrospective cohort study.
Int J Infect Dis. 2025 Jun 9:107946. doi: 10.1016/j.ijid.2025.107946.
PubMed Abstract available

J Infect

BUTLER CC, Hobbs FDR, Little P, Richards D, et al
Ivermectin and COVID-19.
J Infect. 2025 Jun 8:106530. doi: 10.1016/j.jinf.2025.106530.
PubMed

J Med Virol

PEREZ-COZAR F, Cal-Sabater P, Rybakowska P, Arribas-Rodriguez E, et al
High-Dimensional Immunophenotyping of Post-COVID-19 and Post-Influenza Patients Reveals Persistent and Specific Immune Signatures After Acute Respiratory Infection.
J Med Virol. 2025;97:e70435.
PubMed Abstract available

FERNANDEZ-DE-LAS-PENAS C, Arendt-Nielsen L, Gil-Crujera A, Gomez-Sanchez SM, et al
ACE1 rs1799752 Polymorphism Is not Associated With the Presence of Post-COVID-19 Condition.
J Med Virol. 2025;97:e70438.
PubMed

J Virol

COTTIGNIES-CALAMARTE A, Marteau F, He F, Belouzard S, et al
Direct pharmacological AMPK activation inhibits mucosal SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy flux and the type I IFN response.
J Virol. 2025 Jun 12:e0039425. doi: 10.1128/jvi.00394.
PubMed Abstract available

LIU M, Aryal B, Niu X, Wang Q, et al
Engineering a recombination-resistant live attenuated vaccine candidate with suppressed interferon antagonists for PEDV.
J Virol. 2025 Jun 12:e0045125. doi: 10.1128/jvi.00451.
PubMed Abstract available

MORGAN AL, Vu MN, Zhou Y, Lokugamage KG, et al
The furin cleavage site is required for pathogenesis, but not transmission, of SARS-CoV-2.
J Virol. 2025 Jun 10:e0046725. doi: 10.1128/jvi.00467.
PubMed Abstract available

FOSTER CSP, Walker GJ, Jean T, Wong M, et al
Long-term serial passaging of SARS-CoV-2 reveals signatures of convergent evolution.
J Virol. 2025 Jun 9:e0036325. doi: 10.1128/jvi.00363.
PubMed Abstract available

LOKUGAMAGE KG, Zhou Y, Alvarado RE, Plante JA, et al
Convergent evolution in nucleocapsid facilitated SARS-CoV-2 adaptation for human infection.
J Virol. 2025 Jun 12:e0209124. doi: 10.1128/jvi.02091.
PubMed Abstract available

LI C, Shi Y, Xie C, Duan K, et al
GSDMD and GSDME exhibit distinct roles in enteric coronavirus PDCoV-induced pyroptosis and inflammatory responses.
J Virol. 2025 Jun 12:e0187624. doi: 10.1128/jvi.01876.
PubMed Abstract available

HARRIS C, Kapingidza AB, San JE, Christopher J, et al
Design of SARS-CoV-2 RBD immunogens to focus immune responses toward conserved coronavirus epitopes.
J Virol. 2025 Jun 13:e0046525. doi: 10.1128/jvi.00465.
PubMed Abstract available

JAMA

GOSTIN LO, Reiss D, Offit PA
Changed Recommendations for COVID-19 Vaccines for Children and Pregnant Women: A Failure of Process, Policy, and Science.
JAMA. 2025 Jun 13. doi: 10.1001/jama.2025.10658.
PubMed

ZETTLER PJ, Cha S, Despres S, Lurie P, et al
FDA Review of Novavax's COVID-19 Vaccine-Regulatory Integrity and Deviations From Standard Practice.
JAMA. 2025 Jun 9. doi: 10.1001/jama.2025.9898.
PubMed

Lancet Infect Dis

URIU K, Okumura K, Uwamino Y, Chen L, et al
Virological characteristics of the SARS-CoV-2 NB.1.8.1 variant.
Lancet Infect Dis. 2025 Jun 6:S1473-3099(25)00356.
PubMed

GUO C, Yu Y, Liu J, Jian F, et al
Antigenic and virological characteristics of SARS-CoV-2 variants BA.3.2, XFG, and NB.1.8.1.
Lancet Infect Dis. 2025 Jun 5:S1473-3099(25)00308.
PubMed

N Engl J Med

MCINTYRE L, Fergusson D, McArdle T, English S, et al
A Crossover Trial of Hospital-Wide Lactated Ringer's Solution versus Normal Saline.
N Engl J Med. 2025 Jun 12. doi: 10.1056/NEJMoa2416761.
PubMed Abstract available

Zhonghua Jie He He Hu Xi Za Zhi

CHEN T, Xu ZJ
[Recomment of the correctly understand and standardize the use of terms and concepts related to interstitial lung disease].
Zhonghua Jie He He Hu Xi Za Zhi. 2025;48:589-591.
PubMed Abstract available

#Neuroinvasive #Oropouche virus in a patient with #HIV from extra-Amazonian #Brazil

{Excerpt} A novel reassortant Oropouche virus (OROV) lineage (with medium [M], large [L], and small [S] RNA segments : M1L2S2) has driven Brazil's largest and most geographically widespread OROV epidemic , expanding beyond the endemic Amazon basin to establish local transmission across multiple Brazilian states and other previously unaffected Latin American countries . The rapid spread of this lineage underscores its evolutionary potential and reinforces its significance as a public health threat .1 Similar to chikungunya and Zika viruses, expanding arboviruses can exhibit unexpected clinical and epidemiological shifts , including vertical transmissions , neuroinvasive effects, and potentially fatal outcomes.2–4 Although OROV typically causes self-limited febrile illness, accumulating clinical and experimental evidence suggests neurotropic potential .5 This Correspondence describes the first confirmed case of neuroinvasive OROV infection caused by the emergent M1L2S2 lineage in ext...

No evidence of immune #exhaustion after repeated #SARS-CoV-2 #vaccination in vulnerable and healthy populations

Abstract Frequent SARS-CoV-2 vaccination in vulnerable populations has raised concerns that this may contribute to T cell exhaustion , which could negatively affect the quality of immune protection. Herein, we examined the impact of repeated SARS-CoV-2 vaccination on T cell phenotypic and functional exhaustion in frail older adults in long-term care (n = 23), individuals on immunosuppressive drugs (n = 10), and healthy adults (n = 43), in Canada . Spike-specific CD4+ and CD8+ T cell levels did not decline in any cohort following repeated SARS-CoV-2 vaccination, nor did the expression of exhaustion markers on spike-specific or total T cells increase. T cell production of multiple cytokines (i.e. polyfunctionality) in response to the spike protein of SARS-CoV-2 did not decline in any cohort following repeated vaccination. None of the cohorts displayed elevated levels of terminally differentiated T cells following multiple SARS-CoV-2 vaccinations. Thus, repeated SARS-CoV-2 vaccination was...

Chimeric #hemagglutinin and #M2 #mRNA #vaccine for broad #influenza subtype protection

Abstract Since multiple and unpredicted influenza viruses cause seasonal epidemics and even high-risk pandemics , developing a universal influenza vaccine is essential to provide broad protection against various influenza subtypes. Combined with the mRNA lipid nanoparticle-encapsulated (mRNA-LNP) vaccine platform and chimeric immunogen strategy , we developed a novel cocktail mRNA vaccine encoding chimeric HAs (cH5/1-BV, cH7/3) and intact M2 (termed Fluaxe), which confers broad protection against major circulating IAVs and IBVs , as well as highly pathogenic avian influenza . Two-dose intramuscular immunization of Fluaxe in mice elicited cross-reactive neutralizing antibodies , T cell responses, and long-lived immunity, resulting in robust protection against multiple lethal influenza virus infections and severe acute lung injuries . In particular, intramuscular administration stimulated systemic immunity together with a prominent lung tropism of memory cells . Moreover, Fluaxe immuniza...

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