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Showing posts from August 6, 2025

#Influenza and Other Respiratory Viruses Research #References (by AMEDEO, August 6 '25)

  BMJ WISE J RFK Jr bans thiomersal from influenza vaccines in "safety" move. BMJ. 2025;390:r1576. PubMed          Epidemiol Infect KELLY GE, Petti S, Noah N Excess respiratory, circulatory, neoplasm, and other mortality rates during the Covid-19 pandemic in the EU and their implications. Epidemiol Infect. 2025;153:e86. PubMed           Abstract available Eur J Epidemiol ORTQVIST AK, Soderling J, Magnus MC, Urhoj SK, et al COVID-19 infection increases the risk of venous thromboembolism during pregnancy and the postpartum period. Eur J Epidemiol. 2025;40:779-788. PubMed           Abstract available BAUMKOTTER R, Yilmaz S, Chalabi J, Ten Cate V, et al Risk tools for predicting long-term sequelae based on symptom profiles after known and undetected SARS-CoV-2 infections in the population. Eur J Epidemiol. 2025;40:789-801. PubMed         ...

#Coronavirus Disease Research #References (by AMEDEO, August 6 '25)

  Am J Respir Crit Care Med MATTHAY MA, Zhou H, Sarma A, Alipanah-Lechner N, et al Treatment with Allogenic Mesenchymal Stromal Cells for Moderate to Severe Acute Respiratory Distress Syndrome: A Double-Blind, Placebo-controlled, Multi-Center, Phase 2b Clinical Trial (STAT). Am J Respir Crit Care Med. 2025 Jul 29. doi: 10.1164/rccm.202411-2254. PubMed           Abstract available Ann Intern Med FELDMAN CH, Santacroce L, Bassett IV, Thaweethai T, et al Social Determinants of Health and Risk for Long COVID in the U.S. RECOVER-Adult Cohort. Ann Intern Med. 2025 Jul 29. doi: 10.7326/ANNALS-24-01971. PubMed           Abstract available Antiviral Res PATEL D, De R, Azadi N, Lee S, et al Discovery of broad-spectrum antivirals targeting viral proteases using in silico structural modeling and cellular analysis. Antiviral Res. 2025;241:106245. PubMed           Abstract avai...

Analysis of the metagenomic assembled #genome of #MERS-CoV and Alpha-CoV from #Camelus dromedarius in #Saudi Arabia

Abstract Background Dromedary camels are known carriers of Middle East respiratory syndrome coronavirus (MERS-CoV). This study aimed to identify respiratory RNA viruses circulating in the nasal cavities of camels that could potentially cause disease in humans. Methods Shotgun metagenomic paired-end sequencing was performed on four pools of nasal swabs collected from 40 camels originating from Sudan and Djibouti, using the MiSeq platform. Results Alphacoronavirus 229E was commonly detected in the camel pools. MERS-CoV was found in both pools from Sudan and one from Djibouti . Camel parainfluenza virus 3 (PIV3) was detected in the male camel pool from Sudan . Furthermore, near-complete (99.9 %) metagenomic assembled genomes (MAGs) of alphacoronavirus 229E (SIAU MAG01) and MERS-CoV (SIAU MAG02) were retrieved from the female camel pool from Sudan . Another MAG of alphacoronavirus 229E (SIAU MAG03) was recovered from a male camel pool imported from Sudan . In the phylogenetic analysis, SIA...

Attachment #Patterns of Avian #Influenza #H5 Clade 2.3.4.4b Virus in Respiratory Tracts of Marine #Mammals, North #Atlantic Ocean

Abstract Highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b virus infections have caused substantial mortality events in marine mammals in recent years. We hypothesized that the high number of infections and disease severity could be related to cell tropism in respiratory tracts . Therefore, we examined the attachment pattern of an H5N1 clade 2.3.4.4b virus (H52022) as a measure for cell tropism in the respiratory tracts of harbor seals, gray seals, harbor porpoises, and bottlenose dolphins and compared it with an H5N1 clade 2.1.3.2 virus (H52005) and a human seasonal H3N2 virus using virus histochemistry. Both H5 viruses attached abundantly to olfactory and respiratory mucosa in the upper respiratory tract of both seal species. H52022 attached more abundantly than H52005 to epithelial cells in the lower respiratory tract of all species. The observed attachment possibly explains the susceptibility of marine mammal species for recent H5N1 viruses and the observed development of se...